149882-10-0 (勒托替康,11H-1,4-Dioxino[2,3-g]pyrano[3',4':6,7]indolizino[1,2-b]quinoline-9,12(8H,14H)-dione,8-ethyl-2,3-dihydro-8-hydroxy-15-[(4-methyl-1-piperazinyl)methyl]-, (8S)-)

CAS号:
149882-10-0
中文名称:
勒托替康
英文名称:
11H-1,4-Dioxino[2,3-g]pyrano[3',4':6,7]indolizino[1,2-b]quinoline-9,12(8H,14H)-dione,8-ethyl-2,3-dihydro-8-hydroxy-15-[(4-methyl-1-piperazinyl)methyl]-, (8S)-
分子式:
C28H30N4O6
分子量:
518.561007022858
简介:
Lurtotecan (GI147211; OSI-211) 是一种半合成喜树碱类似物,是一种拓扑异构酶 I (topoisomerase I) 抑制剂。Lurtotecan 具有抗癌作用。

勒托替康(149882-10-0)名称与标识符

名称

中文别名:
勒托替康;
英文别名:
11H-1,4-Dioxino[2,3-g]pyrano[3',4':6,7]indolizino[1,2-b]quinoline-9,12(8H,14H)-dione,8-ethyl-2,3-dihydro-8-hydroxy-15-[(4-methyl-1-piperazinyl)methyl]-, (8S)-;11H-1,4-Dioxino[2,3-g]pyrano[3',4':6,7]indolizino[1,2-b]quinoline-9,12(8H,14H)-dione,8-ethyl-2,3-dihydro-8-hydroxy-15-[(4-met;11H-1,4-Dioxino[2,3-g]pyrano[3',4':6,7]indolizino[1,2-b]quinoline-9,12(8H,14H)-dione,8-ethyl-2...;Lurtotecan;(7-(4-methylpiperazinomethylene)-10,11-ethylenedioxy-20(S)-camptothecin);11H-1,4-Dioxino(2,3-g)pyrano(3',4':6,7)indolizino(1,2-b)quinoline-9,12(8H,14H)-dione,8-ethyl-2,3-dihydro-8-hydroxy-15-((4-methyl-1-piperazinyl)methyl)-,(8S);7-[(4-methylpiperazino)methyl]-10,11-(ethylenedioxy)-(20S)-camptothecin;GG 211;NX 211;OSI-211;Osi 211;Gi 147211;Lurtotecan [inn];RVFGKBWWUQOIOU-NDEPHWFRSA-N;11H-1,4-Dioxino(2,3-G)pyrano(3',4':6,7)indolizino(1,2-B)quinoline-9,12(8H,14H)-dione, 8-ethyl-2,3-dihydro-8-hydroxy-15-((4-methyl-1-piperazinyl)methyl)-, (8S)-;A936765;CHEMBL341028;DB12222;BDBM50036130;MS-29621;NS00071655;4J1L80T08I;OSI211;7-(4-methylpiperazinomethylene)-10,11-ethylenedioxy-20(S)-camptothecin;NX211 cpd;HY-13670;SCHEMBL19208;Gl147211C;CHEMBL305666;D-MYO-INOSITOL2,4,5-TRISPHOSPHATE,HEXAAMMONIUMSALT;11H-1,4-DIOXINO(2,3-G)PYRANO(3',4':6,7)INDOLIZINO(1,2-B)QUINOLINE-9,12(8H,14H)-DIONE, 8-ETHYL-2,3-DIHYDRO-8-HYDROXY-15-((4-METHYL-1-PIPERAZINYL)METHYL)-, (S);GI-147211;GI147211;(18S)-18-ethyl-18-hydroxy-2-[(4-methylpiperazin-1-yl)methyl]-6,9,20-trioxa-13,24-diazahexacyclo[12.11.0.03,12.05,10.015,24.017,22]pentacosa-1,3,5(10),11,13,15,17(22)-heptaene-19,23-dione;LURTOTECAN [WHO-DD];CS-0007547;149882-10-0;UNII-4J1L80T08I;GG 211; GI 147211; Lurtotecan; NX 211; OSI 211;8-ethyl-8-hydroxy-15-(4-methylhexahydro-1-pyrazinylmethyl)-(8S)-2,3,8,9,12,14-hexahydro-11H-[1,4]dioxino[2,3-g]pyrano[3'',4'':6,7]indolizino[1,2-b]quinoline-9,12-dione with trifluoroaceticacid;GG-211;GL-147211C;(S)-8-Ethyl-8-hydroxy-15-((4-methylpiperazin-1-yl)methyl)-2,3,11,14-tetrahydro-12H-[1,4]dioxino[2,3-g]pyrano[3',4':6,7]indolizino[1,2-b]quinoline-9,12(8H)-dione;(S)-8-ethyl-8-hydroxy-15-((4-methylpiperazin-1-yl)methyl)-11,14-dihydro-2H-[1,4]dioxino[2,3-g]pyrano[3',4':6,7]indolizino[1,2-b]quinoline-9,12(3H,8H)-dione;GW-211;Gl 147211C;GG211;(8S)-8-ETHYL-2,3-DIHYDRO-8-HYDROXY-15-((4-METHYL-1-PIPERAZINYL)METHYL)-11H-P-DIOXINO(2,3-G)PYRANO(3',4':6,7)INDOLIZINO(1,2-B)QUINOLINE-9,12(8H,14H)-DIONE;NX-211;Q6704977;DTXSID30164422;(18S)-18-ethyl-18-hydroxy-2-((4-methylpiperazin-1-yl)methyl)-6,9,20-trioxa-13,24-diazahexacyclo(12.11.0.0^(3,12).0^(5,10).0^(15,24).0^(17,22))pentacosa-1(14),2,4,10,12,15,17(22)-heptaene-19,23-dione;(18S)-18-ethyl-18-hydroxy-2-[(4-methylpiperazin-1-yl)methyl]-6,9,20-trioxa-13,24-diazahexacyclo[12.11.0.0^{3,12}.0^{5,10}.0^{15,24}.0^{17,22}]pentacosa-1(14),2,4,10,12,15,17(22)-heptaene-19,23-dione;DA-75160;DTXCID6086913;lurtotecanum;

标识符

InChIKey:
RVFGKBWWUQOIOU-NDEPHWFRSA-N
Inchi:
1S/C28H30N4O6/c1-3-28(35)20-11-22-25-18(14-32(22)26(33)19(20)15-38-27(28)34)17(13-31-6-4-30(2)5-7-31)16-10-23-24(12-21(16)29-25)37-9-8-36-23/h10-12,35H,3-9,13-15H2,1-2H3/t28-/m0/s1
SMILES:
O1C([C@](CC)(C2C=C3C4C(CN3C(C=2C1)=O)=C(C1C=C2C(=CC=1N=4)OCCO2)CN1CCN(C)CC1)O)=O

勒托替康(149882-10-0)物化性质

实验特性

  • LogP : 1.47400
  • PSA : 106.36000
  • 折射率 : 1.73
  • 沸点 : 844.8°Cat760mmHg
  • 闪点 : 464.7°C
  • 颜色与性状 : Solid powder
  • 密度 : 1.5

计算特性

  • 精确分子量 : 518.21700
  • 氢键供体数量 : 1
  • 氢键受体数量 : 10
  • 可旋转化学键数量 : 3
  • 同位素质量 : 518.216535
  • 重原子数量 : 38
  • 复杂度 : 1070
  • 同位素原子数量 : 0
  • 确定原子立构中心数量 : 1
  • 不确定原子立构中心数量 : 0
  • 确定化学键立构中心数量 : 0
  • 不确定化学键立构中心数量 : 0
  • 共价键单元数量 : 1
  • 疏水参数计算参考值(XlogP) : 0.3
  • 互变异构体数量 : 无
  • 表面电荷 : 0
  • 拓扑分子极性表面积 : 105

勒托替康(149882-10-0)推荐厂家 更多厂家(7)

公司名称手机号/电话联系人QQ微信询单
北京索莱宝科技有限公司 18101056239
010-50973130
龚思雨 3193328036
询单
上海瀚思化工有限公司 18939883912
021-34536277
顾经理 3003949364
询单
上海麦克林生化科技股份有限公司 15221275939
021-50706066
沈经理 269348414
询单
上海源溪生物科技有限公司 13564518121李经理 1724405207 询单
上海源叶生物科技有限公司 15026964105
15026964105
汤思磊 2881489226
询单
上海赛可锐生物科技有限公司 13003271654
021-58000709
赛可锐生物 3004122151
询单
上海阿拉丁生化科技股份有限公司 13167063860
13167063860
阿拉丁 3004013043
询单

勒托替康(149882-10-0)相关文献