17342-08-4 ((S)-( )-5-羟甲基-2-吡咯烷酮,(5S)-5-(hydroxymethyl)pyrrolidin-2-one)

_100%

反应条件：

1.1 Reagents: Sodium borohydride Solvents: Ethanol , Water

参考文献：

Synthesis of Novel Heterocyclic Compounds as Potential Pharmaceuticals

Bhattacharya, Kaberi, 1991, , ,

合成路线：1 步

98-79-3

_100%

反应条件：

1.1 Reagents: Methanol , Thionyl chloride ; 2 h, -15 °C
1.2 Reagents: Sodium borohydride Solvents: Ethanol ; 12 h, 0 °C

参考文献：

Asymmetric intramolecular crossed-benzoin reactions by N-heterocyclic carbene catalysis

Enders, Dieter; Niemeier, Oliver; Balensiefer, Tim, Angewandte Chemie, 2006, 45(9), 1463-1467

合成路线：1 步

_100%

反应条件：

1.1 Reagents: Sodium borohydride Solvents: Methanol , Tetrahydrofuran ; -10 °C; < 5 °C; 1 h, < 5 °C
1.2 Reagents: Hydrochloric acid Solvents: Water ; pH 2, 0 °C; 0 °C → rt; 3 h, rt

参考文献：

Stereoselective synthesis of trans-threo-trans-oligopyrrolidines: Potential agents for RNA cleavage

Arndt, Hans-Dieter; Welz, Ruediger; Mueller, Sabine; Ziemer, Burkhart; Koert, Ulrich, Chemistry - A European Journal, 2004, 10(16), 3945-3962

合成路线：1 步

_100%

反应条件：

1.1 Reagents: Sodium borohydride Solvents: Ethanol

参考文献：

Stereoselective synthesis and evaluation of all stereoisomers of Z4349, a novel and selective μ-opioid analgesic

Napoletano, M.; Della Bella, D.; Fraire, C.; Grancini, G.; Masotto, C.; et al, Bioorganic & Medicinal Chemistry Letters, 1995, 5(6), 589-92

合成路线：1 步

_99%

反应条件：

1.1 Reagents: Sodium borohydride Solvents: Ethanol

参考文献：

Late-Stage Diversification of Chiral N-Heterocyclic-Carbene Precatalysts for Enantioselective Homoenolate Additions

Zheng, Pinguan; Gondo, Chenaimwoyo A.; Bode, Jeffrey W., Chemistry - An Asian Journal, 2011, 6(2), 614-620

合成路线：1 步

_99%

反应条件：

1.1 Reagents: Sodium borohydride Solvents: Ethanol ; overnight, rt
1.2 Reagents: Hydrochloric acid Solvents: Water

参考文献：

New chiral diamide ligands: synthesis and application in allylic alkylation

Bateman, Lorraine; Breeden, Simon W.; O'Leary, Patrick, Tetrahedron: Asymmetry, 2008, 19(3), 391-396

合成路线：1 步

_98%

反应条件：

1.1 Reagents: Sodium borohydride Solvents: Methanol

参考文献：

The Stereochemistry of Electrophilic Attack on Chiral Dienylmethylsilanes

Jones, Graeme Robert, 1992, , ,

合成路线：1 步

3006017-87-1

_96%

反应条件：

1.1 Solvents: Methanol , Acetone ; 15 min, rt; 24 h, rt

参考文献：

Benzoyldiisopropylchlorosilane: a visible light photocleavable alcohol protecting group

Lind, Florian; Markelov, Kirill; Studer, Armido, Chemical Science, 2023, 14(44), 12615-12620

合成路线：1 步

_94%

反应条件：

1.1 Reagents: Sodium borohydride Solvents: Ethanol

参考文献：

Synthesis of new optically active 2-pyrrolidinones

Moutevelis-Minakakis, Panagiota; Papavassilopoulou, Eleni; Mavromoustakos, Thomas, Molecules, 2013, 18, 50-73

合成路线：1 步

_94%

反应条件：

1.1 Reagents: Sodium borohydride Solvents: Methanol

参考文献：

Studies directed towards the synthesis of (-)-ebelactone A

Mandal, Ajay K., 1999, , ,

合成路线：1 步

_94%

反应条件：

1.1 Reagents: Sodium borohydride Solvents: Methanol

参考文献：

Approaches Towards the Synthesis of Ebelactone-a using Organosilicon Chemistry

Archibald, Sarah Catherine, 1992, , ,

合成路线：1 步

98-79-3

_93%

反应条件：

1.1 Reagents: Methanol , Thionyl chloride Solvents: Methanol ; rt
1.2 Reagents: Sodium borohydride Solvents: Ethanol ; rt

参考文献：

First total synthesis of oteromycin utilizing one-pot four-step cascade reaction strategy

Uchiro, Hiromi; Shionozaki, Nobuhiro; Tanaka, Ryo; Kitano, Hiroyuki; Iwamura, Naoki; et al, Tetrahedron Letters, 2013, 54(6), 506-511

合成路线：1 步

_93%

反应条件：

1.1 Reagents: Sodium borohydride Solvents: Ethanol

参考文献：

Synthesis, in silico docking experiments of new 2-pyrrolidinone derivatives and study of their anti-inflammatory activity

Moutevelis-Minakakis, Panagiota; Papavassilopoulou, Eleni; Michas, George; Georgikopoulou, Kalliopi; Ragoussi, Maria-Eleni; et al, Bioorganic & Medicinal Chemistry, 2011, 19(9), 2888-2902

合成路线：1 步

_92%