2136247-12-4 (MD-224 | PROTAC,MD-224)

化合物MD-224;

(3'R,4'S,5'R)-6''-Chloro-4'-(3-chloro-2-fluorophenyl)-N-(4-((5-(2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)pent-4-yn-1-yl)carbamoyl)phenyl)-2''-oxodispiro[cyclohexane-1,2'-pyrrolidine-3',3''-indoline]-5'-carboxamide;CID 131986956;MD-224;Dispiro[cyclohexane-1,2'-pyrrolidine-3',3''-[3H]indole]-5'-carboxamide, 6''-chloro-4'-(3-chloro-2-fluorophenyl)-N-[4-[[[5-[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1-oxo-1H-isoindol-4-yl]-4-pentyn-1-yl]amino]carbonyl]phenyl]-1'',2''-dihydro-2''-oxo-, (3'R,4'S,5'R)-;11,E1/E2/E3 Enzyme,leukemia,PROTACs,E2 conjugating enzyme,MD 224;MD224,inhibit,PROTAC,Ubiquitin activating enzyme,Ubiquitin ligase,Inhibitor,MDM-2/p53,cancer,MD-224,E1 activating enzyme,Ubiquitin conjugating enzyme,E3 ligating enzyme,RS4;GLXC-20459;MS-31660;MD-224?;(3'R,4'S,5'R)-6''-chloro-4'-(3-chloro-2-fluorophenyl)-N-[4-({5-[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-4-yl]pent-4-yn-1-yl}carbamoyl)phenyl]-2''-oxo-1''H-dispiro[cyclohexane-1,2'-pyrrolidine-3',3''-indole]-5'-carboxamide;CHEMBL5187116;SCHEMBL19436923;(3'R,4'S,5'R)-6''-chloro-4'-(3-chloro-2-fluorophenyl)-N-[4-({5-[2-(2,6-dioxopiperidin-3-yl)-1-oxo-2,3-dihydro-1H-isoindol-4-yl]pent-4-yn-1-yl}carbamoyl)phenyl]-2''-oxo-1'',2''-dihydrodispiro[cyclohexane-1,2'-pyrrolidine-3',3''-indole]-5'-carboxamide;EN300-24791869;AKOS040733700;2136247-12-4;MD224;DA-75378;GTPL12914;EX-A3426;CS-0082057;G16972;HY-114312;

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1S/C48H43Cl2FN6O6/c49-29-16-19-34-36(25-29)54-46(63)48(34)39(32-12-8-13-35(50)40(32)51)41(56-47(48)22-4-2-5-23-47)44(61)53-30-17-14-28(15-18-30)42(59)52-24-6-1-3-9-27-10-7-11-31-33(27)26-57(45(31)62)37-20-21-38(58)55-43(37)60/h7-8,10-19,25,37,39,41,56H,1-2,4-6,20-24,26H2,(H,52,59)(H,53,61)(H,54,63)(H,55,58,60)/t37?,39-,41+,48+/m0/s1

ClC1C=CC2=C(C=1)NC([C@@]12[C@@H](C2C=CC=C(C=2F)Cl)[C@H](C(NC2C=CC(C(NCCCC#CC3=CC=CC4C(N(CC=43)C3C(NC(CC3)=O)=O)=O)=O)=CC=2)=O)NC21CCCCC2)=O