302964-08-5 (达沙替尼中间体,Dasatinib Int N-1)

快速询单

结构式：

达沙替尼中间体MOL文件

CAS号：

302964-08-5

中文名称：

达沙替尼中间体

英文名称：

Dasatinib Int N-1

分子式：

C₁₆H₁₃Cl₂N₅OS

分子量：

394.28

API：

Dasatinib

达沙替尼中间体(302964-08-5)名称与标识符

名称

中文别名：

N-(2-氯-6-甲基苯基)-2-[(6-氯-2-甲基-4-嘧啶基)氨基]-5-噻唑甲酰胺;达沙中二;氯-6-甲基苯基)-2-((6-氯-2-甲基-4-嘧啶基)氨基)-5- 噻唑甲酰胺;N-(2-氯-6-甲基苯基)-2-((6-氯-2-甲基-4-嘧啶基)氨基)-5-噻唑甲酰胺;N-(2-氯-6-甲基苯基)-2-[(6-氯-2-甲基-4-嘧啶基)基]-5-噻唑甲酰胺;N-(2-氯-6-甲基苯基)-2-[(6-氯-2-甲基-4-嘧啶基)氨基]-5-噻唑酰胺;...[(6-氯-2-甲基-4-嘧啶基)氨基]-5-噻唑甲酰胺;N-(2-氯-6-甲基苯基)-2-'(6-氯-2-甲基-4-嘧啶基)氨基-5-噻唑甲酰胺;N-(2-氯-6-甲基苯基)-2-[(6-氯-2-甲基-4-嘧啶基)氨基]-5-噻唑甲;达沙替尼中间体08-5;达沙替尼中间体1;达莎替尼中间体2;达沙替尼中间体;达沙替尼中二;

英文别名：

N-(2-Chloro-6-methylphenyl)-2-[(6-chloro-2-methyl-4-pyrimidinyl)amino]-5-thiazolecarboxamide;Dasatinib Int N-1;N-(2-Chloro-6-methylphenyl)-2-[(6-chloro-2-methyl-4-yrimidinyl)amino]-5-thiazolecarboxamide;N-(2-chloro-6-methylphenyl)-2-[(6-chloro-2-methylpyrimidin-4-yl)amino];CAY10697;N-(2-Chloro-6-methyl-phenyl)-2-[(6-chloro-2-methyl-pyrimidin-4-yl)amino]thiazole-5-carboxamide;2-(6-Chloro-2-methylpyrimidin-4-ylamino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide;5-Thiazolecarboxamide, N-(2-chloro-6-methylphenyl)-2-[(6-chloro-2-methyl-4-pyrimidinyl)amino]-;2-((6-Chloro-2-methylpyrimidin-4-yl)amino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide;2-[(6-Chloro-2-methylpyrimidin-4-yl)amino]-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide;Dasatinib Intermediate;N-(2-chloro-6-methylphenyl)-2-[(6-chloro-2-methylpyrimidin-4-yl)amino]-1,3-thiazole-5-carboxamide;N-(2-Chloro-6-methylphenyl)-2-[(6-chloro-2-methyl-4-pyrimidinyl)amino]-5-thiazolecarboxamide]-;DTXSID20460723;QFN5DH4342;EC 695-686-7;2-((6-chloro-2-methylpyrimidin-4-yl) amino)-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide;NS00008082;MFCD11045075;SB55490;C16H13Cl2N5OS;2-(6-chloro-2-methylpyrimidin-4-ylamino)- N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide;CS-W019750;2-[(6-Chloro-2-methyl-4-pyrimidyl)amino]-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide;2-[(6-chloro-2-methylpyrimidin-4-yl)amino]-N-(2-chloro-6-methylphenyl)-1,3-thiazole-5-carboxamide;CHEMBL5171348;Q-101347;5-Thiazolecarboxamide, N-(2-chloro-6-methylphenyl)-2-[(6-chloro-2-methyl-4-pyrimidinyl)amino]-; N-(2-Chloro-6-methylphenyl)-2-[(6-chloro-2-methyl-4-pyrimidinyl)amino]-5-thiazolecarboxamide; 2-[(6-Chloro-2-methylpyrimidin-4-yl)amino]-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide;SY039789;2-((6-Chloro-2-methylpyrimidin-4-yl)amino)-N-(2-chloro-6-methylphenyl)-1,3-thiazole-5-carboxamide;AKOS015888619;302964-08-5;C3675;AS-13682;BCP10594;2-((6-chloro-2-methylpyrimidin-4-yl)amino)-N-(2-chloro-6-methylphenyl)thiazole-5-carbox amide;AC-8511;2-(6-Chloro-2-methylpyrimidin-4-ylamino)-N-(2-chloro-6-methyl phenyl)thiazole-5-carboxamide;SCHEMBL1146860;N-(2-Chloro-6-methylphenyl)-2-[(6-chloro-2-methylpyrimidin-4-yl)amino]thiazole-5-carboxamide;LMXUWARKUIELGT-UHFFFAOYSA-N;

标识符

MDL：

MFCD11045075

InChIKey：

LMXUWARKUIELGT-UHFFFAOYSA-N

Inchi：

1S/C16H13Cl2N5OS/c1-8-4-3-5-10(17)14(8)23-15(24)11-7-19-16(25-11)22-13-6-12(18)20-9(2)21-13/h3-7H,1-2H3,(H,23,24)(H,19,20,21,22)

SMILES：

CC1=CC=CC(Cl)=C1NC(=O)C1=CN=C(NC2=CC(Cl)=NC(C)=N2)S1

达沙替尼中间体(302964-08-5)物化性质

实验特性

LogP : 4.99860
PSA : 108.04000
折射率 : 1.716
熔点 : 333-335°C
密度 : 1.516

计算特性

精确分子量 : 393.02200
氢键供体数量 : 2
氢键受体数量 : 6
可旋转化学键数量 : 5
同位素质量 : 393.0217866g/mol
重原子数量 : 25
复杂度 : 474
同位素原子数量 : 0
确定原子立构中心数量 : 0
不确定原子立构中心数量 : 0
确定化学键立构中心数量 : 0
不确定化学键立构中心数量 : 0
共价键单元数量 : 1
疏水参数计算参考值（XlogP） : 5
互变异构体数量 : 11
表面电荷 : 0
拓扑分子极性表面积 : 108Å²

达沙替尼中间体(302964-08-5)安全信息

危害声明：H302-H315-H319-H332-H335
警示性声明：P261; P264; P270; P271; P280; P301+P312; P302+P352; P304+P340; P312; P322; P330; P363; P501
储存条件： Inert atmosphere,2-8°C
信号词： Warning

达沙替尼中间体(302964-08-5)海关数据

海关编码：

2934100090

海关数据：

中国海关编码：

2934100090

概述：

2934100090. 结构上含有一个非稠合噻唑环的化合物(不论是否氢化). 增值税率:17.0%. 退税率:9.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

申报要素：

品名, 成分含量, 用途

Summary：

2934100090 other compounds containing an unfused thiazole ring (whether or not hydrogenated) in the structure VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:20.0%

达沙替尼中间体(302964-08-5)生产方法和用途

用途：

达沙替尼中间体

达沙替尼中间体(302964-08-5)推荐厂家更多厂家(105)

公司名称	手机号/电话	联系人	QQ	询单
山东柯尔生物科技有限公司	15376831117	王先生	318544585	询单
江苏倍达医药科技有限公司	18994340901 0512-63009836	贺慧	540534176	询单
上海源叶生物科技有限公司	15026964105 15026964105	汤思磊	2881489226	询单
山东铂源药业股份有限公司	19862156242	姜经理	1431366413	询单
上海吉至生化科技有限公司	18117592386 021-57481218	吉至试剂	3007522982	询单
湖北扬信医药科技有限公司	13092795037 0714-3996388	熊磊	3003473323	询单
郑州阿尔法化工有限公司	15324716602 0371-55013243	刘经理	2853979810	询单
深圳菲斯生物科技有限公司	18925202235	周美娇	2850179284	询单
湖北瑞诺医药科技有限公司	13165688766	汪经理	3008058303	询单
江西伯业医药科技有限公司	15377010747 027-81625225	李端慧	3266171690	询单

达沙替尼中间体(302964-08-5)上下游

达沙替尼硼酸,B-(1,3,5 - 三甲基-1H-吡唑-4- 基) - 2-甲基-4-氨基-6-氯嘧啶 2-甲基-4,6-二氯嘧啶 5-Thiazolecarboxamide, 2-bromo-N-(2-chloro-6-methylphenyl)- 2-氯-n-(2-氯-6-甲基苯基)噻唑-5-羧酰胺 2-氨基-N-(2-氯-6-甲基苯基)-5-噻唑酰胺 2-氯-6-甲基苯基异氰酸酯 Thiourea, (6-chloro-2-methyl-4-pyrimidinyl)- N-(4-甲氧基苄基)-2-氯-N-(2-氯-6-甲基苯基)-1,3-噻唑-5-羧酰胺 N-(4-甲氧基苄基)-2-(6-氯-2-甲基嘧啶-4-基氨基)-N-(2-氯-6-甲基苯基)-1,3-噻唑-5-羧酰胺 2-氯-6-甲基苯胺

达沙替尼中间体(302964-08-5)参考资料

Beilstein：

N183541

PubChem CID：

11269410

达沙替尼中间体(302964-08-5) MSDS

基础信息

Material Safety Data Sheet

Section 1. Identi?cation of the substance
Product Name: N-(2-Chloro-6-methylphenyl)-2-[(6-chloro-2-methyl-4-pyrimidinyl)amino]-5-thiazolecarboxamide
Synonyms:

Section 2. Hazards identi?cation
Harmful by inhalation, in contact with skin, and if swallowed.

Section 3. Composition/information on ingredients.
    Ingredient name:        N-(2-Chloro-6-methylphenyl)-2-[(6-chloro-2-methyl-4-pyrimidinyl)amino]-5-thiazolecarboxamide
    302964-08-5
    CAS number:

Section 4. First aid measures
    Skin contact:        Immediately wash skin with copious amounts of water for at least 15 minutes while removing
    contaminated clothing and shoes. If irritation persists, seek medical attention.
    Eye contact:        Immediately wash skin with copious amounts of water for at least 15 minutes. Assure adequate
    ?ushing of the eyes by separating the eyelids with ?ngers. If irritation persists, seek medical
    attention.
    Remove to fresh air. In severe cases or if symptoms persist, seek medical attention.
    Inhalation:
    Ingestion:        Wash out mouth with copious amounts of water for at least 15 minutes. Seek medical attention.

Section 5. Fire ?ghting measures
    In the event of a ?re involving this material, alone or in combination with other materials, use dry
    powder or carbon dioxide extinguishers. Protective clothing and self-contained breathing apparatus
    should be worn.

Section 6. Accidental release measures
    Personal precautions: Wear suitable personal protective equipment which performs satisfactorily and meets local/state/national
    standards.
    Respiratory precaution:        Wear approved mask/respirator
    Hand precaution:        Wear suitable gloves/gauntlets
    Skin protection:        Wear suitable protective clothing
    Eye protection:        Wear suitable eye protection
    Methods for cleaning up: Mix with sand or similar inert absorbent material, sweep up and keep in a tightly closed container
    for disposal. See section 12.
    Environmental precautions: Do not allow material to enter drains or water courses.

Section 7. Handling and storage
    Handling:        This product should be handled only by, or under the close supervision of, those properly quali?ed
    in the handling and use of potentially hazardous chemicals, who should take into account the ?re,
    health and chemical hazard data given on this sheet.
    Storage:        Store in closed vessels, refrigerated.

Section 8. Exposure Controls / Personal protection
    Engineering Controls: Use only in a chemical fume hood.
    Personal protective equipment: Wear laboratory clothing, chemical-resistant gloves and safety goggles.
    General hydiene measures: Wash thoroughly after handling. Wash contaminated clothing before reuse.

Section 9. Physical and chemical properties
    Appearance:        Not speci?ed
    No data
    Boiling point:
    Melting point:        No data
    Flash point:        No data
    Density:        No data
    Molecular formula:        C16H13Cl2N5OS
    Molecular weight:        394.3

Section 10. Stability and reactivity
    Conditions to avoid: Heat, ?ames and sparks.
    Materials to avoid: Oxidizing agents.
    Possible hazardous combustion products: Carbon monoxide, nitrogen oxides, hydrogen chloride, sulfur oxides.

Section 11. Toxicological information
No data.

Section 12. Ecological information
No data.

Section 13. Disposal consideration
Arrange disposal as special waste, by licensed disposal company, in consultation with local waste
disposal authority, in accordance with national and regional regulations.

Section 14. Transportation information
Non-harzardous for air and ground transportation.

Section 15. Regulatory information
    No chemicals in this material are subject to the reporting requirements of SARA Title III, Section
    302, or have known CAS numbers that exceed the threshold reporting levels established by SARA
    Title III, Section 313.

SECTION 16 - ADDITIONAL INFORMATION
N/A