35511-15-0 (4-羟基-2-甲基-2H-1,2-苯并噻嗪-3-羧酸甲酯-1,1-二氧化物,Methyl 4-hydroxy-2-methyl-2H-1,2-benzothiazine-3-carboxylate 1,1-dioxide)

快速询单

结构式：

4-羟基-2-甲基-2H-1,2-苯并噻嗪-3-羧酸甲酯-1,1-二氧化物MOL文件

CAS号：

35511-15-0

中文名称：

4-羟基-2-甲基-2H-1,2-苯并噻嗪-3-羧酸甲酯-1,1-二氧化物

英文名称：

Methyl 4-hydroxy-2-methyl-2H-1,2-benzothiazine-3-carboxylate 1,1-dioxide

分子式：

C₁₁H₁₁NO₅S

分子量：

269.273741960526

API：

Meloxicam

4-羟基-2-甲基-2H-1,2-苯并噻嗪-3-羧酸甲酯-1,1-二氧化物(35511-15-0)名称与标识符

名称

中文别名：

2-甲基-4-羟基-2H-1,2-苯并异噻嗪-3-羧酸乙酯-1,1-二氧化物;4-羟基-2-甲基-2H-1,2-苯并噻嗪-3-羧酸甲酯-1,1-二氧化物;吡罗昔康杂质J;吡罗昔康甲基物;吡罗昔康杂质J(EP);甲基4-羟基-2-甲基-2H-1,2-苯并噻嗪-3-羧酸盐 1,1-二氧化物;美洛昔康杂质E(EP);盐酸特拉唑嗪杂质B(EP) 标准品;甲基物;

英文别名：

Methyl 2-methyl-4-hydroxy-2H-1,2-benzothiazine-3-carboxylate 1,1-dioxide;Methyl4-hydroxy-2-methyl-2H-1,2-benzothiazine3-carboxylate1,1-dioxide;2-METHYL-4-HYDROXY-2H-1,2-BENZOTHIAZINE-3-CARBOXYLIC METHYL ESTER-1,1-DIOXIDE;2-METHYL-4-HYDROXY-2H-1,2-BENZOTHIAZINE-3-CARBOXYLIC ACID METHYL ESTER 1,1-DIOXIDE;2-Methyl-4-hydroxy-2H-1,2-benzisothiazine-3-carboxylic acid ethyl ester-1,1-diox;2-Methyl-4-Hydroxy-2H-1,2-Benzotiazine-3-CarboxylicAicdEthylEster-1,1-Dioxide;Methyl 4-Hydroxy-2-methyl-2H-1,2-benzothiazine-3-carboxylate 1,1-Dioxide (Piroxicam Impurity J);2H-1,2-Benzothiazine-3-carboxylic acid, 4-hydroxy-2-methyl-, methyl ester, 1,1-dioxide;methyl 4-hydroxy-2-methyl-1,1-dioxo-1λ<sup>6</sup>,2-benzothiazine-3-carboxylate;Methyl 4-Hydroxy-2-methyl-2H-1,2-benzothiazine-3-carboxylate 1,1-Dioxide (Piroxicam Impurity J);2-Methyl-4-hydroxy-2H-1,2-benzothiazine-3-carboxylic methyl ester-1,1-;4-hydroxy-2-methyl-3-methoxycarbonyl-2H-1,2-benzothiazine-1,1-dioxide;methyl 4-hydroxy-2-methyl-1,1-dioxo-2H-1,2-benzothiazine-3-carboxylate;Methyl 4-hydroxy-2-methyl-2H-1,2-benzothiazine-3-carboxylate-1,1-dioxide;2-Methyl-4-hydroxy-2H-1,2-benzothiazine-3-carboxylicacidethyl ester-1,1-dioxide;Methyl 4-hydroxy-2-methyl-2H-1,2-benzothiazine-3-carboxylate 1,1-dioxide;Z7C4J6BW2K;methyl 4-hydroxy-2-methyl-2H-benzo[e][1,2]thiazine-3-carboxylate 1,1-dioxide;Methyl 4-hydroxy-2-methyl-(2H)-1,2-benzothiazine-3-carboxylate-1,1-dioxide;PIROXICAM IMPURITY J [EP IMPURITY];Q27295106;methyl 4-hydroxy-2-methyl-1,1-dioxo-2H-1,2-benzothiazine3-carboxylate;MFCD00071766;CHEMBL4176626;SCHEMBL6796426;DTXSID30189019;FT-0671839;2-METHYL-4-HYDROXY-2H-1,2-BENZOTHIAZINE-3-CARBOXYLICMETHYLESTER-1,1-DIOXIDE;UNII-Z7C4J6BW2K;methyl 4-hydroxy-2-methyl-1,1-dioxo-1,2-dihydro-1lambda6-benzo[e][1,2]thiazine-3-carboxylate;FT-0671838;methyl 4-hydroxy-2-methyl-1,1-dioxobenzo[e]1,2-thiazine-3-carboxylate;HMS1552I18;Meloxicam Imp. E (EP); Piroxicam Imp. J (EP); Methyl 4-Hydroxy-2-methyl-2H-1,2-benzothiazine-3-carboxylate 1,1-Dioxide; Meloxicam Impurity E; Piroxicam Impurity J;35511-15-0;A822844;SY104830;methyl 4-hydroxy-2-methyl-1,1-dioxo-1lambda6,2-benzothiazine-3-carboxylate;2H-1,2-Benzothiazine-3-carboxylic acid, 4-hydroxy-2-methyl-, methylester, 1,1-dioxide;4-HYDROXY-2-METHYL-2H-1,2-BENZOTHIAZINE-3-CARBOXYLIC ACID METHYL ESTER 1,1-DIOXIDE;2-Methyl-4-hydroxy-2H-1,2-benzothiazine-3-carboxylic acid methyl ester-1,1-dioxide;AKOS000278208;EINECS 252-601-4;CS-0084724;W-106666;(3E)-3-[hydroxy(methoxy)methylene]-2-methyl-1,1-dioxo-1$l^{6},2-benzothiazin-4-one;Methyl 2-methyl-4-hydroxy-2H-1,2-benzothiazine-3-carboxylate 1,1-dioxide;methyl 4-hydroxy-2-methyl- 1,1-dioxo-2H1,2-benzothiazine-3-carboxylate;NGHIOTWSWSQQNT-UHFFFAOYSA-N;Piroxicam EP Impurity J;DS-1081;BDBM50283922;CCG-152412;NS00029868;TimTec1_006530;Methyl2-methyl-4-hydroxy-2H-1,2-benzothiazine-3-carboxylate1,1-dioxide;methyl 4-hydroxy-2-methyl-1,1-dioxo-2H-1lambda6,2-benzothiazine-3-carboxylate;Methyl 4-Hydroxy-2-methyl-2H-1,2-benzothiazine-3-carboxylate 1,1-Dioxide(Piroxicam Impurity J);MELOXICAM IMPURITY E [EP IMPURITY];AC-19608;Methyl 4-hydroxy-2-methyl-2H-1,2-benzothiazine3-carboxylate1,1-dioxide;AE-641/00011001;Super Phos 105; Condensed Phosphoric Acids; PPA;PIROXICAM IMPURITY J (EP IMPURITY);MELOXICAM IMPURITY E (EP IMPURITY);DTXCID10111510;METHYL 4-HYDROXY-2-METHYL-1,1-DIOXO-1??,2-BENZOTHIAZINE-3-CARBOXYLATE;

标识符

MDL：

MFCD00071766

InChIKey：

NGHIOTWSWSQQNT-UHFFFAOYSA-N

Inchi：

1S/C11H11NO5S/c1-12-9(11(14)17-2)10(13)7-5-3-4-6-8(7)18(12,15)16/h3-6,13H,1-2H3

SMILES：

S1(C2C=CC=CC=2C(=C(C(=O)OC)N1C)O)(=O)=O

4-羟基-2-甲基-2H-1,2-苯并噻嗪-3-羧酸甲酯-1,1-二氧化物(35511-15-0)物化性质

实验特性

LogP : 1.73900
PSA : 92.29000
折射率 : 1.632
沸点 : 439.9°C at 760 mmHg
熔点 : 169-172°C
闪点 : 219.8 °C
颜色与性状 : 白色粉末
密度 : 1.514

计算特性

精确分子量 : 269.03600
氢键供体数量 : 1
氢键受体数量 : 6
可旋转化学键数量 : 2
同位素质量 : 269.036
重原子数量 : 18
复杂度 : 490
同位素原子数量 : 0
确定原子立构中心数量 : 0
不确定原子立构中心数量 : 0
确定化学键立构中心数量 : 0
不确定化学键立构中心数量 : 0
共价键单元数量 : 1
疏水参数计算参考值（XlogP） : 2.8
拓扑分子极性表面积 : 92.3

4-羟基-2-甲基-2H-1,2-苯并噻嗪-3-羧酸甲酯-1,1-二氧化物(35511-15-0)安全信息

安全说明： H303+H313+H333
危害声明：H302-H315-H319-H332-H335
警示性声明：P261; P264; P271; P280; P302+P352; P304+P340; P305+P351+P338; P312; P321; P332+P313; P337+P313; P362; P403+P233; P405; P501
储存条件： Store at room temperature
信号词： Warning

4-羟基-2-甲基-2H-1,2-苯并噻嗪-3-羧酸甲酯-1,1-二氧化物(35511-15-0)国际标准相关数据

EINECS：

252-601-4

4-羟基-2-甲基-2H-1,2-苯并噻嗪-3-羧酸甲酯-1,1-二氧化物(35511-15-0)海关数据

海关编码：

2934991000

海关数据：

中国海关编码：

2934991000

概述：

2934991000. 磺内酯及磺内酰胺. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%

申报要素：

品名, 成分含量, 用途

Summary：

2934991000. sultones and sultams. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

4-羟基-2-甲基-2H-1,2-苯并噻嗪-3-羧酸甲酯-1,1-二氧化物(35511-15-0)生产方法和用途

用途：

是合成炎痛喜康等镇痛药物的中间体

4-羟基-2-甲基-2H-1,2-苯并噻嗪-3-羧酸甲酯-1,1-二氧化物(35511-15-0)推荐厂家更多厂家(32)

公司名称	手机号/电话	联系人	QQ	询单
深圳菲斯生物科技有限公司	18925202235	周美娇	2850179284	询单
湖北扬信医药科技有限公司	13092795037 0714-3996388	熊磊	3003473323	询单
湖北瑞诺医药科技有限公司	13165688766	汪经理	3008058303	询单
上海瀚思化工有限公司	18939883912 021-34536277	顾经理	3003949364	询单
深圳振强生物技术有限公司	13670046396 86-755-66853366	颜经理	2851296953	询单
湖北诺纳科技有限公司	18995657604 027-59209883	吴经理	2933307129	询单
南通众合化工新材料有限公司	18762756250 0513-55074056	胡经理	2369399482	询单
上海一基实业有限公司	13311756052 021-60526763 13311756052 13311756131	胡经理	2355265332	询单
上海一基实业有限公司	13311756131 021-60548336 QQ：2355265332 QQ:2851717387	胡经理	2355265332	询单
赫澎（上海）生物科技有限公司	13122891558 186-16545970	张硕	3418426269	询单

4-羟基-2-甲基-2H-1,2-苯并噻嗪-3-羧酸甲酯-1,1-二氧化物(35511-15-0)上下游

N'-甲基美洛昔康戊地昔布杂质F 美洛昔康甲醇钠吡罗昔康杂质标准品 4-羟基-2H-1,2-苯并噻嗪-3-羧酸甲酯 1,1-二氧化物 3-氧代-1,2-苯并异噻唑-2(3H)乙酸甲酯-1,1-二氧化物碘甲烷硫酸二甲酯 methyl 2-chloro-2-(3-hydroxy-2-methyl-1,1-dioxido-2,3-dihydrobenzo[d]isothiazol-3-yl)acetate 氯乙酸甲酯

4-羟基-2-甲基-2H-1,2-苯并噻嗪-3-羧酸甲酯-1,1-二氧化物(35511-15-0)参考资料

Reaxys RN：

Beilstein：

M183977

PubChem CID：

54676532

4-羟基-2-甲基-2H-1,2-苯并噻嗪-3-羧酸甲酯-1,1-二氧化物(35511-15-0) MSDS

基础信息

Material Safety Data Sheet

Section 1. Identi?cation of the substance
Product Name: 2-Methyl-4-hydroxy-2H-1,2-benzothiazine-3-carboxylic methyl ester-1,1-dioxide
Synonyms:

Section 2. Hazards identi?cation
Harmful by inhalation, in contact with skin, and if swallowed.

Section 3. Composition/information on ingredients.
Ingredient name: 2-Methyl-4-hydroxy-2H-1,2-benzothiazine-3-carboxylic methyl ester-1,1-dioxide
CAS number: 35511-15-0

Section 4. First aid measures
    Skin contact:        Immediately wash skin with copious amounts of water for at least 15 minutes while removing
    contaminated clothing and shoes. If irritation persists, seek medical attention.
    Eye contact:        Immediately wash skin with copious amounts of water for at least 15 minutes. Assure adequate
    ?ushing of the eyes by separating the eyelids with ?ngers. If irritation persists, seek medical
    attention.
    Inhalation:        Remove to fresh air. In severe cases or if symptoms persist, seek medical attention.
    Ingestion:        Wash out mouth with copious amounts of water for at least 15 minutes. Seek medical attention.

Section 5. Fire ?ghting measures
    In the event of a ?re involving this material, alone or in combination with other materials, use dry
    powder or carbon dioxide extinguishers. Protective clothing and self-contained breathing apparatus
    should be worn.

Section 6. Accidental release measures
    Personal precautions: Wear suitable personal protective equipment which performs satisfactorily and meets local/state/national
    standards.
    Respiratory precaution:        Wear approved mask/respirator
    Hand precaution:        Wear suitable gloves/gauntlets
    Skin protection:        Wear suitable protective clothing
    Eye protection:        Wear suitable eye protection
    Methods for cleaning up: Mix with sand or similar inert absorbent material, sweep up and keep in a tightly closed container
    for disposal. See section 12.
    Environmental precautions: Do not allow material to enter drains or water courses.

Section 7. Handling and storage
    Handling:        This product should be handled only by, or under the close supervision of, those properly quali?ed
    in the handling and use of potentially hazardous chemicals, who should take into account the ?re,
    health and chemical hazard data given on this sheet.
    Store in closed vessels, refrigerated.
    Storage:

Section 8. Exposure Controls / Personal protection
    Engineering Controls: Use only in a chemical fume hood.
    Personal protective equipment: Wear laboratory clothing, chemical-resistant gloves and safety goggles.
    General hydiene measures: Wash thoroughly after handling. Wash contaminated clothing before reuse.

Section 9. Physical and chemical properties
    Appearance:        Not speci?ed
    Boiling point:        No data
    No data
    Melting point:
    Flash point:        No data
    Density:        No data
    Molecular formula:        C11H11NO5S
    Molecular weight:        269.3

Section 10. Stability and reactivity
    Conditions to avoid: Heat, ?ames and sparks.
    Materials to avoid: Oxidizing agents.
    Possible hazardous combustion products: Carbon monoxide, nitrogen oxides, sulfur oxides.

Section 11. Toxicological information
No data.

Section 12. Ecological information
No data.

Section 13. Disposal consideration
Arrange disposal as special waste, by licensed disposal company, in consultation with local waste
disposal authority, in accordance with national and regional regulations.

Section 14. Transportation information
Non-harzardous for air and ground transportation.

Section 15. Regulatory information
    No chemicals in this material are subject to the reporting requirements of SARA Title III, Section
    302, or have known CAS numbers that exceed the threshold reporting levels established by SARA
    Title III, Section 313.

SECTION 16 - ADDITIONAL INFORMATION
N/A