52-24-4 (三亚乙基硫代磷酰胺,Thio-TEPA)

三亚乙基硫代磷酰胺;N,N’,N’’-三乙撑硫代磷酰胺;塞替派;噻替派;三胺硫磷;噻替哌;三乙基硫代磷铵 即:THIOTEPA;三亚乙基硫代磷酸胺;1,1',1"-硫次膦基三氮丙啶;三乙烯硫代磷酰胺;三(1-吖丙啶基)硫代磷酰;二苯基膦乙酸乙酯;呋塞米;噻替哌,三亚乙基硫代磷酰胺;噻替派 Thio-TEPA;三亚乙基硫代磷酰胺 USP标准品;三亚乙基硫代磷酰胺（噻替哌）;三亚乙基硫代磷酰胺, 塞替派;三亚乙基硫代磷酰胺, 噻替哌;唾替派;N,N',N''-三乙撑硫代磷酰胺;1,1',1''-硫次膦基三氮丙啶;

Tri(aziridin-1-yl)phosphine sulfide;SALOR-INT L169250-1EA;THIOFOZIL;THIOTEF;THIO-TEP;THIO-TEPA;TIOFOSFAMID;TIOFOSYL;TIOFOZIL;TIO-TEF;TRIETHYLENETHIOPHOSPHORAMIDE;TRIS(1-AZIRIDINYL)PHOSPHINE SULFIDE;TRIS(AZIRIDINYL)PHOSPHINE SULFIDE;1,1,1"-phosphinothioylidynetris-aziridin;1,1’,1’’-phosphinothioylidynetris-aziridin;1,1’,1’’-phosphinothioylidynetrisaziridine;cbc806495;girostan;ledertepa;n,n’,n"-triethylene-phosphorothioictriamid;Tri(1-aziridinyl)phosphine sulfide;1,1',1''-Phosphorothioyltriaziridine;Thiophosphoramide;Thiotepa;Triethylenethiophosp;1,1’,1″-phosphinothioylidynetris[aziridine];1,1’,1″-phosphorothioyltris(aziridine);N,N',N''-Triethylenethiophosphoramide;N,N‘,N’‘-Triethylenethiophosphoramide;phosphorothioic tri(ethyleneamide);N,N′,N″-Triethylenethiophosphoramide;N,N',N"-Triethylenethiophosphoramide;Thiophosphamide;Thioplex;Tespamin;Oncotepa;Tespamine;Stepa;Oncotiotepa;Tifosyl;Oncothio-tepa;TESPA;TSPA;Thio-tepa S;Thiotriethylenephosphoramide;TIO TEF;Thiophosphamidum;Triethylene thiophosphoramide;Triaziridinyl;Z1201619320;52-24-4;triethylenethiophosphormide;Tris-(1 -aziridinyl)phosphine sulfide;NCI-C01649;Phosphorothioic triamide, N,N',N''-triethylene-;Thiotepum [INN-Latin];NCGC00095042-03;Rethio (TN);NINDS_000817;BRD-K09631521-001-05-7;NSC6396;THIOTEPA [VANDF];N,N',N-Triethylenethiophosphamide;THIOTEPA [MART.];CS-3119;WR-45312;NCI60_013117;KBio2_007305;SK 6882;tris(aziridin-1-yl)-sulfanylidene-lambda5-phosphane;triethylenethiophosphortriamide;905Z5W3GKH;s1775;Thiotepa, United States Pharmacopeia (USP) Reference Standard;Tiotepa;NSC758455;AB00052346_07;Phosphoric tri(ethyleneamide);N,N',N''-Triethylenephosphorothioic triamide;Tiotepa [INN-Spanish];tris(1-aziridinyl)-phosphine sulfide;THIOTEPA [WHO-DD];N,N',N''-Tri-1,2-ethanediylthiophosphoramide;C07641;HMS2232P17;SR-05000001855-1;THIOTEPA [USP-RS];MLS002207150;Phosphine sulfide, tris(1-aziridinyl)-;Thiotepa [BAN:INN:JAN];Thio-TEPA, 98%, solid;N,N''-Triethylenethiophosphoramide;Aziridine, 1,1',1''-phosphinothioylidynetris-;THIOTEPA [USP MONOGRAPH];THIOTEPA [EMA EPAR];N,N',N'-Triethylenethiophosphamide;KBio2_004737;tris(aziridin-1-yl)-$l^{5}-phosphanethione;D00583;Spectrum4_000208;MLS001333084;AKOS005267118;CCRIS 586;IDI1_000817;tris(aziridin-1-yl)-;tris(aziridin-1-yl)-lambda5-phosphanethione;Triaziridinylphosphine sulfide;tris(aziridin-1-yl)-thioxo-$l^{5}-phosphane;KBio3_002688;EN300-120883;AI 3-24916;Phosphorothioic triamide, N,N',N'-triethylene-;N,N',N'-Triethylenethiophosphoramide;NCGC00095042-06;Tox21_400065;Aziridine, 1,1,1'-phosphinothioylidynetris-;4-20-00-00052 (Beilstein Handbook Reference);Phosphorothioic triamide, N,N',N''-triethylene;Thiophosphoramide, N,N',N''-tri-1,2-ethanediyl-;C6H12N3PS;AS-16885;Thioplex (TN);N,N',N''-Triethylenethiophosphamide;N,N''-Tri-1,2-ethanediylthiophosphoramide;N,N',N''-Tri-1,2-ethanediylphosphorothioic triamide;Thiophosphoramide, N,N',N-triethylene-;N,N',N'''-Triethylenethiophosphhoramide;CBC 806495;CHEMBL671;Spectrum_001689;:thio-tepa;Tox21_111399;HMS2093E05;DB04572;Thiophosphoramide,N',N'' -triethylene-;Tris(ethylenimino)thiophosphate;BIDD:GT0127;N,N',N-Triethylenethiophosphoramide;N,N''-Triethylenethiophosphamide;NSC 6396;1,1',1''-Phosphinothioylidynetrisaziridine;Thiotepum;NCGC00095042-04;NCGC00095042-09;WR 45312;AZIRIDINE,1,1',1''-PHOSPHINOTHIOYLIDYNETRIS-;Thiophosphoramide, N,N',N'' -triethylene-;AZIRIDINE, 1,1',1'-PHOSPHINOTHIOYLIDYNETRIS-;BCP04110;Thiophosphoramide,N',N''-tri-1,2-ethanediyl-;A828998;BRN 0145978;SPECTRUM1503324;SPBio_001434;Thioplex (TN) (Immunex);AB00052346-06;NCGC00095042-02;UNII-905Z5W3GKH;Thiophosphoramide, N,N',N'-triethylene-;THIOTEPA [JAN];Pharmakon1600-01503324;WLN: T3NTJ APS&- AT3NTJ&- AT3NTJ;Tri-1-aziridinylphosphine sulfide;CHEBI:9570;NCGC00095042-05;DTXCID201339;thiotepa-;N,N',N''-Tri-1,2-et hanediylthiophosphoramide;1,1',1''-PHOSPHINOTHIOYLIDYNETRIS(AZIRIDINE);Tris(1-aziridinyl)phosphine sulfide (Thiotepa);tepadina;N,N''-Tri-1,2-ethanediylphosphorothioic triamide;MLS001333083;NCGC00095042-07;Tepadina (TN);THIOTEPA [MI];THIOTEPA [INN];CCG-39776;DTXSID0021339;Aziridine,1',1''-phosphinothioylidynetris-;Phosphorothioic triamide,N',N''-triethylene;Spectrum3_001594;Triethylenethiophosphorotriamide;E?-phosphanethione;BSPBio_003188;Triethylenethiop hosphoramide;Q-201826;THIOTEPA [IARC];KBio1_000817;CAS-52-24-4;Tris(aziridinyl)-phosphine sulfide (thio-tepa);NCGC00095042-08;HMS1922A14;THIOTEPA [HSDB];1-[Di(1-aziridinyl)phosphorothioyl]aziridine #;SCHEMBL4760;DivK1c_000817;N,N',N''-Triethylenethiophosphortriamide;SMR000058542;KBioSS_002169;KBioGR_000815;1631739-26-8;NCGC00095042-01;Q416507;MLS006009972;HY-17574;HSDB 3258;Thiotepa [USP:INN:BAN:JAN];Phosphorothioic triamide, N,N',N-triethylene-;LS-170;NSC-6396;FT-0600281;Phosphorothioic triamide, N,N',N''-tri-1,2-ethanediyl-;MFCD00145452;Thiophosphoramide, N,N',N''-triethylene-;MLS003389372;BDBM50418086;Phosphorothioic acid triethylenetriamide;THIOTEPA [ORANGE BOOK];Aziridine, 1,1,1-phosphinothioylidynetris-;Tri(ethyleneimino)thiophosphoramide;Thiotepa [USAN:INN:BAN:JAN];D00YZA;tris(aziridin-1-yl)-sulfanylidenephosphorane;SR-05000001855-5;AMY33389;KBio2_002169;Spectrum5_001641;GTPL7622;SR-05000001855;N,N''-Triethylenephosphorothioic triamide;1,1''-Phosphinothioylidynetrisaziridine;HMS502I19;HMS3372D10;Tris(1-aziridinyl)phosphine sulphide;Aziridine,1,1',1'-phosphinothioylidynetris-;NSC-758455;Thiotepa (Thioplex);AI3-24916;EINECS 200-135-7;Thiotepa (JAN/USP/INN);Spectrum2_001557;SBI-0051814.P002;GC10080;Phosphorothioic triamide,N',N''-tri-1,2-ethanediyl-;thiotepa?;1ST164080;NS00010011;ALBB-034802;BRD-K09631521-001-09-9;BRD-K09631521-001-11-5;Tepylute;Oncothiotepa;N,N',N'Triethylenethiophosphamide;THIOTEPA (USP MONOGRAPH);Tri1aziridinylphosphine sulfide;Thiofosfamide;HMS3753E09;HY-17574R;Aziridine,1,1',1'phosphinothioylidynetris;1,1',1''Phosphinothioylidynetrisaziridine;N,N',N''Triethylenethiophosphortriamide;Thio Tepa;Thio-TEPA (Standard);Thiotepa S;N,N',N''Tri1,2ethanediylphosphorothioic triamide;Phosphine sulfide, tris(1aziridinyl);Thiophosphoramide, N,N',N'triethylene;Tris(aziridinyl)phosphine sulfide; Triethylenethiophosphoramide;Tris(aziridin-1-yl)phosphine sulfide;FT03758;Thiotepa (USP:INN:BAN:JAN);N,N', N''-Triethylenethiophosphoramide;WR45312;Phosphorothioic triamide, N,N',N'triethylene;N,N',N'Triethylenethiophosphoramide;N,N',N''Triethylenephosphorothioic triamide;Phosphorothioic triamide, N,N',N''tri1,2ethanediyl;tris(aziridin-1-yl)-$l^(5)-phosphanethione;Tris(1aziridinyl)phosphine sulfide;THIOTEPA (MART.);THIOTEPA (IARC);Tris(1aziridinyl)phosphine sulphide;THIOTEPA (USP-RS);Tiotepa (INN-Spanish);1,1',1\\'-phosphinothioylidynetrisaziridine;200-135-7;Thiophosphoramide, N,N',N''tri1,2ethanediyl;Thiotepum (INN-Latin);N,N',N''Tri1,2ethanediylthiophosphoramide;L01AC01;Rethio;1,1',1''-Phosphinothioyldynetrisaziridine;

MFCD00145452

FOCVUCIESVLUNU-UHFFFAOYSA-N

1S/C6H12N3PS/c11-10(7-1-2-7,8-3-4-8)9-5-6-9/h1-6H2

S=P(N1CC1)(N1CC1)N1CC1

200-135-7

2933990090

将乙撑亚胺、三乙胺和无水苯冷却至0℃以下，搅拌下滴加硫氯化磷和苯的溶液，温度控制在5℃以下，加毕，室温下搅拌2-3h，过滤。滤饼为三乙胺盐酸盐，用无水苯洗涤。洗、滤液合并，减压蒸去苯，残液加石油醚析出结晶，冷却过滤。结晶用石油醚重结晶，得成品塞替派。收率79.4%。