65954-93-0 (Adenosine 5'-(tetrahydrogen triphosphate), adenylyl-(5'→2')-adenylyl-(5'→2')-,Adenosine, 5'-O-[hydroxy[[hydroxy(phosphonooxy)phosphinyl]oxy]phosphinyl]adenylyl-(2'→5')-adenylyl-(2'→5')-)

快速询单

结构式：

Adenosine 5'-(tetrahydrogen triphosphate), adenylyl-(5'→2')-adenylyl-(5'→2')-MOL文件

CAS号：

65954-93-0

中文名称：

Adenosine 5'-(tetrahydrogen triphosphate), adenylyl-(5'→2')-adenylyl-(5'→2')-

英文名称：

Adenosine, 5'-O-[hydroxy[[hydroxy(phosphonooxy)phosphinyl]oxy]phosphinyl]adenylyl-(2'→5')-adenylyl-(2'→5')-

分子式：

C₃₀H₄₀N₁₅O₂₅P₅

分子量：

1165.59290885925

Adenosine 5'-(tetrahydrogen triphosphate), adenylyl-(5'→2')-adenylyl-(5'→2')-(65954-93-0)名称与标识符

名称

英文别名：

adenosine triphosphate adenosine monophosphate adenosine monophosphate; 2-5A ; 5'-O- [Hydroxy[[hydroxy(phosphonooxy)phosphinyl]oxy]phosphinyl]adenylyl-(2'→5')-adenylyl-(2'→5')-adenosine;Adenosine 5'-(tetrahydrogen triphosphate), adenylyl-(5'→2')-adenylyl-(5'→2')-;Adenosine, 5'-O-[hydroxy[[hydroxy(phosphonooxy)phosphinyl]oxy]phosphinyl]adenylyl-(2'→5')-adenylyl-(2'→5')-;65954-93-0;Adenosine 5'-(tetrahydrogen triphosphate), adenylyl-(5'-2')-adenylyl-(5'-2')-;Pppa2'-5'A2'-5'A;[[(2R,3R,5R)-5-(6-aminopurin-9-yl)-4-[[(2R,3R,4R,5R)-5-(6-aminopurin-9-yl)-4-[[(2R,3S,4R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] phosphono hydrogen phosphate;Ppapapa;Pppa(1)'P(5)'A(2)'P(5)'A;5'-O-[Hydroxy[[hydroxy(phosphonooxy)phosphinyl]oxy]phosphinyl]adenylyl-(2'→5')-adenylyl-(2'→5')-adenosine;2-5A;

标识符

InChIKey：

RTAGLZBJCCVJET-MFSXEPBNSA-N

Inchi：

1S/C30H40N15O25P5/c31-22-13-25(37-4-34-22)43(7-40-13)28-19(49)16(46)10(64-28)1-61-72(53,54)67-20-17(47)11(65-29(20)44-8-41-14-23(32)35-5-38-26(14)44)2-62-73(55,56)68-21-18(48)12(3-63-74(57,58)70-75(59,60)69-71(50,51)52)66-30(21)45-9-42-15-24(33)36-6-39-27(15)45/h4-12,16-21,28-30,46-49H,1-3H2,(H,53,54)(H,55,56)(H,57,58)(H,59,60)(H2,31,34,37)(H2,32,35,38)(H2,33,36,39)(H2,50,51,52)/t10-,11-,12-,16-,17-,18-,19-,20-,21?,28?,29-,30-/m1/s1

SMILES：

P(=O)(O)(OC[C@@H]1[C@H]([C@H]([C@H](N2C=NC3C(N)=NC=NC2=3)O1)OP(=O)(O)OC[C@@H]1[C@H]([C@H](C(N2C=NC3C(N)=NC=NC2=3)O1)O)O)O)OC1[C@H](N2C=NC3C(N)=NC=NC2=3)O[C@H](COP(=O)(O)OP(=O)(O)OP(=O)(O)O)[C@H]1O

Adenosine 5'-(tetrahydrogen triphosphate), adenylyl-(5'→2')-adenylyl-(5'→2')-(65954-93-0)物化性质

计算特性

精确分子量 : 1165.10078681g/mol
氢键供体数量 : 13
氢键受体数量 : 37
可旋转化学键数量 : 20
同位素质量 : 1165.10078681g/mol
重原子数量 : 75
复杂度 : 2270
同位素原子数量 : 0
确定原子立构中心数量 : 10
不确定原子立构中心数量 : 2
确定化学键立构中心数量 : 0
不确定化学键立构中心数量 : 0
共价键单元数量 : 1
疏水参数计算参考值（XlogP） : -10.9
拓扑分子极性表面积 : 589Å²

Adenosine 5'-(tetrahydrogen triphosphate), adenylyl-(5'→2')-adenylyl-(5'→2')-(65954-93-0)推荐厂家更多厂家(2)

公司名称	手机号/电话	联系人	QQ	微信	询单
上海楷森生物科技有限公司	17558870519 175-58870519	赵经理	3003926540		询单
杭州六可生物科技有限公司	15658003402 0086-571-86912261	Susan	3671025517		询单

Adenosine 5'-(tetrahydrogen triphosphate), adenylyl-(5'→2')-adenylyl-(5'→2')-(65954-93-0)合成路线

合成路线：1 步

反应条件：

1.1R:Tris buffer, R:MgCl2, R:Cleland's reagent, C:69106-44-1, S:H2O, 3 h, 30°C, pH 7.5; 5 min, 95°C

参考文献：

High yield synthesis, purification and characterisation of the RNase L activators 5'-triphosphate 2'-5'-oligoadenylates

By Morin, B. et al, Antiviral Research, 2010, 87(3), 345-352

合成路线：1 步

反应条件：

1.1R:Glycerol, R:HSCH2CH2OH, R:Mg(OAc)2, R:KCl, S:H2O, 20 h, 37°C

参考文献：

Dimeric Structure of Pseudokinase RNase L Bound to 2-5A Reveals a Basis for Interferon-Induced Antiviral Activity

By Huang, Hao et al, Molecular Cell, 2014, 53(2), 221-234

合成路线：1 步

61172-40-5

65954-93-0

反应条件：

1.1

参考文献：

Practical synthesis of 2'-5'-linked oligoadenylates (2-5A oligomers)

By Noyori, Ryoji et al, Australian Journal of Chemistry, 1992, 45(1), 205-25

合成路线：7 步

反应条件：

1.1R:t-BuMgCl, S:THF
1.1R:t-BuMgCl, S:THF
2.1S:DMF, S:THF
2.2R:Cl2CHCO2H, S:CH2Cl2
3.1S:DMF, S:THF
3.2R:Cl2CHCO2H, S:CH2Cl2
4.1R:2,6-Lutidine, S:THF
4.2R:I2, R:H2O, S:THF, S:Et2O
5.1R:Cu-Zn alloy, R:MeC(=O)CH2C(=O)Me, S:DMF
5.2R:
5.3R:
5.4R:NH3
5.5R:Bu4N+ •F-, S:THF
6.1R:Diimidazolyl ketone, R:Et3N, R:(C8H17)3N, S:DMF

参考文献：

A convenient synthesis of 2'-5'-linked oligoribonucleotides

By Hayakawa, Y. et al, Tetrahedron Letters, 1985, 26(6), 761-4

合成路线：3 步

反应条件：

1.1R:2-PySSPy-2, R:PPh3, S:DMSO
2.1R:C:Pb(NO3)2
3.1S:DMF

参考文献：

Expedient chemical synthesis of sequence-specific 2',5'-oligonucleotides

By Imai, Jiro and Torrence, Paul F., Journal of Organic Chemistry, 1985, 50(9), 1418-26

51963-61-2(磷酸腺苷钠) 1927-31-7(2'-脱氧腺苷 5'-三磷酸酯) 29984-33-6(单磷酸阿糖腺苷) 18422-05-4(腺苷-5'-单磷酸一水合物) 80584-92-5(三嗪聚羧酸三乙醇胺盐 Irgacor L184) 807295-35-8(2,4-IMIDAZOLIDINEDIONE, 5-(4-PIPERIDINYL)-) 807319-94-4((2S)-1-Isopropyl-2-methylpiperazine) 80812-32-4(3-(p-Tolylsulfonylamino)-5-fluorouracil)

问答

960化工网为您提供Adenosine 5'-(tetrahydrogen triphosphate), adenylyl-(5'→2')-adenylyl-(5'→2')-专业化合物百科信息，包括中文名，英文名，分子式，分子量，以及该化合物的CasNo.65954-93-0,相关理化性质;并提供了优质生产厂家信息包括厂家名称和联系方式等。 WAP版:65954-93-0 国际站:65954-93-0

65954-93-0 (Adenosine 5'-(tetrahydrogen triphosphate), adenylyl-(5'→2')-adenylyl-(5'→2')-,Adenosine, 5'-O-[hydroxy[[hydroxy(phosphonooxy)phosphinyl]oxy]phosphinyl]adenylyl-(2'→5')-adenylyl-(2'→5')-)

Adenosine 5'-(tetrahydrogen triphosphate), adenylyl-(5'→2')-adenylyl-(5'→2')-(65954-93-0)名称与标识符

名称

标识符

Adenosine 5'-(tetrahydrogen triphosphate), adenylyl-(5'→2')-adenylyl-(5'→2')-(65954-93-0)物化性质

计算特性

Adenosine 5'-(tetrahydrogen triphosphate), adenylyl-(5'→2')-adenylyl-(5'→2')-(65954-93-0)推荐厂家 更多厂家(2)

Adenosine 5'-(tetrahydrogen triphosphate), adenylyl-(5'→2')-adenylyl-(5'→2')-(65954-93-0)合成路线

目录

Adenosine 5'-(tetrahydrogen triphosphate), adenylyl-(5'→2')-adenylyl-(5'→2')-(65954-93-0)推荐厂家更多厂家(2)