77449-94-6 (顺式-4-羟基-D-脯氨酸盐酸盐,Cis-4-Hydroxy-D-proline hydrochloride)

快速询单

结构式：

顺式-4-羟基-D-脯氨酸盐酸盐MOL文件

CAS号：

77449-94-6

中文名称：

顺式-4-羟基-D-脯氨酸盐酸盐

英文名称：

Cis-4-Hydroxy-D-proline hydrochloride

分子式：

C₅H₁₀ClNO₃

分子量：

167.590800762177

简介：

cis-4-Hydroxy-D-proline (hydrochloride) 是不可降解 (non-cleavable) 的 ADC linker，用于合成抗体偶联活性分子 (ADCs)。cis-4-Hydroxy-D-proline (hydrochloride) 也是一个基于烷基链 (alkyl chain) 的 PROTAC linker，可用于合成 PROTAC。

顺式-4-羟基-D-脯氨酸盐酸盐(77449-94-6)名称与标识符

名称

中文别名：

顺式-4-羟基-D-脯氨酸盐酸盐;顺式-4-羟基-D-脯氨酸盐酸盐(3周-1个月);顺式-(D)-4-羟基脯氨酸盐酸盐;顺式-D-羟脯氨酸盐酸盐;顺式-4-羟基-脯氨酸盐酸盐;(2R,4R)-4-羟基吡咯烷-2-羧酸盐酸盐;顺-4-羟基-D-脯氨酸（盐酸盐形式的）;顺式-(D)-4-羟基脯氨酸盐酸盐顺式-D-羟脯氨酸盐酸盐顺式-4-羟基-脯氨酸盐酸盐;

英文别名：

Cis-4-Hydroxy-D-proline hydrochloride;CIS-4-HYDROXY-D-PROLINE HCL;(2R,4R)-4-Hydroxy-pyrrolidine-2-carboxylic acid hydrochloride;cis-4-Hydroxy-D-proline hydrochloride ((2R,4R)-4-Hydroxy-pyrrolidine-2-carboxylic acid hydrochloride);cis-4-Hydro×y-D-proline hydrochloride;(2R,4R)-4-hydroxyproline hydrochloride;(2R,4R)-4-hydroxypyrrolidine-2-carboxylic acid hydrochloride;(4-(2-chlorophenyl)thiazol-2-yl)Methanol;Cis-4-OH-D-pro-OH HCl;cis-D-Hyp-OH.HCl;D-Proline, 4-hydroxy-,hydrochloride (1:1), (4R)-;Cis-4-Hydroxy-D-proline, HCl;SCHEMBL2257034;rel-(2R,4R)-4-Hydroxypyrrolidine-2-carboxylic acid hydrochloride;A24032;J-500995;(2R,4R)-4-hydroxypyrrolidine-2-carboxylic acid;hydrochloride;DTXSID00487236;77449-94-6;AM20100769;Cis-4-Hydroxy-D Proline hydrochloride;AC-4323;MFCD09749867;EN300-131411;Z1198181174;D-PROLINE, 4-HYDROXY-, HYDROCHLORIDE, (4R)-;DS-0995;cis-4-Hydroxy-D-proline (hydrochloride);YEJFFQAGTXBSTI-VKKIDBQXSA-N;HY-76104;(2R,4R)-4-hydroxypyrrolidine-2-carboxylic acid HCl;AKOS000278429;CS-M0679;

标识符

MDL：

MFCD09749867

InChIKey：

YEJFFQAGTXBSTI-VKKIDBQXSA-N

Inchi：

1S/C5H9NO3.ClH/c7-3-1-4(5(8)9)6-2-3;/h3-4,6-7H,1-2H2,(H,8,9);1H/t3-,4-;/m1./s1

SMILES：

Cl.O[C@H]1CN[C@@H](C(=O)O)C1

顺式-4-羟基-D-脯氨酸盐酸盐(77449-94-6)物化性质

实验特性

LogP : -0.07540
PSA : 69.56000
沸点 : 368.6℃ at 760 mmHg
熔点 : 114-126°C
闪点 : 368.6 °C at 760 mmHg
颜色与性状 : White to Yellow Solid
比旋光度 : +16.5°-+19.8° (c=1, MeOH)

计算特性

精确分子量 : 167.03500
氢键供体数量 : 3
氢键受体数量 : 4
可旋转化学键数量 : 1
同位素质量 : 167.0349209g/mol
重原子数量 : 10
复杂度 : 125
同位素原子数量 : 0
确定原子立构中心数量 : 2
不确定原子立构中心数量 : 0
确定化学键立构中心数量 : 0
不确定化学键立构中心数量 : 0
共价键单元数量 : 2
拓扑分子极性表面积 : 69.6Å²

顺式-4-羟基-D-脯氨酸盐酸盐(77449-94-6)安全信息

危害声明：H315; H319; H335
警示性声明：P261; P264; P271; P280; P302+P352; P304+P340; P305+P351+P338; P312; P321; P332+P313; P337+P313; P362; P403+P233; P405; P501
储存条件： Store at room temperature
信号词： Warning

顺式-4-羟基-D-脯氨酸盐酸盐(77449-94-6)海关数据

海关编码：

2933990090

海关数据：

中国海关编码：

2933990090

概述：

2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

申报要素：

品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

Summary：

2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

顺式-4-羟基-D-脯氨酸盐酸盐(77449-94-6)推荐厂家更多厂家(47)

公司名称	手机号/电话	联系人	QQ	询单
成都普康生物科技有限公司	15982136729 028-82550498	魏经理	2885173398	询单
郑州长宽科技有限公司	18530983798 0371-63769919	Betty	1696268314	询单
郑州阿尔法化工有限公司	15324716602 0371-55013243	刘经理	2853979810	询单
湖北方德新材料有限公司	18086096695	邱经理	1462312301	询单
山东玖玥生物科技有限公司	15553333686	张文杰	643971	询单
上海瀚思化工有限公司	18939883912 021-34536277	顾经理	3003949364	询单
上海一基实业有限公司	13311756052 021-60526763 13311756052 13311756131	胡经理	2355265332	询单
铼博（上海）生化科技有限公司	13311756052 021-60536361 13311756052 13311756131	张经理	2851717387	询单
上海腾准生物科技有限公司	19821570922 021-34053661	张经理	3003871136	询单
上海绩祥生物科技有限公司	13093077543	陆经理	3985448220	询单

顺式-4-羟基-D-脯氨酸盐酸盐(77449-94-6)上下游

顺式-4-羟基-D-脯氨酸甲酯顺式-N-cbz-L-羟脯氨酸正-Boc-顺式-4-羟基-D-脯氨酸 BOC-L-羟脯氨酸 L-羟基脯氨酸

顺式-4-羟基-D-脯氨酸盐酸盐(77449-94-6) MSDS

基础信息

Material Safety Data Sheet

Section 1. Identi?cation of the substance
Product Name: Cis-4-Hydroxy-D-proline, HCl
Synonyms: (2R,4R)-4-Hydroxypyrrolidine-2-carboxylic acid hydrochloride

Section 2. Hazards identi?cation
Harmful by inhalation, in contact with skin, and if swallowed.

Section 3. Composition/information on ingredients.
Ingredient name: Cis-4-Hydroxy-D-proline, HCl
CAS number: 77449-94-6

Section 4. First aid measures
    Skin contact:        Immediately wash skin with copious amounts of water for at least 15 minutes while removing
    contaminated clothing and shoes. If irritation persists, seek medical attention.
    Eye contact:        Immediately wash skin with copious amounts of water for at least 15 minutes. Assure adequate
    ?ushing of the eyes by separating the eyelids with ?ngers. If irritation persists, seek medical
    attention.
    Inhalation:        Remove to fresh air. In severe cases or if symptoms persist, seek medical attention.
    Ingestion:        Wash out mouth with copious amounts of water for at least 15 minutes. Seek medical attention.

Section 5. Fire ?ghting measures
    In the event of a ?re involving this material, alone or in combination with other materials, use dry
    powder or carbon dioxide extinguishers. Protective clothing and self-contained breathing apparatus
    should be worn.

Section 6. Accidental release measures
    Personal precautions: Wear suitable personal protective equipment which performs satisfactorily and meets local/state/national
    standards.
    Respiratory precaution:        Wear approved mask/respirator
    Hand precaution:        Wear suitable gloves/gauntlets
    Skin protection:        Wear suitable protective clothing
    Eye protection:        Wear suitable eye protection
    Methods for cleaning up: Mix with sand or similar inert absorbent material, sweep up and keep in a tightly closed container
    for disposal. See section 12.
    Environmental precautions: Do not allow material to enter drains or water courses.

Section 7. Handling and storage
    Handling:        This product should be handled only by, or under the close supervision of, those properly quali?ed
    in the handling and use of potentially hazardous chemicals, who should take into account the ?re,
    health and chemical hazard data given on this sheet.
    Storage:        Store in closed vessels.

Section 8. Exposure Controls / Personal protection
    Engineering Controls: Use only in a chemical fume hood.
    Personal protective equipment: Wear laboratory clothing, chemical-resistant gloves and safety goggles.
    General hydiene measures: Wash thoroughly after handling. Wash contaminated clothing before reuse.

Section 9. Physical and chemical properties
    Appearance:        Not speci?ed
    Boiling point:        No data
    Melting point:        No data
    Flash point:        No data
    Density:        No data
    Molecular formula: C5H9NO3.ClH
    Molecular weight: 167.6

Section 10. Stability and reactivity
    Conditions to avoid: Heat, ?ames and sparks.
    Materials to avoid: Oxidizing agents.
    Possible hazardous combustion products: Carbon monoxide, nitrogen oxides, hydrogen chloride.

Section 11. Toxicological information
No data.

Section 12. Ecological information
No data.

Section 13. Disposal consideration
Arrange disposal as special waste, by licensed disposal company, in consultation with local waste
disposal authority, in accordance with national and regional regulations.

Section 14. Transportation information
Non-harzardous for air and ground transportation.

Section 15. Regulatory information
    No chemicals in this material are subject to the reporting requirements of SARA Title III, Section
    302, or have known CAS numbers that exceed the threshold reporting levels established by SARA
    Title III, Section 313.

SECTION 16 - ADDITIONAL INFORMATION
N/A