78628-80-5 (盐酸特比萘芬,Terbinafine hydrochloride)

盐酸特比萘芬;(E)-N-(6,6-二甲基-2-庚烯-4-炔基)-N-甲基-1-萘甲胺盐酸盐;特比萘芬盐酸盐;特比萘芬;特比萘酚;盐酸特比萘酚;特拉萘芬盐酸盐;反-N-(6,6-二甲基-2-庚烯-4-炔基)-N-甲基-1-萘基甲胺盐酸盐;(E)-N-(6,6-二甲基-2-庚烯-4-炔;二氨甲基环己基甲烷;反-N-(6,6-二甲基-2-庚-4-炔基)-N-甲基-1-萘基甲胺盐酸盐;甲氧苄啶;萘甲胺盐酸盐;特比萘芬 盐酸特比萘芬;特比萘芬系统适应性 EP标准品;特比萘芬盐酸盐 标准品;特比萘芬盐酸盐及其杂质标准品;盐酸特比奈芬;盐酸特比奈酚;盐酸特比萘fen;盐酸特比萘芬 EP标准品;盐酸特比萘芬 USP标准品;盐酸特比萘芬TERBINAFINE HYDROCHLORIDE;盐酸特比萘芬TERBINAFINE HYDROCHLORIDE78628;盐酸特比萘酚 标准品;(E)-N-(6,6-二甲基庚-2- 烯-4-炔基)-N-甲基-1-萘甲胺盐酸盐;特比奈酚;特比萘芬,盐酸D5;特比萘芬,盐酸D7;特比萘酚盐酸盐;植物组织果糖含量测试盒;trans-N-(6,6-Dimethyl-2-hepten-4-ylyl)-N-methyl-1-naphthylmethylamine 盐酸盐;(E)-N,6,6-三甲基-N-(萘-1-基甲基)庚-2-烯-4-炔-1-胺盐酸盐;盐酸特比萘芬，医药级,纯度:>99%;(E)-N-(6,6-二甲基庚-2-烯-4-炔基)-N-甲基-1-萘甲胺盐酸盐;

TERBINAFINE HYDROCHLORIDE;(e)-n-(6,6-dimethyl-2-hepten-4-ynyl)-n-methyl-1-naphthalenemethanamine monohydrochloride;(E)-N-(6,6-DIMETHYL-2-HEPTEN-4-YNYL)-N-METHYL-1-NAPHTHYLMETHYLAMINE HYDROCHLORIDE;LAMISIL;N-[(2E)-6,6-DIMETHYL-2-HEPTEN-4-YNYL]-N-METHYL-1-NAPHTHALENEMETHANAMINE;n,6,6-trimethyl-n-(naphthalen-1-ylmethyl)hept-2-en-4-yn-1-amine hydrochloride;TERBINAFINE HCL;TRANS-N-(6,6-DIMETHYL-2-HEPTEN-4-YNYL)-N-METHYL-1-NAPHTHYLMETHYLAMINE HYDROCHLORIDE;(e)-n-(6,6-dimethyl-2-hepten-4-ynyl)-n-methyl-1-naphthalenemethylaminehydroc;lamosil;n-(6,6-dimethyl-2-hepten-4-ynyl)-n-methyl-1-naphthalenemethanamin(e)-1-naphthalenemethanaminmon;n-(6,6-dimethyl-2-hepten-4-ynyl)-n-methyl-1-naphthalenemethanamin(e)-1-naphthalenemethanaminmonohydrochloride;TerbutalineSulfateBase;Lamisil, N-[(2E)-6,6-Dimethyl-2-hepten-4-ynyl]-N-methyl-1-naphthalenemethanamine;1-Naphthalenemethanamine, N-(2E)-6,6-dimethyl-2-hepten-4-ynyl-N-methyl-, hydrochloride;TERNBINAFINEHCL;({[(2E)-6,6-Dimethylhept-2-en-4-yn-1-yl](methyl)amino}methyl)naphthalene hydrochloride;Trebinafine hydrochloride;1-(3,5-Dihydroxyphenyl)-2-(tert-butylamino)ethanol;Terbutaline;N,6,6-Trimethyl-N-(1-naphthylmethyl)hept-2-en-4-yn-1-amine hydrochloride;TERBINAFINE;Terbinafine (hydrochloride);Terbinafine Hydrochl;terbinafine hydrochloride;Terbinafine Hydrochioride;trans-N-(6,6-Dimethyl-2-hepten-4-ylyl)-N-methyl-1-naphthylmethylamine hydrochloride;(E)-N,6,6-Trimethyl-N-(naphthalen-1-ylmethyl)hept-2-en-4-yn-1-amine Hydrochloride;[ "" ];Lamisil Krem;Lamisil AT;Terbinafinum [Latin];Terbinafina [Spanish];MycoVa;Terbinafinum;Terbinafina;Zabel;CPD000469152;012C11ZU6G;(E)-N-(6,6-Dimethyl-2-hepten-4-ynyl)-N-methyl-1-naphthalenemethylamine hydrochloride;C21H26ClN;Terbinafine h;TDT 067 hydrochloride;Terbine;SMR000469152;Terbinafinum (Latin);TERBINAFINE HYDROCHLORIDE (USP MONOGRAPH);Terbinafine hydrochloride (Lamisil);SF 86-327 hydrochloride;[(2Z)-6,6-dimethylhept-2-en-4-yn-1-yl](methyl)[(naphthalen-1-yl)methyl]amine hydrochloride;Good Neighbor Pharmacy;NSC-759113;NSC759113;NC00276;Lamisil ATfor Jock Itch;Terbinafine hydrochloride (USP:JAN);CHEMBL1200832;SW197656-2;SilkaAntifungal;Terbinafine hydrochloride [USP:JAN];Lamisil (TN);SCHEMBL36795;HY-17395;Bramazil;Terbinafine (as hydrochloride);(E)-N,6,6-trimethyl-N-(naphthalen-1-ylmethyl)hept-2-en-4-yn-1-aminehydrochloride;InnoNyx;MLS001401424;(E)-N,6,6-trimethyl-N-(naphthalen-1-ylmethyl)hept-2-en-4-yn-1-amine;hydrochloride;UNII-012C11ZU6G;DTXSID90229223;Antifungal Foot;s2557;Pharmakon1600-01505392;Terbinafine hydrochloride (JP17/USP);Terbinafine hydrochloride, Pharmaceutical Secondary Standard; Certified Reference Material;[(E)-6,6-dimethylhept-2-en-4-ynyl]-methyl-(naphthalen-1-ylmethyl)azanium;chloride;Terbinafine hydrochloride, United States Pharmacopeia (USP) Reference Standard;DTXCID10151714;(2E)-N,6,6-trimethyl-N-(1-naphthylmethyl)hept-2-en-4-yn-1-amine hydrochloride;SilkaJock Itch;(E)-N-(6,6-DIMETHYL-2-HEPTEN-4-YNYL)-N-METHYL-1-NAPHTHALENEMETHYLAMINE, HYDROCHLORIDE;TERBINAFINE HYDROCHLORIDE (EP MONOGRAPH);Terbinafine hydrochloride, >=98%;SF-86327;CVS PharmacyAthletes Foot;WalgreensAthletes Foot;terbinafin hydrochloride;ShopkoAthletes Foot;Terbinafine Hydochloride;NS00076449;Bramizil;lamisilat;Muzonal;GoodSenseTerbinafine Hydrochloride;Q27147212;Terbinafine HCl?;Lamisil AT Cream;CS-1123;1-Naphthalenemethanamine, N-(6,6-dimethyl-2-hepten-4-ynyl)-N-methyl-, (E)-, monohydrochloride;Terbinafine Hydrochloride,(S);(2E)-N,6,6-Trimethyl-N-(1-naphthylmethyl)hept-2-en-4-yn-1-amine hydrochloride (1:1);(Z)-N,6,6-Trimethyl-N-(naphthalen-1-ylmethyl)hept-2-en-4-yn-1-amine hydrochloride;SilkaGel;TERBINAFINE HYDROCHLORIDE [VANDF];LamisilAT Jock Itch;Athletes foot;Terbina;TERBINAFINE HYDROCHLORIDE [ORANGE BOOK];SCHEMBL36793;NM-100060;MLS001304037;78628-80-5 (HCl);KS-1289;CHEBI:77614;TerbiFoam;Terbisil;DRG-0286;MFCD00145430;AC-761;(2E)-N,6,6-trimethyl-N-(1-naphthylmethyl)hept-2-en-4-yn-1-aminium chloride;D2049;NSC 759113;TERBINAFINE HYDROCHLORIDE [USP MONOGRAPH];(2E)-N,6,6-Trimethyl-N-(naphthalen-1-ylmethyl)hept-2-en-4-yn-1-amine monohydrochloride;LS-14899;EC 616-640-4;TERBINAFINE HYDROCHLORIDE [JAN];terbinafine monohydrochloride;AKOS015844100;Terbinafine hydrochloride, Antibiotic for Culture Media Use Only;Terbinafine Tablets 250 mg;TERBINAFINE HYDROCHLORIDE (USP-RS);BCP9000834;KrogerAntifungal;HTU-520;Terbinafine for system suitability, European Pharmacopoeia (EP) Reference Standard;BT164461;TERBINAFINE HYDROCHLORIDE [EP MONOGRAPH];1-NAPHTHALENEMETHANAMINE, N-(6,6-DIMETHYL-2-HEPTEN-4-YNYL)-N-METHYL-, (E)-, HYDROCHLORIDE;TERBINAFINE HYDROCHLORIDE [USP-RS];1-Naphthalenemethanamine, N-[(2E)-6,6-dimethyl-2-hepten-4-yn-1-yl]-N-methyl-, hydrochloride (1:1);[(2E)-6,6-dimethylhept-2-en-4-yn-1-yl](methyl)(naphthalen-1-ylmethyl)amine hydrochloride;Afogan;Terbinafine hydrochloride, European Pharmacopoeia (EP) Reference Standard;(E)-N-(6,6-Dimethyl-2-hepten-4-ynyl)-N-methyl-1-naphthalenemethanamine hydrochloride;TERBINAFINE HYDROCHLORIDE [WHO-DD];AKOS025149216;TERBINAFINE HCL 5%;TERBINAFINE HYDROCHLORIDE [MART.];MLS001066620;Q-201790;Shoprite;TERBINAFINE HYDROCHLORIDE [MI];D02219;CCG-101026;TERBINAFINE HYDROCHLORIDE (MART.);(2E)-N,6,6-TRIMETHYL-N-(NAPHTHALEN-1-YLMETHYL)HEPT-2-EN-4-YN-1-AMINE HYDROCHLORIDE;78628-80-5;

MFCD00145430

BWMISRWJRUSYEX-SZKNIZGXSA-N

1S/C21H25N.ClH/c1-21(2,3)15-8-5-9-16-22(4)17-19-13-10-12-18-11-6-7-14-20(18)19;/h5-7,9-14H,16-17H2,1-4H3;1H/b9-5+;

Cl[H].N(C([H])([H])[H])(C([H])([H])/C(/[H])=C(\[H])/C#CC(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H])C([H])([H])C1=C([H])C([H])=C([H])C2=C([H])C([H])=C([H])C([H])=C12

245-385-8

2921499090

1.1,1-二氯-3,3-二甲基丁烷的制备在反应瓶中加入氯代叔丁烷186g(2mol)、无水三氯化铝9g,冷至-30oC.在 搅拌下通入氯乙烯气体(由1,2-二氯乙烷250g,NaOH150g和无水乙醇200ml在50~90oC反应制得),约1.5h通完,然后在30min内,缓慢升温至-15oC.在剧烈搅拌下,加入200mol/L盐酸150ml,分出有机层,用水(100ml×2)洗涤,无水MgSO4干燥,过滤#将滤液在室温下减压除去过量的氯乙烯,得粗品1,1-二氯-3,3-二甲基丁烷311g(定量),可直接用于下步反应,分析样品经蒸馏制得. 2.叔丁基乙炔的制备 在反应瓶中加入KOH115g(2mol)和DMSO200ml,反应瓶上的冷凝管通50oC的温水,反应瓶用油浴加热至140oC,在搅拌下滴加上步制备的化合物1,1-二氯-3,3-二甲基丁烷77.5g(0.5mol),2h加完,再在140~170oC搅拌反应10h.得粗产物32g,经蒸馏得经蒸馏得叔丁基乙炔26g,收率63.41%, 3.6,6-二甲基庚-1-烯-4-炔-3-醇的制备 在干燥的反应瓶中加入干燥的镁屑25.20g(1.04mol)、无水乙醚400ml,于室温搅拌下滴加新蒸馏的溴乙烷127g(1.16mol)的无水乙醚80ml溶液,滴加速度以能保持乙醚回流为准#加完后继续搅拌回流反应2h.在室温下,向反应瓶内形成的EtMgBr乙醚溶液中,搅拌滴加上步制备的化合物叔丁基乙炔82g(1mol)的无水乙醚(120ml)溶液,约3h滴加完,室温继续搅拌,直至白色固体形成,放置过夜.在冰/盐浴冷却下,在形成的炔烃格氏试剂的乙醚悬浊液中,于搅拌下滴加新蒸馏的丙烯醛60g(1.07mol)的无水乙醚100ml溶液,约3.5h加完,滴毕,于室温下搅拌过夜.在冰浴冷却下和搅拌下加入NH4Cl饱和水溶液150ml,搅拌充分后静置分层,分出醚层,水层用乙醚(100ml...

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