79-05-0 (丙酰胺,Propionamide)

_100%

反应条件：

1.1 Reagents: Formic acid Catalysts: Palladium (supported on fibrous-structured silica nanospheres) Solvents: Methanol , Water ; 12 h, 100 °C

参考文献：

Palladium Nanoparticles Supported on Fibrous-Structured Silica Nanospheres (KCC-1): An Efficient and Selective Catalyst for the Transfer Hydrogenation of Alkenes

Qureshi, Ziyauddin S.; Sarawade, Pradip B.; Albert, Matthias; D'Elia, Valerio; Hedhili, Mohamed N.; et al, ChemCatChem, 2015, 7(4), 635-642

合成路线：1 步

_100%

反应条件：

1.1 Reagents: Aldoxime Catalysts: Cupric chloride Solvents: Methanol ; 4 h, 65 °C

参考文献：

A heterogeneous catalytic method for the conversion of nitriles into amides using molecular sieves modified with copper(II)

Kiss, Arpad; Hell, Zoltan, Tetrahedron Letters, 2011, 52(45), 6021-6023

合成路线：1 步

_100%

反应条件：

1.1 Reagents: Hydrogen Catalysts: Nickel boride (resin bound) Solvents: Methanol

参考文献：

An excellent nickel boride catalyst for the selective hydrogenation of olefins

Choi, Jaesung; Yoon, Nung Min, Synthesis, 1996, (5), 597-599

合成路线：1 步

_100%

反应条件：

1.1 Reagents: Hydrogen Catalysts: Palladium, dichloro[1-[(dimethylamino)methyl]-2-[(4-methylphenyl)thio]ferrocene-… Solvents: Acetone

参考文献：

Application of palladium ferrocenyl amine sulfide complexes in the hydrogenation of carbon-carbon double and triple bonds

Ali, Hussein M.; Naiini, Ahmad A.; Brubaker, Carl H. Jr., Journal of Molecular Catalysis, 1992, 77(2), 125-34

合成路线：1 步

123-38-6

_99%

反应条件：

1.1 Reagents: Sodium bicarbonate , Hydroxyamine hydrochloride Catalysts: 2761983-03-1 Solvents: Water ; 2 h, 313 K

参考文献：

Mechanochemical synthesis of half-sandwich iridium/rhodium complexes with 8-hydroxyquinoline derivatives ligands

Jia, Wei-Guo ; Li, Xiao-Dong ; Zhi, Xue-Ting ; Zhong, Rui, Applied Organometallic Chemistry, 2022, 36(4),

合成路线：1 步

_99%

反应条件：

1.1 Reagents: Hydrogen Catalysts: Phosphine, tris(4-ethenylphenyl)-, polymer with 1,3,5-tribromobenzene (post-treated with Pd nanoparticles) Solvents: Ethanol ; 1 h, 1 atm, rt

参考文献：

Palladium/Phosphorus-Doped Porous Organic Polymer as Recyclable Chemoselective and Efficient Hydrogenation Catalyst under Ambient Conditions

Ding, Zong-Cang; Li, Cun-Yao; Chen, Jun-Jia; Zeng, Jia-Hao; Tang, Hai-Tao; et al, Advanced Synthesis & Catalysis, 2017, 359(13), 2280-2287

合成路线：1 步

_99%

反应条件：

1.1 Reagents: Hydrogen Solvents: Ethanol ; 1 h, 2 MPa, 100 °C

参考文献：

Reactivity and mechanism investigation of selective hydrogenation of 2,3,5-trimethylbenzoquinone on in situ generated metallic cobalt

Su, Diefeng; Wei, Zhongzhe; Mao, Shanjun; Wang, Jing; Li, Yi; et al, Catalysis Science & Technology, 2016, 6(12), 4503-4510

合成路线：1 步

_99%

反应条件：

1.1 Reagents: Hydrogen Catalysts: Palladium , Carbon Solvents: Ethanol ; 0.5 h, 1 bar, 30 °C

参考文献：

Highly efficient and chemoselective hydrogenation of α,β-unsaturated carbonyls over Pd/N-doped hierarchically porous carbon

Wei, Zhongzhe; Gong, Yutong; Xiong, Tianyi; Zhang, Pengfei; Li, Haoran; et al, Catalysis Science & Technology, 2015, 5(1), 397-404

合成路线：1 步

_99%

反应条件：

1.1 Catalysts: Manganese oxide (MnO2) Solvents: Water ; 15 min, 100 psi, 70 °C

参考文献：

Mild and Selective Heterogeneous Catalytic Hydration of Nitriles to Amides by Flowing through Manganese Dioxide

Battilocchio, Claudio; Hawkins, Joel M.; Ley, Steven V., Organic Letters, 2014, 16(4), 1060-1063

合成路线：1 步

_99%

反应条件：

1.1 Reagents: Hydrogen Solvents: Methanol ; 29 bar, 30 °C

参考文献：

Large Centimeter-Sized Macroporous Ferritin Gels as Versatile Nanoreactors

Kumari, Sushma; Kulkarni, Amol; Kumaraswamy, Guruswamy; Sen Gupta, Sayam, Chemistry of Materials, 2013, 25(23), 4813-4819

合成路线：1 步

_96%

反应条件：

1.1 Reagents: Water Catalysts: [2,6-Bis(diphenylmethyl)-4-methylbenzenamine]dichloro[(1,2,3,4,5,6-η)-1-methyl-4… ; 4 h, rt

参考文献：

Water-soluble superbulky (η6-p-cymene) ruthenium(II) amine: an active catalyst in the oxidative homocoupling of arylboronic acids and the hydration of organonitriles

Nirmala, Muthukumaran; Adinarayana, Mannem; Ramesh, Karupnaswamy; Maruthupandi, Mannarsamy; Vaddamanu, Moulali; et al, New Journal of Chemistry, 2018, 42(18), 15221-15230

合成路线：1 步

_96%

反应条件：

1.1 Catalysts: Ruthenium(1+), dichloro[(1,2,3,4,5,6-η)-1-methyl-4-(1-methylethyl)benzene][1-[3-… (supported on silica-coated nanoferrite) Solvents: Water ; 2 h, 100 - 120 psi, 150 °C

参考文献：

Chemistry by Nanocatalysis: First Example of a Solid-Supported RAPTA Complex for Organic Reactions in Aqueous Medium

Garcia-Garrido, Sergio E.; Francos, Javier; Cadierno, Victorio; Basset, Jean-Marie; Polshettiwar, Vivek, ChemSusChem, 2011, 4(1), 104-111

合成路线：1 步

79-09-4

_96%

反应条件：

1.1 Reagents: Niobium pentachloride Solvents: Dichloromethane ; rt
1.2 Reagents: Ammonia ; 0.5 h, rt; rt → 50 °C; 1 h, 40 - 50 °C

参考文献：

Niobium pentachloride promoted conversion of carboxylic acids to carboxamides: Synthesis of the 4-aryl-1,2,3,4-tetrahydroisoquinoline alkaloid structures

Nery, Marcelo S.; Ribeiro, Renata P.; Lopes, Claudio C.; Lopes, Rosangela S. C., Synthesis, 2003, (2), 272-276

合成路线：1 步

123-38-6

_95%

反应条件：

1.1 Reagents: Potassium bicarbonate , Hydroxyamine hydrochloride Catalysts: Cobalt oxide (Co3O4) , Copper Solvents: Acetonitrile , Water ; 1 MPa, rt; 6 h, 140 °C

参考文献：

Kinetic Analysis of Consecutive/Parallel Transformation of Furfural to Biomass-Based Primary Amide by Using a "Concentration-Time" Integral

Yang, Shengwen; Chen, Jinzhu, ACS Catalysis, 2023, 13(1), 113-131

合成路线：1 步

_95%

反应条件：

1.1 Reagents: Sodium borohydride Catalysts: Cuprous chloride Solvents: Ethanol ; rt; 30 h, rt
1.2 Reagents: Hydrochloric acid Solvents: Water ; pH 5 - 6, rt

参考文献：

Selective reduction of α,β-unsaturated amides with NaBH4-CuCl/EtOH

Li, Jian-ping; Zhang, Yong-xia; Su, Ling-yun; Meng, Ge; Guo, Hai-ming, Henan Shifan Daxue Xuebao, 2012, 40(2), 101-103

合成路线：1 步

120157-99-5

_95%

反应条件：

1.1 Reagents: Trifluoroacetic acid Solvents: Dichloromethane

参考文献：

A new method for the synthesis of amides from amines: ruthenium tetroxide oxidation of N-protected alkylamines

Tanaka, Kenichi; Yoshifuji, Shigeyuki; Nitta, Yoshihiro, Chemical & Pharmaceutical Bulletin, 1988, 36(8), 3125-9

合成路线：1 步

_94%

反应条件：

1.1 Reagents: Formic acid Catalysts: Palladium diacetate , 1,1′-(9,9-Dimethyl-9H-xanthene-4,5-diyl)bis[1,1-diphenylphosphine] Solvents: Water ; 20 h, 90 °C

参考文献：

Facile Pd-catalyzed chemoselective transfer hydrogenation of olefins using formic acid in water

Liu, Tianxiang; Zeng, Yongming; Zhang, Hongxi; Wei, Ting; Wu, Xia; et al, Tetrahedron Letters, 2016, 57(43), 4845-4849

合成路线：1 步

_94%

反应条件：

1.1 Catalysts: Tricyclohexylphosphine , Bis[(1,2,5,6-η)-1,5-cyclooctadiene]di-μ-methoxydirhodium Solvents: Toluene , Tetrahydrofuran ; 15 min, 25 °C
1.2 Solvents: Isopropanol , Water ; 24 h, 25 °C

参考文献：

RhI-catalyzed hydration of organonitriles under ambient conditions

Goto, Akihiro; Endo, Kohei; Saito, Susumu, Angewandte Chemie, 2008, 47(19), 3607-3609

合成路线：1 步

_93%