79069-13-9 (BOC-L-丙氨醇,Boc-L-alaninol)

反应条件：

1.1 Reagents: Sodium borohydride Solvents: Methanol , Tetrahydrofuran ; 20 min, 65 °C; 1 h, 65 °C

参考文献：

Synthesis and antimalarial activity of new 4-aminoquinolines active against drug resistant strains

Kondaparla, Srinivasarao; Soni, Awakash; Manhas, Ashan; Srivastava, Kumkum; Puri, Sunil K.; et al, RSC Advances, 2016, 6(107), 105676-105689

合成路线：1 步

_100%

反应条件：

1.1 Reagents: Triethylamine Solvents: Methanol ; 12 h, 0 °C

参考文献：

Novel Analogues of Istaroxime, a Potent Inhibitor of Na+,K+-ATPase: Synthesis and Structure-Activity Relationship

Gobbini, Mauro; Armaroli, Silvia; Banfi, Leonardo; Benicchio, Alessandra; Carzana, Giulio; et al, Journal of Medicinal Chemistry, 2008, 51(15), 4601-4608

合成路线：1 步

_100%

反应条件：

1.1 Reagents: Sodium hydroxide Solvents: Water ; rt → 0 °C
1.2 Solvents: 1,4-Dioxane ; 3 h, rt
1.3 Reagents: Ammonium chloride Solvents: Water ; pH 8, rt

参考文献：

Aplyronine A, a potent antitumor macrolide of marine origin, and the congeners aplyronines B and C: isolation, structures, and bioactivities

Ojika, Makoto; Kigoshi, Hideo; Yoshida, Yoshifumi; Ishigaki, Takeshi; Nisiwaki, Masanori; et al, Tetrahedron, 2007, 63(15), 3138-3167

合成路线：1 步

_99%

反应条件：

1.1 Reagents: Triethylamine Solvents: Dichloromethane ; rt

参考文献：

Discovery of a novel chemotype of potent human ENaC blockers using a bioisostere approach. Part 2: α-Branched quaternary amines

Hunt, Thomas; Atherton-Watson, Hazel C.; Collingwood, Stephen P.; Coote, Kevin J.; Czarnecki, Sarah; et al, Bioorganic & Medicinal Chemistry Letters, 2012, 22(8), 2877-2879

合成路线：1 步

_99%

反应条件：

1.1 Reagents: Triethylamine Solvents: Tetrahydrofuran ; 0 °C; 0 °C → rt; 1.5 h, rt

参考文献：

Enantiopure 1,4-Benzoxazines via 1,2-Cyclic Sulfamidates. Synthesis of Levofloxacin

Bower, John F.; Szeto, Peter; Gallagher, Timothy, Organic Letters, 2007, 9(17), 3283-3286

合成路线：1 步

631914-55-1

_98%

反应条件：

1.1 Reagents: Lithium chloride , Sodium borohydride Solvents: Tetrahydrofuran ; rt

参考文献：

Synthesis of α-(R)-/γ-(S)-dimethyl substituted peptide nucleic acid submonomer using Mitsunobu reaction

Abdelbaky, Ahmed S.; Prokhorov, Ivan A.; Smirnov, Igor P.; Koroleva, Kristina M.; Shvets, Vitaliy I.; et al, Letters in Organic Chemistry, 2019, 16(5), 437-446

合成路线：1 步

_97%

反应条件：

1.1 Catalysts: Thiamine hydrochloride ; 3 min, rt

参考文献：

Thiamine hydrochloride as a recyclable organocatalyst for the efficient and chemoselective N-tert-butyloxycarbonylation of amines

Ingale, Ajit P. ; Garad, Dnyaneshwar N. ; Ukale, Dattatraya ; Thorat, Nitin M. ; Shinde, Sandeep V., Synthetic Communications, 2021, 51(24), 3791-3804

合成路线：1 步

_97%

反应条件：

1.1 3 min, rt

参考文献：

Ultrasound promoted environmentally benign, highly efficient, and chemoselective N-tert-butyloxycarbonylation of amines by reusable sulfated polyborate

Pise, Ashok A. ; Ingale, Ajit P. ; Dalvi, Navnath R., Synthetic Communications, 2021, 51(24), 3768-3780

合成路线：1 步

_97%

反应条件：

1.1 Reagents: Diisopropylethylamine Solvents: Tetrahydrofuran ; 0 °C; 6 h, rt

参考文献：

Novel enantioselective fluorescent sensors for malate anion based on acridine

Li, Qian; Xu, Kuoxi ; Song, Pan; Dai, Yanpeng; Yang, Li; et al, Dyes and Pigments, 2014, 109, 169-174

合成路线：1 步

28875-17-4

_97%

反应条件：

1.1 Reagents: Lithium aluminum hydride Solvents: Tetrahydrofuran ; 0 °C; 0 °C → rt
1.2 Reagents: Sodium hydroxide , Hydrogen peroxide Solvents: Water ; rt
1.3 Solvents: Diethyl ether ; 30 min, rt

参考文献：

New Building Block for Polyhydroxylated Piperidine: Total Synthesis of 1,6-Dideoxynojirimycin

Rengasamy, Rajesh; Curtis-Long, Marcus J.; Seo, Woo Duck; Jeong, Seong Hun; Jeong, Ill-Yun; et al, Journal of Organic Chemistry, 2008, 73(7), 2898-2901

合成路线：1 步

_97%

反应条件：

1.1 Reagents: Triethylamine Solvents: Acetonitrile ; 24 h, rt

参考文献：

L-Glutamic acid and L-alanine derivatives as building blocks for the synthesis of a chiral monomer precursor of AABB-type polyamide

Gomez, Romina V.; Orgueira, Hernan A.; Varela, Oscar, ARKIVOC (Gainesville, 2003, (10), 201-208

合成路线：1 步

_96%

反应条件：

1.1 Catalysts: Tungstate ; 5 min, rt

参考文献：

Sulfated tungstate: A highly efficient, recyclable and ecofriendly catalyst for chemoselective N-tert butyloxycarbonylation of amines under the solvent-free conditions

Ingale, Ajit P. ; Shinde, Sandeep V. ; Thorat, Nitin M., Synthetic Communications, 2021, 51(16), 2528-2543

合成路线：1 步

28875-17-4

_96%