79887-09-5 (4-丁基苯乙炔,1-butyl-4-ethynylbenzene)

反应条件：

1.1 Reagents: Potassium carbonate Solvents: Methanol ; 4 h, rt
1.2 Solvents: Water ; rt

参考文献：

The synthesis of [1,2,3]-triazole-based bent core liquid crystals via microwave-mediated 'Click Reaction' and their mesomorphic behaviour

Wang, Kunlun; et al, Liquid Crystals, 2019, 46(2), 257-271

合成路线：1 步

202524-78-5

_90%

反应条件：

1.1 Reagents: Potassium carbonate Solvents: Methanol ; 4 h, rt

参考文献：

Synthesis of substituted helicenes by Ir-catalyzed annulative coupling of biarylcarboxylic acid chlorides with alkynes

Kamikawa, Ken; et al, Bulletin of the Chemical Society of Japan, 2018, 91(7), 1069-1074

合成路线：1 步

155906-12-0

_85%

反应条件：

1.1 Reagents: Sodium hydroxide Solvents: Toluene ; 10 h, reflux

参考文献：

Synthesis and characterization of the multi-photon absorption and excited-state properties of a neat liquid 4-propyl 4'-butyl diphenyl acetylene

Khoo, Iam Choon; et al, Journal of Materials Chemistry, 2009, 19(40), 7525-7531

合成路线：1 步

_55%

反应条件：

1.1 Reagents: Triethylamine Catalysts: Cuprous iodide , Tetrakis(triphenylphosphine)palladium ; rt; 21 h, 90 °C
1.2 Reagents: Potassium carbonate Solvents: Methanol ; 3 h, rt

参考文献：

Reaction Selectivity in On-Surface Chemistry by Surface Coverage Control-Alkyne Dimerization versus Alkyne Trimerization

Klaasen, Henning; et al, Chemistry - A European Journal, 2018, 24(57), 15303-15308

合成路线：1 步

反应条件：

1.1 Reagents: Triethylamine Catalysts: Cuprous iodide , Dichlorobis(triphenylphosphine)palladium ; 16 h, 40 °C

参考文献：

Metal-free oxidative phosphinylation of aryl alkynes to β-ketophosphine oxides via visible-light photoredox catalysis

Bu, Mei-jie; et al, Catalysis Science & Technology, 2016, 6(2), 413-416

合成路线：2 步

反应条件：

1.1 Reagents: Triethylamine Catalysts: Cuprous iodide , Dichlorobis(triphenylphosphine)palladium Solvents: Tetrahydrofuran ; 18 h, 70 °C
2.1 Reagents: Potassium carbonate Solvents: Methanol ; 21 h, rt
2.2 Reagents: Hydrochloric acid Solvents: Water ; rt

参考文献：

Regio- and stereoselective synthesis of bromoalkenes by homolytic hydrobromination of alkynes with hydrogen bromide

Kumaki, Wataru; et al, Tetrahedron, 2022, 110,

合成路线：1 步

20651-67-6

反应条件：

1.1 Reagents: Triethylamine Catalysts: Cuprous iodide , Dichlorobis(triphenylphosphine)palladium Solvents: Tetrahydrofuran ; 12 h, rt
1.2 Reagents: Potassium carbonate Solvents: Methanol ; 3 h, rt

参考文献：

BF3·OEt2-Promoted Propargyl Alcohol Rearrangement/[1,5]-Hydride Transfer/Cyclization Cascade Affording Tetrahydroquinolines

Zhao, Shuang; et al, Organic Letters, 2019, 21(11), 3990-3993

合成路线：2 步

20651-67-6

反应条件：

1.1 Reagents: Diisopropylamine Catalysts: Triphenylphosphine , Palladium chloride , Cuprous iodide ; 1.5 h, 60 °C; 60 °C → rt
1.2 Reagents: Diisopropylamine ; 12 h, rt
2.1 Reagents: Potassium carbonate Solvents: Methanol ; 4 h, rt
2.2 Solvents: Water ; rt

参考文献：

The synthesis of [1,2,3]-triazole-based bent core liquid crystals via microwave-mediated 'Click Reaction' and their mesomorphic behaviour

Wang, Kunlun; et al, Liquid Crystals, 2019, 46(2), 257-271

合成路线：1 步

748186-50-7

反应条件：

1.1 Reagents: Potassium hydroxide Solvents: Ethanol ; reflux

参考文献：

Synthesis and property of liquid crystal compounds: trans-cyclohexyltolan-type with lateral fluorines

Wang, Xiao-Wei; et al, Yingyong Huaxue, 2004, 21(3), 281-285

合成路线：2 步

115-19-5

反应条件：

1.1 Reagents: Triethylamine Catalysts: Cuprous iodide , Dichlorobis(triphenylphosphine)palladium Solvents: Triethylamine ; rt; overnight, reflux; reflux → rt
2.1 Reagents: Sodium hydroxide Solvents: Toluene ; 10 h, reflux

参考文献：

Synthesis and characterization of the multi-photon absorption and excited-state properties of a neat liquid 4-propyl 4'-butyl diphenyl acetylene

Khoo, Iam Choon; et al, Journal of Materials Chemistry, 2009, 19(40), 7525-7531

合成路线：2 步

26206-42-8

反应条件：

1.1 Reagents: Bromine Catalysts: Carbon tetrachloride
2.1 Reagents: Potassium hydroxide Solvents: Ethanol ; reflux

参考文献：

Synthesis and property of liquid crystal compounds: trans-cyclohexyltolan-type with lateral fluorines

Wang, Xiao-Wei; et al, Yingyong Huaxue, 2004, 21(3), 281-285

合成路线：3 步

104-13-2

反应条件：

1.1 Reagents: Sodium nitrite , Hydrochloric acid Solvents: Water ; 0 °C; 1 h, 0 °C
1.2 Reagents: Potassium iodide Solvents: Water ; 0 °C; overnight, rt
2.1 Reagents: Diisopropylamine Catalysts: Triphenylphosphine , Palladium chloride , Cuprous iodide ; 1.5 h, 60 °C; 60 °C → rt
2.2 Reagents: Diisopropylamine ; 12 h, rt
3.1 Reagents: Potassium carbonate Solvents: Methanol ; 4 h, rt
3.2 Solvents: Water ; rt

参考文献：

The synthesis of [1,2,3]-triazole-based bent core liquid crystals via microwave-mediated 'Click Reaction' and their mesomorphic behaviour

Wang, Kunlun; et al, Liquid Crystals, 2019, 46(2), 257-271

合成路线：3 步

125639-56-7

反应条件：

1.1 Reagents: p-Toluenesulfonic acid
2.1 Reagents: Bromine Catalysts: Carbon tetrachloride
3.1 Reagents: Potassium hydroxide Solvents: Ethanol ; reflux

参考文献：

Synthesis and property of liquid crystal compounds: trans-cyclohexyltolan-type with lateral fluorines

Wang, Xiao-Wei; et al, Yingyong Huaxue, 2004, 21(3), 281-285

合成路线：4 步

37920-25-5

反应条件：

1.1 Reagents: Hydrogen , Nickel ; 1.8 MPa
2.1 Reagents: p-Toluenesulfonic acid
3.1 Reagents: Bromine Catalysts: Carbon tetrachloride
4.1 Reagents: Potassium hydroxide Solvents: Ethanol ; reflux

参考文献：

Synthesis and property of liquid crystal compounds: trans-cyclohexyltolan-type with lateral fluorines

Wang, Xiao-Wei; et al, Yingyong Huaxue, 2004, 21(3), 281-285

合成路线：5 步

104-51-8

75-36-5