80565-30-6 (4&#x27;-氯联苯-4-甲醛,4-(4-chlorophenyl)benzaldehyde)

_100%

反应条件：

1.1 Reagents: Potassium carbonate Catalysts: Palladium diacetate , Poly[oxy[(chloromethyl)-1,2-ethanediyl]] (reaction products with methylimidazole and bis(trifluoromethylsulfonyl…) Solvents: Water ; 1.5 h, 60 °C

参考文献：

From a single helix to a helical porous metalloenzyme catalyst based on temperature sensitive polyionic liquids

Li, Xinjuan; et al, Polymer Chemistry, 2022, 13(33), 4789-4797

合成路线：1 步

15164-44-0

_82%

反应条件：

1.1 Catalysts: Potassium carbonate , Palladium (aminoterephthalate chromium MOF supported) , Tris[μ-[2-amino-1,4-benzenedicarboxylato(2-)-κO1:κO′1]]diaquahydroxy-μ3-oxotrich… Solvents: Ethanol ; 1 h, 0.1 MPa, 70 °C

参考文献：

Palladium nanoparticles encapsulated in MIL-101-NH2 catalyzed one-pot reaction of Suzuki-Knoevenagel reaction

Li, Jia-Xin; et al, Inorganic Chemistry Communications, 2019, 103, 82-86

合成路线：1 步

15164-44-0

_79%

反应条件：

1.1 Reagents: Tripotassium phosphate Catalysts: 2241142-82-3 Solvents: Polyethylene glycol ; 24 h, 140 °C

参考文献：

A new diphosphine-carbonyl complex of ruthenium: an efficient precursor for C-C and C-N bond coupling catalysis

Mukherjee, Aparajita; et al, Dalton Transactions, 2018, 47(30), 10264-10272

合成路线：1 步

104-88-1

_99%

反应条件：

1.1 Reagents: Sodium carbonate Catalysts: 2460801-03-8 Solvents: Water ; 5 h, 30 °C

参考文献：

(N-Heterocyclic carbene) ion-pair palladium complexes: Suzuki-Miyaura cross-coupling studies in neat water under mild conditions

Chen, Ming-Tsz ; et al, Applied Organometallic Chemistry, 2020, 34(12),

合成路线：1 步

104-88-1

_89%

反应条件：

1.1 Reagents: Potassium carbonate Catalysts: Palladium chloride , N′-[2,6-Bis(1-methylethyl)phenyl]-N-(6-methyl-2-pyridinyl)benzenecarboximidamide Solvents: Dimethylformamide , Water ; 8 h, 110 °C

参考文献：

Efficient pyridylbenzamidine ligands for palladium-catalyzed Suzuki-Miyaura reaction

Huang, Ying-Tang; et al, Applied Organometallic Chemistry, 2012, 26(12), 701-706

合成路线：1 步

_99%

反应条件：

1.1 Reagents: Cesium carbonate Catalysts: 2953069-79-7 Solvents: Dimethylformamide , Water ; 48 h, rt

参考文献：

Pd-PEPPSI type complexes bearing unsymmetrical NHC ligand with phenyl-substituted backbone: Highly efficient catalysts for Heck-Mizoroki and Suzuki-Miyaura cross-coupling reactions

Korukcu, Meliha Cetin; et al, Applied Organometallic Chemistry, 2023, 37(5),

合成路线：1 步

_99%

反应条件：

1.1 Reagents: Tripotassium phosphate Solvents: Ethanol , Water ; 1 h, rt

参考文献：

Palladium-Anchored N-Heterocyclic Carbenes in a Porous Organic Polymer: A Heterogeneous Composite Catalyst for Eco-Friendly C-C Coupling

Let, Sumanta; et al, Journal of Organic Chemistry, 2022, 87(24), 16655-16664

合成路线：1 步

_99%

反应条件：

1.1 Reagents: Potassium carbonate , Oxygen Catalysts: Polyethylene glycol , 1820646-53-4 Solvents: Water ; 4 h, 70 °C

参考文献：

A self-assembled bisoxazoline/Pd composite microsphere as an excellent catalyst for Suzuki-Miyaura coupling reactions

Wang, Junke; et al, Green Chemistry, 2016, 18(4), 967-973

合成路线：1 步

_95%

反应条件：

1.1 Reagents: Sodium dodecyl sulfate , Tripotassium phosphate , Oxygen Catalysts: Disodium tetrachloropalladate Solvents: Water ; 5 min, 100 °C

参考文献：

Aerobic ligand-free Suzuki coupling catalyzed by in situ-generated palladium nanoparticles in water

Saha, Debasree; et al, Tetrahedron Letters, 2009, 50(9), 1003-1006

合成路线：1 步

_75%

反应条件：

1.1 Reagents: Potassium carbonate Catalysts: Copper , Iodine Solvents: Polyethylene glycol ; 36 h, 140 °C; 140 °C → rt

参考文献：

Highly efficient copper(0)-catalyzed Suzuki-Miyaura cross-coupling reactions in reusable PEG-400

Mao, Jincheng; et al, Tetrahedron, 2008, 64(18), 3905-3911

合成路线：1 步

_60%

反应条件：

1.1 Reagents: Tripotassium phosphate Catalysts: Palladium diacetate Solvents: Dimethylformamide , Water ; overnight, rt

参考文献：

Synthesis and antimicrobial activity evaluation of aminoguanidine derivatives containing a biphenyl moiety

Yu, Haihong; et al, Youji Huaxue, 2019, 39(5), 1497-1502

合成路线：1 步

29540-84-9

_79%

反应条件：

1.1 Reagents: Water , Potassium fluoride Catalysts: [1,3-Bis(2,4,6-trimethylphenyl)-2-imidazolidinylidene]chloro[(1,2,3-η)-1-(1,1-di… Solvents: Tetrahydrofuran ; 12 h, 25 °C

参考文献：

N-Heterocyclic Carbene Ligand-Controlled Chemodivergent Suzuki-Miyaura Cross Coupling

Reeves, Emily K.; et al, Journal of Organic Chemistry, 2019, 84(18), 11799-11812

合成路线：1 步

17151-48-3

_75%

反应条件：

1.1 Catalysts: Tetrakis(triphenylphosphine)palladium Solvents: Toluene

参考文献：

The Stille reaction

Farina, Vittorio; et al, Organic Reactions (Hoboken, 1997, 50,

合成路线：1 步

_71%

反应条件：

1.1 Reagents: Potassium acetate , Bis(pinacolato)diborane Catalysts: Triphenylphosphine , [1,1′-Bis(diphenylphosphino)ferrocene]dichloropalladium Solvents: Toluene ; rt; overnight, reflux
1.2 Reagents: Sodium carbonate Catalysts: Tetrakis(triphenylphosphine)palladium , Tetrabutylammonium hydrogen sulfate Solvents: Water ; overnight, reflux

参考文献：

One-pot preparation of unsymmetrical biaryls via Suzuki cross-coupling reaction of aryl halide using phase-transfer catalyst in a biphasic solvent system

Miura, Masanori; et al, Synthetic Communications, 2007, 37(5), 667-674

合成路线：1 步

_50%

反应条件：

1.1 Reagents: Potassium acetate , Bis(pinacolato)diborane Catalysts: [1,1′-Bis(diphenylphosphino)ferrocene]dichloropalladium Solvents: Dimethylformamide
1.2 Reagents: Sodium carbonate Catalysts: [1,1′-Bis(diphenylphosphino)ferrocene]dichloropalladium

参考文献：

One pot biaryl synthesis via in situ boronate formation

Giroux, Andre; et al, Tetrahedron Letters, 1997, 38(22), 3841-3844

合成路线：1 步

857005-52-8

75-52-5

_68%

反应条件：

1.1 Reagents: Iodosylbenzene Solvents: Methanol ; 5 min, 25 °C
1.2 Reagents: Sodium methoxide Solvents: Methanol ; 25 °C
1.3 Reagents: Boron trifluoride etherate Solvents: Dichloromethane ; 25 °C

参考文献：

Destruction and Construction: Application of Dearomatization Strategy in Aromatic Carbon-Nitrogen Bond Functionalization

Wang, Shuo-En; et al, Angewandte Chemie, 2015, 54(46), 13655-13658

合成路线：1 步

22494-48-0

_58%

反应条件：

1.1 Reagents: Cesium carbonate , Oxygen Catalysts: Ceria , Palladium Solvents: Mesitylene ; 30 h, 150 °C

参考文献：

Controlling Multiple Active Sites on Pd-CeO2 for Sequential C-C Cross-coupling and Alcohol Oxidation in One Reaction System

Ko, Wonjae; et al, ChemCatChem, 2022, 14(4),

合成路线：1 步

反应条件：

1.1 Reagents: Sodium carbonate Catalysts: Tetrakis(triphenylphosphine)palladium Solvents: Acetonitrile , Water ; 3 h, 80 °C

参考文献：

Discovery of selective protein arginine methyltransferase 5 inhibitors and biological evaluations

Ji, Sen; et al, Chemical Biology & Drug Design, 2017, 89(4), 585-598

合成路线：1 步

4885-02-3

2051-62-9

反应条件：

1.1 Reagents: Titanium tetrachloride Solvents: Dichloromethane

参考文献：

Synthesis of water soluble 8-substituted 5-deazaflavins

Link, P. A. J.; et al, Journal of Heterocyclic Chemistry, 1985, 22(3), 873-8

合成路线：2 步

813-19-4

反应条件：

1.1 Catalysts: Tetrakis(triphenylphosphine)palladium Solvents: Toluene
2.1 Catalysts: Tetrakis(triphenylphosphine)palladium Solvents: Toluene

参考文献：

The Stille reaction

Farina, Vittorio; et al, Organic Reactions (Hoboken, 1997, 50,

合成路线：2 步

358-23-6

106-48-9

反应条件：

1.1 Reagents: Pyridine Solvents: Dichloromethane ; 15 min, 0 °C; 0 °C → rt; 16 h, rt
1.2 Reagents: Hydrochloric acid Solvents: Water ; rt
2.1 Reagents: Water , Potassium fluoride Catalysts: [1,3-Bis(2,4,6-trimethylphenyl)-2-imidazolidinylidene]chloro[(1,2,3-η)-1-(1,1-di… Solvents: Tetrahydrofuran ; 12 h, 25 °C

参考文献：

N-Heterocyclic Carbene Ligand-Controlled Chemodivergent Suzuki-Miyaura Cross Coupling

Reeves, Emily K.; et al, Journal of Organic Chemistry, 2019, 84(18), 11799-11812

合成路线：2 步

18282-51-4

反应条件：

1.1 Reagents: Cesium carbonate Catalysts: Ceria , Palladium Solvents: Methanol ; 15 h, 60 °C
2.1 Reagents: Cesium carbonate , Oxygen Catalysts: Ceria , Palladium Solvents: Mesitylene ; 30 h, 150 °C

参考文献：

Controlling Multiple Active Sites on Pd-CeO2 for Sequential C-C Cross-coupling and Alcohol Oxidation in One Reaction System

Ko, Wonjae; et al, ChemCatChem, 2022, 14(4),

合成路线：2 步

586-75-4

反应条件：

1.1 Reagents: Tributylstannane Catalysts: Tetrakis(triphenylphosphine)palladium Solvents: Benzene
2.1 Catalysts: Tetrakis(triphenylphosphine)palladium Solvents: Toluene

参考文献：

The Stille reaction

Farina, Vittorio; et al, Organic Reactions (Hoboken, 1997, 50,

合成路线：2 步

813-19-4

637-87-6

反应条件：

1.1 Reagents: Nickel bromide Solvents: Hexamethylphosphoramide
2.1 Catalysts: Tetrakis(triphenylphosphine)palladium Solvents: Toluene

参考文献：

The Stille reaction

Farina, Vittorio; et al, Organic Reactions (Hoboken, 1997, 50,

合成路线：1 步

29304-86-7

_38%