81470-51-1 ((2S)-5-氧代-1,2-吡咯烷二甲酸 2-叔丁基 1-苄基酯,Z-Pyr-OtBu)

_100%

反应条件：

1.1 Catalysts: 4-(Dimethylamino)pyridine Solvents: Tetrahydrofuran ; overnight, rt

参考文献：

Regioselective opening of N-Cbz glutamic and aspartic anhydrides with carbon nucleophiles

Deguest, Geoffrey; et al, Tetrahedron: Asymmetry, 2006, 17(14), 2120-2125

合成路线：1 步

24424-99-5

_98%

反应条件：

1.1 Reagents: 4-(Dimethylamino)pyridine

参考文献：

A novel post SPPS thioesterification

Nagaike, Fumihiro; et al, Peptide Science, 2006, 42, 165-168

合成路线：1 步

35418-16-7

501-53-1

_90%

反应条件：

1.1 Reagents: Sodium hydride Solvents: Tetrahydrofuran ; 30 min, rt
1.2 20 h, rt

参考文献：

Stereoselective Construction of the 5-Hydroxy Diazabicyclo[4.3.1]decane-2-one Scaffold, a Privileged Motif for FK506-Binding Proteins

Bischoff, Matthias; et al, Organic Letters, 2014, 16(20), 5254-5257

合成路线：1 步

35418-16-7

31139-36-3

_85%

反应条件：

1.1 Reagents: 4-(Dimethylamino)pyridine Solvents: Acetonitrile

参考文献：

Convenient N-protection of L-pyroglutamic acid esters

Jain, Rahul, Organic Preparations and Procedures International, 2001, 33(4), 405-409

合成路线：1 步

16881-39-3

_81%

反应条件：

1.1 Reagents: Methanesulfonic acid , 3-Oxo-9-azabicyclo[3.3.1]non-9-yloxy , Lithium perchlorate Solvents: Acetonitrile , Water ; rt

参考文献：

Selective Electrochemical Oxidation of Functionalized Pyrrolidines

Deprez, Nicholas R. ; et al, Organic Letters, 2021, 23(22), 8834-8837

合成路线：1 步

_79%

反应条件：

1.1 Reagents: Perchloric acid Solvents: Water ; rt; 16 h, rt
1.2 Reagents: Sodium bicarbonate Solvents: Water ; rt

参考文献：

Synthesis and evaluation of novel orally active p53-MDM2 interaction inhibitors

Miyazaki, Masaki; et al, Bioorganic & Medicinal Chemistry, 2013, 21(14), 4319-4331

合成路线：1 步

反应条件：

1.1 Catalysts: Perchloric acid

参考文献：

Synthesis and siderophore activity of albomycin-like peptides derived from N5-acetyl-N5-hydroxy-L-ornithine

Dolence, E. Kurt; et al, Journal of Medicinal Chemistry, 1991, 34(3), 956-68

合成路线：1 步

75-65-0

_41%

反应条件：

1.1 Reagents: Oxalyl chloride Solvents: Dimethylformamide , Acetonitrile
1.2 Reagents: Pyridine Solvents: Dimethylformamide , Acetonitrile

参考文献：

Amino acid synthesis using (L)-pyroglutamic acid as a chiral starting material

Baldwin, Jack E.; et al, Tetrahedron, 1989, 45(23), 7459-68

合成路线：1 步

_40%

反应条件：

1.1 Reagents: Dicyclohexylcarbodiimide Solvents: Tetrahydrofuran
1.2 Reagents: Dicyclohexylamine Solvents: Tetrahydrofuran
1.3 Catalysts: Perchloric acid

参考文献：

N5-Acetyl-N5-hydroxy-L-ornithine-derived siderophore-carbacephalosporin β-lactam conjugates: iron transport mediated drug delivery

Dolence, E. Kurt; et al, Journal of Medicinal Chemistry, 1990, 33(2), 461-4

合成路线：1 步

24424-99-5

反应条件：

1.1 Catalysts: 4-(Dimethylamino)pyridine Solvents: Tetrahydrofuran

参考文献：

Regioselective opening of N-Cbz glutamic and aspartic anhydrides with carbon nucleophiles

Deguest, Geoffrey; et al, Tetrahedron: Asymmetry, 2006, 17(14), 2120-2125

合成路线：1 步

57732-63-5

反应条件：

1.1 Reagents: Lithium bis(trimethylsilyl)amide Solvents: Tetrahydrofuran

参考文献：

The synthesis of γ-substituted glutamic acids via a glutamic acid γ-enolate synthon

Johnstone, Andrew N. C.; et al, Tetrahedron Letters, 1994, 35(34), 6335-8

合成路线：2 步

100-59-4

反应条件：

1.1 Solvents: Tetrahydrofuran ; 4 h, -78 °C
1.2 Reagents: Citric acid Solvents: Water
2.1 Catalysts: 4-(Dimethylamino)pyridine Solvents: Tetrahydrofuran ; overnight, rt

参考文献：

Regioselective opening of N-Cbz glutamic and aspartic anhydrides with carbon nucleophiles

Deguest, Geoffrey; et al, Tetrahedron: Asymmetry, 2006, 17(14), 2120-2125

合成路线：2 步

反应条件：

1.1 Reagents: Di-tert-butyl dicarbonate Catalysts: 4-(Dimethylamino)pyridine Solvents: Tetrahydrofuran
2.1 Catalysts: 4-(Dimethylamino)pyridine Solvents: Tetrahydrofuran

参考文献：

Regioselective opening of N-Cbz glutamic and aspartic anhydrides with carbon nucleophiles

Deguest, Geoffrey; et al, Tetrahedron: Asymmetry, 2006, 17(14), 2120-2125

合成路线：2 步

反应条件：

1.1 Reagents: Dicyclohexylcarbodiimide Solvents: Tetrahydrofuran
1.2 Reagents: Dicyclohexylamine Solvents: Tetrahydrofuran
2.1 Catalysts: Perchloric acid

参考文献：

Synthesis and siderophore activity of albomycin-like peptides derived from N5-acetyl-N5-hydroxy-L-ornithine

Dolence, E. Kurt; et al, Journal of Medicinal Chemistry, 1991, 34(3), 956-68

合成路线：2 步

34324-92-0

反应条件：

1.1 Solvents: Tetrahydrofuran ; -78 °C; -78 °C → rt; 2 h, rt
1.2 Reagents: Citric acid Solvents: Water
2.1 Catalysts: 4-(Dimethylamino)pyridine Solvents: Tetrahydrofuran ; overnight, rt

参考文献：

Regioselective opening of N-Cbz glutamic and aspartic anhydrides with carbon nucleophiles

Deguest, Geoffrey; et al, Tetrahedron: Asymmetry, 2006, 17(14), 2120-2125

合成路线：2 步

591-51-5

反应条件：

1.1 Solvents: Tetrahydrofuran ; 4 h, -78 °C
1.2 Reagents: Citric acid Solvents: Water
2.1 Catalysts: 4-(Dimethylamino)pyridine Solvents: Tetrahydrofuran ; overnight, rt

参考文献：

Regioselective opening of N-Cbz glutamic and aspartic anhydrides with carbon nucleophiles

Deguest, Geoffrey; et al, Tetrahedron: Asymmetry, 2006, 17(14), 2120-2125

合成路线：2 步

反应条件：

1.1 Reagents: tert-Butylmagnesium chloride Solvents: Tetrahydrofuran ; 4 h, -78 °C
1.2 Reagents: Citric acid Solvents: Water
2.1 Catalysts: 4-(Dimethylamino)pyridine Solvents: Tetrahydrofuran ; overnight, rt

参考文献：

Regioselective opening of N-Cbz glutamic and aspartic anhydrides with carbon nucleophiles

Deguest, Geoffrey; et al, Tetrahedron: Asymmetry, 2006, 17(14), 2120-2125

合成路线：2 步

98-79-3