817638-96-3 (7-羟基-3- [4-(4-甲氧基苯基)-1H-1,2,3-三唑-1-基]-2H-1-苯并吡喃-2-酮,2H-1-Benzopyran-2-one, 7-hydroxy-3-[4-(4-methoxyphenyl)-1H-1,2,3-triazol-1-yl]-)

_90%

反应条件：

1.1 Reagents: Sodium ascorbate Catalysts: Copper sulfate , 2767570-12-5 (Copper complexes and reduced) Solvents: Water ; 12 h, 40 °C

参考文献：

Highly efficient catalytic performance on CuAAC reaction by polymer-like supramolecular self-assemblies-Cu(I) in aqueous solution

Deng, Bin ; Yang, Jing ; Guo, Mengbi ; Yang, Rui, Applied Organometallic Chemistry, 2022, 36(6),

合成路线：1 步

_59%

反应条件：

1.1 Catalysts: Cuprous iodide Solvents: Methanol , Dimethylformamide ; 12 h, reflux

参考文献：

Design and synthesis of 3-triazolo-coumarins and their applications in scavenging radicals and protecting DNA

Liu, Zhihui; Wang, Yingnan; Sun, Jingbo; Yang, Yang; Liu, Qingwen; et al, Chemical Research in Chinese Universities, 2015, 31(4), 526-533

合成路线：1 步

_31%

反应条件：

1.1 Catalysts: Copper , Copper sulfate Solvents: Dimethylformamide , tert-Butanol , Water ; 1 h, rt → 80 °C

参考文献：

Transition metal-catalyzed synthesis of new 3-substituted coumarin derivatives as antibacterial and cytostatic agents

Sokol, Ivana; Toma, Mateja ; Krnic, Mia; Macan, Andrijana Mescic ; Drenjancevic, Domagoj; et al, Future Medicinal Chemistry, 2021, 13(21), 1865-1884

合成路线：1 步

反应条件：

1.1 Reagents: Sodium ascorbate ; 24 h, 40 °C

参考文献：

A nanoscale MOF-based heterogeneous catalytic system for the polymerization of N-carboxyanhydrides enables direct routes toward both polypeptides and related hybrid materials

Liu, Ying; Ren, Zhongwu; Zhang, Nannan; Yang, Xiaoxin; Wu, Qihua; et al, Nature Communications, 2023, 14(1),

合成路线：1 步

反应条件：

1.1 Catalysts: Sodium ascorbate , Phosphate(1-), hexafluoro-, hydrogen, compd. with rel-(3aR,3′aR,3′′aR,4R,4′R,4′′… (quaternized with butylimidazole, complexes with copper or palladium) Solvents: Dimethyl sulfoxide , Water ; rt

参考文献：

A Dense-Shell Macromolecular Scaffold for Catalyst- or Substrate-Guided Catalysis in a Cellular Environment

Lu, Qing; Bai, Silei; Chen, Zhiyong; Zheng, Nan; Feng, Xinxin; et al, ACS Materials Letters, 2020, 2(1), 89-94

合成路线：1 步

反应条件：

1.1 Reagents: Sodium ascorbate Solvents: Water ; pH 7.4

参考文献：

Enzyme-like Click Catalysis by a Copper-Containing Single-Chain Nanoparticle

Chen, Junfeng; Wang, Jiang ; Bai, Yugang; Li, Ke; Garcia, Edzna S.; et al, Journal of the American Chemical Society, 2018, 140(42), 13695-13702

合成路线：1 步

反应条件：

1.1 Reagents: Sodium ascorbate Catalysts: Copper (polymer-supported) , L-Asparagine, N2-[(1,1-dimethylethoxy)carbonyl]-N-[2-[(3aR,4R,7S,7aS)-1,3,3a,4,7… (deprotected, intramolecularly cross-linked by Cu complexation, reduced) ; rt

参考文献：

A Highly Efficient Single-Chain Metal-Organic Nanoparticle Catalyst for Alkyne-Azide "Click" Reactions in Water and in Cells

Bai, Yugang; Feng, Xinxin; Xing, Hang; Xu, Yanhua; Kim, Boo Kyung; et al, Journal of the American Chemical Society, 2016, 138(35), 11077-11080

合成路线：1 步