823-78-9 (间溴溴苄,3-Bromobenzyl bromide)

932-77-4

反应条件：

1.1 Reagents: Cyanuric chloride Solvents: Dimethylformamide ; 25 °C
1.2 Reagents: Sodium bromide Solvents: Dichloromethane ; 10 h, 25 °C
1.3 25 min, rt

参考文献：

A chemoselective, easy bromination of (hydroxymethyl)phenols

Nieddu, Giammario; De Luca, Lidia; Giacomelli, Giampaolo, Synthesis, 2008, (24), 3937-3940

合成路线：1 步

_95%

反应条件：

1.1 Reagents: N-Bromosuccinimide Catalysts: Azobisisobutyronitrile Solvents: Carbon tetrachloride ; 3.5 h, reflux

参考文献：

Synthesis and bioactivity of some imidazole- and triazole-ether compounds

Li, Zai-feng; et al, Jingxi Huagong, 2005, 22(8), 619-624

合成路线：1 步

_82%

反应条件：

1.1 Reagents: N-Bromosuccinimide Solvents: Acetonitrile ; 13 min, 60 °C

参考文献：

A Scalable Procedure for Light-Induced Benzylic Brominations in Continuous Flow

Cantillo, David; et al, Journal of Organic Chemistry, 2014, 79(1), 223-229

合成路线：1 步

_78%

反应条件：

1.1 Reagents: N-Bromosuccinimide Catalysts: Benzoyl peroxide Solvents: Carbon tetrachloride ; reflux

参考文献：

Design, synthesis and biological evaluation of low molecular weight CXCR4 ligands

Sakyiamah, Maxwell M.; et al, Bioorganic & Medicinal Chemistry, 2019, 27(6), 1130-1138

合成路线：1 步

1878-67-7

_92%

反应条件：

1.1 Reagents: Dibromoisocyanuric acid Catalysts: Silver(1+), bis(1,10-phenanthroline-κN1,κN10)-, (T-4)-, 1,1,1-trifluoromethanesu… Solvents: 1,2-Dichloroethane ; 1 h, rt

参考文献：

Silver-Catalyzed Decarboxylative Bromination of Aliphatic Carboxylic Acids

Tan, Xinqiang; et al, Organic Letters, 2017, 19(7), 1634-1637

合成路线：1 步

_86%

反应条件：

1.1 Reagents: Phosphorus tribromide Solvents: Toluene ; 0 - 5 °C; 30 min, rt; 2 h, 100 °C

参考文献：

Development of Chromen-4-one Derivatives as (Ant)agonists for the Lipid-Activated G Protein-Coupled Receptor GPR55 with Tunable Efficacy

Schoeder, Clara T.; et al, ACS Omega, 2019, 4(2), 4276-4295

合成路线：1 步

_82%

反应条件：

1.1 Reagents: Tetrabutylammonium iodide , Triphenylphosphine Solvents: 1,2-Dibromoethane ; 2 h, 60 °C

参考文献：

Halogenation through Deoxygenation of Alcohols and Aldehydes

Chen, Jia; et al, Organic Letters, 2018, 20(10), 3061-3064

合成路线：1 步

_61%

反应条件：

1.1 Reagents: Phosphorus tribromide Solvents: Dichloromethane ; 0 °C; 2 h, rt
1.2 Reagents: Sodium bicarbonate Solvents: Water ; rt

参考文献：

Synthesis and Biological Evaluation of Small Molecules as Potential Anticancer Multitarget Agents

Pla-Lopez, Alberto; et al, International Journal of Molecular Sciences, 2022, 23(13),

合成路线：2 步

3132-99-8

反应条件：

1.1 Reagents: Sodium borohydride Solvents: Methanol ; rt; 30 min, rt
2.1 Reagents: Phosphorus tribromide Solvents: Dichloromethane ; 15 min, 0 °C
2.2 Reagents: Sodium bicarbonate Solvents: Water

参考文献：

Synthesis of α-Aryldiazophosphonates via a Diazo Transfer Reaction

Beletskaya, Irina P.; et al, Journal of Organic Chemistry, 2022, 87(5), 2748-2757

合成路线：2 步

585-76-2

反应条件：

1.1 Reagents: Lithium aluminum hydride Solvents: Tetrahydrofuran ; 30 min, > rt; 4 h, rt
1.2 Reagents: Sulfuric acid Solvents: Water ; 0 - 5 °C
2.1 Reagents: Phosphorus tribromide Solvents: Toluene ; 0 - 5 °C; 30 min, rt; 2 h, 100 °C

参考文献：

Development of Chromen-4-one Derivatives as (Ant)agonists for the Lipid-Activated G Protein-Coupled Receptor GPR55 with Tunable Efficacy

Schoeder, Clara T.; et al, ACS Omega, 2019, 4(2), 4276-4295

合成路线：1 步