82911-78-2 (Fmoc-L-丝氨酸甲酯,Fmoc-Ser-OMe)

_100%

反应条件：

1.1 Reagents: Sodium bicarbonate Solvents: 1,4-Dioxane , Water ; 30 min, 0 °C; overnight, 0 °C

参考文献：

C-Glycosyl Amino Acids through Hydroboration-Cross-Coupling of exo-Glycals and Their Application in Automated Solid-Phase Synthesis

Koch, Stefan; et al, Chemistry - A European Journal, 2013, 19(22), 7020-7041

合成路线：1 步

_86%

反应条件：

1.1 Reagents: Sodium bicarbonate Solvents: Tetrahydrofuran , Water ; 1 h, 0 °C; 0 °C → 18 °C; 18 h, 18 °C

参考文献：

A Rapid and Mild Sulfation Strategy Reveals Conformational Preferences in Therapeutically Relevant Sulfated Xylooligosaccharides

Vo, Yen; et al, Chemistry - A European Journal, 2021, 27(38), 9830-9838

合成路线：1 步

171820-93-2

_99%

反应条件：

1.1 Catalysts: Zincate(1-), μ4-oxohexakis[μ-(2,2,2-trifluoroacetato-κO:κO′)](2,2,2-trifluoroace… Solvents: Methanol ; 12 h, 70 °C

参考文献：

Tetranuclear zinc cluster: a dual purpose catalyst for per-O-acetylation and de-O-acetylation of carbohydrates

Lin, Ting-Wei; et al, RSC Advances, 2016, 6(63), 58749-58754

合成路线：1 步

2093426-16-3

_99%

反应条件：

1.1 Catalysts: Zincate(1-), μ4-oxohexakis[μ-(2,2,2-trifluoroacetato-κO:κO′)](2,2,2-trifluoroace… Solvents: Methanol ; 12 h, 70 °C

参考文献：

Tetranuclear zinc cluster: a dual purpose catalyst for per-O-acetylation and de-O-acetylation of carbohydrates

Lin, Ting-Wei; et al, RSC Advances, 2016, 6(63), 58749-58754

合成路线：1 步

_98%

反应条件：

1.1 Reagents: Thionyl chloride ; > 1 min, 0 °C
1.2 0 °C; 4 h, 0 °C

参考文献：

Sterically Hindered 2,4,6-Tri-tert-butylpyridinium Salts as Single Hydrogen Bond Donors for Highly Stereoselective Glycosylation Reactions of Glycals

Ghosh, Titli; et al, Organic Letters, 2019, 21(10), 3490-3495

合成路线：1 步

_96%

反应条件：

1.1 Reagents: Thionyl chloride Solvents: Methanol

参考文献：

Design, Syntheses, and Bioactivities of Conformationally Locked Pin1 Ground State Inhibitors

Wang, Xiaodong J., 2005, , ,

合成路线：1 步

_92%

反应条件：

1.1 Reagents: Dowex 50WX2 ; overnight, reflux

参考文献：

L-serine-functionalized montmorillonite decorated with Au nanoparticles: A new highly efficient catalyst for the reduction of 4-nitrophenol

Rocha, Mariana; et al, Journal of Catalysis, 2018, 361, 143-155

合成路线：1 步

_97%

反应条件：

1.1 Reagents: Sodium bicarbonate Solvents: 1,4-Dioxane , Water ; 5 h, 25 °C
1.2 Reagents: Hydrochloric acid Solvents: Water ; 25 °C

参考文献：

Solution-phase automated synthesis of an α-amino aldehyde as a versatile intermediate

Masui, Hisashi; et al, Beilstein Journal of Organic Chemistry, 2017, 13, 106-110

合成路线：1 步

_97%

反应条件：

1.1 Reagents: Sodium bicarbonate Solvents: 1,4-Dioxane , Water ; 30 min, rt
1.2 rt; 24 h, rt

参考文献：

Coupled Conformational Equilibria in β-Sheet Peptide-Dendron Conjugates

Shao, Hui; et al, Journal of the American Chemical Society, 2007, 129(7), 1884-1885

合成路线：1 步

_93%

反应条件：

1.1 Reagents: Sodium bicarbonate Solvents: Tetrahydrofuran , Water ; rt

参考文献：

Total synthesis and structure revision of boholamide A

Han, Fangzhi; et al, Organic Letters, 2021, 23(13), 4976-4980

合成路线：1 步

171820-89-6

_95%

反应条件：

1.1 Catalysts: Indium triflate ; 15 min, rt

参考文献：

In(III) triflate-catalyzed detritylation and glycosylation by solvent-free ball milling

Kumar, Vajinder; et al, Carbohydrate Research, 2014, 397, 18-26

合成路线：1 步

171820-89-6

_94%

反应条件：

1.1 Catalysts: 2,4,6-Triphenylpyrylium tetrafluoroborate Solvents: Dichloromethane ; 5 min, rt; 2 h, rt

参考文献：

Photocatalytic Cleavage of Trityl Protected Thiols and Alcohols

Murakami, Sho; et al, Synthesis, 2023, 55(9), 1367-1374

合成路线：1 步

360785-59-7

_95%

反应条件：

1.1 Reagents: Sodium azide Solvents: Methanol

参考文献：

Mild and selective sodium azide mediated cleavage of p-nitrobenzoic esters

Gomez-Vidal, Jose A.; et al, Organic Letters, 2001, 3(16), 2477-2479

合成路线：1 步

74-88-4

_95%

反应条件：

1.1 Reagents: Potassium carbonate Solvents: Dimethylformamide ; 30 min, rt; rt → 0 °C
1.2 0 °C

参考文献：

Synthesis and Applications of a Light-Fluorous Glycosyl Donor

Zhang, Fa; et al, Journal of Organic Chemistry, 2009, 74(6), 2594-2597

合成路线：1 步

334-88-3

_90%

反应条件：

1.1 Solvents: Diethyl ether ; 30 min, rt
1.2 Solvents: Water ; rt

参考文献：

Synthesis of chlorophyll-amino acid conjugates as models for modification of proteins with chromo/fluorophores

Tamiaki, Hitoshi; et al, Bioorganic & Medicinal Chemistry, 2014, 22(4), 1421-1428

合成路线：1 步

1094708-49-2

_89%

反应条件：

1.1 Reagents: Benzenemethanaminium, N,N,N-triethyl-, (T-4)-tetrathioxomolybdate(2-) (2:1) Solvents: Acetonitrile ; 1 h, 28 °C

参考文献：

Propargyloxycarbonyl as a protecting group for the side chains of serine, threonine and tyrosine

Ramesh, Ramapanicker; et al, Journal of Chemical Sciences (Bangalore, 2008, 120(1), 163-173

合成路线：1 步

82911-71-5

_89%

反应条件：

1.1 Reagents: Sodium bicarbonate Solvents: Acetone

参考文献：

9-Fluorenylmethyl 1-benzotriazolyl carbonate(3-oxy-benzotriazolinium-1-carboxylic acid 9H-fluoren-9-ylmethyl ester)

Wardrop, Duncan J.; et al, e-EROS Encyclopedia of Reagents for Organic Synthesis, 2003, 1, 1-2

合成路线：1 步

82911-71-5

反应条件：

1.1 Catalysts: Sodium bicarbonate Solvents: Acetone

参考文献：

9-Fluorenylmethyl 1-benzotriazolyl carbonate

Wardrop, Duncan J.; et al, e-EROS Encyclopedia of Reagents for Organic Synthesis, 2001, ,

合成路线：1 步

28920-43-6

24184-43-8

_55%

反应条件：

1.1 Reagents: Sodium bicarbonate Solvents: Ethyl acetate , Water ; 45 min, 0 °C

参考文献：

A modified fluoro-Pummerer reaction with DAST and NIS for synthesis of β-amino-α-fluoro-sulfides from corresponding β-amino-sulfides

Chen, Hongju; et al, Tetrahedron, 2015, 71(14), 2089-2094

合成路线：1 步

28920-43-6

_51%