83-53-4 (1,4-二溴萘,1,4-Dibromonaphthalene)

_100%

反应条件：

1.1 Reagents: Bromine Catalysts: 1-Butyl-3-methylimidazolium bromide Solvents: Water ; 40 min, 70 °C

参考文献：

An environment-friendly method for synthesis of 1,4-dibromonaphthalene in aqueous solution of ionic liquids

Zhao, Xinhua; et al, Catalysis Communications, 2008, 9(13), 2179-2182

合成路线：1 步

_90%

反应条件：

1.1 Reagents: Bromine Solvents: Dichloromethane ; -30 °C

参考文献：

Polybrominated methoxy- and hydroxynaphthalenes

Berkil Akar, Kiymet; et al, Turkish Journal of Chemistry, 2016, 40(2), 332-346

合成路线：1 步

_90%

反应条件：

1.1 Reagents: Bromine Solvents: Dichloromethane ; -30 °C

参考文献：

Functionalization of naphthalene: a novel synthetic route to brominated naphthoquinones

Cakmak, Osman; et al, ARKIVOC (Gainesville, 2012, (7), 274-281

合成路线：1 步

332035-27-5

_95%

反应条件：

1.1 Reagents: Potassium tert-butoxide Solvents: Tetrahydrofuran
1.2 Solvents: Water
1.3 Solvents: Diethyl ether

参考文献：

Bromination of tetralin. Short and efficient synthesis of 1,4-dibromonaphthalene

Cakmak, Osman; et al, Collection of Czechoslovak Chemical Communications, 2000, 65(11), 1791-1804

合成路线：1 步

_90%

反应条件：

1.1 Reagents: Bromine Solvents: Dichloromethane ; -30 °C; 48 h, -30 °C; -30 °C → 0 °C
1.2 Reagents: Sodium bisulfite Solvents: Water ; cooled

参考文献：

Scalable Synthesis of N,N'-Di(2,3-dihydroxy-propyl)-1,4-naphthalenedipropanamide and Its 1,4-Endoperoxide as a Singlet Oxygen-Releasing Molecule

Gemki, Michael ; et al, Organic Process Research & Development, 2021, 25(12), 2747-2753

合成路线：1 步

2298-07-9

_83%

反应条件：

1.1 Reagents: Carbon tetrabromide , (Phenylmethoxy)[4-(trifluoromethyl)benzoyl]azanyl 2,2-dimethylpropanoate Solvents: Acetonitrile ; 5 min, rt; 10 h, rt
1.2 Reagents: Sodium bicarbonate Solvents: Water ; rt

参考文献：

Direct Deaminative Functionalization

Dherange, Balu D. ; et al, Journal of the American Chemical Society, 2023, 145(1), 17-24

合成路线：1 步

2298-07-9

_31%

反应条件：

1.1 Reagents: Bromotrichloromethane , Benzoyl(phenylmethoxy)azanyl 2,2-dimethylpropanoate Solvents: Acetonitrile ; 2 - 3 h, rt; 12 h, rt

参考文献：

Deaminative bromination, chlorination, and iodination of primary amines

Xue, Jiang-Hao; et al, iScience, 2023, 26(3),

合成路线：1 步

91-17-8

_14%

反应条件：

1.1 Reagents: Bromine

参考文献：

Bromination of Decalin and Its Derivatives. 9. High Temperature Bromination

Dastan, Arif; et al, Journal of Organic Chemistry, 1997, 62(12), 4018-4022

合成路线：2 步

119-64-2

反应条件：

1.1 Reagents: Bromine Solvents: Carbon tetrachloride
2.1 Reagents: Potassium tert-butoxide Solvents: Tetrahydrofuran
2.2 Solvents: Water
2.3 Solvents: Diethyl ether

参考文献：

Bromination of tetralin. Short and efficient synthesis of 1,4-dibromonaphthalene

Cakmak, Osman; et al, Collection of Czechoslovak Chemical Communications, 2000, 65(11), 1791-1804

合成路线：1 步

_99%

反应条件：

1.1 Reagents: Bromine Catalysts: Synclyst 13 Solvents: Dichloromethane ; 45 min, 25 °C; 6 h, 25 °C

参考文献：

Effects of structured solids on regioselectivity of dibromination of naphthalene

Smith, Keith ; et al, Catalysts, 2021, 11(5),

合成路线：1 步

_90%

反应条件：

1.1 Reagents: Bromine Solvents: Dichloromethane

参考文献：

Selective bromination of 1-bromonaphthalene: efficient synthesis of bromonaphthalene derivatives

Cakmak, Osman; et al, Tetrahedron, 2002, 58(28), 5603-5609

合成路线：2 步

反应条件：

1.1 Reagents: Bromine
2.1 Reagents: Bromine

参考文献：

Bromination of naphthalene and derivatives: high temperature bromination. XI

Dastan, Arif; et al, Tetrahedron, 1999, 55(44), 12853-12864

合成路线：1 步

_94%

反应条件：

1.1 Reagents: Bromine Solvents: Dichloromethane ; 45 min, 25 °C

参考文献：

Effects of structured solids on regioselectivity of dibromination of naphthalene

Smith, Keith ; et al, Catalysts, 2021, 11(5),

合成路线：1 步

_92%

反应条件：

1.1 Reagents: Alumina , Copper bromide (CuBr2) Solvents: Chlorobenzene

参考文献：

Selective halogenation of aromatic hydrocarbons with alumina-supported copper(II) halides

Kodomari, Mitsuo; et al, Journal of Organic Chemistry, 1988, 53(9), 2093-4

合成路线：1 步

_87%

反应条件：

1.1 Reagents: Lead tetraacetate , Magnesium oxide , Lithium bromide

参考文献：

Solid-state reaction of a lead tetraacetate-metal halide system with naphthalene under mechanical activation

Nikishin, G. I.; et al, Russian Chemical Bulletin (Translation of Izvestiya Akademii Nauk, 1998, 47(7), 1353-1355

合成路线：1 步

_90%

反应条件：

1.1 Reagents: Bromine Solvents: Dichloromethane

参考文献：

Selective bromination of 1-bromonaphthalene: efficient synthesis of bromonaphthalene derivatives

Cakmak, Osman; et al, Tetrahedron, 2002, 58(28), 5603-5609

合成路线：1 步

_73%

反应条件：

1.1 Reagents: Bromine

参考文献：

Bromination of naphthalene and derivatives: high temperature bromination. XI

Dastan, Arif; et al, Tetrahedron, 1999, 55(44), 12853-12864

合成路线：1 步

252937-60-3

_74%

52238-54-7

参考文献：

Bromination of naphthalene and derivatives: high temperature bromination. XI

Dastan, Arif; et al, Tetrahedron, 1999, 55(44), 12853-12864

合成路线：1 步

86-55-5

_54%

反应条件：

1.1 Reagents: Tripotassium phosphate , Tetrabutylammonium tribromide Solvents: Acetonitrile ; 16 h, 100 °C

参考文献：

Transition-metal-free decarboxylative bromination of aromatic carboxylic acids

Quibell, Jacob M.; et al, Chemical Science, 2018, 9(15), 3860-3865

合成路线：2 步

191021-28-0