837-18-3 (N-(苄基)苯磺酰胺,N-Benzylbenzenesulfonamide)

反应条件：

1.1 Reagents: (Dimethyl sulfide)trihydroboron Solvents: Tetrahydrofuran ; rt; 15 min, reflux
1.2 Reagents: Hydrochloric acid Solvents: Water

参考文献：

Synthesis of N-alkylsulfonamides by borane-dimethyl sulfide reduction of N-acylsulfonamides

James, Samantha N.; et al, Tetrahedron Letters, 2015, 56(16), 2059-2061

合成路线：1 步

108-98-5

_99%

反应条件：

1.1 Reagents: Hydrogen peroxide , Zirconium chloride (ZrCl4) Solvents: Acetonitrile , Water ; 25 °C
1.2 Reagents: Pyridine ; 2 min, 25 °C
1.3 Reagents: Hydrochloric acid Solvents: Water ; acidified, 25 °C

参考文献：

Direct conversion of thiols and disulfides into sulfonamides

Bahrami, Kiumars; et al, Tetrahedron Letters, 2010, 51(37), 4843-4846

合成路线：1 步

108-98-5

_96%

反应条件：

1.1 Reagents: Benzyltrimethylammonium chloride , 1,3-Dichloro-5,5-dimethylhydantoin Solvents: Acetonitrile , Water ; 1 - 2 min, rt; 30 min, rt
1.2 1 - 2 min, rt; 30 min, rt

参考文献：

Convenient one-pot synthesis of sulfonamides from thiols and disulfides using 1,3-dichloro-5,5-dimethylhydantoin (DCH)

Veisi, Hojat, Bulletin of the Korean Chemical Society, 2012, 33(2), 383-386

合成路线：1 步

108-98-5

_96%

反应条件：

1.1 Reagents: Chlorosuccinimide , Tetrabutylammonium chloride , Water Solvents: Acetonitrile ; 1 - 2 min, 0 °C; 30 min, 0 °C
1.2 1 - 2 min, rt; 1 h, rt

参考文献：

Convenient one-pot synthesis of sulfonamides and sulfonyl azides from thiols using N-chlorosuccinimide

Veisi, Hojat; et al, Synlett, 2011, (16), 2315-2320

合成路线：1 步

882-33-7

_99%

反应条件：

1.1 Reagents: Hydrogen peroxide , Zirconium chloride (ZrCl4) Solvents: Acetonitrile , Water ; 25 °C
1.2 Reagents: Pyridine ; 1 min, 25 °C
1.3 Reagents: Hydrochloric acid Solvents: Water ; acidified, 25 °C

参考文献：

Direct conversion of thiols and disulfides into sulfonamides

Bahrami, Kiumars; et al, Tetrahedron Letters, 2010, 51(37), 4843-4846

合成路线：1 步

882-33-7

_96%

反应条件：

1.1 Reagents: Benzyltrimethylammonium chloride , 1,3-Dichloro-5,5-dimethylhydantoin Solvents: Acetonitrile , Water ; 1 - 2 min, rt; 30 min, rt
1.2 1 - 2 min, rt; 30 min, rt

参考文献：

Convenient one-pot synthesis of sulfonamides from thiols and disulfides using 1,3-dichloro-5,5-dimethylhydantoin (DCH)

Veisi, Hojat, Bulletin of the Korean Chemical Society, 2012, 33(2), 383-386

合成路线：1 步

882-33-7

_88%

反应条件：

1.1 Reagents: Pivaloyl chloride , Water Solvents: Acetonitrile ; 0 °C; 15 min, 0 °C
1.2 0 °C; 10 min, 0 °C; 0 °C → rt; 30 min, rt

参考文献：

Synthesis of Sulfonic Acid Derivatives by Oxidative Deprotection of Thiols Using tert-Butyl Hypochlorite

Joyard, Yoann; et al, Organic Letters, 2013, 15(9), 2294-2297

合成路线：1 步

_99%

反应条件：

1.1 Reagents: Triethylamine Solvents: Dichloromethane ; overnight, rt

参考文献：

Light-Driven Reductive Cleavage of Sulfonamides Promoted by Thiourea Organophotosensitizers

Brom, Jules; et al, Journal of Organic Chemistry, 2023, 88(9), 5923-5935

合成路线：1 步

_99%

反应条件：

1.1 Reagents: Triethylamine Solvents: Dichloromethane ; overnight, rt

参考文献：

[2.2]Paracyclophane-based coumarins: effective organo-photocatalysts for light-induced desulfonylation processes

Brom, Jules; et al, ChemRxiv, 2023, 1, 1-11

合成路线：1 步

_98%

反应条件：

1.1 Solvents: Dichloromethane ; 0 °C; 15 min, rt
1.2 Solvents: Water

参考文献：

Palladium-Catalyzed Regio- and Chemo-selective Reactions of 2-Bromobenzyl Bromides: Expanding the Scope for the Synthesis of Biaryls Fused to a Seven-Membered Sultam

Laha, Joydev K.; et al, European Journal of Organic Chemistry, 2015, 2015(36), 7885-7891

合成路线：1 步

100-51-6

_99%

反应条件：

1.1 Reagents: Potassium carbonate Catalysts: Palladium diacetate ; 4 h, 120 °C
1.2 Reagents: Ethyl acetate

参考文献：

Palladium-Catalyzed N-Alkylation of Amides and Amines with Alcohols Employing the Aerobic Relay Race Methodology

Yu, Xiaochun; et al, Chinese Journal of Chemistry, 2012, 30(10), 2322-2332

合成路线：1 步

100-51-6

_99%

反应条件：

1.1 Reagents: Potassium carbonate Catalysts: (SP-4-3)-Carbonylchlorobis(triphenylphosphine)rhodium ; 8 h, 120 °C

参考文献：

Discovery and Mechanistic Studies of a General Air-Promoted Metal-Catalyzed Aerobic N-Alkylation Reaction of Amides and Amines with Alcohols

Liu, Chuanzhi; et al, Journal of Organic Chemistry, 2011, 76(14), 5759-5773

合成路线：1 步

130552-90-8

_99%

反应条件：

1.1 Reagents: Formic acid , Triethylamine Catalysts: Chloro[(1S,2S,3aS,7aS)-octahydro-N-[4-(trifluoromethyl)phenyl]-1H-indole-2-carbo… Solvents: Water ; 1 min, rt

参考文献：

Amide Iridium Complexes As Catalysts for Transfer Hydrogenation Reduction of N-sulfonylimine

Wen, Huiling; et al, Journal of Organic Chemistry, 2021, 86(5), 3850-3859

合成路线：1 步

13909-34-7

_99%

反应条件：

1.1 Reagents: Boronic acid, B,B′-1,4-phenylenebis-, polymer with 2,2′-oxybis[ethanamine] hydro… Solvents: THF-d8 ; 12 h, rt

参考文献：

Polyboramines for Hydrogen Release: Polymers Containing Lewis Pairs in their Backbone

Ledoux, Audrey; et al, Angewandte Chemie, 2015, 54(52), 15744-15749

合成路线：1 步

67723-11-9

_96%

反应条件：

1.1 Reagents: Aluminum chloride Solvents: Acetonitrile ; 18 h, 80 °C
1.2 Reagents: Water

参考文献：

Chemoselective Cleavage of Acylsulfonamides and Sulfonamides by Aluminum Halides

Sang, Dayong ; et al, Journal of Organic Chemistry, 2022, 87(5), 3586-3595

合成路线：1 步

873-55-2

_95%

反应条件：

1.1 Reagents: Iodine , Oxygen Solvents: 1,2-Dichloroethane ; 16 h, 25 °C

参考文献：

Metal-Free Direct Construction of Sulfonamides via Iodine-Mediated Coupling Reaction of Sodium Sulfinates and Amines at Room Temperature

Wei, Wei; et al, Advanced Synthesis & Catalysis, 2015, 357(5), 987-992

合成路线：1 步

873-55-2

_86%

反应条件：

1.1 Reagents: m-Chloroperbenzoic acid , Tetrabutylammonium bromide Solvents: Methanol , Tetrahydrofuran ; 12 h, rt
1.2 Reagents: Sodium thiosulfate Solvents: Water
1.3 Reagents: Sodium carbonate Solvents: Water
1.4 Reagents: Water

参考文献：

One-Pot Synthesis of Sulfonamides from Sodium Sulfinates and Amines via Sulfonyl Bromides

Wu, Sixue; et al, Synlett, 2016, 27(19), 2699-2704

合成路线：1 步

873-55-2

_83%

反应条件：

1.1 Reagents: Lithium perchlorate Solvents: Water ; 1 h

参考文献：

Electrochemical synthesis of sulfonamides in a graphite powder macroelectrode

Vicente, Dmistocles A.; et al, Green Chemistry, 2020, 22(16), 5262-5266

合成路线：1 步

188413-33-4

_95%

反应条件：

1.1 Reagents: Samarium iodide (SmI2) Solvents: Tetrahydrofuran
1.2 Reagents: Iodine

参考文献：

Synthesis of enantiomerically pure 1,2-diamines by reductive coupling of tricarbonyl(benzaldimine)chromium complexes

Taniguchi, Nobukazu; et al, Synlett, 1997, (1), 51-53

合成路线：1 步

28539-12-0

100-58-3

_94%

反应条件：

1.1 Solvents: Tetrahydrofuran
1.2 Reagents: Hydrochloric acid Solvents: Water

参考文献：

The chemistry of N-substituted benzotriazoles. Part 19 [1]. N-alkylation of sulfonamides

Katritzky, Alan R.; et al, Chemica Scripta, 1989, 29(1), 27-31

合成路线：1 步

515-42-4

_93%

反应条件：

1.1 Reagents: Cyanuric chloride Catalysts: 18-Crown-6 Solvents: Acetone ; 20 min, 80 °C; 80 °C → rt
1.2 Reagents: Sodium hydroxide Solvents: Tetrahydrofuran ; 10 min, 50 °C

参考文献：

An Easy Microwave-Assisted Synthesis of Sulfonamides Directly from Sulfonic Acids

De Luca, Lidia; et al, Journal of Organic Chemistry, 2008, 73(10), 3967-3969

合成路线：1 步

515-42-4

_86%

反应条件：

1.1 Catalysts: Copper bromide (CuBr2) Solvents: Acetonitrile , Water ; 10 - 15 min, 120 °C

参考文献：

Microwave assisted, Cu-catalyzed synthesis of sulfonamides using sodium sulfinates and amines

Nikam, Anil; et al, Phosphorus, 2023, 198(10), 800-807

合成路线：1 步

515-42-4

_84%

反应条件：

1.1 Reagents: Triphenylphosphine , Bromine Solvents: Acetonitrile
1.2 Reagents: Triethylamine
1.3 Reagents: Water

参考文献：

Preparation of sulfonamides from sodium sulfonates. Ph3PBr2 and Ph3PCl2 as a mild halogenating reagent for sulfonyl bromides and sulfonyl chlorides

Kataoka, Tadashi; et al, Synthesis, 1998, (4), 423-426

合成路线：1 步

589-18-4

100-51-6

_92%

反应条件：

1.1 Catalysts: Potassium carbonate , Iodobenzene diacetate ; 24 h, 135 °C

参考文献：

Green and scalable aldehyde-catalyzed transition metal-free dehydrative N-alkylation of amides and amines with alcohols

Xu, Qing; et al, Advanced Synthesis & Catalysis, 2013, 355(1), 73-80

合成路线：1 步

100-58-3

_90%

反应条件：

1.1 Reagents: Sulfur dioxide Solvents: Tetrahydrofuran ; 0.5 h, -10 °C; -10 °C → rt; rt → 0 °C
1.2 Reagents: Acetic acid , Sodium hypochlorite ; 0 °C → rt; 3 h, rt

参考文献：

Efficient and Practical Synthesis of Sulfonamides Utilizing SO2 Gas Generated On Demand

Leung, Gulice Yiu Chung; et al, Organic Process Research & Development, 2020, 24(4), 546-554

合成路线：1 步

622-79-7

_90%

反应条件：

1.1 Reagents: Iron , Ammonium chloride Solvents: Methanol

参考文献：

Direct conversion of azides to carbamates and sulfonamides using Fe/NH4Cl: effect of sonication

Chandrasekhar, S.; et al, Tetrahedron Letters, 2000, 41(41), 7969-7972

合成路线：1 步

6829-91-0

_90%

反应条件：

1.1 Reagents: m-Chloroperbenzoic acid Solvents: Dichloromethane ; 30 min, rt

参考文献：

One-pot synthesis of sulfonamides from methyl sulfinates using ultrasound

Garcia Ruano, Jose L.; et al, Tetrahedron, 2011, 67(16), 2905-2910

合成路线：1 步

98-11-3

_83%

反应条件：

1.1 Reagents: 4-Methylmorpholine , 2,4-Dichloro-6-hydroxy-s-triazine (Wang resin grafted) Solvents: Dichloromethane ; 0 °C → rt
1.2 20 min, rt
1.3 rt; 1.0 h, rt
1.4 Reagents: Water ; rt

参考文献：

Solid-supported dichloro[1,3,5]-triazine: a versatile synthetic auxiliary for direct synthesis of N-sulfonylamines from sulfonic acid and amine

Gholap, Somnath S.; et al, Jordan Journal of Chemistry, 2012, 7(3), 279-285

合成路线：1 步

108-88-3

_75%

反应条件：

1.1 Reagents: tert-Butyl peroxide Catalysts: Nickel acetate ; 24 h, 120 °C

参考文献：

Nickel-catalyzed product-controllable amidation and imidation of sp3 C-H bonds in substituted toluenes with sulfonamides

Li, Ze-lin; et al, Organic & Biomolecular Chemistry, 2017, 15(6), 1317-1320

合成路线：1 步

108-88-3

_67%