84889-09-8 ((S)-2-((S)-2-((((9-芴基)甲氧基)羰基)氨基)-3-苯基丙烷氨基)-3-苯基丙酸,Fmoc-Phe-Phe-OH)

反应条件：

1.1 Reagents: Trifluoroacetic acid Solvents: Dichloromethane ; 1 h, rt

参考文献：

Facile synthesis of a peptidic Au(I)-metalloamphiphile and its self-assembly into luminescent micelles in water

Kemper, Benedict; Hristova, Yana R.; Tacke, Sebastian; Stegemann, Linda; van Bezouwen, Laura S.; et al, Chemical Communications (Cambridge, 2015, 51(25), 5253-5256

合成路线：1 步

_99%

反应条件：

1.1 Catalysts: Thermolysin Solvents: Water ; 48 h, pH 8, rt

参考文献：

Enzymatic optical resolution via acylation-hydrolysis on a solid support

Ulijn, Rein V.; Bisek, Nicola; Flitsch, Sabine L., Organic & Biomolecular Chemistry, 2003, 1(4), 621-622

合成路线：1 步

_99%

反应条件：

1.1 Catalysts: Thermolysin Solvents: Water
1.2 Reagents: Trifluoroacetic acid

参考文献：

Protease-Catalyzed Peptide Synthesis on Solid Support

Ulijn, Rein V.; Baragana, Beatriz; Halling, Peter J.; Flitsch, Sabine L., Journal of the American Chemical Society, 2002, 124(37), 10988-10989

合成路线：1 步

_94%

反应条件：

1.1 Reagents: Piperidine Solvents: Dimethylformamide ; 30 min, rt
1.2 Reagents: Triethyl phosphite , 2-(1-Methylethyl)-5-nitro-1,2-benzisothiazol-3(2H)-one Catalysts: Copper(2+), tetrakis(1-methylimidazole)-, diiodide Solvents: Dimethylformamide ; 30 min, rt
1.3 Reagents: Trifluoroacetic acid Solvents: Dichloromethane ; 30 min, rt

参考文献：

Benzoisothiazolone (BIT): A fast, efficient, and recyclable redox reagent for solid phase peptide synthesis

Bukya, Hemalatha; Nayani, Kiranmai ; Gangireddy, Pavankumar; Mainkar, Prathama S., European Journal of Organic Chemistry, 2020, 2020(33), 5358-5362

合成路线：1 步

_86%

反应条件：

1.1 Reagents: 4-Methylmorpholine Solvents: Tetrahydrofuran ; rt; 5 min, rt
1.2 Reagents: Isobutyl chloroformate ; rt → -15 °C; 10 min, -15 °C; -15 °C → 0 °C
1.3 Reagents: Tetrabutylammonium hydroxide Solvents: Dimethyl sulfoxide , Water ; 30 min, 0 °C
1.4 Reagents: Hydrochloric acid Solvents: Water ; pH 2 - 3

参考文献：

α-N-Protected dipeptide acids: a simple and efficient synthesis via the easily accessible mixed anhydride method using free amino acids in DMSO and tetrabutylammonium hydroxide

Verardo, G.; Gorassini, A., Journal of Peptide Science, 2013, 19(5), 315-324

合成路线：1 步

_82%

反应条件：

1.1 Reagents: Triethylamine Solvents: Acetonitrile ; rt → 0 °C
1.2 Reagents: 4-Nitrophenyl chloroformate ; 5 min, 0 °C
1.3 Catalysts: 4-(Dimethylamino)pyridine ; 50 min, rt
1.4 Reagents: Triethylamine Solvents: Water ; 5 min, rt; 100 min, rt
1.5 Reagents: Hydrochloric acid Solvents: Water ; pH 2, 4 °C

参考文献：

Peptide coupling of unprotected amino acids through in situ p-nitrophenyl ester formation

Gagnon, Paul; Huang, Xicai; Therrien, Eric; Keillor, Jeffrey W., Tetrahedron Letters, 2002, 43(43), 7717-7719

合成路线：1 步

_81%

反应条件：

1.1 Reagents: Dicyclohexylcarbodiimide , N-Hydroxysuccinimide Solvents: Tetrahydrofuran ; rt; 12 h, rt
1.2 Reagents: Sodium carbonate Solvents: Water ; 36 h, rt
1.3 Reagents: Hydrochloric acid Solvents: Water ; acidified, rt

参考文献：

Designing a vehicle-free anti-bacterial topical hydrogel from Fmoc-diphenylalanine

Roy, Nabanita; Datta, Hemanta Kumar; Roy, Rajdip; Dastidar, Parthasarathi, Chemical Communications (Cambridge, 2023, 59(61), 9400-9403

合成路线：1 步

1586761-17-2

_77%