86123-10-6 (Fmoc-D-苯丙氨酸,Fmoc-D-Phe-OH)

反应条件：

1.1 Reagents: Sodium bicarbonate Solvents: Acetonitrile , Water ; overnight, rt
1.2 Reagents: Hydrochloric acid ; pH 2

参考文献：

Synthesis of Carboxylic Acids, Esters, and Amides from 1,1-Dibromoalkenes via Oxidation of Alkynyl Boronate Intermediates

Tao, Lei; et al, ChemistrySelect, 2021, 6(33), 8532-8536

合成路线：1 步

185509-10-8

_96%

反应条件：

1.1 Reagents: Sulfuric acid Solvents: 1,4-Dioxane , Water

参考文献：

Highly Practical Methodology for the Synthesis of D- and L-α-Amino Acids, N-Protected α-Amino Acids, and N-Methyl-α-amino Acids

Myers, Andrew G.; et al, Journal of the American Chemical Society, 1997, 119(4), 656-673

合成路线：1 步

_91%

反应条件：

1.1 Reagents: Diisopropylethylamine Solvents: 1,4-Dioxane

参考文献：

Application of metal-free triazole formation in the synthesis of cyclic RGD-DTPA conjugates

van Berkel, Sander S.; et al, ChemBioChem, 2008, 9(11), 1805-1815

合成路线：1 步

_86%

反应条件：

1.1 Reagents: Sodium carbonate Solvents: 1,4-Dioxane , Water ; rt → 0 °C; 5 min, 0 °C; 7 h, rt
1.2 Reagents: Hydrochloric acid Solvents: Water ; pH 2

参考文献：

Mechanistic insights into the slow peptide bond formation with D-amino acids in the ribosomal active site

Melnikov, Sergey V.; et al, Nucleic Acids Research, 2019, 47(4), 2089-2100

合成路线：1 步

_67%

反应条件：

1.1 Reagents: Sodium carbonate Solvents: Tetrahydrofuran , Water ; 10 min, 0 °C; 2 h, 0 °C
1.2 Reagents: Hydrochloric acid Solvents: Water ; acidified

参考文献：

Structure-Based Design of Pseudopeptidic Inhibitors for SIRT1 and SIRT2

Huhtiniemi, Tero; et al, Journal of Medicinal Chemistry, 2011, 54(19), 6456-6468

合成路线：1 步

170899-07-7

_90%

反应条件：

1.1 Reagents: Sodium hydroxide Solvents: Water
1.2 -

参考文献：

Highly Practical Methodology for the Synthesis of D- and L-α-Amino Acids, N-Protected α-Amino Acids, and N-Methyl-α-amino Acids

Myers, Andrew G.; et al, Journal of the American Chemical Society, 1997, 119(4), 656-673

合成路线：1 步

1086452-13-2

_85%

反应条件：

1.1 Reagents: Trifluoroacetic acid ; 12 min, 110 °C

参考文献：

Convenient synthetic route to an enantiomerically pure Fmoc α-amino acid

Taber, Douglass F.; et al, Journal of Organic Chemistry, 2008, 73(23), 9334-9339

合成路线：1 步

126727-04-6

参考文献：

Synergistic effects on enantioselectivity of zwitterionic chiral stationary phases for separations of chiral acids, bases, and amino acids by HPLC

Hoffmann, Christian V.; et al, Analytical Chemistry (Washington, 2008, 80(22), 8780-8789

合成路线：1 步

参考文献：

Total synthesis and stereochemical assignment of sunshinamide and its anticancer activity

Mondal, Joyanta; et al, Organic Letters, 2020, 22(3), 1188-1192

合成路线：2 步

170115-96-5

100-39-0

反应条件：

1.1 Reagents: Diisopropylamine , Butyllithium , Lithium chloride Solvents: Tetrahydrofuran , Hexane
1.2 -
2.1 Reagents: Sodium hydroxide Solvents: Water
2.2 -

参考文献：

Highly Practical Methodology for the Synthesis of D- and L-α-Amino Acids, N-Protected α-Amino Acids, and N-Methyl-α-amino Acids

Myers, Andrew G.; et al, Journal of the American Chemical Society, 1997, 119(4), 656-673

合成路线：2 步

170115-96-5

100-44-7

反应条件：

1.1 Reagents: Diisopropylamine , Butyllithium , Lithium chloride Solvents: Tetrahydrofuran , Hexane
1.2 -
2.1 Reagents: Sodium hydroxide Solvents: Water
2.2 -

参考文献：

Highly Practical Methodology for the Synthesis of D- and L-α-Amino Acids, N-Protected α-Amino Acids, and N-Methyl-α-amino Acids

Myers, Andrew G.; et al, Journal of the American Chemical Society, 1997, 119(4), 656-673

合成路线：2 步

1086452-11-0

82911-69-1

反应条件：

1.1 Reagents: 2-Iodoxybenzoic acid Solvents: Methanol
1.2 Reagents: Sodium carbonate Solvents: 1,4-Dioxane , Water ; rt
2.1 Reagents: Trifluoroacetic acid ; 12 min, 110 °C

参考文献：

Convenient synthetic route to an enantiomerically pure Fmoc α-amino acid

Taber, Douglass F.; et al, Journal of Organic Chemistry, 2008, 73(23), 9334-9339

合成路线：2 步

170115-96-5

620-05-3

反应条件：

1.1 Reagents: Diisopropylamine , Butyllithium , Lithium chloride Solvents: Tetrahydrofuran , Hexane
1.2 -
2.1 Reagents: Sodium hydroxide Solvents: Water
2.2 -

参考文献：

Highly Practical Methodology for the Synthesis of D- and L-α-Amino Acids, N-Protected α-Amino Acids, and N-Methyl-α-amino Acids

Myers, Andrew G.; et al, Journal of the American Chemical Society, 1997, 119(4), 656-673

合成路线：3 步

158393-62-5

90-04-0

反应条件：

1.1 Reagents: Rhodium, tetrakis[μ-(octanoato-κO:κO′)]di-, (Rh-Rh) Solvents: Diethyl ether ; 10 min, rt → 45 °C; 3 h, 45 °C
2.1 Reagents: 2-Iodoxybenzoic acid Solvents: Methanol
2.2 Reagents: Sodium carbonate Solvents: 1,4-Dioxane , Water ; rt
3.1 Reagents: Trifluoroacetic acid ; 12 min, 110 °C

参考文献：

Convenient synthetic route to an enantiomerically pure Fmoc α-amino acid

Taber, Douglass F.; et al, Journal of Organic Chemistry, 2008, 73(23), 9334-9339

合成路线：3 步

185508-77-4

反应条件：

1.1 Reagents: Hydrochloric acid Solvents: Methanol , Water
2.1 Reagents: Butyllithium , Lithium chloride Solvents: Tetrahydrofuran , Hexane
2.2 -
3.1 Reagents: Sodium hydroxide Solvents: Water
3.2 -

参考文献：

Highly Practical Methodology for the Synthesis of D- and L-α-Amino Acids, N-Protected α-Amino Acids, and N-Methyl-α-amino Acids

Myers, Andrew G.; et al, Journal of the American Chemical Society, 1997, 119(4), 656-673

合成路线：3 步

4530-20-5

90-82-4

反应条件：

1.1 Reagents: Triethylamine , Pivaloyl chloride Solvents: Dichloromethane
1.2 Reagents: Triethylamine
2.1 Reagents: Diisopropylamine , Butyllithium , Lithium chloride Solvents: Tetrahydrofuran , Hexane
2.2 -
3.1 Reagents: Sodium hydroxide Solvents: Water
3.2 -

参考文献：

Highly Practical Methodology for the Synthesis of D- and L-α-Amino Acids, N-Protected α-Amino Acids, and N-Methyl-α-amino Acids

Myers, Andrew G.; et al, Journal of the American Chemical Society, 1997, 119(4), 656-673

合成路线：3 步

90-82-4

616-34-2

反应条件：

1.1 Catalysts: Butyllithium Solvents: Tetrahydrofuran , Hexane
1.2 Solvents: Tetrahydrofuran
2.1 Reagents: Diisopropylamine , Butyllithium , Lithium chloride Solvents: Tetrahydrofuran , Hexane
2.2 -
3.1 Reagents: Sodium hydroxide Solvents: Water
3.2 -

参考文献：

Highly Practical Methodology for the Synthesis of D- and L-α-Amino Acids, N-Protected α-Amino Acids, and N-Methyl-α-amino Acids

Myers, Andrew G.; et al, Journal of the American Chemical Society, 1997, 119(4), 656-673

合成路线：4 步

1086452-12-1

反应条件：

1.1 Reagents: 4-Acetamidobenzenesulfonyl azide , 1,8-Diazabicyclo[5.4.0]undec-7-ene Solvents: Acetonitrile ; 10 min, 0 °C; 3 h, 35 °C
2.1 Reagents: Rhodium, tetrakis[μ-(octanoato-κO:κO′)]di-, (Rh-Rh) Solvents: Diethyl ether ; 10 min, rt → 45 °C; 3 h, 45 °C
3.1 Reagents: 2-Iodoxybenzoic acid Solvents: Methanol
3.2 Reagents: Sodium carbonate Solvents: 1,4-Dioxane , Water ; rt
4.1 Reagents: Trifluoroacetic acid ; 12 min, 110 °C

参考文献：

Convenient synthetic route to an enantiomerically pure Fmoc α-amino acid

Taber, Douglass F.; et al, Journal of Organic Chemistry, 2008, 73(23), 9334-9339

合成路线：5 步

101023-15-8

98-88-4