862772-11-0 ((Cyclo(Arg-Gly-Asp-D-Phe-Cys))

快速询单

结构式：

Cyclo(Arg-Gly-Asp-D-Phe-Cys)MOL文件

CAS号：

862772-11-0

英文名称：

Cyclo(Arg-Gly-Asp-D-Phe-Cys)

分子式：

C₂₄H₃₄N₈O₇S

分子量：

578.641163349152

简介：

Cyclo(Arg-Gly-Asp-D-Phe-Cys) (Cyclo RGDfC) 是一种对 αvβ3 具有高亲和力的环状 RGD 多肽，能够破坏细胞整合素相互作用。Cyclo(Arg-Gly-Asp-D-Phe-Cys) 抑制胚胎干细胞 (ESC) 的多能性基因表达，并在体内抑制 mESC 的致瘤潜力。Cyclo(Arg-Gly-Asp-D-Phe-Cys) 可用于肿瘤相关的研究。

多肽：

RGD多肽

Cyclo(Arg-Gly-Asp-D-Phe-Cys)(862772-11-0)名称与标识符

名称

英文别名：

cyclo (Arg-Ala-Asp-d-Phe-Cys);c(RGDfC);CYCLO (ARG-GLY-ASP-D-PHE-CYS);CYCLO(-ARG-GLY-ASP-D-PHE-CYS);Cyclo(-RGDfC), avb3 Integrin Binding Cyclic RGD Peptide;C(RADfC);CYCLO(RADFC);cyclo(RGDFC);Cyclo(Arg-Gly-Asp-D-Phe-Cys);4: PN: WO2020023462 PAGE: 42 claimed protein;862772-11-0;2-[5-Benzyl-11-[3-(diaminomethylideneamino)propyl]-3,6,9,12,15-pentaoxo-8-(sulfanylmethyl)-1,4,7,10,13-pentazacyclopentadec-2-yl]acetic acid;DA-62574;SCHEMBL23018575;Cyclo(RGDfC)?;

标识符

MDL：

MFCD18782480

InChIKey：

WNYJVAMZRBTOPE-YVSFHVDLSA-N

Inchi：

1S/C24H34N8O7S/c25-24(26)27-8-4-7-14-20(36)28-11-18(33)29-16(10-19(34)35)22(38)31-15(9-13-5-2-1-3-6-13)21(37)32-17(12-40)23(39)30-14/h1-3,5-6,14-17,40H,4,7-12H2,(H,28,36)(H,29,33)(H,30,39)(H,31,38)(H,32,37)(H,34,35)(H4,25,26,27)/t14-,15+,16-,17-/m0/s1

SMILES：

C(C1C=CC=CC=1)[C@@H]1C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CC(=O)O)C(=O)N1

Cyclo(Arg-Gly-Asp-D-Phe-Cys)(862772-11-0)物化性质

计算特性

精确分子量 : 578.22711663g/mol
氢键供体数量 : 9
氢键受体数量 : 9
可旋转化学键数量 : 9
同位素质量 : 578.22711663g/mol
重原子数量 : 40
复杂度 : 969
同位素原子数量 : 0
确定原子立构中心数量 : 0
不确定原子立构中心数量 : 4
确定化学键立构中心数量 : 0
不确定化学键立构中心数量 : 0
共价键单元数量 : 1
疏水参数计算参考值（XlogP） : -2.2
拓扑分子极性表面积 : 248Å²

Cyclo(Arg-Gly-Asp-D-Phe-Cys)(862772-11-0)推荐厂家更多厂家(23)

公司名称	手机号/电话	联系人	QQ	询单
江西探真生物技术有限公司	13758194781 13758194781	吴经理	764619768	询单
江西探真生物技术有限公司	13758194781 13758194781	吴经理	764619768	询单
杭州肽佳生物科技有限公司	13336049365 0571-87213919	来经理	3007955256	询单
上海源叶生物科技有限公司	15026964105 15026964105	汤思磊	2881489226	询单
上海瀚思化工有限公司	18939883912 021-34536277	顾经理	3003949364	询单
上海绩祥生物科技有限公司	18605105771	李经理	1799924424	询单
上海源溪生物科技有限公司	13564518121	李经理	1724405207	询单
南兴化工（江苏）有限公司	18651116180 0512-66387035	闵慧萍	3771156959	询单
南兴化工（江苏）有限公司	18651116180 0512-66387035	闵慧萍	3771156959	询单
四川维克奇生物科技有限公司	13348961525	杨洋	2851167780	询单

Cyclo(Arg-Gly-Asp-D-Phe-Cys)(862772-11-0)合成路线

合成路线：1 步

_54%

反应条件：

1.1 Reagents: 1-Hydroxybenzotriazole , Diisopropylethylamine , 1-[Bis(dimethylamino)methylene]-1H-benzotriazolium hexafluorophosphate(1-) 3-oxi… Solvents: Dimethylformamide ; 1 - 3 h, rt
1.2 Reagents: Piperidine Solvents: Dimethylformamide ; rt
1.3 Reagents: 1-Hydroxybenzotriazole , Diisopropylethylamine , 1-[Bis(dimethylamino)methylene]-1H-benzotriazolium hexafluorophosphate(1-) 3-oxi… Solvents: Dimethylformamide ; 1 - 3 h, rt
1.4 Reagents: Piperidine Solvents: Dimethylformamide ; rt
1.5 Reagents: 1-Hydroxybenzotriazole , Diisopropylethylamine , 1-[Bis(dimethylamino)methylene]-1H-benzotriazolium hexafluorophosphate(1-) 3-oxi… Solvents: Dimethylformamide ; 1 - 3 h, rt
1.6 Reagents: Piperidine Solvents: Dimethylformamide ; rt
1.7 Reagents: Acetic acid , 2,2,2-Trifluoroethanol Solvents: Dichloromethane ; 90 min, rt
1.8 Reagents: Sodium bicarbonate , Diphenylphosphoryl azide Solvents: Dimethylformamide ; 48 h, rt
1.9 Reagents: Trifluoroacetic acid Solvents: Water ; rt

参考文献：

4D biomaterials for light-guided angiogenesis

Farrukh, Aleeza; et al, Advanced Functional Materials, 2019, 29(6),

合成路线：1 步

_32%

反应条件：

1.1 -
1.2 -
1.3 -
1.4 -
1.5 -
1.6 -
1.7 Reagents: Diisopropylethylamine , 1-[Bis(dimethylamino)methylene]-1H-benzotriazolium hexafluorophosphate(1-) 3-oxi… Solvents: Dimethylformamide ; 16 h, rt
1.8 Reagents: Trifluoroacetic acid , Triisopropylsilane Solvents: Water ; 90 min, rt

参考文献：

Multimerization of cRGD peptides by click chemistry: synthetic strategies, chemical limitations, and influence on biological properties

Wangler, Carmen; et al, ChemBioChem, 2010, 11(15), 2168-2181

合成路线：1 步

_32%

反应条件：

1.1 rt
1.2 Reagents: Piperidine Solvents: Dimethylformamide ; 7 min, rt
1.3 Reagents: Diisopropylethylamine , 1-[Bis(dimethylamino)methylene]-1H-benzotriazolium hexafluorophosphate(1-) 3-oxi… Solvents: Dimethylformamide ; 30 min, rt
1.4 Reagents: Piperidine Solvents: Dimethylformamide ; 7 min, rt
1.5 Reagents: Diisopropylethylamine , 1-[Bis(dimethylamino)methylene]-1H-benzotriazolium hexafluorophosphate(1-) 3-oxi… Solvents: Dimethylformamide ; 30 min, rt
1.6 Reagents: Piperidine Solvents: Dimethylformamide ; 7 min, rt
1.7 Reagents: Diisopropylethylamine , 1-[Bis(dimethylamino)methylene]-1H-benzotriazolium hexafluorophosphate(1-) 3-oxi… Solvents: Dimethylformamide ; 30 min, rt
1.8 Reagents: Piperidine Solvents: Dimethylformamide ; 7 min, rt
1.9 Reagents: Diisopropylethylamine , 1-[Bis(dimethylamino)methylene]-1H-benzotriazolium hexafluorophosphate(1-) 3-oxi… Solvents: Dimethylformamide ; 30 min, rt
1.10 Reagents: Piperidine Solvents: Dimethylformamide ; 7 min, rt
1.11 Reagents: Trifluoroacetic acid , Triisopropylsilane Solvents: Water ; 60 min, rt

参考文献：

Aiming at the tumor-specific accumulation of MGMT-inhibitors: First description of a synthetic strategy towards inhibitor-peptide conjugates

Waengler, Bjoern; et al, Tetrahedron Letters, 2020, 61(19),

合成路线：1 步

反应条件：

1.1 Reagents: 2,4,6-Trimethylpyridine Solvents: Dichloromethane ; 18 h, rt
1.2 Reagents: 2,4,6-Trimethylpyridine , 1-[Bis(dimethylamino)methylene]-5-chloro-1H-benzotriazolium 3-oxide hexafluoroph… Solvents: Dimethylformamide , Dichloromethane ; 4 h, rt
1.3 Reagents: 2,4,6-Trimethylpyridine , 1-[Bis(dimethylamino)methylene]-5-chloro-1H-benzotriazolium 3-oxide hexafluoroph… Solvents: Dimethylformamide , Dichloromethane ; 4 h, rt
1.4 Reagents: 2,4,6-Trimethylpyridine , 1-[Bis(dimethylamino)methylene]-5-chloro-1H-benzotriazolium 3-oxide hexafluoroph… Solvents: Dimethylformamide , Dichloromethane ; 4 h, rt
1.5 Reagents: 2,4,6-Trimethylpyridine , 1-[Bis(dimethylamino)methylene]-5-chloro-1H-benzotriazolium 3-oxide hexafluoroph… Solvents: Dimethylformamide , Dichloromethane ; 4 h, rt
1.6 Reagents: 1,1,1,3,3,3-Hexafluoro-2-propanol Solvents: Dichloromethane ; 3.5 min, rt
1.7 Reagents: 2,4,6-Trimethylpyridine , 1-[Bis(dimethylamino)methylene]-5-chloro-1H-benzotriazolium 3-oxide hexafluoroph… Solvents: Dimethylformamide , Dichloromethane ; 4 d, rt
1.8 Reagents: Trifluoroacetic acid , Triisopropylsilane Solvents: Water ; 5 h, rt

参考文献：

Synthesis of Biomolecule-Modified Mesoporous Silica Nanoparticles for Targeted Hydrophobic Drug Delivery to Cancer Cells

Ferris, Daniel P.; et al, Small, 2011, 7(13), 1816-1826

合成路线：1 步

2086234-17-3

862772-11-0

反应条件：

1.1 Reagents: Tris(2-carboxyethyl)phosphine , Monosodium phosphate , Mesna Solvents: Water ; 72 h, pH 5.6, 50 °C

参考文献：

A facile N-mercaptoethoxyglycinamide (MEGA) linker approach to peptide thioesterification and cyclization

Shelton, Patrick M. M.; et al, Journal of the American Chemical Society, 2017, 139(11), 3946-3949

合成路线：1 步

862772-11-0

326003-46-7

862772-11-0

参考文献：

Tumor targeting RGD conjugated bio-reducible polymer for VEGF siRNA expressing plasmid delivery

Kim, Hyun Ah; et al, Biomaterials, 2014, 35(26), 7543-7552

合成路线：2 步

参考文献：

Tumor targeting RGD conjugated bio-reducible polymer for VEGF siRNA expressing plasmid delivery

Kim, Hyun Ah; et al, Biomaterials, 2014, 35(26), 7543-7552

合成路线：2 步

反应条件：

1.1 Reagents: Diisopropylethylamine , O-(7-Azabenzotriazol-1-yl)-N,N,N′,N′-tetramethyluronium hexafluorophosphate Solvents: Dimethylformamide ; 24 h, rt
1.2 Reagents: Piperidine Solvents: Dimethylformamide ; 25 min, rt
1.3 Reagents: Diisopropylethylamine , O-(7-Azabenzotriazol-1-yl)-N,N,N′,N′-tetramethyluronium hexafluorophosphate Solvents: Dimethylformamide ; 24 h, rt
1.4 Reagents: Piperidine Solvents: Dimethylformamide ; 25 min, rt
1.5 Reagents: Diisopropylethylamine , O-(7-Azabenzotriazol-1-yl)-N,N,N′,N′-tetramethyluronium hexafluorophosphate Solvents: Dimethylformamide ; 24 h, rt
1.6 Reagents: Piperidine Solvents: Dimethylformamide ; 25 min, rt
1.7 Reagents: Diisopropylethylamine , O-(7-Azabenzotriazol-1-yl)-N,N,N′,N′-tetramethyluronium hexafluorophosphate Solvents: Dimethylformamide ; 24 h, rt
1.8 Reagents: Piperidine Solvents: Dimethylformamide ; 25 min, rt
1.9 Reagents: Diisopropylethylamine , O-(7-Azabenzotriazol-1-yl)-N,N,N′,N′-tetramethyluronium hexafluorophosphate Solvents: Dimethylformamide ; 24 h, rt
1.10 Reagents: Piperidine Solvents: Dimethylformamide ; 25 min, rt
1.11 Reagents: Trifluoroacetic acid , Triisopropylsilane , Water ; 1 - 2 h, rt
2.1 Reagents: Tris(2-carboxyethyl)phosphine , Monosodium phosphate , Mesna Solvents: Water ; 72 h, pH 5.6, 50 °C

参考文献：

A facile N-mercaptoethoxyglycinamide (MEGA) linker approach to peptide thioesterification and cyclization

Shelton, Patrick M. M.; et al, Journal of the American Chemical Society, 2017, 139(11), 3946-3949

合成路线：2 步

2416257-25-3

2411936-91-7

862772-11-0

反应条件：

1.1 Reagents: Potassium carbonate , Tetrabutylammonium bromide Catalysts: Palladium diacetate Solvents: Ethanol , Water ; 10 min, 150 °C
2.1 Reagents: 1-Hydroxybenzotriazole , Diisopropylethylamine , 1-[Bis(dimethylamino)methylene]-1H-benzotriazolium hexafluorophosphate(1-) 3-oxi… Solvents: Dimethylformamide ; 1 - 3 h, rt
2.2 Reagents: Piperidine Solvents: Dimethylformamide ; rt
2.3 Reagents: 1-Hydroxybenzotriazole , Diisopropylethylamine , 1-[Bis(dimethylamino)methylene]-1H-benzotriazolium hexafluorophosphate(1-) 3-oxi… Solvents: Dimethylformamide ; 1 - 3 h, rt
2.4 Reagents: Piperidine Solvents: Dimethylformamide ; rt
2.5 Reagents: 1-Hydroxybenzotriazole , Diisopropylethylamine , 1-[Bis(dimethylamino)methylene]-1H-benzotriazolium hexafluorophosphate(1-) 3-oxi… Solvents: Dimethylformamide ; 1 - 3 h, rt
2.6 Reagents: Piperidine Solvents: Dimethylformamide ; rt
2.7 Reagents: Acetic acid , 2,2,2-Trifluoroethanol Solvents: Dichloromethane ; 90 min, rt
2.8 Reagents: Sodium bicarbonate , Diphenylphosphoryl azide Solvents: Dimethylformamide ; 48 h, rt
2.9 Reagents: Trifluoroacetic acid Solvents: Water ; rt

参考文献：

4D biomaterials for light-guided angiogenesis

Farrukh, Aleeza; et al, Advanced Functional Materials, 2019, 29(6),

合成路线：3 步

79-08-3

1221405-59-9

862772-11-0

反应条件：

1.1 Reagents: Piperidine Solvents: Dimethylformamide ; 25 min, rt
1.2 Reagents: Diisopropylcarbodiimide Solvents: Dimethylformamide ; 45 min, rt
1.3 Solvents: Dimethyl sulfoxide , Dimethylformamide ; 24 - 48 h, rt
2.1 Reagents: Diisopropylethylamine , O-(7-Azabenzotriazol-1-yl)-N,N,N′,N′-tetramethyluronium hexafluorophosphate Solvents: Dimethylformamide ; 24 h, rt
2.2 Reagents: Piperidine Solvents: Dimethylformamide ; 25 min, rt
2.3 Reagents: Diisopropylethylamine , O-(7-Azabenzotriazol-1-yl)-N,N,N′,N′-tetramethyluronium hexafluorophosphate Solvents: Dimethylformamide ; 24 h, rt
2.4 Reagents: Piperidine Solvents: Dimethylformamide ; 25 min, rt
2.5 Reagents: Diisopropylethylamine , O-(7-Azabenzotriazol-1-yl)-N,N,N′,N′-tetramethyluronium hexafluorophosphate Solvents: Dimethylformamide ; 24 h, rt
2.6 Reagents: Piperidine Solvents: Dimethylformamide ; 25 min, rt
2.7 Reagents: Diisopropylethylamine , O-(7-Azabenzotriazol-1-yl)-N,N,N′,N′-tetramethyluronium hexafluorophosphate Solvents: Dimethylformamide ; 24 h, rt
2.8 Reagents: Piperidine Solvents: Dimethylformamide ; 25 min, rt
2.9 Reagents: Diisopropylethylamine , O-(7-Azabenzotriazol-1-yl)-N,N,N′,N′-tetramethyluronium hexafluorophosphate Solvents: Dimethylformamide ; 24 h, rt
2.10 Reagents: Piperidine Solvents: Dimethylformamide ; 25 min, rt
2.11 Reagents: Trifluoroacetic acid , Triisopropylsilane , Water ; 1 - 2 h, rt
3.1 Reagents: Tris(2-carboxyethyl)phosphine , Monosodium phosphate , Mesna Solvents: Water ; 72 h, pH 5.6, 50 °C

参考文献：

A facile N-mercaptoethoxyglycinamide (MEGA) linker approach to peptide thioesterification and cyclization

Shelton, Patrick M. M.; et al, Journal of the American Chemical Society, 2017, 139(11), 3946-3949

合成路线：3 步

2416257-21-9

862772-11-0

反应条件：

1.1 Reagents: Trifluoroacetic acid Solvents: Dichloromethane ; 1 h, rt
2.1 Reagents: Potassium carbonate , Tetrabutylammonium bromide Catalysts: Palladium diacetate Solvents: Ethanol , Water ; 10 min, 150 °C
3.1 Reagents: 1-Hydroxybenzotriazole , Diisopropylethylamine , 1-[Bis(dimethylamino)methylene]-1H-benzotriazolium hexafluorophosphate(1-) 3-oxi… Solvents: Dimethylformamide ; 1 - 3 h, rt
3.2 Reagents: Piperidine Solvents: Dimethylformamide ; rt
3.3 Reagents: 1-Hydroxybenzotriazole , Diisopropylethylamine , 1-[Bis(dimethylamino)methylene]-1H-benzotriazolium hexafluorophosphate(1-) 3-oxi… Solvents: Dimethylformamide ; 1 - 3 h, rt
3.4 Reagents: Piperidine Solvents: Dimethylformamide ; rt
3.5 Reagents: 1-Hydroxybenzotriazole , Diisopropylethylamine , 1-[Bis(dimethylamino)methylene]-1H-benzotriazolium hexafluorophosphate(1-) 3-oxi… Solvents: Dimethylformamide ; 1 - 3 h, rt
3.6 Reagents: Piperidine Solvents: Dimethylformamide ; rt
3.7 Reagents: Acetic acid , 2,2,2-Trifluoroethanol Solvents: Dichloromethane ; 90 min, rt
3.8 Reagents: Sodium bicarbonate , Diphenylphosphoryl azide Solvents: Dimethylformamide ; 48 h, rt
3.9 Reagents: Trifluoroacetic acid Solvents: Water ; rt

参考文献：

4D biomaterials for light-guided angiogenesis

Farrukh, Aleeza; et al, Advanced Functional Materials, 2019, 29(6),

合成路线：4 步

2416257-20-8

129460-09-9

862772-11-0

反应条件：

1.1 Reagents: Dicyclohexylcarbodiimide Catalysts: 4-(Dimethylamino)pyridine Solvents: Dichloromethane ; 24 h, rt
1.2 Reagents: Sodium bicarbonate Solvents: Water ; rt
2.1 Reagents: Trifluoroacetic acid Solvents: Dichloromethane ; 1 h, rt
3.1 Reagents: Potassium carbonate , Tetrabutylammonium bromide Catalysts: Palladium diacetate Solvents: Ethanol , Water ; 10 min, 150 °C
4.1 Reagents: 1-Hydroxybenzotriazole , Diisopropylethylamine , 1-[Bis(dimethylamino)methylene]-1H-benzotriazolium hexafluorophosphate(1-) 3-oxi… Solvents: Dimethylformamide ; 1 - 3 h, rt
4.2 Reagents: Piperidine Solvents: Dimethylformamide ; rt
4.3 Reagents: 1-Hydroxybenzotriazole , Diisopropylethylamine , 1-[Bis(dimethylamino)methylene]-1H-benzotriazolium hexafluorophosphate(1-) 3-oxi… Solvents: Dimethylformamide ; 1 - 3 h, rt
4.4 Reagents: Piperidine Solvents: Dimethylformamide ; rt
4.5 Reagents: 1-Hydroxybenzotriazole , Diisopropylethylamine , 1-[Bis(dimethylamino)methylene]-1H-benzotriazolium hexafluorophosphate(1-) 3-oxi… Solvents: Dimethylformamide ; 1 - 3 h, rt
4.6 Reagents: Piperidine Solvents: Dimethylformamide ; rt
4.7 Reagents: Acetic acid , 2,2,2-Trifluoroethanol Solvents: Dichloromethane ; 90 min, rt
4.8 Reagents: Sodium bicarbonate , Diphenylphosphoryl azide Solvents: Dimethylformamide ; 48 h, rt
4.9 Reagents: Trifluoroacetic acid Solvents: Water ; rt

参考文献：

4D biomaterials for light-guided angiogenesis

Farrukh, Aleeza; et al, Advanced Functional Materials, 2019, 29(6),

合成路线：1 步

1643565-26-7

862772-11-0

1584664-33-4

参考文献：

Printed Degradable Optical Waveguides for Guiding Light into Tissue

Feng, Jun; et al, Advanced Functional Materials, 2020, 30(45),

82354-34-5(（1S，7aS）-六氢-1H-吡咯嗪-1-基甲基（2R，3S）-2,3-二羟基-2-（丙-2-基）丁酸酯) 82-70-2(1,4-Benzenedipropanoic acid, .α.,.α.'-diacetyl-.β.,.β.'-dioxo-, diethyl ester (en)) 82392-83-4(2,2-二乙氧基乙脒) 823-94-9(2,4,6-trimethyl-1,3,5-triazine-2,4,6-三甲基-1,3,5-三嗪) 827571-80-2(3-Chloro-4-methylaniline) 824-93-1(1,4-BIS(CHLOROMETHYL)CYCLOHEXANE) 824959-83-3(JWH 213) 82765-47-7((2R)-2-(Dodecanoyloxy)-3-(palmitoyloxy)propyl 2-(trimethylammonio )ethyl phosphate)

960化工网为您提供Cyclo(Arg-Gly-Asp-D-Phe-Cys)专业化合物百科信息，包括中文名，英文名，分子式，分子量，以及该化合物的CasNo.862772-11-0,相关理化性质;并提供了优质生产厂家信息包括厂家名称和联系方式等。 WAP版:862772-11-0 国际站:862772-11-0

862772-11-0 ((Cyclo(Arg-Gly-Asp-D-Phe-Cys))

Cyclo(Arg-Gly-Asp-D-Phe-Cys)(862772-11-0)名称与标识符

名称

标识符

Cyclo(Arg-Gly-Asp-D-Phe-Cys)(862772-11-0)物化性质

计算特性

Cyclo(Arg-Gly-Asp-D-Phe-Cys)(862772-11-0)推荐厂家 更多厂家(23)

Cyclo(Arg-Gly-Asp-D-Phe-Cys)(862772-11-0)合成路线

目录

Cyclo(Arg-Gly-Asp-D-Phe-Cys)(862772-11-0)推荐厂家更多厂家(23)