867-13-0 (膦酰基乙酸三乙酯,Triethyl phosphonoacetate)

_100%

参考文献：

Domino-reduction-aldolization Reactions Catalyzed Inter- and Intramolecularly by Chiral Copper Complexes

Deschamp, Julia, 2008, , ,

合成路线：1 步

_100%

参考文献：

Development of Catalysts for the Addition of N-H and O-H to Carbon-Carbon Double Bonds

Taylor, Jason Guy, 2008, , ,

合成路线：1 步

_100%

反应条件：

1.1 30 min, 60 - 80 °C

参考文献：

Synthesis and spectroscopic characterization of [1'-14C]ubiquinone-2, [1'-14C]-5-demethoxy-5-hydroxyubiquinone-2, and [1'-14C]-5-demethoxyubiquinone-2

Van der Klei, Anita; et al, European Journal of Organic Chemistry, 2002, (17), 3015-3023

合成路线：1 步

74-96-4

_100%

参考文献：

Studies on the synthesis of vitamin D metabolites and analogs. Synthesis of 1α,3β,25-trihydroxy-21-norcholesta-5,7-diene triacetate

Pumar, M. C.; et al, Anales de Quimica, 1988, 84(1), 105-11

合成路线：1 步

_97%

反应条件：

1.1 Catalysts: Iodine ; 2 h, 80 °C

参考文献：

Synthesis of triethyl phosphonoacetate esters catalyzed by iodine

Cai, Xiaohua; et al, Huaxue Yanjiu, 2006, 17(1), 41-43

合成路线：1 步

_93%

反应条件：

1.1 2 h, 120 °C; 2 h, 165 °C

参考文献：

Simple synthesis of new 3-substituted 4-(3-chloro-4-fluorophenyl)-1H-pyrrole derivatives and their anticancer activity in vitro

Lan, Lan; et al, Heterocycles, 2014, 89(2), 375-397

合成路线：1 步

78-40-0

_94%

反应条件：

1.1 1.5 h, 156 °C; 2.5 h, 156 °C

参考文献：

Study on the synthesis of ethyl 2-(diethoxyphosphoryl)-3-methylbutanoate

Zhao, Jianbin; et al, Guangdong Huagong, 2013, 40(22),

合成路线：1 步

78-40-0

_92%

反应条件：

1.1 rt → 100 °C; 2 h, 100 °C

参考文献：

Synthesis and α-glucosidase inhibitory activity of cinnamic amides

Cai, Xiao-Hua; et al, Youji Huaxue, 2007, 27(1), 77-81

合成路线：1 步

141-78-6

589-57-1

_93%

反应条件：

1.1 Reagents: Lithium diisopropylamide Solvents: Diethyl ether
1.2 -

参考文献：

Reaction of diethyl phosphorochloridite with enolates: a general method for synthesis of β-keto phosphonates and α-phosphono esters through carbon-phosphorus bond formation

Lee, Koo; et al, Journal of Organic Chemistry, 1991, 56(19), 5556-60

合成路线：1 步

_60%

反应条件：

1.1 Reagents: Sodium Solvents: Diethyl ether

参考文献：

Synthesis of the sex pheromone of Lygus lineolaris (Heteroptera miridae)

Shakirzyanova, G. S.; et al, Chemistry of Natural Compounds (Translation of Khimiya Prirodnykh Soedinenii), 2001, 36(6), 623-624

合成路线：1 步

反应条件：

1.1 Reagents: Sodium hydroxide Catalysts: Benzyltriethylammonium chloride Solvents: Dichloromethane , Water

参考文献：

Synthesis of dialkyl alkoxycarbonylmethanephosphonates (alkyl dialkoxyphosphinylacetates) using phase-transfer catalysis

Ye, Weizhen; et al, Synthesis, 1985, (10), 986-8

合成路线：1 步

544429-59-6

237735-50-1

_83%

反应条件：

1.1 Reagents: 1,8-Diazabicyclo[5.4.0]undec-7-ene , Lithium chloride

参考文献：

Enantioselective Total Synthesis of the Antitumor Macrolide Rhizoxin D

Lafontaine, Jennifer A.; et al, Journal of Organic Chemistry, 2003, 68(11), 4215-4234

合成路线：1 步

623-73-4

_83%

反应条件：

1.1 Catalysts: Copper(II) acetylacetonate ; heated

参考文献：

Diethyl phosphonite

Green, Kenneth, e-EROS Encyclopedia of Reagents for Organic Synthesis, 2001, 1, 1-3

合成路线：1 步

623-73-4

_83%

反应条件：

1.1 Catalysts: Copper(II) acetylacetonate Solvents: Benzene

参考文献：

A new one-pot synthesis of dialkyl phosphonates from diazo compounds and dialkyl hydrogen phosphites

Polozov, A. M.; et al, Synthesis, 1990, (6), 515-17

合成路线：1 步

623-73-4

_2%

反应条件：

1.1 Catalysts: Trifluoromethanesulfonic acid Solvents: Benzene

参考文献：

Trifluoromethanesulfonic acid-catalyzed reaction of diazo compounds with dialkyl phosphites to form phosphonates

Polozov, A. M.; et al, Zhurnal Obshchei Khimii, 1992, 62(6), 1429-30

合成路线：1 步

683-08-9

105-58-8

_74%

反应条件：

1.1 Reagents: Lithium diisopropylamide Solvents: Tetrahydrofuran , Hexane
1.2 Solvents: Tetrahydrofuran

参考文献：

α-Lithioalkylphosphonates as functional group carriers. An in situ acrylic ester synthesis

Tay, M. K.; et al, Synthetic Communications, 1988, 18(12), 1349-62

合成路线：1 步

683-08-9

105-58-8

参考文献：

Carboxylic acid esters: synthesis from carbonic acid derivatives

Collier, S. J., Science of Synthesis, 2006, 20, 665-709

合成路线：1 步

3095-95-2

64-17-5

_56%

反应条件：

1.1 Reagents: PyBOP Solvents: Dichloromethane ; rt; 2 h, rt

参考文献：

Development of potent inhibitors of the coxsackievirus 3C protease

Lee, Eui Seung; et al, Biochemical and Biophysical Research Communications, 2007, 358(1), 7-11

合成路线：1 步

3095-95-2

64-17-5

反应条件：

1.1 Reagents: 4-(Dimethylamino)pyridine , 1-Ethyl-3-(3′-dimethylaminopropyl)carbodiimide hydrochloride Solvents: Dichloromethane ; 30 min, rt

参考文献：

Synthesis and evaluation of designed PKC modulators for enhanced cancer immunotherapy

Hardman, Clayton ; et al, Nature Communications, 2020, 11(1),

合成路线：1 步

反应条件：

1.1 Reagents: Triethyl phosphite ; 5 h, 150 °C
1.2 Reagents: Phosphorus pentachloride ; 16 h, 80 °C

参考文献：

Rational design of a minimal and highly enriched CYP102A1 mutant library with improved regio-, stereo- and chemoselectivity

Seifert, Alexander; et al, ChemBioChem, 2009, 10(5), 853-861

合成路线：1 步

23755-73-9

反应条件：

1.1 Reagents: 2,6-Lutidine , Ethyl vinyl ether Catalysts: Tris(2,2′-bipyridyl)ruthenium(II) chloride Solvents: Acetonitrile ; 24 h, rt

参考文献：

A Visible Light Ru-Catalyzed Photoredox Access to Substituted Dihydrofurans

Victoria-Miguel, Jorge; et al, Journal of Organic Chemistry, 2022, 87(14), 9088-9099

合成路线：1 步

28845-75-2

参考文献：

Synthesis of halogenated phosphonoacetate esters

McKenna, Charles E.; et al, Journal of Organic Chemistry, 1986, 51(26), 5467-70

合成路线：1 步

34159-39-2

反应条件：

1.1 Reagents: Water Catalysts: Sulfuric acid

参考文献：

Reaction of haloacetylenephosphonates with nucleophilic anions

Garibina, V. A.; et al, Zhurnal Obshchei Khimii, 1985, 55(9), 1994-2006

合成路线：2 步

4851-52-9

141-52-6

反应条件：

1.1 Solvents: Diethyl ether
2.1 Reagents: Water Catalysts: Sulfuric acid

参考文献：

Reaction of haloacetylenephosphonates with nucleophilic anions

Garibina, V. A.; et al, Zhurnal Obshchei Khimii, 1985, 55(9), 1994-2006

合成路线：2 步

1498-42-6

反应条件：

1.1 Reagents: Guaiacol , Triethylamine Solvents: Diethyl ether , Toluene ; 0 °C; 30 min, 0 °C; 0 °C → rt; 3 h, rt
2.1 30 min, 120 °C

参考文献：

Asymmetric Gold(I)-Catalyzed Tandem Hydroarylation-Nazarov Cyclization: Enantioselective Access to Cyclopentenones

Solas, Marta ; et al, Angewandte Chemie, 2022, 61(35),

合成路线：2 步

237735-33-0

反应条件：

1.1 Solvents: Tetrahydrofuran , Water ; rt → 0 °C
1.2 Reagents: N-methylmorpholine N-oxide , Osmium tetroxide Solvents: Water ; overnight, 0 °C
1.3 Reagents: Sodium sulfite Solvents: Water
1.4 Reagents: Hydrochloric acid Solvents: Ethyl acetate , Water
1.5 Reagents: Sodium periodate Solvents: Tetrahydrofuran , Water ; 1 h, rt
2.1 Reagents: 1,8-Diazabicyclo[5.4.0]undec-7-ene , Lithium chloride

参考文献：

Enantioselective Total Synthesis of the Antitumor Macrolide Rhizoxin D

Lafontaine, Jennifer A.; et al, Journal of Organic Chemistry, 2003, 68(11), 4215-4234

合成路线：2 步

615-52-1