86-96-4 (2,4-喹唑啉二酮,Benzoyleneurea)

反应条件：

1.1 Reagents: 1,8-Diazabicyclo[5.4.0]undec-7-ene Solvents: Ethylene glycol ; 24 h, 1 bar, 60 °C

参考文献：

Room-temperature conversion of CO2 into quinazoline-2,4(1H,3H)-dione using deep eutectic solvents at atmospheric pressure with high efficiency

Chen, Yu; et al, Reaction Chemistry & Engineering, 2022, 7(9), 1968-1977

合成路线：1 步

1885-29-6

124-38-9

_99%

反应条件：

1.1 Catalysts: Phosphonium, tributylethyl-, salt with 1-methyl-2,4-imidazolidinedione (1:1) ; 30 h, 0.1 MPa, 353.15 K

参考文献：

Efficient Synthesis of Quinazoline-2,4(1H,3H)-dione via Simultaneous Activated CO2 and 2-Aminobenzonitrile by 1-Methylhydantoin Anion-Functionalized Ionic Liquid through the Multiple-Site Cooperative Interactions

Chen, Tingting; et al, ACS Sustainable Chemistry & Engineering, 2022, 10(32), 10699-10711

合成路线：1 步

1885-29-6

68-12-2

_99%

反应条件：

1.1 Reagents: Carbon dioxide Solvents: Water ; rt → 150 °C; 5 h, 5 MPa, 150 °C

参考文献：

Carbon Dioxide Mediated Novel Synthesis of Quinazoline-2,4(1H,3H)-dione in Water

Rasal, Kalidas B.; et al, Organic Process Research & Development, 2016, 20(12), 2067-2073

合成路线：1 步

2242-77-5

_99%

反应条件：

1.1 Reagents: Sodium hydroxide Solvents: Methanol , Water ; 3 h, pH 10, reflux; reflux → rt
1.2 Reagents: Hydrochloric acid Solvents: Water ; pH 3, rt

参考文献：

Discovery of novel potent and selective ligands for 5-HT2A receptor with quinazoline scaffold

Deng, Xinxian ; et al, Bioorganic & Medicinal Chemistry Letters, 2015, 25(18), 3970-3974

合成路线：1 步

2242-77-5

反应条件：

1.1 Reagents: Potassium hydroxide Solvents: Methanol , Water ; pH 10, reflux

参考文献：

Discovery of novel quinazolines as potential anti-tubulin agents occupying three zones of colchicine domain

Li, Wenlong; et al, Bioorganic Chemistry, 2019, 83, 380-390

合成路线：1 步

62-56-6

_98%

反应条件：

1.1 Reagents: Diglyme ; 5 h, reflux

参考文献：

Synthesis and Characterization of New Bistriazole Quinazolinediones and their Urease Inhibition Activities

Akyuz, Gulay; et al, Letters in Organic Chemistry, 2023, 20(3), 258-264

合成路线：1 步

_98%

反应条件：

1.1 Reagents: 1,8-Diazabicyclo[5.4.0]undec-7-ene , Sulfur Solvents: Tetrahydrofuran

参考文献：

Facile synthesis of 2,4-dioxo-1,2,3,4-tetrahydroquinazolines by sulfur-assisted carbonylation with carbon monoxide

Miyata, Toshiyuki; et al, Heteroatom Chemistry, 1991, 2(4), 473-5

合成路线：1 步

_64%

反应条件：

1.1 Reagents: Oxygen Catalysts: Cobalt salen Solvents: Methanol

参考文献：

Salcomine

Parker, Kathlyn A.; et al, e-EROS Encyclopedia of Reagents for Organic Synthesis, 2001, 1, 1-3

合成路线：1 步

_51%

反应条件：

1.1 Reagents: Potassium carbonate , Sulfur Solvents: Dimethylformamide
1.2 Reagents: Oxygen
1.3 Reagents: Hydrochloric acid Solvents: Water

参考文献：

Convenient synthesis of heterocycles by sulfur-assisted carbonylation at ordinary pressure and temperature

Mizuno, Takumi; et al, Heteroatom Chemistry, 1994, 5, 437-40

合成路线：1 步

57-13-6

_96%

反应条件：

1.1 Solvents: Dimethylacetamide ; 3 min; rt

参考文献：

A green, facile, and one-pot synthesis of 2,4-(1H,3H)-quinazolinediones under microwave irradiations

Nikpour, Farzad; et al, Chemistry Letters, 2005, 34(10), 1438-1439

合成路线：1 步

57-13-6

_95%

反应条件：

1.1 3 h, 180 °C; 180 °C → 120 °C
1.2 Reagents: Sodium hydroxide Solvents: Water
1.3 Reagents: Hydrochloric acid Solvents: Water ; acidified

参考文献：

Synthesis, characterisation and biological evaluation of quinazoline derivatives as novel anti-microbial agents

Prabhakar, V.; et al, Organic Chemistry: Current Research, 2016, 5(4), 174/1-174/14

合成路线：1 步

116465-86-2

_95%

反应条件：

1.1 Solvents: Water

参考文献：

4H-3,1-Benzoxazin-4-ones. II. Reaction of 1,2-dihydro-2-imino-4H-3,1-benzoxazin-4-ones with nucleophilic reagents and their conversion to 1,2,3,4-tetrahydroquinazoline-2,4-diones; mechanism of condensation reactions of the carboxyl group triggered by carbodiimides

Doleschall, Gabor; et al, Monatshefte fuer Chemie, 1964, 95(4-5), 1068-82

合成路线：3 步

116465-86-2

反应条件：

1.1 Reagents: Diisopropylcarbodiimide Solvents: Dimethylformamide ; 20 min, 130 °C
2.1 Reagents: Sulfuric acid Solvents: Acetic acid ; 15 min, 110 °C
3.1 Reagents: Potassium hydroxide Solvents: Water ; 15 min, reflux
3.2 Reagents: Acetic acid ; acidified

参考文献：

Oxidative Ring Expansion of Spirocyclic Oxindole Derivatives

Bergman, Jan; et al, Journal of Organic Chemistry, 2014, 79(19), 9065-9073

合成路线：1 步

530-62-1

_95%

反应条件：

1.1 Reagents: Ammonia Solvents: Dichloromethane ; 30 min, reflux
1.2 2 h, reflux

参考文献：

One-pot Syntheses of Some New 2,4(1H,3H)-quinazolinedione Derivatives in the Absence of Catalyst

Mohammadi, Ali Asghar, Journal of Heterocyclic Chemistry, 2017, 54(3), 2075-2078

合成路线：1 步

590-28-3

_95%

反应条件：

1.1 Reagents: Acetic acid Solvents: Polyethylene glycol ; rt → 60 °C; 10 min, 50 - 60 °C

参考文献：

A facile and convenient approach for the one-pot synthesis of 2,4(1H,3H)-quinazolinediones

Sharafi-Kolkeshvandi, Mahnaz; et al, Chinese Chemical Letters, 2012, 23(4), 431-433

合成路线：1 步

590-28-3

_92%

反应条件：

1.1 Reagents: Acetic acid Solvents: Water ; overnight, rt
1.2 Reagents: Sodium hydroxide ; 4 h, rt
1.3 Reagents: Hydrochloric acid Solvents: Water ; < pH 1, rt

参考文献：

Eco-efficient one-pot synthesis of quinazoline-2,4(1H,3H)-diones at room temperature in water

Tian, Xin-Chuan; et al, Chemical & Pharmaceutical Bulletin, 2014, 62(8), 824-829

合成路线：1 步

124-38-9

_95%

反应条件：

1.1 Reagents: Triphenyl phosphite , 1,5-Diazabicyclo[4.3.0]non-5-ene Solvents: Acetonitrile ; 1 h, rt

参考文献：

Synthesis of N-Unsubstituted and N3-Substituted Quinazoline-2,4(1H,3H)-diones from o-Aminobenzamides and CO2 at Atmospheric Pressure and Room Temperature

Zhang, Lin ; et al, Organic Letters, 2023, 25(14), 2471-2475

合成路线：1 步

610-15-1

_95%

反应条件：

1.1 Reagents: Triethylamine Catalysts: Selenium Solvents: Tetrahydrofuran ; 11 h, 2 MPa, 170 °C

参考文献：

Metal and phosgene-free synthesis of 1H-quinazoline-2,4-diones by selenium-catalyzed carbonylation of o-nitrobenzamides

Wu, Xiaowei; et al, Tetrahedron Letters, 2010, 51(11), 1500-1503

合成路线：1 步

610-15-1

_28%

反应条件：

1.1 Catalysts: Stannous chloride , Dichlorobis(triphenylphosphine)palladium Solvents: Tetrahydrofuran

参考文献：

Palladium complex-catalyzed intermolecular reductive N-heterocyclization: novel synthesis of quinazoline derivatives from 2-nitrobenzaldehyde or 2-nitrophenyl ketones with formamide

Akazome, Motohiro; et al, Journal of Organometallic Chemistry, 1995, 494(1-2), 229-33

合成路线：1 步

88-96-0

_95%

反应条件：

1.1 Reagents: Iodobenzene diacetate Solvents: Methanol ; rt

参考文献：

ONSH: Optimization of Oxidative Alkylamination Reactions through Study of the Reaction Mechanism

Verbeeck, Stefan; et al, Journal of Organic Chemistry, 2010, 75(15), 5126-5133

合成路线：1 步

88-96-0

_95%

反应条件：

1.1 Reagents: Iodobenzene diacetate Solvents: Methanol

参考文献：

Oxidative cyclization of diamides by phenyliodoso acetate

Beckwith, Athelstan L. J.; et al, Australian Journal of Chemistry, 1990, 43(3), 451-61

合成路线：1 步

24424-99-5

_94%

反应条件：

1.1 Catalysts: 4-(Dimethylamino)pyridine Solvents: Acetonitrile ; 12 h, rt

参考文献：

DMAP-Catalyzed One-Pot Synthesis of Quinazoline-2,4-diones from 2-Aminobenzamides and Di-tert-butyl Dicarbonate

Chen, Hui; et al, ACS Omega, 2020, 5(16), 9614-9623

合成路线：1 步

_92%

反应条件：

1.1 Reagents: Urea Solvents: Dimethylformamide

参考文献：

Syntheses of heterocycles. LXXXIX. Reactions of isatoic anhydride with derivatives of urea and thiourea

Kappe, Thomas; et al, Monatshefte fuer Chemie, 1967, 98(1), 214-18

合成路线：1 步

反应条件：

1.1 Reagents: Urea ; rt

参考文献：

Synthesis and analgesic activity of 6-amino-2-piperazinylquinazolines

Kornylov, A. Yu.; et al, Visnik Odes'koho Natsional'noho Universitetu, 2021, 26(1), 74-84

合成路线：1 步

参考文献：

Product class 13: quinazolines

Kikelj, D., Science of Synthesis, 2004, 16, 573-749

合成路线：1 步

917-61-3

_92%

反应条件：

1.1 Solvents: Acetic acid , Water ; 35 °C; 30 min, 35 °C
1.2 Reagents: Sodium hydroxide ; cooled; 12 h, cooled
1.3 Reagents: Sulfuric acid Solvents: Water ; pH 7

参考文献：

Synthesis, spectroscopic characterization and X-ray analysis of 6-nitroquinazoline-2,4(1H,3H)-dione

Kesternich, Viictor; et al, Journal of the Chilean Chemical Society, 2013, 58(3), 1817-1819

合成路线：1 步

31143-83-6

590-28-3

_92%

反应条件：

1.1 Reagents: Acetic acid Solvents: Polyethylene glycol ; 25 min, 50 - 60 °C

参考文献：

Condensation reaction of ethyl 4-oxo-4H-benzo[d][1,3]oxazine-2-carboxylates with potassium cyanate: 2,4(1H,3H)-quinazolinediones synthesis

Nikpour, Farzad; et al, Heterocycles, 2012, 85(11), 2745-2748

合成路线：1 步

32315-10-9

_92%

反应条件：

1.1 Catalysts: Iodine Solvents: 1-Butyl-3-methylimidazolium tetrafluoroborate ; 45 min, 80 °C; 80 °C → rt

参考文献：

Green Synthesis of Quinazolinone Derivatives Catalyzed by Iodine in Ionic Liquid

Wang, Shu-Liang; et al, Synthetic Communications, 2012, 42(3), 341-349

合成路线：1 步

2698351-47-0

_90%