88075-18-7 (对三甲基硅基苯酚,4-(2-trimethylsilylethynyl)phenol)

_100%

反应条件：

1.1 Reagents: Triethylamine Catalysts: Cuprous iodide , Dichlorobis(triphenylphosphine)palladium ; 3 h, 80 °C

参考文献：

Boosting Endogenous Copper(I) for Biologically Safe and Efficient Bioorthogonal Catalysis via Self-Adaptive Metal-Organic Frameworks

Zhu, Jiawei; et al, Journal of the American Chemical Society, 2023, 145(3), 1955-1963

合成路线：1 步

_100%

反应条件：

1.1 Reagents: Triethylamine Catalysts: Cuprous iodide , Dichlorobis(triphenylphosphine)palladium ; 3 h, 80 °C

参考文献：

NIR-II Light Leveraged Dual Drug Synthesis for Orthotopic Combination Therapy

Zhao, Huisi; et al, ACS Nano, 2022, 16(12), 20353-20363

合成路线：1 步

_100%

反应条件：

1.1 Reagents: Triethylamine Catalysts: Cuprous iodide , Dichlorobis(triphenylphosphine)palladium ; 3 h, 80 °C

参考文献：

A DNAzyme-augmented bioorthogonal catalysis system for synergistic cancer therapy

You, Yawen; et al, Chemical Science, 2022, 13(26), 7829-7836

合成路线：1 步

106-41-2

_97%

反应条件：

1.1 Reagents: N,N,N′,N′-Tetramethylethylenediamine Catalysts: Cuprous iodide , Disodium tetrachloropalladate , 2-[Bis(1,1-dimethylethyl)phosphino]-1-phenyl-1H-indole Solvents: N,N,N′,N′-Tetramethylethylenediamine ; 20 h, 80 °C; 80 °C → rt
1.2 Reagents: Water ; rt

参考文献：

Palladium catalysts for highly selective Sonogashira reactions of aryl and heteroaryl bromides

Torborg, Christian; et al, ChemSusChem, 2008, 1(1-2), 91-96

合成路线：1 步

106-41-2

_76%

反应条件：

1.1 Reagents: Triethylamine Catalysts: Dichlorobis(triphenylphosphine)palladium , 1-Butyl-3-methylimidazolium tetrafluoroborate ; 5 min, 80 °C

参考文献：

Microwave-assisted, copper-free Sonogashira coupling between aryl halides and terminal alkynes using recyclable ionic liquid and catalyst

Duc, Dau Xuan ; et al, Letters in Organic Chemistry, 2022, 19(1), 28-33

合成路线：1 步

106-41-2

反应条件：

1.1 Catalysts: Cuprous iodide , Dichlorobis(triphenylphosphine)palladium Solvents: Triethylamine ; 1.5 h, 80 °C

参考文献：

Sequential Sonogashira and Glaser coupling reactions: facile access to 1,4-disubstituted 1,3-butadiynes from aryl bromide

Gong, Yanfang; et al, Tetrahedron Letters, 2016, 57(20), 2143-2146

合成路线：1 步

18803-26-4

_85%

反应条件：

1.1 Reagents: Triethylamine Catalysts: Cuprous iodide , Dichlorobis(triphenylphosphine)palladium ; 1 h, rt

参考文献：

4-Alkynylphenyl imidazolylpropyl ethers as selective histamine H3-receptor antagonists with high oral central nervous system activity

Krause, Michael; et al, Journal of Medicinal Chemistry, 1998, 41(21), 4171-4176

合成路线：1 步

165825-13-8

_85%

反应条件：

1.1 Reagents: Lithium hydroxide Solvents: Methanol , Tetrahydrofuran , Water ; 30 min, 0 °C

参考文献：

One-pot click synthesis of 1N-Alkyl-4-aryl-1,2,3-triazoles from protected arylalkynes and alkyl bromides

Ladouceur, Sebastien; et al, Synthesis, 2011, (22), 3604-3611

合成路线：1 步

6224-91-5

_82%

反应条件：

1.1 Reagents: Triethylamine Catalysts: Cuprous iodide , Dichlorobis(triphenylphosphine)palladium Solvents: 1,4-Dioxane ; 20 h, 45 °C

参考文献：

Twisting and piezochromism of phenylene-ethynylenes with aromatic interactions between side chains and main chains

Pawle, R. H.; et al, Chemical Science, 2014, 5(11), 4184-4188

合成路线：1 步

106-48-9

_58%

反应条件：

1.1 Reagents: Triethylamine Catalysts: Dichlorobis(triphenylphosphine)palladium , 1-Butyl-3-methylimidazolium tetrafluoroborate ; 5 min, 80 °C

参考文献：

Microwave-assisted, copper-free Sonogashira coupling between aryl halides and terminal alkynes using recyclable ionic liquid and catalyst

Duc, Dau Xuan ; et al, Letters in Organic Chemistry, 2022, 19(1), 28-33

合成路线：1 步

492448-51-8

_20%

反应条件：

1.1 Reagents: Triethylamine Catalysts: Cuprous iodide , Tetrakis(triphenylphosphine)palladium Solvents: Tetrahydrofuran ; 10 min, 40 °C
1.2 10 h, 40 °C; 4 h, 40 °C
1.3 Reagents: Sodium chloride Solvents: Water

参考文献：

Palladium-catalyzed carbon-carbon coupling reactions using aryl Grignards

Gottardo, Christine; et al, Tetrahedron Letters, 2002, 43(39), 7091-7094

合成路线：2 步

1927-95-3