882-36-0 (4-氯-2-甲基-N-乙酰乙酰苯胺,N-benzyl-3-oxobutanamide)

_98%

反应条件：

1.1 Catalysts: Manganese(1+), [[2,2′-[1,2-ethanediylbis[(nitrilo-κN)methylidyne]]bis[phenolato-… Solvents: Toluene

参考文献：

Transesterification of β-keto esters catalyzed by transition metal complexes in a novel heterogeneous way

Kantam, M. Lakshmi; et al, Catalysis Letters, 1999, 62(1), 67-69

合成路线：1 步

_89%

反应条件：

1.1 Reagents: Boron trifluoride etherate Solvents: Dichloromethane ; 24 h, rt
1.2 Solvents: Acetonitrile ; 3 h, rt
1.3 Reagents: Sodium acetate Solvents: Ethanol , Water ; overnight, reflux

参考文献：

Synthesis of α-Alkyl-β-Hydroxy Amides through Biocatalytic Dynamic Kinetic Resolution Employing Alcohol Dehydrogenases

Mendez-Sanchez, Daniel; et al, Advanced Synthesis & Catalysis, 2019, 361(11), 2706-2712

合成路线：1 步

_78%

反应条件：

1.1 Reagents: 1,1,1,3,3,3-Hexafluoro-2-propanol ; 12 h, 80 °C

参考文献：

HFIP-mediated strategy towards β-oxo amides and subsequent Friedel-Craft type cyclization to 2-quinolinones using recyclable catalyst

Kabi, Arup K.; et al, Tetrahedron Letters, 2020, 61(46),

合成路线：1 步

5394-63-8

_95%

反应条件：

1.1 1 min, 178 °C

参考文献：

An efficient and rapid synthesis of β-carboxamide derivatives, using 2,2-dimethyl-2H,4H-1,3-dioxin-4-ones, by microwave irradiation

Miriyala, Bruhaspathy; et al, Tetrahedron Letters, 2003, 44(43), 7957-7959

合成路线：1 步

5394-63-8

_79%

反应条件：

1.1 Reagents: Sodium acetate Solvents: Tetrahydrofuran ; 24 h, reflux

参考文献：

Mild and high-yielding synthesis of β-keto esters and β-ketoamides

Sridharan, Vellaisamy; et al, Synthesis, 2010, (6), 1053-1057

合成路线：1 步

141-97-9

_89%

反应条件：

1.1 Catalysts: Triacylglycerol lipase Solvents: 1,4-Dioxane

参考文献：

Chemoenzymic aminolysis and ammonolysis of β-ketoesters

Garcia, Maria Jesus; et al, Tetrahedron Letters, 1993, 34(38), 6141-2

合成路线：1 步

141-97-9

_79%

反应条件：

1.1 Reagents: 1,1,1,3,3,3-Hexafluoro-2-propanol ; 12 h, 80 °C

参考文献：

HFIP-mediated strategy towards β-oxo amides and subsequent Friedel-Craft type cyclization to 2-quinolinones using recyclable catalyst

Kabi, Arup K.; et al, Tetrahedron Letters, 2020, 61(46),

合成路线：1 步

141-97-9

_75%

反应条件：

1.1 Solvents: Polyethylene glycol ; 1.5 h, 120 °C

参考文献：

Facile eco-friendly synthesis of novel chromeno[4,3-b]pyridine-2,5-diones and evaluation of their antimicrobial and antioxidant properties

Jaggavarapu, Satyanarayana Reddy; et al, Journal of Chemical Sciences (Bangalore, 2014, 126(1), 187-195

合成路线：1 步

1118-84-9

_79%

反应条件：

1.1 Reagents: 1,1,1,3,3,3-Hexafluoro-2-propanol ; 12 h, 80 °C

参考文献：

HFIP-mediated strategy towards β-oxo amides and subsequent Friedel-Craft type cyclization to 2-quinolinones using recyclable catalyst

Kabi, Arup K.; et al, Tetrahedron Letters, 2020, 61(46),

合成路线：1 步

153373-75-2

75-36-5

_39%

反应条件：

1.1 Reagents: Butyllithium , Zirconocene, dichloride Solvents: Tetrahydrofuran , Hexane
1.2 Solvents: Tetrahydrofuran
1.3 Reagents: Sodium bicarbonate Solvents: Water

参考文献：

New transformations from a 3-silyloxy-2-aza-1,3-diene: consecutive Zr-mediated retro-Brook rearrangement and reactions with electrophiles

Gandon, Vincent; et al, Tetrahedron, 2000, 56(26), 4467-4472

合成路线：1 步

65399-20-4

反应条件：

1.1 Solvents: Chloroform-d ; 0.5 h, 25 °C

参考文献：

A Chemoselective Route to β-Enamino Esters and Thioesters

Xin, Dongyue; et al, Organic Letters, 2014, 16(8), 2108-2110

合成路线：1 步

72324-39-1

反应条件：

1.1 Solvents: 1,4-Dioxane ; reflux

参考文献：

2,2-Dimethyl-1,3-dioxane-4,6-dione - First Update to document cited in CA149:245849

Yonemitsu, Osamu; et al, e-EROS Encyclopedia of Reagents for Organic Synthesis, 2007, ,

合成路线：1 步

10128-99-1

反应条件：

1.1 Catalysts: Methanol

参考文献：

Radiation-controlled electroluminescence in triple-band emitting electroluminescent materials

Singh, Geeta; et al, Indian Journal of Physics, 1992, (3), 387-90

合成路线：1 步

2437309-87-8

反应条件：

1.1 Reagents: Sodium acetate Solvents: Ethanol , Water ; overnight, reflux

参考文献：

Synthesis of α-Alkyl-β-Hydroxy Amides through Biocatalytic Dynamic Kinetic Resolution Employing Alcohol Dehydrogenases

Mendez-Sanchez, Daniel; et al, Advanced Synthesis & Catalysis, 2019, 361(11), 2706-2712

合成路线：2 步

100494-88-0

反应条件：

1.1 Solvents: Acetonitrile ; 3 h, rt
2.1 Reagents: Sodium acetate Solvents: Ethanol , Water ; overnight, reflux

参考文献：

Synthesis of α-Alkyl-β-Hydroxy Amides through Biocatalytic Dynamic Kinetic Resolution Employing Alcohol Dehydrogenases

Mendez-Sanchez, Daniel; et al, Advanced Synthesis & Catalysis, 2019, 361(11), 2706-2712

合成路线：2 步

5394-63-8

106-54-7

反应条件：

1.1 Solvents: Xylene ; 30 min, 145 °C
2.1 Solvents: Chloroform-d ; 0.5 h, 25 °C

参考文献：

A Chemoselective Route to β-Enamino Esters and Thioesters

Xin, Dongyue; et al, Organic Letters, 2014, 16(8), 2108-2110

合成路线：3 步