883-92-1 (6-氯-2-氧代-2H-苯并吡喃-3-羧酸,6-Chloro-2-oxo-2H-chromene-3-carboxylic acid)

_99%

反应条件：

1.1 Catalysts: Sodium azide Solvents: Water ; 20 h, 24 - 26 °C
1.2 Reagents: Hydrogen ion Solvents: Water ; acidified, cooled

参考文献：

Room Temperature One-Pot Green Synthesis of Coumarin-3-carboxylic Acids in Water: A Practical Method for the Large-Scale Synthesis

Brahmachari, Goutam, ACS Sustainable Chemistry & Engineering, 2015, 3(9), 2350-2358

合成路线：1 步

_98%

反应条件：

1.1 Catalysts: β-Cyclodextrin Solvents: Water ; 20 min, 70 °C

参考文献：

Synthesis of xanthene and coumarin derivatives in water by using β-Cyclodextrin

Kamat, Siddharth R. ; et al, Research on Chemical Intermediates, 2021, 47(3), 911-924

合成路线：1 步

_98%

反应条件：

1.1 Solvents: Water ; 55 min, rt

参考文献：

Aqueous Extract of Acacia concinna Pods: An Efficient Surfactant Type Catalyst for Synthesis of 3-Carboxycoumarins and Cinnamic Acids via Knoevenagel Condensation

Chavan, Hemant V.; et al, ACS Sustainable Chemistry & Engineering, 2013, 1(8), 929-936

合成路线：1 步

70384-80-4

_95%

反应条件：

1.1 Reagents: Sodium hydroxide Solvents: Ethanol , Water ; 2 h, reflux; cooled
1.2 Reagents: Hydrochloric acid Solvents: Water ; rt

参考文献：

Synthesis, characterization and antimicrobial activity of a series of substituted coumarin-3-carboxylato silver(I) complexes

Creaven, Bernadette S.; et al, Inorganica Chimica Acta, 2006, 359(12), 3976-3984

合成路线：1 步

70384-80-4

_94%

反应条件：

1.1 Reagents: Sodium hydroxide Solvents: Water
1.2 Reagents: Hydrochloric acid Solvents: Water

参考文献：

Synthesis of coumarin-3-O-acylisoureas by dicyclohexylcarbodiimide

Bonsignore, Leonardo; et al, Journal of Heterocyclic Chemistry, 1995, 32(2), 573-7

合成路线：1 步

70384-80-4

_93%

反应条件：

1.1 Reagents: Sodium hydroxide , Hydrochloric acid Solvents: Water

参考文献：

Biological evaluation of coumarin derivatives as mushroom tyrosinase inhibitors

Liu, Jinbing; et al, Food Chemistry, 2012, 135(4), 2872-2878

合成路线：1 步

18362-30-6

_91%

反应条件：

1.1 Catalysts: Ammonium acetate Solvents: Water ; 2 - 3 h, rt
1.2 Reagents: Hydrochloric acid Solvents: Water ; pH 4 - 5

参考文献：

Discovery of 2H-Chromen-2-one Derivatives as G Protein-Coupled Receptor-35 Agonists

Wei, Lai; et al, Journal of Medicinal Chemistry, 2017, 60(1), 362-372

合成路线：1 步

1570-64-5

_88%

反应条件：

1.1 Reagents: tert-Butyl hydroperoxide ; 2.5 h, 80 °C

参考文献：

A Practical Synthesis of 3-Functionalized Coumarins from o-Cresols and Active Methylene Compounds under Metal and Catalyst-Free Conditions Using tert-Butyl Hydrogen Peroxide

Chauhan, Swati; et al, ChemistrySelect, 2020, 5(29), 9030-9033

合成路线：1 步

1602641-58-6

_85%

反应条件：

1.1 Solvents: Ethanol ; 10 min, reflux

参考文献：

Synthesis of 5-arylidene-2,2-dimethyl-1,3-dioxane-4,6-diones and coumarin-3-carboxylic acids via reaction of nitrones and Meldrum's acid

Kumar, Dhruva; et al, Indian Journal of Chemistry, 2013, (8), 1157-1160

合成路线：1 步

28447-81-6

_85%

反应条件：

1.1 Reagents: Sodium bicarbonate Solvents: Water ; 2 h, pH 8.3, 90 °C; pH 8.3, 90 °C → rt
1.2 Reagents: Hydrochloric acid Solvents: Water ; pH 2, rt

参考文献：

One-pot synthesis of 3-carboxycoumarins via consecutive Knoevenagel and Pinner reactions in water

Fringuelli, Francesco; et al, Synthesis, 2003, (15), 2331-2334

合成路线：1 步

反应条件：

1.1 Catalysts: Acetic acid , Piperidine Solvents: Ethanol ; 6 h, reflux
1.2 Reagents: Sodium hydroxide Solvents: Water ; 0.5 h, reflux
1.3 Reagents: Hydrochloric acid Solvents: Water ; pH 2, 0 °C

参考文献：

Design and synthesis of novel vitamin D-coumarin hybrids using microwave irradiation

Zhang, Hengrui; et al, Journal of Chemical Research, 2017, 41(12), 684-687

合成路线：2 步

反应条件：

1.1 Catalysts: Piperidine Solvents: Ethanol ; overnight, reflux
2.1 Reagents: Sodium hydroxide Solvents: Ethanol , Water ; 1 h, reflux
2.2 Reagents: Hydrochloric acid Solvents: Water

参考文献：

A Ru(II)-catalyzed C-H activation and annulation cascade for the construction of highly coumarin-fused benzo[a]quinolizin-4-ones and pyridin-2-ones

Wang, Jing; et al, Organic Chemistry Frontiers, 2023, 10(11), 2680-2687

合成路线：2 步

反应条件：

1.1 Catalysts: Piperidine Solvents: Ethanol ; 14 - 18 h, reflux
2.1 Reagents: Sodium hydroxide Solvents: Water ; 20 min, reflux; cooled
2.2 Reagents: Hydrochloric acid Solvents: Water

参考文献：

Design, synthesis and biological evaluation of coumarin-based N-hydroxycinnamamide derivatives as novel histone deacetylase inhibitors with anticancer activities

Ding, Jiaoli; et al, Bioorganic Chemistry, 2020, 101,

合成路线：1 步

2416400-44-5

反应条件：

1.1 2 h, reflux

参考文献：

Novel coumarin-thiazolyl ester derivatives as potential DNA gyrase Inhibitors: Design, synthesis, and antibacterial activity

Liu, Hao; et al, Bioorganic Chemistry, 2020, 100,

合成路线：1 步

参考文献：

Decarboxylative, trienamine mediated cycloaddition for the synthesis of 3,4-dihydrocoumarin derivatives

Albrecht, Anna; et al, Organic & Biomolecular Chemistry, 2019, 17(17), 4238-4242

合成路线：1 步

参考文献：

Dearomatizative and Decarboxylative Reaction Cascade in the Aminocatalytic Synthesis of 3,4-Dihydrocoumarins

Bojanowski, Jan; et al, Asian Journal of Organic Chemistry, 2019, 8(6), 844-848

合成路线：3 步

反应条件：

1.1 Reagents: Sodium acetate , Hydroxyamine hydrochloride Solvents: Acetonitrile , Water
2.1 -
3.1 Reagents: Sodium hydroxide Solvents: Water

参考文献：

Inhibition of monoamine oxidases by coumarin-3-acyl derivatives: biological activity and computational study

Chimenti, Franco; et al, Bioorganic & Medicinal Chemistry Letters, 2004, 14(14), 3697-3703

合成路线：1 步

742503-72-6

反应条件：

1.1 Reagents: Sodium hydroxide Solvents: Water

参考文献：

Inhibition of monoamine oxidases by coumarin-3-acyl derivatives: biological activity and computational study

Chimenti, Franco; et al, Bioorganic & Medicinal Chemistry Letters, 2004, 14(14), 3697-3703

合成路线：2 步

18362-30-6

反应条件：

1.1 Catalysts: Piperidine Solvents: Ethanol ; rt
2.1 Reagents: Sodium hydroxide , Hydrochloric acid Solvents: Water

参考文献：

Biological evaluation of coumarin derivatives as mushroom tyrosinase inhibitors

Liu, Jinbing; et al, Food Chemistry, 2012, 135(4), 2872-2878

合成路线：2 步

321-14-2

反应条件：

1.1 Reagents: Piperidine Solvents: Ethanol , Acetic acid ; 12 h, 80 °C
2.1 Reagents: Sodium hydroxide Solvents: Ethanol ; reflux

参考文献：

Evaluation of novel N'-(3-hydroxybenzoyl)-2-oxo-2H-chromene-3-carbohydrazide derivatives as potential HIV-1 integrase inhibitors

Jesumoroti, Omobolanle J.; et al, MedChemComm, 2019, 10(1), 80-88

合成路线：2 步

106-48-9

67-66-3

反应条件：

1.1 Reagents: Sodium hydroxide Catalysts: Tributylamine Solvents: Ethanol , Water ; 60 °C; 40 min, 60 °C; cooled
1.2 Reagents: Hydrochloric acid Solvents: Water ; pH 2
2.1 Catalysts: Acetic acid , Piperidine Solvents: Ethanol ; 6 h, reflux
2.2 Reagents: Sodium hydroxide Solvents: Water ; 0.5 h, reflux
2.3 Reagents: Hydrochloric acid Solvents: Water ; pH 2, 0 °C

参考文献：

Design and synthesis of novel vitamin D-coumarin hybrids using microwave irradiation

Zhang, Hengrui; et al, Journal of Chemical Research, 2017, 41(12), 684-687

合成路线：2 步

109-77-3