886-38-4 (1,2-二苯基环丙烯-3-酮,Diphenylcyclopropenone)

反应条件：

1.1 Reagents: Water Solvents: Acetonitrile

参考文献：

Synthesis of diphenylcyclopropenone

Breslow, Ronald; Haynie, Robert; Mirra, Joseph, Journal of the American Chemical Society, 1959, 81, 247-8

合成路线：1 步

121104-69-6

_89%

反应条件：

1.1 Reagents: Hydrochloric acid Solvents: Chloroform , Water

参考文献：

Cyclopropenone oximes. Preparation and reaction with isocyanates

Yoshida, Hiroshi; Ohtsuka, Hideki; Yoshida, Keisuke; Totani, Yoshiyuki; Ogata, Tsuyoshi; et al, Bulletin of the Chemical Society of Japan, 1988, 61(12), 4347-51

合成路线：1 步

_85%

反应条件：

1.1 Reagents: Aluminum chloride Solvents: Dichloromethane ; -78 °C; 2 h, -78 °C; -78 °C → rt; 2 h, rt
1.2 Reagents: Water ; rt

参考文献：

Palladium-Catalyzed C-C Bond Activation of Cyclopropenone: Modular Access to Trisubstituted α,β-Unsaturated Esters and Amides

Nanda, Tanmayee ; Biswal, Pragati; Pati, Bedadyuti Vedvyas; Banjare, Shyam Kumar; Ravikumar, Ponneri Chandrababu, Journal of Organic Chemistry, 2021, 86(3), 2682-2695

合成路线：1 步

_85%

反应条件：

1.1 Reagents: Aluminum chloride Solvents: Dichloromethane ; -78 °C; 2 h, -78 °C; -78 °C → rt; 2 h, rt
1.2 Reagents: Water ; rt

参考文献：

A Palladium-Catalyzed Cascade C-C Activation of Cyclopropenone and Carbonylative Amination: Easy Access to Highly Functionalized Maleimide Derivatives

Nanda, Tanmayee ; Ravikumar, P. C., Organic Letters, 2020, 22(4), 1368-1374

合成路线：1 步

_85%

反应条件：

1.1 Catalysts: Aluminum chloride Solvents: Dichloromethane ; -78 °C; 2 h, -78 °C; -78 °C → rt; 2 h, rt
1.2 Reagents: Water

参考文献：

Polysubstituted pyrrole derivatives via 1,2-alkenyl migration of novel γ-amino-α,β-unsaturated aldehydes and α-diazocarbonyls

Cai, Shuting; Zeng, Jing; Li, Yongxin; Liu, Xue-Wei, RSC Advances, 2014, 4(14), 7275-7278

合成路线：1 步

2570-01-6

_75%

参考文献：

Strain assisted α-cleavage reactions of thio ketones: diphenylcyclopropenethione

Singh, Sharat; Bhadbhade, M. M.; Venkatesan, K.; Ramamurthy, V., Journal of Organic Chemistry, 1982, 47(18), 3550-3

合成路线：1 步

103-82-2

_67%

反应条件：

1.1 Reagents: Dicyclohexylcarbodiimide , 4-(Dimethylamino)pyridine Solvents: Tetrahydrofuran ; 24 h, rt
1.2 Reagents: Bromine Solvents: Acetic acid ; rt; 3 h, rt
1.3 Reagents: Triethylamine Solvents: Dichloromethane ; 1 h, rt

参考文献：

Cascade Ring-Opening Dual Halogenation of Cyclopropenones with Saturated Oxygen Heterocycles

Miao, Wei-Hang; Gao, Wen-Xia ; Huang, Xiao-Bo; Liu, Miao-Chang ; Zhou, Yun-Bing ; et al, Organic Letters, 2021, 23(24), 9425-9430

合成路线：1 步

1237706-56-7

501-65-5

_66%

反应条件：

1.1 Solvents: Benzene ; 16 h, 60 °C
1.2 Reagents: Hydrochloric acid Solvents: Acetic acid , Water ; 2 h, 80 °C

参考文献：

Alkyne and Reversible Nitrile Activation: N,N'-Diamidocarbene-Facilitated Synthesis of Cyclopropenes, Cyclopropenones, and Azirines

Moerdyk, Jonathan P.; Bielawski, Christopher W., Journal of the American Chemical Society, 2012, 134(14), 6116-6119

合成路线：1 步

_63%

反应条件：

1.1 Reagents: Aluminum chloride Solvents: Dichloromethane ; 30 min, rt; 90 min, rt
1.2 Reagents: Sodium hydroxide Solvents: Water ; rt

参考文献：

Synthesis, characterization, and oxidation electrochemistry of some novel 1,2-dithiol-3-ones and 1,2-dithiol-3-thiones containing aryl and metallocenyl fragments

Sanchez Garcia, Jessica J.; Joo-Cisneros, Rene S.; Garcia-Bassoco, David; Flores-Alamo, Marcos ; Stivalet, Jose M. Mendez; et al, Journal of Organometallic Chemistry, 2021, 944,

合成路线：1 步

_60%

反应条件：

1.1 Reagents: Triethylamine Solvents: Dichloromethane ; 1 h, rt

参考文献：

Rh(III)-Catalyzed [3 + 3] Annulation Reaction of Cyclopropenones and Sulfoxonium Ylides toward Trisubstituted 2-Pyrones

Zhou, Peng; Yang, Wei-Tao; Rahman, Anis Ur; Li, Guigen ; Jiang, Bo, Journal of Organic Chemistry, 2020, 85(2), 360-366

合成路线：1 步

_60%

反应条件：

1.1 Reagents: Triethylamine Solvents: Dichloromethane ; 1 h, 23 °C; 30 min, 23 °C
1.2 Reagents: Sulfuric acid Solvents: Water ; 0 °C

参考文献：

Cyclopropenium-Activated Cyclodehydration of Diols

Kelly, Brendan D.; Lambert, Tristan H., Organic Letters, 2011, 13(4), 740-743

合成路线：1 步

_60%

反应条件：

1.1 Reagents: Triethylamine Solvents: Dichloromethane ; 1 h, 23 °C; 30 min, 23 °C
1.2 Reagents: Sulfuric acid Solvents: Water ; cooled
1.3 Reagents: Sodium carbonate ; neutralized

参考文献：

Aromatic cation activation of alcohols: conversion to alkyl chlorides using dichlorodiphenylcyclopropene

Kelly, Brendan D.; Lambert, Tristan H., Journal of the American Chemical Society, 2009, 131(39), 13930-13931

合成路线：1 步

_60%

反应条件：

1.1 Reagents: Triethylamine Solvents: Dichloromethane

参考文献：

Synthesis of cyclopropenones by a modified Favorskii reaction

Breslow, Ronald; Posner, Judd; Krebs, Adolf, Journal of the American Chemical Society, 1963, 85,

合成路线：1 步

81290-20-2

501-65-5

_58%

反应条件：

1.1 Reagents: Sodium iodide Solvents: Tetrahydrofuran ; 6 h, 100 °C
1.2 Reagents: Water ; 12 h, rt

参考文献：

Deconstructive Cycloaromatization Strategy toward N,O-Bidentate Ligands from Indolizines and Cyclopropenones

Zhou, Jinlei; Shi, Xiaotian; Zheng, Huitao; Chen, Guangxian; Zhang, Chen; et al, Organic Letters, 2022, 24(17), 3238-3243

合成路线：1 步

_55%

反应条件：

1.1 Reagents: Triethylamine Solvents: Dichloromethane ; 1 h, rt; 30 min, rt
1.2 Reagents: Sulfuric acid Solvents: Water ; 0 °C

参考文献：

Cyclopropenone Catalyzed Substitution of Alcohols with Mesylate Ion

Nacsa, Eric D.; Lambert, Tristan H., Organic Letters, 2013, 15(1), 38-41

合成路线：1 步

103-82-2

_46%

反应条件：

1.1 Reagents: Dicyclohexylcarbodiimide Catalysts: 4-(Dimethylamino)pyridine Solvents: Tetrahydrofuran ; 60 min, rt
1.2 Reagents: Bromine Solvents: Acetic acid ; rt; 3 h, rt
1.3 Reagents: Triethylamine Solvents: Dichloromethane ; 1 h, rt

参考文献：

Iron-Catalyzed One-Step Synthesis of Isothiazolone/1,2-Selenazolone Derivatives via [3+1+1] Annulation of Cyclopropenones, Anilines, and Elemental Chalcogens

Wang, Hongchen; Yan, Rulong, Advanced Synthesis & Catalysis, 2022, 364(4), 715-719

合成路线：1 步

_45%

反应条件：

1.1 Reagents: Triethylamine Solvents: Dichloromethane ; 1 h, rt; 30 min, rt

参考文献：

Gas-phase synthesis of hydrodiphenylcyclopropenylium via nonclassical Favorskii rearrangement from alkali-cationized α,α'-dibromodibenzyl ketone

Zhao, Zhi-Xiong; Wang, Hao-Yang; Xu, Chu; Guo, Yin-Long, Rapid Communications in Mass Spectrometry, 2010, 24(17), 2665-2672

合成路线：1 步

_45%

反应条件：

1.1 Reagents: Triethylamine Solvents: Dichloromethane

参考文献：

Diphenylcyclopropenone

Breslow, Ronald; Eicher, Theo; Krebs, Adolf; Peterson, Ruth A.; Posner, Judd, Journal of the American Chemical Society, 1965, 87(6), 1320-5

合成路线：1 步

102-04-5

_44%

反应条件：

1.1 Reagents: Acetic acid , Triethylamine , Bromine Solvents: Acetic acid , Dichloromethane

参考文献：

Diphenylcyclopropenone

Breslow, R.; Posner, J., Organic Syntheses, 1967, 47, 62-3

合成路线：1 步

81290-20-2

501-65-5