888-12-0 (4-氟-1,3-二氧戊环-2 - 酮,(2E)-1-(2-Hydroxyphenyl)-3-phenyl-2-propen-1-one)

_97%

反应条件：

1.1 Reagents: Potassium hydroxide Solvents: Ethanol ; 2 h, reflux

参考文献：

Domino synthesis of novel 3-alkenyl benzofuran derivatives- base mediated condensation cascade reaction

Mundhe, Priyanka; Bhanwala, Neeru; Saini, Surbhi Mahender; Sumanth, Gopavaram; Shivaprasad, Kondreddy; et al, Tetrahedron, 2023, 132,

合成路线：1 步

_95%

反应条件：

1.1 Reagents: Sodium hydroxide , Alumina Solvents: Dichloromethane ; 4 - 5 min
1.2 Reagents: Hydrochloric acid Solvents: Water ; neutralized, cooled

参考文献：

I2-Al2O3: a suitable heterogeneous catalyst for the synthesis of flavones under microwave irradiation

Sarda, Swapnil R.; Jadhav, Wamanrao N.; Pawar, Rajendra P., International Journal of ChemTech Research, 2009, 1(3), 539-543

合成路线：1 步

_94%

反应条件：

1.1 Reagents: Sodium hydroxide Solvents: Ethanol , Water ; 5 min, reflux
1.2 Reagents: Hydrochloric acid Solvents: Water ; acidified, cooled

参考文献：

MW assisted synthesis of some pyrazoles containing benzotriazole moiety: an environmentally benign approach

Tiwari, Urvashi; Ameta, Chetna; Rawal, Manish K.; Ameta, Rakshit; Punjabi, Pinki B., Indian Journal of Chemistry, 2013, (3), 432-439

合成路线：1 步

_94%

反应条件：

1.1 Reagents: Potassium hydroxide Solvents: Ethanol , Water ; 2 - 24 h, 20 °C
1.2 Reagents: Hydrochloric acid Solvents: Water ; pH 2, 20 °C

参考文献：

Hydroxychalcones as potential antiangiogenic agents

Karki, Radha; Kang, Youra; Kim, Chul Hoon; Kwak, Kyungsook; Kim, Jung-Ae; et al, Bulletin of the Korean Chemical Society, 2012, 33(9), 2925-2929

合成路线：1 步

2254250-96-7

_93%

反应条件：

1.1 Reagents: Stannane, hydroxytrimethyl- Solvents: 1,2-Dichloroethane ; 3 h, 60 °C

参考文献：

Highly Chemoselective Deprotection of the 2,2,2-Trichloroethoxycarbonyl (Troc) Protecting Group

Trost, Barry M. ; Kalnmals, Christopher A. ; Tracy, Jacob S. ; Bai, Wen-Ju, Organic Letters, 2018, 20(24), 8043-8046

合成路线：1 步

_93%

反应条件：

1.1 Reagents: Potassium hydroxide Solvents: Methanol , Water ; 24 h, rt

参考文献：

Enantioselective Halo-oxy- and Halo-azacyclizations Induced by Chiral Amidophosphate Catalysts and Halo-Lewis Acids

Lu, Yanhui; Nakatsuji, Hidefumi; Okumura, Yukimasa; Yao, Lu; Ishihara, Kazuaki, Journal of the American Chemical Society, 2018, 140(19), 6039-6043

合成路线：1 步

_93%

反应条件：

1.1 Reagents: Sodium hydroxide Solvents: Ethanol , Water ; rt; rt → 50 °C; 30 min, 50 °C; 5 h, 50 °C; 24 h, rt
1.2 Reagents: Hydrochloric acid Solvents: Water ; acidified, 0 °C

参考文献：

Enantioselective synthesis of flavan-3-ols using a Mitsunobu cyclization

Krohn, Karsten; Ahmed, Ishtiaq; John, Markus, Synthesis, 2009, (5), 779-786

合成路线：1 步

_93%

反应条件：

1.1 Reagents: Potassium hydroxide Solvents: Ethanol ; 2 min
1.2 Solvents: Water ; 0 °C
1.3 Reagents: Hydrochloric acid Solvents: Water ; overnight, 2 - 3 °C

参考文献：

Efficient liquid-phase synthesis of 2'-hydroxychalcones

Stoyanov, Edmont V.; Champavier, Yves; Simon, Alain; Basly, Jean-Philippe, Bioorganic & Medicinal Chemistry Letters, 2002, 12(19), 2685-2687

合成路线：1 步

_92%

反应条件：

1.1 Reagents: Sodium hydroxide Solvents: Ethanol ; 10 min, rt
1.2 overnight, rt
1.3 Reagents: Hydrochloric acid Solvents: Water ; neutralized, cooled

参考文献：

QSAR, in silico docking and in vitro evaluation of chalcone derivatives as potential inhibitors for H1N1 virus neuraminidase

Yaeghoobi, Marzieh; Frimayanti, Neni; Chee, Chin Fei; Ikram, Kusaira K.; Najjar, Belal O.; et al, Medicinal Chemistry Research, 2016, 25(10), 2133-2142

合成路线：1 步

3516-95-8

_91%

反应条件：

1.1 Reagents: Trifluoroacetic acid , Oxygen Catalysts: Palladium diacetate Solvents: Dimethyl sulfoxide ; 9 h, 1 atm, 80 °C

参考文献：

Synthesis of Enones and Enals via Dehydrogenation of Saturated Ketones and Aldehydes

Pan, Gao-Fei; Zhu, Xue-Qing; Guo, Rui-Li; Gao, Ya-Ru; Wang, Yong-Qiang, Advanced Synthesis & Catalysis, 2018, 360(24), 4774-4783

合成路线：1 步

_91%

反应条件：

1.1 Catalysts: Silica , Potassium bisulfate Solvents: Polyethylene glycol ; 7 min, 5.3 - 5.7 bar, 92 - 99 °C

参考文献：

Total synthesis and assignment of the absolute stereochemistry of xanthoangelol J: development of a highly efficient method for Claisen-Schmidt condensation

Kakati, Dwipen; Barua, Nabin C., Tetrahedron, 2014, 70(3), 637-642

合成路线：1 步

_91%

反应条件：

1.1 Catalysts: Alumina , Iodine ; 80 s, 60 °C; 60 °C → rt

参考文献：

Microwave assisted solvent free synthesis of 1,3-diphenylpropenone derivatives

Kakati, Dwipen; Sarma, Jadab C., Chemistry Central Journal, 2011, 5,

合成路线：1 步

_91%

反应条件：

1.1 Reagents: Sodium hydroxide Solvents: Methanol ; 25 s
1.2 Reagents: Hydrochloric acid Solvents: Water ; neutralized

参考文献：

Ecofriendly synthesis and antimicrobial activity of chalcones

Kamboj, Ramesh C.; Arora, Rita; Sharma, Geeta; Kumar, Dinesh; Sharma, Chetan; et al, Pharma Chemica, 2010, 2(3), 157-170

合成路线：1 步

_90%

反应条件：

1.1 Reagents: Sodium hydroxide Solvents: Ethanol ; rt; 12 - 24 h, rt

参考文献：

Stereoselective reduction of flavanones by marine-derived fungi

de Matos, Iara L.; Birolli, Willian G. ; Santos, Darlisson de A.; Nitschke, Marcia; Porto, Andre Luiz M., Molecular Catalysis, 2021, 513,

合成路线：1 步

_90%

反应条件：

1.1 Catalysts: Zinc oxide (ZnO) Solvents: Ethanol , Water ; 15 min, reflux

参考文献：

Graphene-supported ZnO nanoparticles: An efficient heterogeneous catalyst for the Claisen-Schmidt condensation reaction without additional base

Li, Zhuofei; Zhao, Hongyan; Han, Huatao; Liu, Yang; Song, Jinyi; et al, Tetrahedron Letters, 2017, 58(42), 3984-3988

合成路线：1 步

_90%

反应条件：

1.1 Solvents: Ethanol ; 30 min, rt
1.2 Reagents: Potassium hydroxide Solvents: Water ; rt
1.3 Reagents: Hydrochloric acid Solvents: Water ; acidified, 0 °C

参考文献：

Model studies on construction of the oxabicyclic [3.3.1] core of the mulberry Diels-Alder adducts morusalbanol A and 441772-64-1

Tee, Jia Ti; Chee, Chin Fei ; Buckle, Michael J. C.; Lee, Vannajan Sanghiran; Chong, Wei Lim; et al, Tetrahedron Letters, 2015, 56(36), 5082-5085

合成路线：1 步

_90%

反应条件：

1.1 Reagents: Sodium hydroxide Solvents: Methanol , Water ; rt
1.2 20 h, rt
1.3 Reagents: Hydrochloric acid Solvents: Water ; pH 2, rt

参考文献：

Δ1-pyrroline based boranyls: Synthesis, crystal structures and luminescent properties

Cardona, Francisco; Rocha, Joao; Silva, Artur M. S. ; Guieu, Samuel, Dyes and Pigments, 2014, 111, 16-20

合成路线：1 步

_90%