88965-00-8 (6-甲基-2-(4-甲基苯基)咪唑[1,2-a]吡啶,6-methyl-2-(4-methylphenyl)imidazo1,2-apyridine)

_95%

反应条件：

1.1 Reagents: Bromine Catalysts: Aluminum chloride Solvents: Methanol ; 0 - 5 °C; 30 min, 0 - 5 °C
1.2 Reagents: Sodium carbonate Solvents: Water ; 25 - 35 °C

参考文献：

Microwave-assisted synthesis of Imidazo[1,2-a]pyridine derivatives and their anti-inflammatory activity

Budumuru, Pushpalatha; Golagani, Srinivasarao; Pushpanjali, B., International Journal of Pharmaceutical Sciences and Research, 2019, 10(3), 1172-1179

合成路线：1 步

_95%

反应条件：

1.1 Reagents: Bromine Catalysts: Aluminum chloride Solvents: Methanol ; 0 - 5 °C; 30 min, 0 - 5 °C
1.2 Reagents: Sodium carbonate , Water ; 25 - 35 °C

参考文献：

A simple, efficient and scalable synthesis of hypnotic agent, zolpidem

Sumalatha, Yasareni; Reddy, Tamma Ranga; Reddy, Padi Pratap; Satyanarayana, Bollikonda, ARKIVOC (Gainesville, 2008, (2), 315-320

合成路线：1 步

_93%

反应条件：

1.1 Reagents: Oxygen Catalysts: Boron trifluoride etherate , Cuprous iodide Solvents: Water ; 24 h, 60 - 65 °C

参考文献：

Copper(I) Iodide Catalyzed Aerobic Oxidative C-N and C-S bond formations through C-H Activation: Synthesis of Functionalized Imidazo[1,2-a]pyridines

Mohan, Darapaneni Chandra; Rao, Sadu Nageswara; Ravi, Chitrakar; Adimurthy, Subbarayappa, Asian Journal of Organic Chemistry, 2014, 3(5), 609-613

合成路线：1 步

_92%

反应条件：

1.1 Reagents: Sodium bicarbonate Solvents: Methanol ; rt; 12 h, reflux

参考文献：

Synthesis and Structure-Activity Relationships of Imidazopyridine/Pyrimidine- and Furopyridine-Based Anti-infective Agents against Trypanosomiases

Silva, Daniel G. ; Junker, Anna ; de Melo, Shaiani M. G.; Fumagalli, Fernando ; Gillespie, J. Robert ; et al, ChemMedChem, 2021, 16(6), 966-975

合成路线：1 步

_90%

反应条件：

1.1 Reagents: Sodium bicarbonate Solvents: Ethanol ; 6 h, rt

参考文献：

Formation of Methylene Linkage for N-Heterocycles: Sequential C-H and C-O Bond Functionalization of Methanol with Cosolvent Water

Li, Na; Bai, Jinku; Zheng, Xiaolin; Rao, Honghua, Journal of Organic Chemistry, 2019, 84(11), 6928-6939

合成路线：1 步

_90%

反应条件：

1.1 Reagents: Sodium bicarbonate Solvents: Ethanol ; 6 h, rt

参考文献：

Iodide-Catalyzed Phosphorothiolation of Heteroarenes Using P(O)H Compounds and Elemental Sulfur

Shi, Shanshan; Chen, Jun; Zhuo, Shaohua; Wu, Zi'ang; Fang, Meijuan; et al, Advanced Synthesis & Catalysis, 2019, 361(13), 3210-3216

合成路线：1 步

_90%

反应条件：

1.1 Reagents: Sodium bicarbonate Solvents: Ethanol ; 6 h, rt

参考文献：

Iron-Catalyzed Dehydrogenative sp3-sp2 Coupling via Direct Oxidative C-H Activation of Acetonitrile

Su, Huimin; Wang, Luyao; Rao, Honghua ; Xu, Hao, Organic Letters, 2017, 19(9), 2226-2229

合成路线：1 步

_89%

反应条件：

1.1 Reagents: N-Bromosuccinimide Solvents: Water , Polyethylene glycol ; 35 min, 85 °C

参考文献：

Efficient and green microwave-assisted one-pot synthesis of azaindolizines in PEG-400 and water

Wagare, Devendra S.; Farooqui, Mazhar; Keche, Tushar D.; Durrani, Ayesha, Synthetic Communications, 2016, 46(21), 1741-1746

合成路线：1 步

_87%

反应条件：

1.1 Reagents: Oxygen Catalysts: Sodium dodecyl sulfate , Iodine Solvents: Water ; 12 h, 40 °C

参考文献：

Iodine Promoted Efficient Synthesis of 2-Arylimidazo[1,2-a]pyridines in Aqueous Media: A Comparative Study between Micellar Catalysis and an "On-Water" Platform

Bhutia, Zigmee T.; Panjikar, Padmini C.; Iyer, Shruti; Chatterjee, Amrita ; Banerjee, Mainak, ACS Omega, 2020, 5(22), 13333-13343

合成路线：1 步

2227-58-9

_83%

反应条件：

1.1 Reagents: Potassium acetate , Silver carbonate Solvents: 1,4-Dioxane ; 12 h, 110 °C

参考文献：

Ag(I)-Promoted Decarboxylative Annulation of Alkynoic Acids towards 2-Arylimidazo[1,2-a]pyridines

Liu, Yun ; Wang, Ziqing; Lei, Ting; Li, Yuling, ChemistrySelect, 2022, 7(47),

合成路线：1 步

_83%

反应条件：

1.1 Reagents: Oxygen Catalysts: Cuprous iodide , Indium triflate Solvents: N-Methyl-2-pyrrolidone ; 30 h, 1 atm, 100 °C

参考文献：

CuI-Catalyzed Aerobic Oxidative α-Amination Cyclization of Ketones to Access Aryl or Alkenyl-Substituted Imidazoheterocycles

Zhang, Yuanfei; Chen, Zhengkai; Wu, Wenliang; Zhang, Yuhong; Su, Weiping, Journal of Organic Chemistry, 2013, 78(24), 12494-12504

合成路线：1 步

98475-04-8

_76%

反应条件：

1.1 Reagents: β-Cyclodextrin Solvents: Water ; 50 - 55 °C; 5 min, 50 - 55 °C
1.2 18 min, 50 - 55 °C

参考文献：

Aqueous phase synthesis of substituted imidazo[1,2-a]pyridine in the presence of β-cyclodextrin

Kumbhar, Vijay V.; Hangirgekar, Shankar P.; Wadwale, Navanand B., Pharma Chemica, 2013, 5(5), 274-279

合成路线：1 步

_76%

反应条件：

1.1 Reagents: Oxygen Catalysts: Cuprous iodide Solvents: 1,4-Dioxane ; 14 h, 100 °C

参考文献：

Copper catalyzed tandem oxidative C-H amination/cyclizations: Direct access to imidazo[1,2-a]pyridines

Pericherla, Kasiviswanadharaju; Kaswan, Pinku; Khedar, Poonam; Khungar, Bharti; Parang, Keykavous; et al, RSC Advances, 2013, 3(41), 18923-18930

合成路线：1 步

_75%

反应条件：

1.1 Catalysts: Cuprous iodide Solvents: 1,4-Dioxane ; 4 h, 100 °C

参考文献：

Rhodium(II)-Catalyzed Regioselective C3-Alkylation of 2-Arylimidazo[1,2-a]pyridines with Aryl Diazoesters

Kim, Hyunseok; Byeon, Minhyeon; Jeong, Eunchong; Baek, Yonghyeon; Jeong, Seung Jin; et al, Advanced Synthesis & Catalysis, 2019, 361(9), 2094-2106

合成路线：1 步

_73%

参考文献：

Synthesis and antiproliferative activity evaluation of steroidal imidazo[1,2-a]pyridines

Rassokhina, Irina V.; Volkova, Yulia A.; Kozlov, Andrey S.; Scherbakov, Alexander M.; Andreeva, Olga E.; et al, Steroids, 2016, 113, 29-37

合成路线：1 步

_72%

反应条件：

1.1 Reagents: Potassium iodide Catalysts: Trifluoromethanesulfonic acid Solvents: Ethanol , Dimethyl sulfoxide ; 15 h, 80 °C

参考文献：

Solvent-dependence of KI Mediated Electrosynthesis of Imidazo[1,2-a]pyridines

Yi, Yangjie; Xu, Leitao; Liu, Yuyang; Li, Mingfang; Zhang, Lijuan; et al, Chemical Research in Chinese Universities, 2023, 39(2), 318-324

合成路线：1 步

_72%