89691-67-8 (1-(2-溴-4-甲氧基苯基)乙酮,1-(2-Bromo-4-methoxy-phenyl)-ethanone)

_80%

反应条件：

1.1 Reagents: Aluminum chloride Solvents: Dichloromethane ; < 5 °C; < 5 °C; < 5 °C → rt; 1 h, rt
1.2 Reagents: Hydrochloric acid Solvents: Water ; cooled; rt

参考文献：

Synthesis of dibenzo[fg,op]naphthacene derivatives

Cheng, Xiao-hong; Ye, Hui; Yang, Ji-ping, Jishou Daxue Xuebao, 2007, 28(2), 95-99

合成路线：1 步

_77%

反应条件：

1.1 Reagents: Aluminum chloride Solvents: Dichloromethane ; < 5 °C; < 5 °C → rt; 1 h, rt
1.2 Reagents: Hydrochloric acid Solvents: Water ; cooled

参考文献：

Synthesis, X-ray structure and aggregation effect of tetramethoxy substituted dibenzo[fg,op]naphthacene

Cheng, Xiao-Hong; Fu, Chang-Jin, Chinese Journal of Chemistry, 2007, 25(11), 1762-1765

合成路线：1 步

_77%

反应条件：

1.1 Reagents: Aluminum chloride Solvents: Dichloromethane ; < 5 °C; 5 °C → rt; 1 h, rt
1.2 Reagents: Hydrochloric acid Solvents: Water ; cooled

参考文献：

Synthesis and Adsorption of Shape-Persistent Macrocycles Containing Polycyclic Aromatic Hydrocarbons in the Rigid Framework

Cheng, Xiaohong; Heyen, An Ver; Mamdouh, Wael; Uji-i, Hiroshi; De Schryver, Frans; et al, Langmuir, 2007, 23(3), 1281-1286

合成路线：1 步

89691-60-1

_75%

反应条件：

1.1 Reagents: Silica , Pyridinium chlorochromate Solvents: Dichloromethane ; rt

参考文献：

Asymmetric Synthesis and Application of Chiral Spirosilabiindanes

Chang, Xin; Ma, Pei-Long; Chen, Hong-Chao; Li, Chuan-Ying; Wang, Peng, Angewandte Chemie, 2020, 59(23), 8937-8940

合成路线：1 步

_75%

反应条件：

1.1 Reagents: Aluminum chloride Solvents: Dichloromethane ; -20 °C; 3 h, -20 °C

参考文献：

Facile synthesis of 1-naphthols through a copper-catalyzed arylation of methyl ketones with o-bromoacetophenones

Lou, Zhen-Bang; Pang, Xin-Long; Chen, Chao; Wen, Li-Rong; Li, Ming, Chinese Chemical Letters, 2015, 26(10), 1231-1235

合成路线：1 步

_72%

反应条件：

1.1 Reagents: Aluminum chloride Solvents: Dichloromethane ; < 5 °C; overnight, rt

参考文献：

Total synthesis of (±)-bruguierol A via an intramolecular [3+2] cycloaddition of cyclopropane 1,1-diester

Hu, Bao; Xing, Siyang; Ren, Jun; Wang, Zhongwen, Tetrahedron, 2010, 66(30), 5671-5674

合成路线：1 步

_70%

反应条件：

1.1 Reagents: Aluminum chloride Solvents: Dichloromethane ; 0 °C; 0 °C → rt; overnight, rt
1.2 Reagents: Hydrochloric acid Solvents: Water ; cooled

参考文献：

Copper-Catalyzed Nitrogen Atom Transfer to Isoquinolines via C-N Triple Bond Cleavage and Three-Component Cyclization

Su, Lebin; Xie, Shimin; Dong, Jianyu ; Liu, Feng; Yin, Shuang-Feng ; et al, Organic Letters, 2022, 24(32), 5994-5999

合成路线：1 步

_70%

反应条件：

1.1 Reagents: Aluminum chloride Solvents: Dichloromethane ; 0 °C; 0 °C → rt; overnight, rt

参考文献：

Copper-Catalyzed 6-endo-dig Cyclization-Coupling of 2-Bromoaryl Ketones and Terminal Alkynes toward Naphthyl Aryl Ethers in Water

Su, Lebin; Xie, Shimin; Dong, Jianyu ; Pan, Neng; Yin, Shuang-Feng; et al, Organic Letters, 2022, 24(25), 4569-4574

合成路线：1 步

_70%

反应条件：

1.1 Reagents: Aluminum chloride Solvents: Dichloromethane ; 0 °C; 0 °C → rt; overnight, rt
1.2 Reagents: Hydrochloric acid Solvents: Water ; 0 °C

参考文献：

Cu(I)-Catalyzed 6-endo-dig Cyclization of Terminal Alkynes, 2-Bromoaryl Ketones, and Amides toward 1-Naphthylamines: Applications and Photophysical Properties

Su, Lebin; Ren, Tianbing; Dong, Jianyu ; Liu, Lixin; Xie, Shimin; et al, Journal of the American Chemical Society, 2019, 141(6), 2535-2544

合成路线：1 步

_70%

反应条件：

1.1 Catalysts: Aluminum chloride Solvents: Dichloromethane ; 0 °C

参考文献：

Asymmetric synthesis of (-)-9-epi-metazocine

Chen, Qiang; Huo, Xing; Zheng, Huaiji; She, Xuegong, Synlett, 2012, 23(9), 1349-1352

合成路线：1 步

_69%

反应条件：

1.1 Reagents: Aluminum chloride Solvents: Dichloromethane ; rt; overnight, rt
1.2 Reagents: Hydrochloric acid Solvents: Water ; 0 °C

参考文献：

Direct synthesis of 1-naphthylamines enabled by 6-endo-dig cyclization strategy using copper catalysis

Ma, Peng ; Wang, Jianhui ; Liu, Guiyan, Applied Organometallic Chemistry, 2022, 36(6),

合成路线：1 步

871126-87-3

_69%

反应条件：

1.1 Reagents: Water Solvents: Ethyl lactate ; 24 h, 110 °C

参考文献：

Catalyst- and acid-free Markovnikov hydration of alkynes in a sustainable H2O/ethyl lactate system

Dandia, Anshu; Saini, Pratibha; Chithra, M. J.; Vennapusa, Sivaranjana Reddy; Parewa, Vijay, Journal of Molecular Liquids, 2021, 331,

合成路线：1 步

_65%

反应条件：

1.1 Reagents: Aluminum chloride Solvents: Dichloromethane ; 16 h, rt

参考文献：

Synergic "Click" Boronate/Thiosemicarbazone System for Fast and Irreversible Bioorthogonal Conjugation in Live Cells

Akgun, Burcin; Li, Caishun; Hao, Yubin; Lambkin, Gareth; Derda, Ratmir ; et al, Journal of the American Chemical Society, 2017, 139(40), 14285-14291

合成路线：1 步

108-24-7

_63%

反应条件：

1.1 Catalysts: 2210272-60-7 ; overnight, 50 °C

参考文献：

Air-stable μ2-hydroxyl bridged cationic binuclear complexes of zirconocene perfluorooctanesulfonates: their structures, characterization and application

Zhang, Xiaohong; Xu, Xinhua; Li, Ningbo; Liang, Zhiwu; Tang, Zilong, Tetrahedron, 2018, 74(15), 1926-1932

合成路线：1 步

100-06-1

_62%

反应条件：

1.1 Reagents: Sulfuric acid , Bromine Solvents: Methanol ; rt

参考文献：

Synthesis of benzofuran derivatives and their effect on promoting bone formation

Li, Rui-peng; Guo, Li; Zheng, Hu; Qi, Qing-rong, Huaxi Yaoxue Zazhi, 2015, 30(6), 631-634

合成路线：1 步

64-19-7

_61%

反应条件：

1.1 Catalysts: Phosphorus pentoxide Solvents: 1,2-Dichloroethane ; 8 h, 80 °C
1.2 Reagents: Sodium bicarbonate Solvents: Water

参考文献：

P2O5-mediated Friedel-Crafts acylation of activated arenes with carboxylic acid as acylating agent

Kalshetti, Rupali G.; Mandle, Ram D.; Kamble, Sanjay P.; Sudalai, Arumugam, Indian Journal of Chemistry, 2020, (12), 1861-1867

合成路线：1 步

108-24-7

_61%