90315-82-5 ((R)-2-羟基-4-苯基丁酸乙酯,ethyl (2R)-2-hydroxy-4-phenylbutanoate)

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反应条件：

1.1 Reagents: Hydrogen Catalysts: Bis[chloro(norbornadiene)rhodium] , 1,1′-(1R,2S,3S,4S)-Bicyclo[2.2.1]hept-5-ene-2,3-diylbis[1,1-diphenylphosphine]

参考文献：

(+)-(2S,3S)-Bis(diphenylphosphino)bicyclo[2.2.1]hept-5-ene

Whiteker, Gregory T., e-EROS Encyclopedia of Reagents for Organic Synthesis, 2001, 1, 1-2

合成路线：1 步

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反应条件：

1.1 Reagents: Glucose , NADP Catalysts: Carbonyl reductase (NADPH) Solvents: Water ; 24 h, pH 7.0, 4 °C

参考文献：

Biochemical characterisation of a NADPH-dependent carbonyl reductase from Neurospora crassa reducing α- and β-keto esters

Richter, Nina; Hummel, Werner, Enzyme and Microbial Technology, 2011, 48(6-7), 472-479

合成路线：1 步

29678-81-7

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反应条件：

1.1 Reagents: Chlorotrimethylsilane Solvents: Ethanol ; 24 h, rt

参考文献：

A new chemo-enzymatic route to chiral 2-hydroxy-4-phenylbutyrates by combining lactonase-mediated resolution with hydrogenation over Pd/C

Chen, Bing; Yin, Hai-Feng; Wang, Zhen-Sheng; Liu, Jia-Ying; Xu, Jian-He, Chemical Communications (Cambridge, 2010, 46(16), 2754-2756

合成路线：1 步

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反应条件：

1.1 Reagents: Cinchonidine , Sodium bromide Catalysts: Alumina , Platinum

参考文献：

Ultrasonics in asymmetric syntheses. Sonochemical enantioselective hydrogenation of prochiral C=O groups over platinum catalysts

Torok, Bela; Balazsik, Katalin; Szollosi, Gyorgy; Felfoldi, Karoly; Bartok, Mihaly, Chirality, 1999, 11, 470-474

合成路线：1 步

146912-66-5

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反应条件：

1.1 Reagents: Hydrogen Catalysts: Palladium Solvents: Acetic acid ; rt
1.2 Reagents: Sodium bicarbonate ; 4 h, 60 °C

参考文献：

Synthesis of optical active compound Ethyl (R)-2-hydroxy-4-phenylbutyrate

Li, Li-xin; Li, Jun; Xie, Ming-gui, Sichuan Daxue Xuebao, 2003, 35(4), 106-108

合成路线：1 步

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反应条件：

1.1 Reagents: Hydrogen Catalysts: Dihydrocinchonidine , Alumina , Platinum Solvents: Toluene ; 6 MPa, 25 °C

参考文献：

Enantioselective synthesis of ethyl (R)-2-hydroxy-4-phenylbutanoate

Liu, Yu; Li, Xiang; Liu, Xiaocheng; He, Jiajun; Liu, Duan, Huaxue Yu Shengwu Gongcheng, 2009, 26(7), 37-39

合成路线：1 步

244277-48-3

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反应条件：

1.1 Reagents: Hydrogen , Hydrochloric acid Catalysts: Palladium Solvents: Ethanol ; 6 h, rt

参考文献：

Enantio- and regiospecific reduction of ethyl 4-phenyl-2,4-dioxobutyrate with baker's yeast: preparation of (R)-HPB ester

Fadnavis, Nitin W.; Radhika, Kasiraman R., Tetrahedron: Asymmetry, 2004, 15(21), 3443-3447

合成路线：1 步

244277-48-3

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反应条件：

1.1 Reagents: Hydrogen Catalysts: Palladium , Hydrochloric acid Solvents: Ethanol

参考文献：

New Technical Synthesis of Ethyl (R)-2-Hydroxy-4-phenylbutyrate of High Enantiomeric Purity

Herold, P.; Indolese, A. F.; Studer, M.; Jalett, H. P.; Siegrist, U.; et al, Tetrahedron, 2000, 56(35), 6497-6499

合成路线：1 步

_98%

反应条件：

1.1 Reagents: 2-Chloroacetophenone Solvents: Diethyl ether , Water

参考文献：

Stereochemical control in microbial reduction. Part 31: Reduction of alkyl 2-oxo-4-arylbutyrates by baker's yeast under selected reaction conditions

Dao, Duc Hai; Okamura, Mutsuo; Akasaka, Takeshi; Kawai, Yasushi; Hida, Kouichi; et al, Tetrahedron: Asymmetry, 1998, 9(15), 2725-2737

合成路线：1 步

29678-81-7

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反应条件：

1.1 Reagents: Sulfuric acid

参考文献：

Angiotensin-converting enzyme inhibitors. Perhydro-1,4-thiazepin-5-one derivatives

Yanagisawa, Hiroaki; Ishihara, Sadao; Ando, Akiko; Kanazaki, Takuro; Miyamoto, Shuichi; et al, Journal of Medicinal Chemistry, 1987, 30(11), 1984-91

合成路线：1 步

110143-66-3

126-84-1

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反应条件：

1.1 Reagents: Lithium hydroxide Solvents: Ethanol
1.2 Reagents: Hydrochloric acid Solvents: Ethanol

参考文献：

An efficient synthesis of ethyl(R)-2-hydroxy-4-phenylbutyrate: a useful intermediate in the synthesis of converting enzyme inhibitors

Flynn, Gary A.; Beight, Douglas W., Tetrahedron Letters, 1988, 29(4), 423-6

合成路线：1 步

29678-81-7

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反应条件：

1.1 Catalysts: Sulfuric acid Solvents: Ethanol

参考文献：

The design and synthesis of the angiotensin-converting enzyme inhibitor cilazapril and related bicyclic compounds

Attwood, Michael R.; Hassall, Cedric H.; Krohn, Antonin; Lawton, Geoffrey; Redshaw, Sally, Journal of the Chemical Society, 1986, (6), 1011-19

合成路线：1 步

_96%

反应条件：

1.1 Catalysts: Bis[dichloro[η5-(pentamethylcyclopentadienyl)]rhodium] , Benzenaminium, 3,3′-[(1R,2R)-1-amino-2-[[(4-dodecylphenyl)sulfonyl]amino]-1,2-et… Solvents: Water ; 2 h, 40 °C
1.2 Reagents: Formic acid , Sodium formate ; 6 h, 25 °C

参考文献：

Chiral Surfactant-Type Catalyst: Enantioselective Reduction of Long-Chain Aliphatic Ketoesters in Water

Lin, Zechao; Li, Jiahong; Huang, Qingfei; Huang, Qiuya; Wang, Qiwei; et al, Journal of Organic Chemistry, 2015, 80(9), 4419-4429

合成路线：1 步

244277-48-3

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反应条件：

1.1 Reagents: Hydrogen , Hydrochloric acid Catalysts: Palladium Solvents: Ethanol , Water ; 2 h, 25 °C

参考文献：

Chemo-enzymatic synthesis of ethyl (R)-2-hydroxy-4-phenylbutyrate

D'Arrigo, Paola; Pedrocchi-Fantoni, Giuseppe; Servi, Stefano, Tetrahedron: Asymmetry, 2010, 21(8), 914-918

合成路线：1 步

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