920-66-1 (六氟异丙醇,1,1,1,3,3,3-Hexafluoro-2-propanol)

反应条件：

1.1 Reagents: Hydrogen , Hydrofluoric acid Catalysts: Palladium ; 2 h, 1 MPa, 30 °C

参考文献：

HF-mediated equilibrium between fluorinated ketones and the corresponding α-fluoroalcohols

Hayasaka, Tatsuya; Katsuhara, Yutaka; Kume, Takashi; Yamazaki, Takashi, Tetrahedron, 2011, 67(12), 2215-2219

合成路线：1 步

_100%

反应条件：

1.1 Reagents: Hydrogen Catalysts: Palladium , Carbon ; 10 bar, 383 K

参考文献：

Heterogeneous Continuous Flow Hydrogenation of Hexafluoroacetone Trihydrate and Its Kinetic Modeling

Xue, Haotian; Qi, Tingting; Su, Weike; Wu, Ke-Jun; Su, An, Industrial & Engineering Chemistry Research, 2023, 62(15), 6121-6129

合成路线：1 步

_99%

反应条件：

1.1 Catalysts: Ni 3288E ; 3 h, 600 psi, 120 °C

参考文献：

Continuous process for production of hexafluoroisopropanol

, World Intellectual Property Organization, , ,

合成路线：1 步

407588-06-1

_99%

反应条件：

1.1 Reagents: Hydrogen Catalysts: Palladium (supported on coconut husk charcoal) , Silver (containing palladium or rhodium, supported on coconut husk charcoal)

参考文献：

Process for producing fluorinated alcohol by esterification of alcohols, fluorination of alcohol esters, decomposition of fluorinated alcohol esters to fluorinated ketones and acyl fluorides, and catalytic hydrogenation

, World Intellectual Property Organization, , ,

合成路线：1 步

_98%

反应条件：

1.1 Reagents: Hydrogen Catalysts: Ni,B nickel base alloy ; rt → 100 °C; 10 h, 980.6 kPa, 95 - 100 °C

参考文献：

Synthesis of sevoflurane

Li, Bindong; Lu, Chunxu; Feng, Chao, Zhongguo Yiyao Gongye Zazhi, 2007, 38(10), 681-682

合成路线：1 步

_96%

反应条件：

1.1 Reagents: Isopropanol ; 6 h, 240 °C

参考文献：

Uncatalyzed Meerwein-Ponndorf-Verley reduction of trifluoromethyl carbonyl compounds by high-temperature secondary alcohols

Lermontov, Sergei A.; Shkavrov, Sergei V.; Kuryleva, Nina V., Journal of Fluorine Chemistry, 2003, 121(2), 223-225

合成路线：1 步

116-16-5

_94%

反应条件：

1.1 Reagents: Hydrofluoric acid Catalysts: Chromium trioxide ; 2 h, rt → 80 °C
1.2 Reagents: Hydrofluoric acid Catalysts: Chromium trioxide , Palladium chloride ; 50 min, rt → 400 °C
1.3 Reagents: Hydrogen ; 8 h, 0.6 MPa, rt → 80 °C

参考文献：

Method for synthesizing hexafluoroacetone and method for synthesizing hexafluoroisopropanol

, China, , ,

合成路线：1 步

13098-39-0

_92%

反应条件：

1.1 Reagents: Ammonium formate ; 105 - 110 °C; 6 h, reflux; reflux → 89 °C; 89 °C → rt
1.2 Reagents: Formic acid ; cooled

参考文献：

Method of obtaining hexafluoroisopropanol

, Russian Federation, , ,

合成路线：1 步

_91%

反应条件：

1.1 Reagents: Hydrogen Catalysts: Ruthenium ; 1 MPa, 9 °C; 1 h, 12 °C → 54 °C; 1.5 h, 54 °C; 43 °C

参考文献：

Preparation of hexafluoroisopropanol by catalytic hydrogenation of hexafluoroacetone at low temperature

, Japan, , ,

合成路线：1 步

_90%

反应条件：

1.1 Reagents: Ammonia , Phosphonic acid Catalysts: Cupric chloride Solvents: Water ; 10 h, reflux
1.2 Reagents: Sulfuric acid Solvents: Water

参考文献：

Method of producing hexafluoropropanol

, Russian Federation, , ,

合成路线：1 步

_90%

反应条件：

1.1 Reagents: Sodium dihydroethoxyethylaluminate Solvents: Benzene

参考文献：

Reductions by metal alkoxyaluminum hydrides

Malek, Jaroslav, Organic Reactions (Hoboken, 1985, 34,

合成路线：1 步

_90%

反应条件：

1.1 Reagents: Hydrogen Catalysts: Palladium

参考文献：

Method of making hydrofluorocarbons from ketones

, United States, , ,

合成路线：1 步

_81%

反应条件：

1.1 Reagents: Hydrazine hydrate (1:1) ; 30 min, rt; rt → 60 °C; 20 min, 60 °C
1.2 Reagents: Hydrogen peroxide Solvents: Water ; 85 - 90 °C

参考文献：

Production of hexafluoroisopropanol by reduction of hexafluoroacetone

, Russian Federation, , ,

合成路线：1 步

677-71-4

_80%

反应条件：

1.1 Reagents: Sodium bicarbonate , Hydrogen Catalysts: Palladium , Ruthenium

参考文献：

Preparation of high-purity 1,1,1,3,3,3-hexafluoropropan-2-ol from hexafluoroacetone hydrate

, Japan, , ,

合成路线：1 步

_61%

反应条件：

1.1 Solvents: Tetrahydrofuran

参考文献：

Hydrogen bonding in fluoro alcohols

Middleton, W. J.; Lindsey, R. V. Jr., Journal of the American Chemical Society, 1964, 86(22), 4948-52

合成路线：1 步

_46%

反应条件：

1.1 Reagents: Hydrogen Catalysts: Palladium (on carbon) ; 3 - 4 bar; 1 h, 3 - 4 bar

参考文献：

Process for preparing hexafluoroisopropanol by hydrogenation of hexafluoroacetone

, China, , ,

合成路线：1 步

反应条件：

1.1 Reagents: Water ; 10 - 25 min, 90 - 150 °C
1.2 13 - 20 min, 120 - 170 °C
1.3 Reagents: Hydrogen ; 20 - 42 min, 6 - 11 MPa, 120 - 170 °C

参考文献：

Preparation of hexafluoroisopropanol

, China, , ,

合成路线：1 步

反应条件：

1.1 Reagents: Hydrogen Catalysts: Palladium ; 1.5 h, 180 °C

参考文献：

Method for continuously producing hexafluoroisopropanol with hexafluoropropylene oxide as raw material

, China, , ,

合成路线：1 步

677-71-4