92664-05-6 (3-氰基-2-氧代丙酸乙酯钾盐,Potassium 1-cyano-3-ethoxy-2,3-dioxopropan-1-ide)

反应条件：

1.1 Reagents: Potassium Solvents: Diethyl ether , Ethanol ; rt → 0 °C; 30 min, 0 °C
1.2 Reagents: Acetonitrile Solvents: Diethyl ether ; 0 °C → rt; 1 h, rt

参考文献：

New Heterocyclic β-Sheet Ligands with Peptidic Recognition Elements

Rzepecki, P.; Gallmeier, H.; Geib, N.; Cernovska, Katarina; Koenig, B.; et al, Journal of Organic Chemistry, 2004, 69(16), 5168-5178

合成路线：1 步

_98%

反应条件：

1.1 Reagents: Potassium tert-butoxide Catalysts: 18-Crown-6 Solvents: Tetrahydrofuran ; 0 °C; 0 °C → 60 °C
1.2 60 °C; 30 min, 60 °C

参考文献：

Design, synthesis and biological evaluation of new pyrazolylureas and imidazopyrazolecarboxamides able to interfere with MAPK and PI3K upstream signaling involved in the angiogenesis

Meta, Elda; Brullo, Chiara ; Sidibe, Adama; Imhof, Beat A.; Bruno, Olga, European Journal of Medicinal Chemistry, 2017, 133, 24-35

合成路线：1 步

_85%

反应条件：

1.1 Reagents: Potassium tert-butoxide Catalysts: 18-Crown-6 Solvents: Tetrahydrofuran ; rt → 60 °C
1.2 40 min, 60 °C

参考文献：

New geldanamycin derivatives with anti Hsp properties by mutasynthesis

Hermane, Jekaterina; Eichner, Simone; Mancuso, Lena; Schroeder, Benjamin; Sasse, Florenz; et al, Organic & Biomolecular Chemistry, 2019, 17(21), 5269-5278

合成路线：1 步

_84%

反应条件：

1.1 Reagents: Potassium ethoxide Solvents: Diethyl ether , Ethanol , Acetonitrile ; 0 °C → rt

参考文献：

Discovery of Allosteric, Potent, Subtype Selective, and Peripherally Restricted TrkA Kinase Inhibitors

Bagal, Sharan K. ; Omoto, Kiyoyuki; Blakemore, David C.; Bungay, Peter J.; Bilsland, James G.; et al, Journal of Medicinal Chemistry, 2019, 62(1), 247-265

合成路线：1 步

_82%

反应条件：

1.1 Reagents: Potassium tert-butoxide Solvents: Acetonitrile ; rt; 1.5 h, rt

参考文献：

MCT4 inhibitors for treating disease

, World Intellectual Property Organization, , ,

合成路线：1 步

_80%

反应条件：

1.1 Reagents: Potassium tert-butoxide ; 1 h, rt

参考文献：

Synthetic studies of five-membered heteroaromatic derivatives as potassium-competitive acid blockers (P-CABs)

Arikawa, Yasuyoshi; Hasuoka, Atsushi; Nishida, Haruyuki; Hirase, Keizo; Inatomi, Nobuhiro; et al, Bioorganic & Medicinal Chemistry Letters, 2015, 25(10), 2037-2040

合成路线：1 步

_78%

反应条件：

1.1 Reagents: Potassium tert-butoxide Solvents: Acetonitrile ; 1.5 h, rt

参考文献：

Azaaryl-1H-pyrazol-1-yl benzenesulfonamides as CCR9 antagonists and their preparation

, United States, , ,

合成路线：1 步

_78%

反应条件：

1.1 Reagents: Potassium tert-butoxide ; rt; 1.5 h, rt

参考文献：

Preparation of aza-aryl 1H-pyrazol-1-yl benzenesulfonamides as CCR9 antagonists

, United States, , ,

合成路线：1 步

_76%

反应条件：

1.1 Solvents: Diethyl ether , Ethanol ; 0 °C; 30 min, 0 °C
1.2 Solvents: Diethyl ether ; 0 °C → rt; 1.5 h, rt

参考文献：

Preparation of triazine derivatives for treating diseases characterized by undesired cellular proliferation or hyperproliferation

, World Intellectual Property Organization, , ,

合成路线：1 步

_76%

反应条件：

1.1 Reagents: Potassium tert-butoxide Catalysts: 18-Crown-6 Solvents: Tetrahydrofuran ; 0 °C; 0 °C → 60 °C
1.2 60 °C; 30 min, 60 °C; 60 °C → rt

参考文献：

Synthesis, cannabinoid receptor affinity, and molecular modeling studies of substituted 1-aryl-5-(1H-pyrrol-1-yl)-1H-pyrazole-3-carboxamides

Silvestri, Romano; Cascio, Maria Grazia; La Regina, Giuseppe; Piscitelli, Francesco; Lavecchia, Antonio; et al, Journal of Medicinal Chemistry, 2008, 51(6), 1560-1576

合成路线：1 步

反应条件：

1.1 Reagents: Potassium ethoxide

参考文献：

Preparation of heterocyclic glycyl β-alanine derivatives as vitronectin antagonists

, World Intellectual Property Organization, , ,

合成路线：1 步