931-61-3 (2-甲氨基嘧啶,N-methylpyrimidin-2-amine)

反应条件：

1.1 Reagents: Sodium hydroxide Solvents: Ethanol ; 48 h, reflux

参考文献：

Method for preparation of 1-methyl-5-aryl-2-aminoimidazoles and their reactivity

Smirnova, T. A.; Kurapov, P. B.; Vetrova, E. L.; Bass, A. G.; Nam, N. L., Izvestiya Timiryazevskoi Sel'skokhozyaistvennoi Akademii, 2003, (4), 132-141

合成路线：1 步

_90%

反应条件：

1.1 Solvents: Tetrahydrofuran , Water ; 1 h, 0 °C → reflux

参考文献：

Hit-to-lead optimization of novel phenyl imidazole carboxamides that are active against Leishmania donovani

McNamara, Nicole; Saunders, Eleanor; Varghese, Swapna; Zheng, Rebecca; Simpson, Kaylene; et al, European Journal of Medicinal Chemistry, 2022, 240,

合成路线：1 步

_90%

反应条件：

1.1 Reagents: Triethylamine Solvents: Ethanol , Water ; 15 h, 80 °C

参考文献：

N-Methylamino Pyrimidyl Amides (MAPA): Highly Reactive, Electronically-Activated Amides in Catalytic N-C(O) Cleavage

Meng, Guangrong ; Lalancette, Roger; Szostak, Roman; Szostak, Michal, Organic Letters, 2017, 19(17), 4656-4659

合成路线：1 步

109-12-6

74-87-3

_88%

反应条件：

1.1 Solvents: Toluene

参考文献：

The chemistry of the alkali amides. III

Levine, Robert; Fernelius, W. Conard, Chemical Reviews (Washington, 1954, 54, 449-573

合成路线：1 步

_83%

反应条件：

1.1 Solvents: Ethanol

参考文献：

Monomer synthesis. IX. Methylation of 2-aminopyridine

Overberger, C. G.; Kogon, Irving C., Journal of the American Chemical Society, 1954, 76, 1065-8

合成路线：1 步

_82%

反应条件：

1.1 Reagents: Potassium fluoride Solvents: Water ; 17 h, rt → 100 °C
1.2 Reagents: Potassium carbonate Solvents: Water ; cooled

参考文献：

Palladium-catalyzed remote C-H functionalization of 2-aminopyrimidines

Das, Animesh; Jana, Akash; Maji, Biplab, Chemical Communications (Cambridge, 2020, 56(31), 4284-4287

合成路线：1 步

_79%

反应条件：

1.1 Reagents: Triethylamine Solvents: Ethanol

参考文献：

New 5-Aryl-1H-imidazoles Display in Vitro Antitumor Activity against Apoptosis-Resistant Cancer Models, Including Melanomas, through Mitochondrial Targeting

Mathieu, Veronique; Van Den Berge, Emilie; Ceusters, Justine; Konopka, Tomasz; Cops, Antonin; et al, Journal of Medicinal Chemistry, 2013, 56(17), 6626-6637

合成路线：1 步

109-12-6

74-88-4

_75%

反应条件：

1.1 Solvents: Acetone ; 15 h, 75 °C; 75 °C → rt
1.2 Reagents: Sodium hydroxide Solvents: Ethanol , Water ; 0.5 h, 80 °C

参考文献：

Substituted 4-phenyl-2-aminoimidazoles and 4-phenyl-4,5-dihydro-2-aminoimidazoles as voltage-gated sodium channel modulators

Zidar, Nace; Jakopin, Ziga; Madge, David J.; Chan, Fiona; Tytgat, Jan; et al, European Journal of Medicinal Chemistry, 2014, 74, 23-30

合成路线：1 步

1003-58-3

_71%

反应条件：

1.1 Solvents: Water

参考文献：

Simple pyrimidines. III. Methylation and structure of the aminopyrimidines

Brown, D. J.; Hoerger, Earl; Mason, S. F., Journal of the Chemical Society, 1955, 4035, 4035-40

合成路线：1 步

_65%

反应条件：

1.1 Solvents: Ethanol

参考文献：

2-(Dimethylamino)pyrimidine

Overberger, C. G.; Kogon, Irving C.; Minin, Ronald, Organic Syntheses, 1955, 35, 58-9

合成路线：1 步

_30%

反应条件：

1.1 Reagents: Potassium carbonate Solvents: Methanol ; overnight, rt → 80 °C; 80 °C → rt

参考文献：

Preparation of heteroaryloxotetrahydrodiazepinoindolecarboxamide derivatives and analogs for use as RSK inhibitors

, World Intellectual Property Organization, , ,

合成路线：1 步

反应条件：

1.1 Solvents: Ethanol ; 1 h, 150 °C

参考文献：

Compositions providing enhanced antibacterial activity against gram-positive bacteria and use thereof

, World Intellectual Property Organization, , ,

合成路线：1 步

反应条件：

1.1 Solvents: Tetrahydrofuran , Water ; 0 °C; 1 h, 50 °C

参考文献：

Preparation of substituted thiazoles as tubulin polymerization inhibitors useful in the treatment of cancer

, World Intellectual Property Organization, , ,

合成路线：1 步

86755-91-1

反应条件：

1.1 Catalysts: Phenylmagnesium bromide

参考文献：

The role of chelation in the formylation of Grignard reagents with N-formyl amines

Amaratunga, Wimal; Frechet, Jean M. J., Tetrahedron Letters, 1983, 24(11), 1143-6

合成路线：1 步

参考文献：

A Divergent Synthesis of Substituted 2-Aminoimidazoles from 2-Aminopyrimidines

Ermolat'ev, Denis S.; Van der Eycken, Erik V., Journal of Organic Chemistry, 2008, 73(17), 6691-6697

合成路线：1 步