932-17-2 (1-乙酰基-2-吡咯烷酮,1-Acetyl-2-pyrrolidone)

_96%

反应条件：

1.1 2 h, reflux

参考文献：

Transition metal complex catalysts and processes for the hydrogenation of amides

, World Intellectual Property Organization, , ,

合成路线：1 步

_96%

反应条件：

1.1 2 h, reflux

参考文献：

A Highly Active Catalyst for the Hydrogenation of Amides to Alcohols and Amines

John, Jeremy M.; Bergens, Steven H., Angewandte Chemie, 2011, 50(44), 10377-10380

合成路线：1 步

_96%

反应条件：

1.1 Solvents: Acetic anhydride ; 2 h, reflux

参考文献：

Iridium-catalyzed highly enantioselective hydrogenation of exocyclic α,β-unsaturated carbonyl compounds

Tian, Fengtao; Yao, Dongmei; Liu, Yuanyuan; Xie, Fang; Zhang, Wanbin, Advanced Synthesis & Catalysis, 2010, 352, 1841-1845

合成路线：1 步

_96%

反应条件：

1.1 2 h, reflux; reflux → rt

参考文献：

Preparation of 11C-labeled benzyl-lactam compounds and their use as imaging agents

, World Intellectual Property Organization, , ,

合成路线：1 步

5264-35-7

630-08-0

_96%

反应条件：

1.1 Catalysts: Dicobalt octacarbonyl Solvents: 1,2-Dimethoxyethane ; 48 h, 1000 psi, 100 °C

参考文献：

Toward Transition Metal-Catalyzed Carbonylation of Methanol without HI as Copromoter: Catalytic Exocyclic Carbonylation of Cycloimino Esters

Xu, Hongyu; Jia, Li, Organic Letters, 2003, 5(21), 3955-3957

合成路线：1 步

4030-18-6

_90%

反应条件：

1.1 Reagents: Ceric ammonium nitrate Catalysts: Iridium(2+), triaqua[(1,2,3,4,5-η)-1,2,3,4,5-pentamethyl-2,4-cyclopentadien-1-yl… Solvents: Water-d2 ; 30 min, rt

参考文献：

Cp* iridium precatalysts for selective C-H oxidation via direct oxygen insertion: A joint experimental/computational study

Zhou, Meng; Balcells, David; Parent, Alexander R.; Crabtree, Robert H.; Eisenstein, Odile, ACS Catalysis, 2012, 2(2), 208-218

合成路线：1 步

_82%

反应条件：

1.1 Catalysts: Acetyl chloride ; 2 h, reflux

参考文献：

Photocatalytic oxidations of lactams and N-acylamines

Tantayanon, Supawan, 1982, , ,

合成路线：1 步

692-33-1

630-08-0

_82%

反应条件：

1.1 Catalysts: Palladium diiodide , Bis[2-(diphenylphosphino)phenyl] ether Solvents: Toluene ; 20 h, 50 bar, 105 °C

参考文献：

Palladium-Catalyzed Hydroamidocarbonylation of Olefins to Imides

Li, Haoquan; Dong, Kaiwu; Neumann, Helfried; Beller, Matthias, Angewandte Chemie, 2015, 54(35), 10239-10243

合成路线：1 步

4030-18-6

_80%

反应条件：

1.1 Reagents: Pyridine , Sodium perchlorate , Oxygen Catalysts: N-Hydroxyphthalimide Solvents: Acetonitrile

参考文献：

Anodic oxidation of amides and lactams using N-hydroxyphthalimide as a mediator

Masui, Masaichiro; Hara, Seijiro; Ozaki, Shigeko, Chemical & Pharmaceutical Bulletin, 1986, 34(3), 975-9

合成路线：1 步

_77%

反应条件：

1.1 Solvents: Tetrahydrofuran ; 2 h, reflux

参考文献：

Structural modifications of (Z)-3-(2-aminoethyl)-5-(4-ethoxybenzylidene)thiazolidine-2,4-dione that improve selectivity for inhibiting the proliferation of melanoma cells containing active ERK signaling

Jung, Kwan-Young; Samadani, Ramin; Chauhan, Jay; Nevels, Kerrick; Yap, Jeremy L.; et al, Organic & Biomolecular Chemistry, 2013, 11(22), 3706-3732

合成路线：1 步

88-12-0

_75%

反应条件：

1.1 Reagents: Hydrogen peroxide Catalysts: Nitric acid , Tetrakis(triphenylphosphine)palladium Solvents: Dimethylacetamide , Water ; 1 h, 55 °C

参考文献：

Chemoselective Palladium-Catalyzed Oxidation of Vinyl Ether to Acetate Using Hydrogen Peroxide

Kon, Yoshihiro; Tanaka, Shinji; Nakashima, Takuya; Sato, Kazuhiko; Shimada, Hiromichi, Journal of the Chinese Chemical Society (Weinheim, 2014, 61(7), 749-756

合成路线：1 步

4030-18-6

_51%

反应条件：

1.1 Reagents: tert-Butyl hydroperoxide , Iodobenzene diacetate Solvents: Nitromethane , Decane ; 30 min, 0 °C; 18 h, 0 °C
1.2 Reagents: Sodium sulfite

参考文献：

Oxidative transformation of cyclic ethers/amines to lactones/lactams using a DIB/TBHP protocol

Zhao, Yi; Ang, Jascelyn Qian Lin; Ng, Angela Wan Ting; Yeung, Ying-Yeung, RSC Advances, 2013, 3(43), 19765-19768

合成路线：1 步

183208-72-2

_40%

反应条件：

1.1 Reagents: Cupric chloride , Hydrochloric acid , Oxygen Catalysts: Palladium Solvents: Acetonitrile , Water

参考文献：

Palladium(II)-mediated oxidative cyclization of N-acyl aminoalkynes: a new route to γ-lactams

Doan, Huynh Dong; Gore, Jacques; Vatele, Jean-Michel, Tetrahedron Letters, 1999, 40(37), 6765-6768

合成路线：1 步

75694-83-6

_35%

反应条件：

1.1 Reagents: Oxygen Catalysts: 2,6-Dimethoxy-1,4-benzoquinone , (TB-5-22)-[[2,2′-[(Methylimino-κN)bis[3,1-propanediyl(nitrilo-κN)methylidyne]]bi… , Tetracarbonyl-μ-hydro[(1,2,3,4,5-η)-1-hydroxylato-2,3,4,5-tetraphenyl-2,4-cyclop… Solvents: Toluene ; 18 h, 100 °C

参考文献：

Biomimetic Aerobic Oxidation of Amino Alcohols to Lactams

Babu, Beneesh P.; Endo, Yoshinori; Baeckvall, Jan-E., Chemistry - A European Journal, 2012, 18(37), 11524-11527

合成路线：1 步

反应条件：

1.1 Catalysts: 4-(Dimethylamino)pyridine Solvents: Tetrahydrofuran ; 10 - 25 °C; 30 min, 10 - 25 °C
1.2 Solvents: Water ; 30 min, rt

参考文献：

Green preparation of 4-amino-1-butanol and its N-protected derivative

, China, , ,

合成路线：1 步

反应条件：

1.1 5 h, reflux

参考文献：

Design, synthesis, biological evaluation, homology modeling and docking studies of (E)-3-(benzo[d][1,3]dioxol-5-ylmethylene) pyrrolidin-2-one derivatives as potent anticonvulsant agents

Wang, Tiantian; Dong, Shiyang; Chen, Xiaodong; Qian, Kun; Wang, Huayu; et al, Bioorganic & Medicinal Chemistry Letters, 2018, 28(8), 1324-1329

合成路线：1 步

反应条件：

1.1 Solvents: Acetic anhydride ; 1.5 h, reflux

参考文献：

Rhodanine derivatives as novel inhibitors of PDE4

Irvine, Mark W.; Patrick, Graham L.; Kewney, Justin; Hastings, Stuart F.; MacKenzie, Simon J., Bioorganic & Medicinal Chemistry Letters, 2008, 18(6), 2032-2037

合成路线：1 步

75-36-5