93379-54-5 ((S)-(-)-阿替洛尔,(S)-Atenolol)

反应条件：

1.1 Reagents: Hydrogen Catalysts: Palladium Solvents: Methanol ; 24 h, 310 - 345 kPa, 35 - 38 °C

参考文献：

Improved method for synthesis of beta-blocker atenolol of high purity on an industrial scale

, Russian Federation, , ,

合成路线：1 步

1012887-35-2

_97%

反应条件：

1.1 Reagents: Hydrogen Catalysts: Palladium Solvents: Methanol ; 24 h, 45 - 50 psi, 35 - 38 °C

参考文献：

Improved process for the industrial manufacture of atenolol

, India, , ,

合成路线：1 步

_95%

反应条件：

1.1 Solvents: Methanol ; 23 °C
1.2 Reagents: Ammonia ; 23 °C
1.3 Catalysts: Calcium hydride ; 30 h, 23 °C
1.4 Reagents: Ammonium carbonate Solvents: Water ; 1 h, 23 °C

参考文献：

Process for the preparation of pure (S)-enantiomer of atenolol

, Croatia, , ,

合成路线：1 步

136259-71-7

_94%

反应条件：

1.1 Solvents: Water ; 12 h, 10 °C
1.2 Reagents: Hydrochloric acid Solvents: Water ; pH 2
1.3 Reagents: Sodium hydroxide Solvents: Water ; pH 11

参考文献：

Lipase-catalyzed green synthesis of enantiopure atenolol

Dwivedee, Bharat Prasad; Ghosh, Saptarshi; Bhaumik, Jayeeta; Banoth, Linga; Chand Banerjee, Uttam, RSC Advances, 2015, 5(21), 15850-15860

合成路线：1 步

136259-70-6

_91%

反应条件：

1.1 Solvents: Isopropanol ; rt → 38 °C; 7 h, 38 °C

参考文献：

Method for preparation of (S)-Atenolol

, China, , ,

合成路线：1 步

_91%

反应条件：

1.1 Solvents: Water ; rt → 10 °C; 3 h, 10 - 15 °C; 10 h

参考文献：

Process for producing (S)-atenolol of high optical purity from (R)-epichlorohydrin, 4-hydroxyphenylacetamide, and isopropylamine.

, United States, , ,

合成路线：1 步

_90%

反应条件：

1.1 Solvents: Water ; 30 min, rt
1.2 20 - 60 °C; 12 - 24 h

参考文献：

Method for preparing (S)-atenolol

, Korea, , ,

合成路线：1 步

_90%

反应条件：

1.1 Reagents: Potassium carbonate , Cesium fluoride Solvents: Dimethylformamide
1.2 -
1.3 -
1.4 Solvents: Water
1.5 Solvents: Ethyl acetate

参考文献：

CsF in organic synthesis. Regioselective nucleophilic reactions of phenols with oxiranes leading to enantiopure β-blockers

Kitaori, Kazuhiro; Furukawa, Yoshiro; Yoshimoto, Hiroshi; Otera, Junzo, Tetrahedron, 1999, 55(50), 14381-14390

合成路线：1 步

56715-12-9

_90%

反应条件：

1.1 Solvents: Methanol

参考文献：

Preparation of optically active atenolol and its intermediates

, Japan, , ,

合成路线：1 步

56715-12-9

_89%

反应条件：

1.1 Solvents: Methanol

参考文献：

Manufacture of optically active atenolol and its intermediates

, Japan, , ,

合成路线：1 步

56715-12-9

_89%

反应条件：

1.1 Solvents: Methanol

参考文献：

Process for producing optically active atenolol and intermediate thereof

, European Patent Organization, , ,

合成路线：1 步

_80%

反应条件：

1.1 Reagents: Sodium methoxide , Ammonia Solvents: Methanol ; 20 °C; 24 h, 20 °C

参考文献：

Method for preparation of enantiomerically pure (S)-(-)-atenolol and (R)-(+)-atenolol using preparative chromatography on chiral stationary phase of racemic 1-(N-benzyl-N-isopropyl)amino-3-[p-(methoxycarbonylmethylphenoxy)]-2-propanol as key step

, Croatia, , ,

合成路线：1 步

_73%

反应条件：

1.1 Reagents: Ammonium hydroxide Solvents: Methanol , Water ; rt

参考文献：

Asymmetric ring opening of epoxides catalyzed by novel heterobimetallic Schiff-bases containing transition metal salts

Kawthekar, Rahul B.; Bi, Wen-tao; Kim, Geon-Joong, Bulletin of the Korean Chemical Society, 2008, 29(2), 313-318

合成路线：1 步

_72%

反应条件：

1.1 Reagents: Ammonium hydroxide Solvents: Methanol ; 0 - 5 °C; 1 d, rt

参考文献：

An efficient asymmetric synthesis of (S)-atenolol using hydrolytic kinetic resolution

Bose, D. Subhas; Narsaiah, A. Venkat, Bioorganic & Medicinal Chemistry, 2005, 13(3), 627-630

合成路线：1 步

_60%

反应条件：

1.1 Reagents: Ammonium hydroxide

参考文献：

Lipase catalysis in organic solvents. Application to the synthesis of (R)- and (S)-atenolol

Bevinakatti, H. S.; Banerji, A. A., Journal of Organic Chemistry, 1992, 57(22), 6003-5

合成路线：1 步

反应条件：

1.1 Reagents: Ammonium hydroxide Solvents: Methanol

参考文献：

Fabrication of SiO2, Al2O3, and TiO2 Microcapsules with Hollow Core and Mesoporous Shell Structure

Guo, Xiao-Feng; Kim, Yong-Suk; Kim, Geon-Joong, Journal of Physical Chemistry C, 2009, 113(19), 8313-8319

合成路线：1 步

反应条件：

1.1 Reagents: Ammonium hydroxide Solvents: Methanol , Water ; rt

参考文献：

Synthesis and application of bimetallic chiral [Co(salen)]-type complexes: a new catalytic approach to synthesis of optically pure β-blockers via kinetic resolution of epichlorohydrin

Kawthekar, Rahul B.; Bi, Wen-tao; Kim, Geon-Joong, Applied Organometallic Chemistry, 2008, 22(10), 583-591

合成路线：1 步

反应条件：

1.1 Reagents: Ammonium hydroxide Solvents: Methanol , Water

参考文献：

Enantioselective synthesis of β-blockers via hydrolytic kinetic resolution of terminal oxiranes by using bimetallic chiral [{2,2'-[cyclohexane-1,2-diylbis(nitrilomethylidyne)]bis[phenolato]}(2-)]cobalt ([Co(salen)])-type complexes

Kawthekar, Rahul B.; Kim, Geon-Joong, Helvetica Chimica Acta, 2008, 91(2), 317-332

合成路线：1 步

32634-68-7

反应条件：

1.1 Reagents: Sodium hydroxide Solvents: Water ; rt; 2 h, 10 - 15 °C

参考文献：

Resolution of racemic atenolol using (2S,3S)-O,O-di-p-toluoyl tartrate and (2R,3R)-O,O-di-p-toluoyl tartrate to form diastereomeric salts of atenolol followed by fractional crystallization and neutralization of the separated atenolol diastereomeric salts and base neutralization

, World Intellectual Property Organization, , ,

合成路线：1 步

869641-31-6