935-56-8 (1-氯金刚烷,1-Chloroadamantane)

_100%

反应条件：

1.1 Reagents: Oxalyl chloride Catalysts: Dimethylformamide Solvents: Dichloromethane ; rt; 18 h, rt

参考文献：

Preparation of tripartite androgen receptor eliminators useful for treating an androgen receptor signaling-mediated diseases

, World Intellectual Property Organization, , ,

合成路线：1 步

25236-60-6

_98%

反应条件：

1.1 Reagents: Iron chloride (FeCl3) Solvents: Dichloromethane ; 5 min, rt

参考文献：

Iron(III)-Catalyzed Halogenations by Substitution of Sulfonate Esters

Ortega, Nuria; Feher-Voelger, Andres; Brovetto, Margarita; Padron, Juan I.; Martin, Victor S.; et al, Advanced Synthesis & Catalysis, 2011, 353(6), 963-972

合成路线：1 步

_98%

反应条件：

1.1 Reagents: Carbon tetrachloride Catalysts: Acetonitrile , Tris(acetylacetonato)manganese Solvents: Carbon tetrachloride ; 1 h, 200 °C

参考文献：

Chlorination of adamantane and its derivatives by carbon tetrachloride in the presence of manganese, vanadium, and molybdenum-containing catalysts

Khusnutdinov, R. I.; Shchadneva, N. A.; Baiguzina, A. R.; Lavrent'eva, Yu. Yu.; Burangulova, R. Yu.; et al, Neftekhimiya, 2004, 44(2), 148-155

合成路线：1 步

_98%

反应条件：

1.1 Reagents: Carbon tetrachloride Catalysts: Acetonitrile , Tris(acetylacetonato)manganese ; 1 h, 200 °C

参考文献：

Method of synthesis of 1-chloroadamantane and chlorodiamantanes

, Russian Federation, , ,

合成路线：1 步

118334-83-1

_98%

反应条件：

1.1 Reagents: Dabco Solvents: Carbon tetrachloride , tert-Butanol , Water

参考文献：

Photochemical chlorodecarboxylation via an electron transfer mechanism

Okada, Keiji; Okamoto, Kazushige; Oda, Masaji, Journal of the Chemical Society, 1989, (21), 1636-7

合成路线：1 步

612058-38-5

_96%

反应条件：

1.1 Reagents: Diisopropyl azodicarboxylate Solvents: Dichloromethane ; 1 min, rt
1.2 Reagents: Chlorotrimethylsilane ; 15 min, rt

参考文献：

Alkylphosphinites as Synthons for Stabilized Carbocations

Ochmann, Lukas ; Kessler, Mika L.; Schreiner, Peter R., Organic Letters, 2022, 24(7), 1460-1464

合成路线：1 步

56-23-5

_95%

反应条件：

1.1 Reagents: Sulfuric acid Solvents: Carbon tetrachloride

参考文献：

Biologically active polycycloalkanes. 1. Antiviral adamantane derivatives

Aigami, Koji; Inamoto, Yoshiaki; Takaishi, Naotake; Hattori, Kenichi; Takatsuki, Akira; et al, Journal of Medicinal Chemistry, 1975, 18(7), 713-21

合成路线：1 步

828-51-3

_94%

反应条件：

1.1 Reagents: tert-Butyl hypochlorite Catalysts: Silver(1+), bis(1,10-phenanthroline-κN1,κN10)-, (T-4)-, 1,1,1-trifluoromethanesu… Solvents: Acetonitrile ; rt

参考文献：

Catalytic Decarboxylation/Carboxylation Platform for Accessing Isotopically Labeled Carboxylic Acids

Tortajada, Andreu ; Duan, Yaya; Sahoo, Basudev ; Cong, Fei; Toupalas, Georgios; et al, ACS Catalysis, 2019, 9(7), 5897-5901

合成路线：1 步

_94%

反应条件：

1.1 Reagents: Chloroform , Polyisoprene Catalysts: Titanium , Iron(III) acetylacetonate Solvents: Chloroform ; 0.5 h, 25 °C

参考文献：

Chlorination method and catalyst system for the synthesis of 1- and 2-chloroadamantanes from 1- and 2-adamantanols and chloroform

, Russian Federation, , ,

合成路线：1 步

_93%

反应条件：

1.1 Reagents: Carbon tetrachloride Catalysts: Iron(III) acetylacetonate Solvents: Ethanol ; 6 h, 160 °C

参考文献：

Method of producing 1-chloroadamantane

, Russian Federation, , ,

合成路线：1 步

828-51-3

_93%

反应条件：

1.1 Reagents: tert-Butyl hypochlorite Catalysts: Silver(1+), bis(1,10-phenanthroline-κN1,κN10)-, (T-4)-, 1,1,1-trifluoromethanesu… Solvents: Acetonitrile ; 3 h, rt

参考文献：

Silver-catalyzed decarboxylative chlorination of aliphatic carboxylic acids

Wang, Zhentao; Zhu, Lin; Yin, Feng; Su, Zhongquan; Li, Zhaodong; et al, Journal of the American Chemical Society, 2012, 134(9), 4258-4263

合成路线：1 步

_93%

反应条件：

1.1 Reagents: Benzil , Chlorodimethylsilane Catalysts: Indium trichloride Solvents: Dichloromethane ; 82 h, rt

参考文献：

Direct chlorination of alcohols: synthesis of ethyl 3-chloro-3-phenylpropanoate [benzenepropanoic acid, β-chloro-, ethyl ester]

Yasuda, Makoto; Yamasaki, Satoshi; Onishi, Yoshiyuki; Baba, Akio, Organic Syntheses, 2006, 83, 38-44

合成路线：1 步

_93%

反应条件：

1.1 Reagents: Benzil , Chlorodimethylsilane Catalysts: Indium trichloride Solvents: Dichloromethane ; 82 h, rt
1.2 Reagents: Sodium bicarbonate Solvents: Water ; rt

参考文献：

Indium-Catalyzed Direct Chlorination of Alcohols Using Chlorodimethylsilane-Benzil as a Selective and Mild System

Yasuda, Makoto; Yamasaki, Satoshi; Onishi, Yoshiyuki; Baba, Akio, Journal of the American Chemical Society, 2004, 126(23), 7186-7187

合成路线：1 步

_93%

反应条件：

1.1 Reagents: Triphenylphosphine , Selenium, dichlorodimethyl-, (T-4)- Solvents: Chloroform

参考文献：

Triphenylphosphine/Dichloroselenurane: A new reagent for a selective conversion of alcohols into alkyl chlorides

Drabowicz, Jozef; Luczak, Jerzy; Mikolajczyk, Marian, Journal of Organic Chemistry, 1998, 63(25), 9565-9568

合成路线：1 步

_92%

反应条件：

1.1 Reagents: Hydrochloric acid Solvents: Water ; 2 h, rt

参考文献：

2-Ethyl-3-(4-hydroxybenzoyl)benzofuran compounds and their preparation, pharmaceutical compositions and use in the treatment of hyperuricemia and gout

, China, , ,

合成路线：1 步

_91%

反应条件：

1.1 Reagents: Carbon tetrachloride , Phosphine, [4-(1R,2R,4R)-bicyclo[2.2.1]hept-5-en-2-ylphenyl]diphenyl-, rel-, tri… Solvents: Dichloromethane

参考文献：

ROMPgel-Supported Triphenylphosphine with Potential Application in Parallel Synthesis

Aarstad, Erik; Barrett, Anthony G. M.; Hopkins, Brian T.; Koebberling, Johannes, Organic Letters, 2002, 4(11), 1975-1977

合成路线：1 步

768-92-3

_91%

反应条件：

1.1 Reagents: Titanium tetrachloride Solvents: Dichloromethane

参考文献：

Halogen-exchange reactions between alkyl fluorides and boron trihalides or titanium tetrahalides. A convenient synthesis of alkyl halides from alkyl fluorides

Namavari, Mohammad; Satyamurthy, N.; Barrio, Jorge R., Journal of Fluorine Chemistry, 1995, 72(1), 89-93

合成路线：1 步

24375-05-1

_90%

参考文献：

Thermolysis of N,N-dihalo derivatives of bridgehead and neopentylamines to the corresponding halides

Roberts, John T.; Rittberg, Barry R.; Kovacic, Peter; Scalzi, Francis V.; Seely, Michael J., Journal of Organic Chemistry, 1980, 45(26), 5239-43

合成路线：1 步

_89%

反应条件：

1.1 Reagents: Tin tetrachloride

参考文献：

A simple method for the conversion of adamantyl, benzyl and benzyhydryl alcohols to their corresponding bromides and chlorides and the transhalogenation of adamantyl, benzyl, benzhydryl and tertiary alkyl bromides and chlorides

Amrollah-Madjdabadi, A.; Pham, Tung N.; Ashby, E. C., Synthesis, 1989, (8), 614-16

合成路线：1 步

2094-72-6

_89%