93609-84-8 (茚达特罗中间体1,5-acetyl-8-(benzyloxy)-1,2-dihydroquinolin-2-one)

_92%

反应条件：

1.1 Reagents: Potassium carbonate Solvents: Dimethylformamide ; rt; 4 h, rt

参考文献：

Class of bifunctional compounds with quaternary ammonium salt structure

, World Intellectual Property Organization, , ,

合成路线：1 步

_92%

反应条件：

1.1 Reagents: Diisopropylethylamine Solvents: Acetone , Water ; rt → reflux
1.2 reflux; 6 - 7 h, reflux
1.3 Reagents: Water ; 58 °C; 58 °C → 25 °C

参考文献：

Method for preparing 8-substituted oxy-5-((R)-2-halo-l-hydroxy-ethyl)-(1 H)-quinolin-2-ones employing a chiral reduction step

, World Intellectual Property Organization, , ,

合成路线：1 步

_92%

反应条件：

1.1 Reagents: Diisopropylethylamine Solvents: Acetone ; rt → reflux
1.2 reflux; 6 - 7 h, reflux

参考文献：

Process for preparation of 5-(haloacetyl)-8-hydroxy-(1H)-quinolin-2-one derivatives

, World Intellectual Property Organization, , ,

合成路线：1 步

_79%

反应条件：

1.1 Reagents: Potassium carbonate Solvents: Dimethylformamide ; 15 min, rt; rt → 40 °C; 3 h, 40 °C

参考文献：

Discovery of β-arrestin-biased β2-adrenoceptor agonists from 2-amino-2-phenylethanol derivatives

Woo, Anthony Yiu-Ho; Ge, Xin-yue; Pan, Li; Xing, Gang; Mo, Yong-mei; et al, Acta Pharmacologica Sinica, 2019, 40(8), 1095-1105

合成路线：1 步

反应条件：

1.1 Reagents: Potassium carbonate Solvents: Dimethylformamide ; 10 min, rt
1.2 30 min, rt; 2 h, rt
1.3 Solvents: Water ; 20 min, rt

参考文献：

A process for preparing indacaterol and salts thereof

, India, , ,

合成路线：1 步

反应条件：

1.1 Reagents: Potassium carbonate Solvents: Dimethylformamide ; 2 h, rt

参考文献：

Preparation of quaternary ammonium salt compounds such as 1,1-dimethylpiperidin-1-ium and 9,9-dimethyl-3-oxa-9-azatricyclo[3.3.1.02,4]nonan-9-ium compounds as agonists of β2 adrenergic receptor and antagonists of muscarinic receptor

, Japan, , ,

合成路线：1 步

100331-93-9

反应条件：

1.1 Solvents: Acetic anhydride ; 25 - 30 °C; 30 °C → 40 °C; 2 h, 40 °C

参考文献：

Process for the preparation of stereoisomers of carmoterol, their pharmaceutical compositions, and use in therapy

, World Intellectual Property Organization, , ,

合成路线：1 步

反应条件：

1.1 Reagents: Potassium carbonate Solvents: Dimethylformamide ; 2.25 h, rt
1.2 Reagents: Sodium chloride Solvents: Water ; 1 h, 0 °C

参考文献：

Preparation of aryl and heteroaryl compounds having β2 adrenergic receptor agonist and muscarinic receptor antagonist activity

, World Intellectual Property Organization, , ,

合成路线：1 步

反应条件：

1.1 Reagents: Potassium carbonate Solvents: Dimethylformamide ; rt; 2.25 h, rt
1.2 Reagents: Sodium chloride Solvents: Water ; 1 h

参考文献：

Preparation and formulation of crystalline forms of a quinolinone β2 adrenergic receptor agonist for treatment of pulmonary disease

, United States, , ,

合成路线：1 步

反应条件：

1.1 Reagents: Potassium carbonate Solvents: Dimethylformamide ; 2.25 h, rt
1.2 Reagents: Sodium chloride Solvents: Water ; 1 h, 0 °C

参考文献：

Preparation of (diphenyl)(pyrrolidinyl)methyl amides as β2 adrenergic receptor agonist and muscarinic receptor antagonist

, World Intellectual Property Organization, , ,

合成路线：1 步

反应条件：

1.1 Reagents: Potassium carbonate Solvents: Dimethylformamide ; 2.25 h, rt
1.2 Reagents: Sodium chloride Solvents: Water ; 1 h, 0 °C

参考文献：

Preparation of biphenyl derivatives as β2-adrenergic agonists and muscarinic antagonists for pulmonary disorders.

, United States, , ,

合成路线：1 步

反应条件：

1.1 Reagents: Potassium carbonate Solvents: Dimethylformamide ; 2.25 h, rt
1.2 Reagents: Sodium chloride Solvents: Water ; 1 h, rt

参考文献：

Preparation of aryl aniline β-2 adrenergic receptor agonists

, United States, , ,

合成路线：1 步

100331-93-9

反应条件：

1.1 Catalysts: Acetic anhydride

参考文献：

Carbostyril derivative

, European Patent Organization, , ,

合成路线：1 步

100-44-7

反应条件：

1.1 Reagents: Sodium iodide Catalysts: Sodium carbonate

参考文献：

Ether derivatives of oximes with a carbostyril ring. 4. Syntheses and β-blocking activities

Amlaiky, Nourdine; Leclerc, Gerard; Decker, Nicole; Schwartz, Jean, European Journal of Medicinal Chemistry, 1984, 19(4), 341-6

合成路线：1 步

参考文献：

Process for preparing isomers of carmoterol

, United States, , ,

合成路线：1 步