93-85-6 (2-氨基苯并噻唑-6-甲酸,2-amino-1,3-benzothiazole-6-carboxylic acid)

_97%

反应条件：

1.1 Reagents: Iodate(1-), dichloro-, sodium Solvents: Dimethyl sulfoxide , Water ; 5 min, rt; rt → 70 °C; 10 h, 70 °C
1.2 Reagents: Water

参考文献：

A novel system for the synthesis of 2-aminobenzothiazoles using sodium dichloroiodate

Telvekar, Vikas N.; Bachhav, Harshal M.; Bairwa, Vinod Kumar, Synlett, 2012, 23(15), 2219-2222

合成路线：1 步

866000-88-6

_97%

反应条件：

1.1 Reagents: Lithium hydroxide, monohydrate Solvents: Tetrahydrofuran , Water ; 24 h, rt

参考文献：

Preparation of N-(2-amino and 2-hydroxy)phenyl carboxamides as inhibitors of histone deacetylase

, World Intellectual Property Organization, , ,

合成路线：1 步

_89%

反应条件：

1.1 Reagents: Benzyltrimethylammonium dichloroiodate Solvents: Dimethyl sulfoxide , Water ; 1 h, 70 °C; 70 °C → rt
1.2 Reagents: Water ; rt

参考文献：

An efficient one-pot synthesis of 2-aminobenzothiazoles from substituted anilines using benzyltrimethylammonium dichloroiodate and ammonium thiocyanate in DMSO:H2O

Dass, Reuben; Peterson, Matt A., Tetrahedron Letters, 2021, 83,

合成路线：1 步

68867-21-0

_88%

反应条件：

1.1 Reagents: Hydrochloric acid Solvents: Water ; 10 h, 100 °C

参考文献：

A study of the synthesis of benzo[d]thiazolone-6-carboxylic acid

Zhu, Hui; Luo, Zi-li; Yang, Ri-fang; Yun, Liu-hong, Jiefangjun Yaoxue Xuebao, 2011, 27(3), 197-198

合成路线：1 步

_88%

反应条件：

1.1 Reagents: Bromine Solvents: Acetic acid ; 30 min, 5 - 10 °C; 10 °C → rt; 30 min, rt; rt
1.2 Reagents: Ammonium hydroxide Solvents: Water ; pH 6, rt

参考文献：

Salts of 6-carboxy-3-methylbenzothiazolone hydrazone hydrate in colorimetric determination of hydrogen peroxide

, United States, , ,

合成路线：1 步

7366-56-5

_78%

反应条件：

1.1 Reagents: Bromine Solvents: Chloroform ; 1 h, < 10 °C; 30 min, reflux

参考文献：

Synthesis, characterization and analgesic activity of some novel substituted 2-amino benzothiazole derivatives

Raju, D. Nooka; Devi, D. V. R. Subhadra; Aghastina, D. Grace; Rao, K. Govinda; Kumar, K. Sathish, World Journal of Pharmacy and Pharmaceutical Sciences, 2015, 4(5), 1815-1821

合成路线：1 步

302-04-5

_78%

反应条件：

1.1 Reagents: Bromine Solvents: Acetic acid

参考文献：

The exchange adsorption of ions from aqueous solutions by organic zeolites. I. Ion-exchange equilibria

Boyd, G. E.; Schubert, J.; Adamson, A. W., Journal of the American Chemical Society, 1947, 69, 2818-29

合成路线：1 步

_75%

反应条件：

1.1 Reagents: Hydrochloric acid Solvents: Ethanol , Water
1.2 Reagents: Bromine Solvents: Acetic acid ; 2 h, reflux

参考文献：

Synthesis, characterization and pharmacological studies of biologically active benzothiazole derivatives

Maruthamuthu, D.; Rajam, P. Shameela; Stella, P. Christina Ruby; Ranjith, R., World Journal of Pharmaceutical Research, 2014, 3, 1165-1173

合成路线：1 步

_67%

反应条件：

1.1 Reagents: Bromine Solvents: Acetic acid , Water ; rt → 0 °C; 0 - 10 °C; 1 h, 5 °C
1.2 Reagents: Hydrochloric acid Solvents: Water ; 2 h, reflux

参考文献：

Synthesis and anti-microbial activity of some new 2-Amino substituted benzothiazole derivatives

Malik, Jitender K.; Manvi, F. V.; Nanjwade, B. K.; Singh, Sanjiv, Journal of Pharmacy Research, 2009, 2(9), 1383-1384

合成路线：1 步

_67%

反应条件：

1.1 Reagents: Bromine Solvents: Acetic acid , Water ; rt → 0 °C; 0 - 10 °C; 1 h, 5 °C
1.2 Reagents: Hydrochloric acid Solvents: Water ; 2 h, reflux

参考文献：

Synthesis and screening of some new 2-amino substituted-benzothiazole derivatives for antifungal activity

Malik, Jitender K.; Manvi, F. V.; Nanjwade, B. K.; Singh, Sanjiv, Drug Invention Today, 2009, 1(1), 32-34

合成路线：1 步

68867-21-0

_59%

反应条件：

1.1 Reagents: Hydrochloric acid Solvents: Water ; 6 h, 100 °C

参考文献：

Preparation of novel piperazine derivatives as dopamine D3 receptor ligands

, United States, , ,

合成路线：1 步

68867-21-0

_59%

反应条件：

1.1 Reagents: Hydrochloric acid Solvents: Water ; 6 h, 100 °C

参考文献：

Preparation of piperazine derivatives as dopamine d3 receptor ligands

, World Intellectual Property Organization, , ,

合成路线：1 步

66947-92-0

_33%

反应条件：

1.1 Reagents: Sodium hydroxide Solvents: Ethanol , Water ; 4 h, rt

参考文献：

Phenylimidazole derivatives as new inhibitors of bacterial enoyl-ACP reductase FabK

Kitagawa, Hideo; Ozawa, Tomohiro; Takahata, Sho; Iida, Maiko, Bioorganic & Medicinal Chemistry Letters, 2007, 17(17), 4982-4986

合成路线：1 步

反应条件：

1.1 Reagents: Ammonium hydroxide , Iron chloride (FeCl3) , Ferrous chloride Solvents: Water ; 6 h, 80 °C

参考文献：

Preparation and Characterization of a Novel Magnetic Nano Catalyst for Synthesis and Antibacterial Activities of Novel Furan-2(5H)-Ones Derivatives

Hao, Feng; Wang, Xia; Mohammadnia, Majid, Polycyclic Aromatic Compounds, 2022, 42(7), 4255-4269

合成路线：1 步

590-28-3

反应条件：

1.1 Solvents: Acetic acid ; 50 min, rt
1.2 Reagents: Bromine ; 0 °C; 24 h, rt
1.3 Solvents: Water ; 1.5 h, 70 - 80 °C

参考文献：

Dye compound and a labeling method thereof

, Korea, , ,

合成路线：1 步

反应条件：

1.1 Solvents: Acetic acid ; 50 min, rt
1.2 Reagents: Bromine ; 0 °C; 24 h, rt
1.3 Solvents: Water ; 1.5 h, 70 - 80 °C
1.4 Reagents: Ammonia Solvents: Water ; pH 6

参考文献：

Development highly water-soluble fluorescent dyes with preferred binding activities to biomolecules and spectrophotometric properties

, World Intellectual Property Organization, , ,

合成路线：1 步

99-05-8

反应条件：

1.1 Reagents: Acetic acid , Bromine ; 3 h, 0 - 10 °C

参考文献：

Design and synthesis of Quinazolinone, Benzothiazole derivatives bearing guanidinopropanoic acid moiety and their Schiff bases as cytotoxic and antimicrobial agents

Venkatesh, Palani; Tiwari, Vijay Shankar, Arabian Journal of Chemistry, 2016, 9,

合成路线：1 步

反应条件：

1.1 Solvents: Acetic acid ; 10 - 20 min, cooled
1.2 Reagents: Bromine Solvents: Acetic acid ; < 10 °C; 2 - 4 h, rt
1.3 Reagents: Ammonium hydroxide Solvents: Water ; pH 11

参考文献：

Chrysin-benzothiazole conjugates as antioxidant and anticancer agents

Mistry, Bhupendra M.; Patel, Rahul V.; Keum, Young-Soo; Kim, Doo Hwan, Bioorganic & Medicinal Chemistry Letters, 2015, 25(23), 5561-5565

合成路线：1 步

反应条件：

1.1 Reagents: Bromine Solvents: Acetic acid ; < 10 °C; 30 min, < 10 °C
1.2 Solvents: Water

参考文献：

Synthesis, characterization and evaluation for antifungal activity of substituted (diaryl)imidazo[2,1-b]benzothiazoles

Malik, Jitender K.; Soni, Himesh; Singhai, A. K., Journal of Pharmacy Research (Gurgaon, 2013, 7(1), 39-46

合成路线：1 步