938-97-6 (对羟基苯甘氨酸,4-Hydroxyphenylglycine)

反应条件：

1.1 Reagents: Sodium carbonate Solvents: Methanol ; rt → 60 °C; 2 h, 60 °C

参考文献：

Asymmetric resolution of D-p-hydroxyphenylglycine

Yang, Fan; Zhang, Zhenglin; Zou, Jianzhong, Zhongguo Yiyao Gongye Zazhi, 2005, 36(4), 199-200

合成路线：1 步

123-08-0

74-90-8

_97%

反应条件：

1.1 Solvents: Methanol , Water ; 10 min, rt
1.2 Reagents: Trisodium citrate Solvents: Water ; 25 °C; 30 °C
1.3 Reagents: Sulfuric acid ; pH 3
1.4 Reagents: Carbon dioxide , Ammonia Solvents: Water ; 30 °C → 80 °C; 80 °C → 120 °C; 0.8 - 1 MPa, 120 °C → 140 °C; 0.5 MPa, 101 °C
1.5 Reagents: Sodium hydroxide Solvents: Water ; 0.8 - 1 MPa, 178 °C; 0.5 MPa, 101 °C
1.6 Reagents: Sulfuric acid Solvents: Water ; pH 5 - 5.5, < 100 °C; 100 °C → 35 °C

参考文献：

Process for preparation of D,L-phenylglycine derivatives

, China, , ,

合成路线：1 步

86788-93-4

_93%

反应条件：

1.1 Reagents: p-Toluenesulfonic acid Solvents: Acetonitrile

参考文献：

Deprotection of 4-methoxybenzyloxycarbonyl group with p-toluenesulfonic acid in acetonitrile. Application to a large-scale preparation of 7-[D-2-amino-2-(4-hydroxyphenyl)acetamido]cephalosporanic acid

Yamada, Hirotada; Tobiki, Hisao; Tanno, Norihiko; Suzuki, Hiroyuki; Jimpo, Kiyokazu; et al, Bulletin of the Chemical Society of Japan, 1984, 57(11), 3333-4

合成路线：1 步

1198-84-1

_92%

参考文献：

Synthesis of DL-2-(p-hydroxyphenyl)glycine by the ammonolysis of p-hydroxymandelic acid obtained by the condensation of phenol with glyoxylic acid

Powar, Netaji P.; Chandalia, Sampatraj B., Journal of Chemical Technology and Biotechnology, 1989, 46(3), 219-32

合成路线：1 步

123-08-0

67-66-3

_91%

反应条件：

1.1 Reagents: Potassium hydroxide , β-Cyclodextrin , Ammonia Catalysts: Hexadecyltrimethylammonium bromide Solvents: Dichloromethane , Water

参考文献：

Synthesis of p-hydroxyphenylglycine

Liu, Changchun, Huagong Shikan, 2001, 15(9), 25-27

合成路线：1 步

69322-01-6

_91%

反应条件：

1.1 Reagents: Ammonium hydroxide , Ammonium chloride

参考文献：

p-Hydroxyphenylglycine or an N-alkyl or an N,N-dialkyl derivative

, Netherlands, , ,

合成路线：1 步

_90%

反应条件：

1.1 Reagents: Sulfamic acid Solvents: Water ; 45 min, 120 °C

参考文献：

Preparation of DL-4-hydroxyphenylglycine in pulse tube reactor

, China, , ,

合成路线：1 步

_88%

反应条件：

1.1 Catalysts: p-Toluenesulfonic acid ; 20 h, 35 °C
1.2 Reagents: Sodium hydroxide , Sodium bisulfite Solvents: Water ; pH 3, 25 °C

参考文献：

Method for synthesizing p-hydroxyphenylglycine

, China, , ,

合成路线：1 步

4746-62-7

_84%

反应条件：

1.1 Reagents: Phosphoric acid ; rt → 65 °C; 7 h, 60 - 65 °C
1.2 Reagents: Sodium bicarbonate Solvents: Water ; pH 4.8

参考文献：

Process for preparation of 4-hydroxyphenylglycine

, China, , ,

合成路线：1 步

_84%

反应条件：

1.1 Reagents: Sulfamic acid Catalysts: Sulfuric acid Solvents: Water ; 5 - 6 h, 70 °C
1.2 Reagents: Ammonia Solvents: Water ; 24 h, pH 7

参考文献：

Study on synthesis of DL-p-hydroxyphenylglycine

Zhang, Jing; Tu, Wei-ping, Yingyong Huagong, 2003, 32(5), 46-48

合成路线：1 步

_80%

反应条件：

1.1 Reagents: Sulfamic acid Catalysts: Phosphoric acid Solvents: Hexane , Water ; 70 - 75 °C; 2 h; 4 h
1.2 Solvents: Water ; 65 - 70 °C
1.3 Reagents: Ammonia Solvents: Water ; pH 3 - 5

参考文献：

Method for preparation of p-hydroxyphenylglycine

, China, , ,

合成路线：1 步

_78%

反应条件：

1.1 Reagents: Sulfamic acid Catalysts: Sodium hydroxide , Ammonium nitrate , Aluminum hydroxide Solvents: Water ; rt → 60 °C; 7 h, 60 °C; 60 °C → rt
1.2 Reagents: Ammonium hydroxide ; pH 6, rt; 1 h, rt

参考文献：

Solid acid catalyst and preparation method thereof and preparation method of para-hydroxyphenylglycine

, China, , ,

合成路线：1 步

_75%

反应条件：

1.1 Reagents: Sulfamic acid ; 28 °C
1.2 76 °C

参考文献：

An in-depth mechanistic study of the p-hydroxyphenylglycine synthetic process using in situ ATR-IR spectroscopy

Mao, Hai-Fang; Xing, Hui-Min; Jin, Miao-Miao; Liu, Ji-Bo; Yao, Yue-Liang; et al, Analytical Methods, 2022, 14(29), 2833-2840

合成路线：1 步

_75%

反应条件：

1.1 Reagents: Sulfamic acid Catalysts: Benzyltriethylammonium chloride ; rt → 70 °C; 8 h, 70 °C
1.2 Reagents: Ammonium hydroxide Solvents: Water ; pH 7; cooled

参考文献：

Study on synthesis of DL-p-hydroxyphenylglycine

Pei, Lei; Liu, Fusheng; Yu, Shitao, Jingxi Shiyou Huagong Jinzhan, 2007, 8(11), 20-23

合成路线：1 步

123-08-0

7677-24-9

_75%

反应条件：

1.1 Reagents: Benzylamine Solvents: Ethanol
1.2 Solvents: Tetrahydrofuran
1.3 Reagents: Ammonium chloride Solvents: Tetrahydrofuran , Water
1.4 Reagents: Hydrochloric acid Solvents: Water
1.5 Reagents: Hydrogen Catalysts: Palladium Solvents: Methanol

参考文献：

Novel method of preparing hydroxyarylglycines, alkoxyarylglycines and the glycinates thereof, from aromatic aldehydes and benzylamine

, World Intellectual Property Organization, , ,

合成路线：1 步

_74%

反应条件：

1.1 Reagents: 4-Nitrophthalimide ; 10 h, 65 °C; 65 °C → 25 °C

参考文献：

Process for preparation of DL-p-hydroxyphenylglycine

, China, , ,

合成路线：1 步

_73%

反应条件：

1.1 Catalysts: p-Toluenesulfonamide , Ethylene glycol ; 30 °C; 20 °C; 35 °C; 65 °C
1.2 pH 4 - 5
1.3 Reagents: Ammonia Solvents: Water ; pH 7, 35 - 45 °C

参考文献：

Production method and device of D,L-p-hydroxyphenylglycine by adopting staged temperature control of multi-stage tubular reactor, continuous neutralization and kettle-type reactor

, China, , ,

合成路线：1 步

_70%

反应条件：

1.1 Reagents: Stearyldimethylbenzylammonium chloride Solvents: Water ; rt → 60 °C; 15 min, 60 °C
1.2 Reagents: Benzoic acid ; 8 h, 60 °C; 60 °C → rt
1.3 Reagents: Potassium carbonate Solvents: Water ; pH 6, rt

参考文献：

The preparation of D-4-hydroxyphenylglycine

Zhang, Da-shuai; Mu, Shuai; Niu, Duan; Liu, Ying; Wang, Ping-bao; et al, Jingxi Huagong Zhongjianti, 2013, 43(2), 33-36

合成路线：1 步

69322-01-6

_69%