940-62-5 (反式-4-氯肉桂酸,(2E)-3-(4-chlorophenyl)prop-2-enoic acid)

_100%

反应条件：

1.1 Reagents: Pyridine Solvents: Dimethylformamide ; 3 - 5 h, 90 °C
1.2 Reagents: Hydrochloric acid Solvents: Water ; pH 1

参考文献：

Design, synthesis and antibacterial activity of cinnamaldehyde derivatives as inhibitors of the bacterial cell division protein FtsZ

Li, Xin; Sheng, Juzheng; Huang, Guihua; Ma, Ruixin; Yin, Fengxin; et al, European Journal of Medicinal Chemistry, 2015, 97, 32-41

合成路线：1 步

_100%

反应条件：

1.1 Reagents: Pyridine Solvents: Dimethylformamide ; 3 - 5 h, 90 °C
1.2 Reagents: Hydrochloric acid Solvents: Water ; pH 1

参考文献：

Phenylacrylamides as novel FtsZ-targeted potential antimicrobials

Li, Xin; Sheng, Juzheng; Song, Di; Guo, Liwei; Ma, Shutao, Letters in Drug Design & Discovery, 2015, 12(3), 234-240

合成路线：1 步

49678-02-6

_99%

反应条件：

1.1 Reagents: Sodium carbonate , Oxygen Catalysts: Molybdate(4-), cupratehexa-μ3-hydroxyhexa-μ-oxododecaoxohexa-, ammonium (1:4) Solvents: Water ; 12 h, 50 °C

参考文献：

An Efficient Aerobic Oxidation Protocol of Aldehydes to Carboxylic Acids in Water Catalyzed by an Inorganic-Ligand-Supported Copper Catalyst

Yu, Han; Ru, Shi; Zhai, Yongyan; Dai, Guoyong; Han, Sheng; et al, ChemCatChem, 2018, 10(6), 1253-1257

合成路线：1 步

2033-24-1

_99%

反应条件：

1.1 Solvents: Water ; 5 min

参考文献：

A green chemical synthesis of coumarin-3-carboxylic and cinnamic acids using crop-derived products and waste waters as solvents

Fiorito, Serena; Taddeo, Vito Alessandro; Genovese, Salvatore; Epifano, Francesco, Tetrahedron Letters, 2016, 57(43), 4795-4798

合成路线：1 步

_99%

反应条件：

1.1 Reagents: Piperidine Solvents: Pyridine ; 5 h, reflux; cooled
1.2 Reagents: Hydrochloric acid Solvents: Water ; cooled

参考文献：

Expedient Iodocyclization Approach Toward Polysubstituted 3H-Benzo[e]indoles

Martins, Guilherme M.; Zeni, Gilson; Back, Davi F.; Kaufman, Teodoro S.; Silveira, Claudio C., Advanced Synthesis & Catalysis, 2015, 357(14-15), 3255-3261

合成路线：1 步

867-13-0

_99%

反应条件：

1.1 Reagents: Sodium hydride Solvents: Dichloromethane ; 0 °C; 0 °C → rt
1.2 Reagents: Sodium hydroxide Solvents: Methanol , Dichloromethane ; 2 h, rt

参考文献：

Process for preparation of cinnamic acid and derivatives thereof

, China, , ,

合成路线：1 步

99-90-1

_99%

反应条件：

1.1 Reagents: Sodium acetate Catalysts: Palladium alloy, base, Pd 89,Ni 8.2,P 3 Solvents: Dimethylacetamide ; 15 h, 140 °C
1.2 Reagents: Hydrochloric acid Solvents: Water ; acidified, rt

参考文献：

Reusable and Sustainable Nanostructured Skeleton Catalyst: Heck Reaction with Nanoporous Metallic Glass Pd (PdNPore) as a Support, Stabilizer and Ligand-Free Catalyst

Kaneko, Tetsuro; Tanaka, Shinya; Asao, Naoki; Yamamoto, Yoshinori; Chen, Mingwei; et al, Advanced Synthesis & Catalysis, 2011, 353(16), 2927-2932

合成路线：1 步

_99%

反应条件：

1.1 Catalysts: 1-Octanesulfonic acid, 1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8,8-heptadecafluoro-, ytter… Solvents: Toluene , Perfluorodecalin ; 8 h, 80 °C

参考文献：

Ytterbium perfluorooctanesulfonate-catalyzed Knoevenagel condensation in a fluorous biphasic system

Yi, Wen-Bin; Yin, Ya-Qing; Cai, Chun, Organic Preparations and Procedures International, 2006, 39(1), 71-75

合成路线：1 步

20754-21-6

_98%

反应条件：

1.1 Reagents: Lithium hydroxide Solvents: Tetrahydrofuran , Water ; 2 h, rt
1.2 Reagents: Hydrochloric acid Solvents: Water ; pH 5, rt

参考文献：

Design and Synthesis of Bitopic 2-Phenylcyclopropylmethylamine (PCPMA) Derivatives as Selective Dopamine D3 Receptor Ligands

Tan, Liang; Zhou, Qingtong ; Yan, Wenzhong; Sun, Jian; Kozikowski, Alan P.; et al, Journal of Medicinal Chemistry, 2020, 63(9), 4579-4602

合成路线：1 步

_98%

反应条件：

1.1 Catalysts: Dabco Solvents: Dimethylformamide ; 80 min, 100 - 110 °C

参考文献：

A simple and straightforward synthesis of cinnamic acids and ylidene malononitriles via Knoevenagel condensation employing DABCO as catalyst

Nagalakshmi, K.; Diwakar, B. S.; Govindh, B.; Reddy, P. Gopal; Venu, R.; et al, Asian Journal of Chemistry, 2017, 29(7), 1561-1564

合成路线：1 步

_98%

反应条件：

1.1 Reagents: Tributylamine Catalysts: Palladium , Hydroxyethyl cellulose Solvents: Water ; 6 h, 90 °C; cooled
1.2 Reagents: Sodium carbonate Solvents: Water ; 10 min

参考文献：

Preparation of hydroxyethyl cellulose supported palladium complex and its catalytic performance for Heck reaction

Cai, Yonghong; Xu, Ying; Zhang, Lei; Cui, Yuanchen; Li, Enzhong, Henan Daxue Xuebao, 2008, 38(5), 474-478

合成路线：1 步

_98%

反应条件：

1.1 Reagents: Tributylamine , Oxygen Catalysts: Cellulose (reaction products with epichlorohydrin and thiosemicarbazide) Solvents: Water ; 5 h, 110 °C; cooled
1.2 Reagents: Sodium carbonate Solvents: Water ; 10 min
1.3 Reagents: Hydrochloric acid Solvents: Water ; acidified

参考文献：

Synthesis of thiosemicarbazide cellulose supported palladium complex and its catalytic behavior in Heck reaction

Xu, Ying; Cai, Yonghong; Cui, Yuanchen; Li, Jinjin, Shiyou Huagong, 2008, 37(4), 328-332

合成路线：1 步

_97%

反应条件：

1.1 Reagents: Tributylamine Catalysts: Iron oxide (Fe3O4) , Palladium , 2-Propenoic acid, 2-methyl-, methyl ester, polymer with 2-oxiranylmethyl 2-methy… (triethylene tetramine-modified) Solvents: Dimethylformamide ; 3 h, 95 °C; 95 °C → rt

参考文献：

Supported nanosized palladium on superparamagnetic composite microspheres as an efficient catalyst for Heck reaction

Yuan, Dingzhong; Zhang, Qiuyu; Dou, Jinbo, Catalysis Communications, 2010, 11(7), 606-610

合成路线：1 步

31357-32-1

_97%

反应条件：

1.1 Reagents: Zinc Solvents: Acetic acid ; 1 min, rt

参考文献：

Rapid debromination of vic-dibromoalkanes with zinc powder in acetic acid under microwave irradiation

Kuang, Chunxiang; Yang, Qing; Senboku, Hisanori; Tokuda, Masao, Journal of Chemical Research, 2005, (5), 282-284

合成路线：1 步

_97%

反应条件：

1.1 Catalysts: Lithium chloride ; 6 min

参考文献：

Microwave-assisted solvent-free synthesis of trans-cinnamic acids using lithium chloride as catalyst

Mogilaiah, K.; Reddy, G. Randheer, Synthetic Communications, 2004, 34(2), 205-210

合成路线：1 步

49678-02-6

_96%

反应条件：

1.1 Reagents: Sodium carbonate , Oxygen Catalysts: 1-Butanaminium, N,N,N-tributyl-, [μ7-[2-amino-2-[(hydroxy-κO:κO:κO)methyl]-1,3-p… Solvents: Water ; 8 h, 50 °C

参考文献：

An Efficient Iron(III)-Catalyzed Aerobic Oxidation of Aldehydes in Water for the Green Preparation of Carboxylic Acids

Yu, Han; Ru, Shi; Dai, Guoyong; Zhai, Yongyan; Lin, Hualin; et al, Angewandte Chemie, 2017, 56(14), 3867-3871

合成路线：1 步

_96%

反应条件：

1.1 Catalysts: Piperidine Solvents: Pyridine ; 6 h, reflux

参考文献：

Synthesis and SAR study of diarylpentanoid analogues as new anti-inflammatory agents

Leong, Sze Wei; Faudzi, Siti Munirah Mohd; Abas, Faridah; Aluwi, Mohd Fadhlizil Fasihi Mohd; Rullah, Kamal; et al, Molecules, 2014, 19(10), 16058-16081

合成路线：1 步

_96%

反应条件：

1.1 Reagents: Piperidine Solvents: Pyridine ; 1 h, reflux
1.2 Reagents: Hydrochloric acid Solvents: Water ; neutralized, cooled

参考文献：

Design, synthesis, and insecticidal activity of 1,5-diphenyl-1-pentanone analogues

Yang, Shaoxiang; Kang, Tieniu; Rui, Changhui; Yang, Xinling; Sun, Yufeng; et al, Chinese Journal of Chemistry, 2011, 29(11), 2394-2400

合成路线：1 步

_96%

反应条件：

1.1 Catalysts: Piperidine Solvents: Pyridine ; 3 h, reflux

参考文献：

Studies on the synthesis of ammonium salts of 2,4-dichlorophenoxyacetic acid (2,4-D) to enhance its bioregulating potential

Seth, Anubhuti; Garg, Anita; Sharma, M. L., Journal of the Indian Chemical Society, 2011, 88(3), 405-414

合成路线：1 步

_96%