941685-26-3 (4-氯-7-((2-(三甲基甲硅烷基)乙氧基)甲基)-7h-吡咯并[2,3-d]嘧啶,2-[(4-chloropyrrolo[2,3-d]pyrimidin-7-yl)methoxy]ethyl-trimethyl-silane)

_100%

反应条件：

1.1 Reagents: Sodium hydride Solvents: Dimethylformamide ; 1 h, rt
1.2 cooled; 1 h, cooled
1.3 Solvents: Water

参考文献：

Pyrrolopyrimidine-derived compound and pharmaceutical composition and application thereof

, China, , ,

合成路线：1 步

_100%

反应条件：

1.1 Reagents: Sodium hydride Solvents: Dimethylformamide ; cooled; 1 h, cooled
1.2 cooled; 1 h, cooled
1.3 Solvents: Water

参考文献：

Pyrrolopyrimidine-derived compound and pharmaceutical composition and for treating tumor and autoimmune disease

, China, , ,

合成路线：1 步

_100%

反应条件：

1.1 Reagents: Sodium hydride Solvents: Dimethylformamide ; 15 min, rt
1.2 30 min, rt

参考文献：

Preparation of tricyclic compounds for the treatment of immunological and oncological conditions

, World Intellectual Property Organization, , ,

合成路线：1 步

_97%

反应条件：

1.1 Reagents: Sodium hydride Solvents: Dimethylformamide ; -20 - -10 °C; -20 - -10 °C; 2 h, -20 - -10 °C
1.2 Reagents: Acetic acid

参考文献：

Process for synthesis of ruxolitinib

, World Intellectual Property Organization, , ,

合成路线：1 步

_97%

反应条件：

1.1 Reagents: Sodium hydride Solvents: Dimethylformamide ; < 10 °C; 1 h, < 10 °C
1.2 < 10 °C; 10 °C → rt; overnight, rt
1.3 Solvents: Water ; rt

参考文献：

Preparation of azetidine derivatives for treating JAK-related diseases

, World Intellectual Property Organization, , ,

合成路线：1 步

_97%

反应条件：

1.1 Reagents: Sodium hydride Solvents: Dimethylformamide ; 0 °C; 15 min, rt
1.2 30 min, rt

参考文献：

Preparation pyrrolopyrimidinamines as janus kinase 1 selective inhibitor

, Korea, , ,

合成路线：1 步

_97%

反应条件：

1.1 Reagents: Sodium hydride Solvents: Dimethylacetamide ; -5 °C; 60 min, 0 °C
1.2 0 °C; 1 h, 0 °C
1.3 Solvents: tert-Butyl methyl ether , Water ; 0 °C; 10 min, 0 °C

参考文献：

Pyrrolo[2,3-d]pyrimidine derivatives as JAK1 inhibitors and their preparation and use for the treatment of myelodysplastic syndromes

, World Intellectual Property Organization, , ,

合成路线：1 步

_97%

反应条件：

1.1 Reagents: Sodium hydride Solvents: Dimethylacetamide ; -5 °C; 60 min, 0 °C
1.2 0 °C; 1 h, 0 °C
1.3 Reagents: Water

参考文献：

Preparation of piperidin-4-yl azetidine derivatives as JAK1 inhibitors

, World Intellectual Property Organization, , ,

合成路线：1 步

_94%

反应条件：

1.1 Reagents: Sodium hydride Solvents: Dimethylformamide ; 1 h, 20 °C; 20 °C → 0 °C
1.2 12 h, 20 °C

参考文献：

Preparation of bicyclic compounds as JAK inhibitors and uses thereof

, World Intellectual Property Organization, , ,

合成路线：1 步

_94%

反应条件：

1.1 Reagents: Sodium hydride Solvents: Dimethylformamide ; 0 °C; 1 h, 0 °C
1.2 0 °C; 1.5 h, 0 °C → rt
1.3 Reagents: Sodium bicarbonate Solvents: Diethyl ether , Water

参考文献：

Preparation of pyrrolopyrimidine derivatives as TAM inhibitors useful for treatment of cancer

, World Intellectual Property Organization, , ,

合成路线：1 步

_92%

反应条件：

1.1 Reagents: Sodium hydride Solvents: Dimethylformamide ; 1 h, rt
1.2 cooled; 1 h, cooled
1.3 Reagents: Water

参考文献：

Pyrrolopyrimidine crystal as JAK inhibitor and its preparation

, China, , ,

合成路线：1 步

_92%

反应条件：

1.1 Reagents: Sodium hydride Solvents: Dimethylformamide ; 1 h, rt
1.2 cooled; 1 h, cooled
1.3 Reagents: Water

参考文献：

Process for the preparation of (R)-3-amino-β-cyclopentyl-4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazole-1-propanenitrile

, China, , ,

合成路线：1 步

_90%

反应条件：

1.1 Reagents: Sodium hydride Solvents: Dimethylformamide ; 0 °C; 1 h, rt
1.2 0 °C; 1 h, 0 °C
1.3 Reagents: Water

参考文献：

Pyrrolopyrimidine-pyrazole-cyclopentane compounds as Janus kinase inhibitors and their preparation, pharmaceutical compositions and use in the treatment of cancer

, China, , ,

合成路线：1 步

_90%

反应条件：

1.1 Reagents: Sodium hydride Solvents: Dimethylacetamide ; cooled; 15 min, cooled
1.2 cooled
1.3 Reagents: Water

参考文献：

Design and Synthesis of Ligand Efficient Dual Inhibitors of Janus Kinase (JAK) and Histone Deacetylase (HDAC) Based on Ruxolitinib and Vorinostat

Yao, Lianbin; Mustafa, Nurulhuda; Tan, Eng Chong; Poulsen, Anders ; Singh, Prachi; et al, Journal of Medicinal Chemistry, 2017, 60(20), 8336-8357

合成路线：1 步

_90%