94-71-3 (2-羟基苯乙醚,2-Ethoxyphenol)

105-58-8

_100%

反应条件：

1.1 Catalysts: Hydroxylapatite (Ca5(OH)(PO4)3) ; 5 h, 230 °C → 450 °C

参考文献：

Preparation method of catechol monoethyl ether from catechol and diethyl carbonate by gas-solid reaction in presence of hydroxyapatite as catalyst

, China, , ,

合成路线：1 步

105-58-8

_100%

反应条件：

1.1 Catalysts: Zirconium dioxide , Titanium tetrabutoxide , Titania , Zirconium oxychloride octahydrate , Phosphate ; 5 h, 200 °C

参考文献：

Process for the preparation of 2-ethoxyohenol

, China, , ,

合成路线：1 步

492-88-6

_98%

反应条件：

1.1 Catalysts: Ruthenium trichloride , Rhodium oxide (Rh2O3) ; 4 h, rt → 150 °C

参考文献：

Preparation method of o-ethoxyphenol from o-ethyl vanillin

, China, , ,

合成路线：1 步

_96%

反应条件：

1.1 Reagents: Potassium carbonate , Sodium hydroxide Solvents: Toluene , Water ; 5 min, rt
1.2 rt; 5 h, rt → 140 °C; 140 °C → rt
1.3 Reagents: Hydrochloric acid Solvents: Water ; pH 2 - 3

参考文献：

Method for preparing o-hydroxy phenyl alkyl ethers from catechol

, China, , ,

合成路线：1 步

64-67-5

_93%

反应条件：

1.1 Reagents: Sodium hydroxide Catalysts: Benzenemethanaminium, N-methyl-N,N-dioctadecyl-, chloride (1:1) Solvents: Ethanol , Toluene , Water ; 60 °C; 3 h, 60 °C

参考文献：

Study on synthesis of drug intermediate o-ethoxyphenol by phase transfer catalysis

Shu, Xue-jun; Yin, Xu-guang; Yang, Long; Wang, Bo; Sun, Qing; et al, Huaxue Shijie, 2012, 53(2), 95-97

合成路线：1 步

613-69-4

_93%

反应条件：

1.1 Reagents: Hydrogen peroxide , Bis(2-nitrophenyl) diselenide Solvents: Dichloromethane , Water ; 20 h, 25 °C

参考文献：

The Baeyer-Villiger oxidation of ketones and aldehydes

Krow, Grant R., Organic Reactions (Hoboken, 1993, 43,

合成路线：1 步

613-69-4

_93%

反应条件：

1.1 Reagents: Hydrogen peroxide Catalysts: Bis(2-nitrophenyl) diselenide Solvents: Dichloromethane , Water
1.2 Reagents: Potassium hydroxide Solvents: Methanol

参考文献：

The Baeyer-Villiger oxidation of aromatic aldehydes and ketones with hydrogen peroxide catalyzed by selenium compounds. A convenient method for the preparation of phenols

Syper, Ludwik, Synthesis, 1989, (3), 167-72

合成路线：1 步

91589-77-4

274-09-9

_93%

参考文献：

Cleavage of the ether bond. X. The action of organocalcium halides on 1,3-benzoxathiole and 1,3-benzodioxole derivatives

Cabiddu, S.; Melis, S.; Marongiu, E.; Piras, P. P.; Podda, G., Journal of Organometallic Chemistry, 1976, 111(3), 249-55

合成路线：1 步

2979-26-2

_90%

反应条件：

1.1 Reagents: Sodium carbonate , Potassium hydroxide Catalysts: Palladium ; 2 h, 320 °C

参考文献：

Process for preparation of o-alkoxyphenol by dehydrogenation of o-alkoxycyclohexanol

, China, , ,

合成路线：1 步

108-95-2

_90%

反应条件：

1.1 Reagents: Sodium bicarbonate Catalysts: Potassium iodide Solvents: Ethanol ; 20 h, 70 °C

参考文献：

Study on synthesis of guaethol

Cheng, Wenfeng; Zhang, Wenjun; Ren, Chunhe; Xu, Xiaodong; Chen, Meifang, Henan Huagong, 2011, 28(2), 39-41

合成路线：1 步

_90%

反应条件：

1.1 Reagents: Sodium bicarbonate Catalysts: Potassium iodide Solvents: Ethanol ; 20 h, 70 °C

参考文献：

Synthesis of guethol

Cheng, Wen-feng; Zhang, Wen-jun; Ren, Chun-he; Xu, Xiao-dong; Chen, Mei-fang, Zhejiang Huagong, 2011, 42(2), 8-10

合成路线：1 步

64-17-5

_90%

反应条件：

1.1 Reagents: Phosphorus pentoxide , Alumina , Silica Catalysts: Titania

参考文献：

O-Ethylation of catechol with ethanol on Al-P-Ti-Si-O catalyst

Li, Xue-Mei; Zhang, Wen-Xiang; Zhu, Xiao-Mei; Pan, Chun-Liu; Jiang, Da-Zhen; et al, Gaodeng Xuexiao Huaxue Xuebao, 2002, 23(8), 1552-1555

合成路线：1 步

_89%

反应条件：

1.1 Reagents: Sodium hydroxide Catalysts: Polyethylene glycol Solvents: Ethanol ; 1 h, 65 °C; 3.5 h, 65 °C

参考文献：

Study on the synthesis of o-ethoxyphenol

Zhang, Liqiong; Chai, Duoli, Guangdong Huagong, 2009, 36(4), 43-45

合成路线：1 步

_89%

反应条件：

1.1 Reagents: Sodium hydroxide Solvents: Water
1.2 Reagents: Polyethylene glycol

参考文献：

Etherification of phenols catalyzed by solid-liquid phase transfer catalyst PEG-400 without solvent

Cao, Yu-Qing; Pei, Ben-Gao, Synthetic Communications, 2000, 30(10), 1759-1766

合成路线：1 步

_88%

反应条件：

1.1 Reagents: Sodium hydroxide Solvents: Ethanol , Polyethylene glycol ; heated
1.2 1 h, 65 °C; 3.5 h, 65 °C
1.3 Reagents: Hydrogen ion Solvents: Water ; pH 3; cooled

参考文献：

Study on synthesis of perfume intermediate o-ethoxyphenol

Zhang, Li-qiong; Ji, Mu-ge; Wu, Bin; Du, Run-ping; Chai, Duo-li, Jingxi Yu Zhuanyong Huaxuepin, 2006, 14(24), 23-25

合成路线：1 步

917-64-6

274-09-9

_88%

反应条件：

1.1 Reagents: Sulfuric acid

参考文献：

Reaction of substituted benzodioxoles with methylmagnesium iodide under heterogeneous conditions

Beltrame, Paolo; Gelli, Gioanna; Lai, Adolfo; Monduzzi, Maura, Journal of Organic Chemistry, 1976, 41(3), 580-1

合成路线：1 步

94-70-2

_86%

反应条件：

1.1 Reagents: Sulfuric acid Solvents: Water ; rt → 80 °C; 30 min, 80 °C; 80 °C → 18 °C
1.2 Reagents: Sodium nitrite Solvents: Water ; 18 °C
1.3 Reagents: Sulfuric acid , Copper sulfate Solvents: Toluene , Water ; 87 °C

参考文献：

Synthesis of ethyl guaiacol

Lu, Xiao-lan; Feng, Xue-feng; Guo, Hui; Hu, Yu; Guo, Ying; et al, Jiangxi Shifan Daxue Xuebao, 2007, 31(6), 580-583

合成路线：1 步

_86%

反应条件：

1.1 Reagents: Sodium carbonate , Sodium hydroxide Catalysts: Tetramethylammonium bromide Solvents: Toluene , Water ; cooled; heated; 6 h, 0.2 - 1.0 MPa, 100 - 120 °C; 120 °C → rt
1.2 Reagents: Hydrochloric acid Solvents: Water ; pH 5 - 6, rt

参考文献：

Preparation of o-ethoxyphenol from catechol and chloroethane

, China, , ,

合成路线：1 步

_85%

反应条件：

1.1 Reagents: Sodium hydroxide Solvents: Water ; 140 - 145 °C; 145 °C → 165 °C; 160 - 165 °C

参考文献：

Pilot synthesis study of o-ethoxyphenol by alkylation of 1,2-dihydroxybenzene

Yuan, Bing; Wang, Li-fang; Sheng, Guang; Chen, Ji-xin; Wang, Fang, Huagong Keji, 2005, 13(4), 32-34

合成路线：1 步

_85%