94781-89-2 (1-羟基-6-氧代-1,6-二氢吡啶-2-羧酸,1-Hydroxy-6-oxo-1,6-dihydropyridine-2-carboxylic acid)

反应条件：

1.1 Reagents: Potassium hydroxide Solvents: Water ; 12 h, 70 °C
1.2 Reagents: Hydrochloric acid Solvents: Water ; < 20 °C

参考文献：

Synthesis of chromium(III) complex with 1-hydroxy-2-pyridinone-6-carboxylic acid as insulin-mimetic agent and its spectroscopic and computational studies

Yasarawan, Nuttawisit; Thipyapong, Khajadpai; Sirichai, Somsak; Ruangpornvisuti, Vithaya, Journal of Molecular Structure, 2013, 1031, 144-151

合成路线：1 步

_86%

反应条件：

1.1 Reagents: Potassium hydroxide Solvents: Water ; overnight, 80 °C
1.2 Reagents: Hydrochloric acid Solvents: Water ; cooled

参考文献：

Luminescent 1-hydroxy-2-pyridinone chelates of lanthanides

, World Intellectual Property Organization, , ,

合成路线：1 步

142832-29-9

_86%

反应条件：

1.1 Reagents: Potassium hydroxide Solvents: Water ; overnight, 80 °C
1.2 Reagents: Hydrochloric acid Solvents: Water ; cooled

参考文献：

Synthesis and use of polymeric membrane-supported hydroxypyridinone ligands for chelation of metals from aqueous solutions

, World Intellectual Property Organization, , ,

合成路线：1 步

142832-29-9

_86%

反应条件：

1.1 Reagents: Potassium hydroxide Solvents: Water ; overnight, 80 °C; cooled
1.2 Reagents: Hydrochloric acid Solvents: Water

参考文献：

Synthesis and use of solid-supported hydroxypyridinone-containing ligands as selective chelating agents for metal ions

, World Intellectual Property Organization, , ,

合成路线：1 步

_83%

反应条件：

1.1 Reagents: Trifluoroacetic acid , Peracetic acid Solvents: Acetic acid ; 1 h, rt; 12 h, rt → 80 °C

参考文献：

Evaluation of DFO-HOPO as an octadentate chelator for zirconium-89

Allott, L.; Da Pieve, C.; Meyers, J.; Spinks, T.; Ciobota, D. M.; et al, Chemical Communications (Cambridge, 2017, 53(61), 8529-8532

合成路线：1 步

_83%

反应条件：

1.1 Reagents: Potassium hydroxide Solvents: Water ; 3 d, 80 °C; cooled
1.2 Reagents: Hydrochloric acid Solvents: Water ; acidified

参考文献：

New Insights into Structure and Luminescence of EuIII and SmIII Complexes of the 3,4,3-LI(1,2-HOPO) Ligand

Daumann, Lena J.; Tatum, David S.; Snyder, Benjamin E. R.; Ni, Chengbao; Law, Ga-lai; et al, Journal of the American Chemical Society, 2015, 137(8), 2816-2819

合成路线：1 步

_79%

反应条件：

1.1 Reagents: Acetic acid , Trifluoroacetic acid , Peracetic acid ; 1 h, rt; 12 h, rt → 80 °C

参考文献：

Alternative Chelator for 89Zr Radiopharmaceuticals: Radiolabeling and Evaluation of 3,4,3-(LI-1,2-HOPO)

Deri, Melissa A.; Ponnala, Shashikanth; Zeglis, Brian M.; Pohl, Gabor; Dannenberg, J. J.; et al, Journal of Medicinal Chemistry, 2014, 57(11), 4849-4860

合成路线：1 步

_78%

反应条件：

1.1 Reagents: Trifluoroacetic acid Solvents: Acetic acid , Water ; 1 h, rt; overnight, 80 °C

参考文献：

Synthesis and iron chelating properties of hydroxypyridinone and hydroxypyranone hexadentate ligands

Zhou, Tao; Kong, Xiao-Le; Hider, Robert C., Dalton Transactions, 2019, 48(10), 3459-3466

合成路线：1 步

_77%

反应条件：

1.1 Reagents: Peracetic acid Solvents: Acetic acid ; rt → 80 °C; 12 h, 80 °C

参考文献：

Preparation of heterocyclic compounds as metal chelating compounds for use in treating diseases

, World Intellectual Property Organization, , ,

合成路线：1 步

_77%

反应条件：

1.1 Reagents: Peracetic acid Solvents: Acetic acid ; rt → 80 °C; 12 h, 80 °C

参考文献：

Synthesis of novel Iron(III) chelators based on triaza macrocycle backbone and 1-hydroxy-2(H)-pyridin-2-one coordinating groups and their evaluation as antimicrobial agents

Workman, David G.; Hunter, Michael; Dover, Lynn G.; Tetard, David, Journal of Inorganic Biochemistry, 2016, 160, 49-58

合成路线：1 步

_75%

反应条件：

1.1 Reagents: Potassium hydroxide Solvents: Water ; 12 h, rt → 80 °C; 0 °C
1.2 Reagents: Hydrochloric acid Solvents: Water

参考文献：

Synthesis of a new tetradentate chelator with 1-Hydoroxy-2(1H)-pyridinone (HOPO) as chelating unit: Interaction with Fe(III), solution thermodynamics and DFT studies

Dash, Dibyajit; Baral, Minati; Kanungo, B. K., Journal of Molecular Structure, 2020, 1222,

合成路线：1 步

_73%

反应条件：

1.1 Reagents: Acetic anhydride , Hydrogen peroxide Solvents: Water ; 4 h, cooled
1.2 Reagents: Trifluoroacetic acid Solvents: Acetic acid ; 1 h, rt; rt → 80 °C; 10 h, 80 °C
1.3 Reagents: Potassium hydroxide Solvents: Water ; 6 h, rt → 80 °C

参考文献：

Preparation of 2-hydroxy-1-oxo-1,2-dihydroisoquinoline chelating agents and their lanthanide complexes with diagnostic and pharmaceutical applications

, World Intellectual Property Organization, , ,

合成路线：1 步

_73%

反应条件：

1.1 Reagents: Trifluoroacetic acid , Peracetic acid Solvents: Acetic acid , Water

参考文献：

Synthesis and Initial Evaluation for In Vivo Chelation of Pu(IV) of a Mixed Octadentate Spermine-Based Ligand Containing 4-Carbamoyl-3-hydroxy-1-methyl-2(1H)-pyridinone and 6-Carbamoyl-1-hydroxy-2(1H)-pyridinone

Xu, Jide; Durbin, Patricia W.; Kullgren, Birgitta; Ebbe, Shirley N.; Uhlir, Linda C.; et al, Journal of Medicinal Chemistry, 2002, 45(18), 3963-3971

合成路线：1 步

_63%

反应条件：

1.1 Reagents: Trifluoroacetic acid , Peracetic acid Solvents: Acetic acid ; 1 h, rt; overnight, 80 °C; 16 h, 80 °C → rt

参考文献：

Iron(iii) and gallium(iii) metal organic polyhedra, methods of making same, and uses thereof

, World Intellectual Property Organization, , ,

合成路线：1 步

_48%

反应条件：

1.1 Reagents: Acetic anhydride , Hydrogen peroxide Solvents: Water ; 4 h, cooled
1.2 Solvents: Acetic acid , Trifluoroacetic acid ; cooled
1.3 1 h; 10 h, 80 °C; 80 °C → rt; 5 - 6 h, rt → 4 °C
1.4 Reagents: Potassium hydroxide Solvents: Water ; 6 h, reflux
1.5 Reagents: Hydrochloric acid Solvents: Water ; overnight, reflux → 4 °C

参考文献：

Zinc-binding groups modulate selective inhibition of MMPs

Agrawal, Arpita; Romero-Perez, Diego; Jacobsen, Jennifer A.; Villarreal, Francisco J.; Cohen, Seth M., ChemMedChem, 2008, 3(5), 812-820

合成路线：1 步

_37%

反应条件：

1.1 Reagents: Acetic anhydride , Hydrogen peroxide Solvents: Water ; 2 h, 0 °C; 2 h, rt
1.2 Solvents: Acetic acid , Trifluoroacetic acid ; rt; rt; 1 h, rt; 20 h, 75 - 80 °C

参考文献：

Binding of EuIII to 1,2-hydroxypyridinone-modified peptide nucleic acids

de Leon, Arnie R.; Olatunde, Abiola O.; Morrow, Janet R.; Achim, Catalina, Inorganic Chemistry, 2012, 51(23), 12597-12599

合成路线：1 步

反应条件：

1.1 Reagents: Trifluoroacetic acid , Peracetic acid

参考文献：

Compositions for therapeutics, targeted pet imaging and methods of their use

, World Intellectual Property Organization, , ,

合成路线：1 步

反应条件：

1.1 Reagents: Potassium hydroxide Solvents: Water ; 80 °C

参考文献：

Macrocycles for therapeutic and diagnostic applications

, World Intellectual Property Organization, , ,

合成路线：1 步

参考文献：

Preparation of pyran, pyridine and other derivatives and compositions with them for inhibiting influenza RNA polymerase PA subunit endonuclease

, United States, , ,

合成路线：1 步