95092-10-7 (N-甲氧基-N-甲基-2-苯基乙酰胺,N-Methoxy-N-methyl-2-phenylacetamide)

_100%

反应条件：

1.1 Reagents: Pyridine Solvents: Dichloromethane ; 0 °C; 4 h, rt

参考文献：

Structure-Based Drug Design of Mineralocorticoid Receptor Antagonists to Explore Oxosteroid Receptor Selectivity

Nordqvist, Anneli ; O'Mahony, Gavin; Friden-Saxin, Maria; Fredenwall, Marlene; Hogner, Anders; et al, ChemMedChem, 2017, 12(1), 50-65

合成路线：1 步

_100%

反应条件：

1.1 Reagents: Sodium hydroxide Solvents: Tetrahydrofuran , Water ; pH 4.5, rt
1.2 Reagents: 1-Ethyl-3-(3′-dimethylaminopropyl)carbodiimide hydrochloride Solvents: Water ; 0.5 h, pH 4.5, rt; 3 h, rt

参考文献：

Preparation of peptides for treating tumors

, United States, , ,

合成路线：1 步

_99%

反应条件：

1.1 Reagents: Pyridine Solvents: Dichloromethane ; 0 °C; overnight, rt

参考文献：

Assemblies of 1,4-Bis(diarylamino)naphthalenes and Aromatic Amphiphiles: Highly Reducing Photoredox Catalysis in Water

Hyodo, Yuki; Takahashi, Keigo; Chitose, Youhei; Abe, Manabu ; Yoshizawa, Michito; et al, Synlett, 2022, 33(12), 1184-1188

合成路线：1 步

_99%

反应条件：

1.1 Reagents: Pyridine Solvents: Dichloromethane ; 5 min, 0 °C; 10 min, 0 °C; 0 °C → rt; 1 h, rt
1.2 Reagents: Hydrochloric acid Solvents: Water

参考文献：

A Unified Strategy for the Synthesis of Difluoromethyl- and Vinylfluoride-Containing Scaffolds

Duchemin, Nicolas; Buccafusca, Roberto; Daumas, Marc; Ferey, Vincent; Arseniyadis, Stellios, Organic Letters, 2019, 21(20), 8205-8210

合成路线：1 步

_99%

反应条件：

1.1 Solvents: Dichloromethane ; rt → 0 °C
1.2 Reagents: Pyridine ; 5 min, 0 °C; 10 min, 0 °C; 0 °C → rt; 1 h, rt
1.3 Reagents: Hydrochloric acid Solvents: Water ; rt

参考文献：

Sequential C-selective difluoromethylation/Pd-catalyzed decarboxylative protonation: an efficient access to tertiary difluoromethylated Scaffolds

Duchemin, Nicolas; Buccafusca, Roberto; Daumas, Marc; Ferey, Vincent; Arseniyadis, Stellios, ChemRxiv, 2019, 1, 1-8

合成路线：1 步

140-29-4

_99%

反应条件：

1.1 Solvents: Water ; 12 h, pH 6, 30 °C
1.2 0.5 h, rt

参考文献：

Preparation of fosamprenavir intermediate (2R,3S)-1,2-epoxy-3-tert-butoxycarbonylamino-4-phenylbutane

, China, , ,

合成路线：1 步

_99%

反应条件：

1.1 Reagents: Pyridine Solvents: Dichloromethane ; 5 min, 0 °C; 5 min, 0 °C; 1 h, rt

参考文献：

Highly Stereoselective Cyclopropanation of α,β-Unsaturated Carbonyl Compounds with Methyl (Diazoacetoxy)acetate Catalyzed by a Chiral Ruthenium(II) Complex

Chanthamath, Soda; Takaki, Suguru; Shibatomi, Kazutaka; Iwasa, Seiji, Angewandte Chemie, 2013, 52(22), 5818-5821

合成路线：1 步

_98%

反应条件：

1.1 Reagents: Pyridine Solvents: Dichloromethane ; 0 °C; 2 h, 0 °C; 0 °C → rt

参考文献：

Enantioselective synthesis of hydantoins by chiral acid-catalysed condensation of glyoxals and ureas

Aryal, Sushant; Hone, Christopher A.; Polson, Matthew I. J.; Foley, Daniel J., Chemical Science, 2023, 14(29), 7905-7912

合成路线：1 步

_98%

反应条件：

1.1 Reagents: Pyridine Solvents: Dichloromethane

参考文献：

Stereoselective synthesis of substituted N-heterocycles via sequential cross metathesis-reductive cyclization

Gebauer, Julian; Dewi, Purnama; Blechert, Siegfried, Tetrahedron Letters, 2005, 46(1), 43-46

合成路线：1 步

_97%

反应条件：

1.1 Reagents: 1,1′-Carbonyldiimidazole Solvents: Tetrahydrofuran ; 1 h, rt
1.2 Reagents: Trimethylamine Solvents: Acetonitrile ; 1 h, rt
1.3 20 h, rt

参考文献：

Stereoselective synthesis of 2-aryl-4-en-1-ols, promising synthons for the preparation of oxygen heterocycles

Boev, V. I.; Moskalenko, A. I.; Belopukhov, S. L.; Nikonova, G. N., Russian Journal of Organic Chemistry, 2017, 53(2), 169-177

合成路线：1 步

_97%

反应条件：

1.1 Reagents: 1,1′-Carbonyldiimidazole Solvents: Dichloromethane ; rt; 1 h, rt
1.2 overnight, rt

参考文献：

3-Alkoxy-1,2-Dioxolanes: Synthesis and Evaluation as Potential Antimalarial Agents

Schiaffo, Charles E.; Rottman, Matthias; Wittlin, Sergio; Dussault, Patrick H., ACS Medicinal Chemistry Letters, 2011, 2(4), 316-319

合成路线：1 步

_95%

反应条件：

1.1 Reagents: Diisopropylethylamine , O-(7-Azabenzotriazol-1-yl)-N,N,N′,N′-tetramethyluronium hexafluorophosphate Solvents: Dichloromethane ; 6 h, rt

参考文献：

Preparation method of organic arsenic-based type II pyruvate kinase inhibitor, and its application in inhibiting tumor

, China, , ,

合成路线：1 步

_95%

反应条件：

1.1 Reagents: Triethylamine , Diethyl dicarbonate Solvents: Dimethylformamide ; 30 min, -10 °C; 2.5 h, rt

参考文献：

Composition for the treatment of IGF-1R expressing cancer

, World Intellectual Property Organization, , ,

合成路线：1 步

_95%

反应条件：

1.1 Reagents: Triethylamine , Diethyl cyanophosphonate Solvents: Dimethylformamide ; 30 min, -10 °C; 2.5 h, rt

参考文献：

Preparation of monomethyl auristatin F derivatives and their trastuzumab conjugates for treating cancers

, World Intellectual Property Organization, , ,

合成路线：1 步

_95%

反应条件：

1.1 Reagents: Triethylamine , Diethyl cyanophosphonate Solvents: Dimethylformamide ; 30 min, -10 °C; 2.5 h, rt

参考文献：

Preparation of humanized anti-human IGF-1R, HER2 and protein Axl antibodies conjugated with drug for treatment of cancer

, World Intellectual Property Organization, , ,

合成路线：1 步

_95%

反应条件：

1.1 Reagents: Triethylamine , Diethyl cyanophosphonate Solvents: Dimethylformamide ; 30 min, -10 °C; 2.5 h, rt

参考文献：

Preparation of humanized anti-human IGF-1R antibody-drug conjugates for cancer therapy

, World Intellectual Property Organization, , ,

合成路线：1 步

_95%

反应条件：

1.1 Reagents: Pyridine Solvents: Dichloromethane ; 30 min, 0 °C; 30 min, rt

参考文献：

Asymmetric photoredox transition-metal catalysis activated by visible light

Huo, Haohua; Shen, Xiaodong; Wang, Chuanyong; Zhang, Lilu; Roese, Philipp; et al, Nature (London, 2014, 515(7525), 100-103

合成路线：1 步

_95%