956-04-7 (4-氯查尔酮,4-chlorochalcone)

_100%

反应条件：

1.1 Catalysts: Sodium hydroxide , Water , Agar Solvents: Ethanol ; 15 min, 28 - 30 °C

参考文献：

Novel gel-entrapped base catalysts for the Claisen-Schmidt reaction

Chaphekar, Sachin S.; Samant, Shriniwas D., Journal of Chemical Technology and Biotechnology, 2004, 79(7), 769-773

合成路线：1 步

873-76-7

_99%

反应条件：

1.1 Reagents: Potassium hydroxide Catalysts: Titanium nitride Solvents: Toluene ; 10 h, 100 °C

参考文献：

Tuning the Product Selectivity of the α-Alkylation of Ketones with Primary Alcohols using Oxidized Titanium Nitride Photocatalysts and Visible Light

Li, Peifeng; Xiao, Gang ; Zhao, Yilin; Su, Haijia, ACS Catalysis, 2020, 10(6), 3640-3649

合成路线：1 步

_99%

反应条件：

1.1 Catalysts: Sodium hydroxide Solvents: Methanol , Water ; 24 h, rt
1.2 Reagents: Hydrochloric acid Solvents: Water ; acidified

参考文献：

Synthesis of pyrazoline derivatives from chalcones and their antibacterial activity

Yazdan, Shaik Khadar; Sowjanya, K. Renuka; Avinash, K. Sai; Kumari, M. Ratna, Journal of Applicable Chemistry (Lumami, 2013, 2(6), 1679-1682

合成路线：1 步

_98%

反应条件：

1.1 Catalysts: 1H-Imidazolium, 2-methyl-1,3-disulfo-, 2,2,2-trifluoroacetate (1:1) ; 10 min, 100 °C

参考文献：

Bronsted Acidic Ionic Liquids Catalysed Sequential Michael-Like Addition of Indole with Chalcones via Claisen-Schmidt Condensation

Das, Sukanya; Porashar, Bikoshita; Saikia, Susmita; Borah, Ruli, ChemistrySelect, 2020, 5(10), 3041-3047

合成路线：1 步

_98%

反应条件：

1.1 Catalysts: p-Toluenesulfonic acid , Montmorillonite ((Al1.33-1.67Mg0.33-0.67)(Ca0-1Na0-1)0.33Si4(OH)2O10.xH2O) ; 3 h, 80 °C

参考文献：

Synthesis of α,α'-bis(substituted benzylidene)cycloalkanones and chalcones catalyzed with p-Toluenesulfonic acid (PTSA) on montmorillonite K10 under solvent-free conditions

Hashemi, Mohammed M.; Khalili, Behzad; Eftekhari-Sis, Bagher, Organic Chemistry: An Indian Journal, 2006, 2(5-6), 150-157

合成路线：1 步

_98%

反应条件：

1.1 Reagents: Sodium hydroxide Solvents: Water ; 15 min, rt

参考文献：

Aldol condensation in water using polyethylene glycol 400

Tanemura, Kiyoshi; Suzuki, Tsuneo; Nishida, Yoko; Horaguchi, Takaaki, Chemistry Letters, 2005, 34(4), 576-577

合成路线：1 步

_98%

反应条件：

1.1 Catalysts: Alumina , Potassium fluoride ; 30 min, rt

参考文献：

Synthesis of α,β-unsaturated ketones by grinding method

Wang, Shu-Xiang; Li, Ji-Tai; Wang, Zhen-Hua, Youji Huaxue, 2004, 24(4), 447-449

合成路线：1 步

_98%

反应条件：

1.1 Reagents: Water Catalysts: Barium hydroxide Solvents: 1,4-Dioxane

参考文献：

Barium(II) hydroxide as catalyst in organic reactions. 20. Structure-catalytic activity relationship in the Wittig reaction

Climent, M. S.; Marinas, J. M.; Mouloungui, Z.; Le Bigot, Y.; Delmas, M.; et al, Journal of Organic Chemistry, 1989, 54(15), 3695-701

合成路线：1 步

_97%

反应条件：

1.1 Catalysts: Sodium hydroxide Solvents: Ethanol , Water ; 25 °C; 1 - 2 h, 25 °C

参考文献：

Synthesis and evaluation of chalcone derivatives and Schiff bases derivatives as antibacterial agents

Elsharif, Nada; Alnaily, Mohamed; Loujanqi, Amnnah, Journal of Modern Chemistry & Chemical Technology, 2018, 9(3), 1-7

合成路线：1 步

_97%

反应条件：

1.1 Catalysts: Sodium hydroxide Solvents: Ethanol , Water ; 3 - 5 h, rt

参考文献：

Synthesis and antimicrobial activity of some new pyrazoline derivatives bearing sulfanilamido moiety

Almahdi, Maysoon Mohammed ; Saeed, Ahmed Elsadig Mohammed ; Metwally, Nadia Hanafy, European Journal of Chemistry, 2019, 10(1), 30-36

合成路线：1 步

_97%

反应条件：

1.1 Catalysts: Sulfuric acid (silica supported) ; 3 h, 80 °C

参考文献：

Silica sulfuric acid as an efficient and reusable reagent for crossed-aldol condensation of ketones with aromatic aldehydes under solvent-free conditions

Salehi, Peyman; Dabiri, Minoo; Zolfigol, Mohammad Ali; Fard, Mohammad Ali Bodaghi, Journal of the Brazilian Chemical Society, 2004, 15(5), 773-776

合成路线：1 步

111873-49-5

_97%

反应条件：

1.1 Solvents: Tetrahydrofuran

参考文献：

Synthetic applications of organotellurium compounds. 1. A facile synthesis of α,β-unsaturated esters, ketones, and nitriles

Huang, Xian; Xie, Linghong; Wu, Hong, Journal of Organic Chemistry, 1988, 53(20), 4862-4

合成路线：1 步

_96%

反应条件：

1.1 Catalysts: Bromobenzene , Calcium oxide Solvents: Methanol ; 6 h, 60 °C

参考文献：

High efficient Aldol condensation reaction utilizing modified calcium oxide as stable solid base catalyst

Wang, Jin; Yan, Tianlan; Tang, Ying; Miao, Yanqing, Kinetics and Catalysis, 2016, 57(4), 439-445

合成路线：1 步

_96%

反应条件：

1.1 Reagents: Sodium hydroxide Solvents: Ethanol , Water ; 0 - 5 °C; 3 h, 20 - 25 °C
1.2 Reagents: Hydrochloric acid Solvents: Water ; pH 6 - 7

参考文献：

A facial synthesis and antimicrobial activity of some pyrazole derivatives carrying indole

Sarma, K. Narasimha; Subha, M. C. S.; Rao, K. Chowdoji, E-Journal of Chemistry, 2010, 7(3), 745-750

合成路线：1 步

_95%

反应条件：

1.1 Catalysts: Vanadate(1-), dioxo[sulfato(2-)-κO]-, hydrogen (1:1) ; 4 h, 70 °C

参考文献：

Catalytic Synthesis of Chalcones and Pyrazolines Using Nanorod Vanadatesulfuric Acid: An Efficient and Reusable Catalyst

Nasr-Esfahani, Masoud; Daghaghale, Mona; Taei, Mahbube, Journal of the Chinese Chemical Society (Weinheim, 2017, 64(1), 17-24

合成路线：1 步

_95%

反应条件：

1.1 Catalysts: Naphthalene (reaction products with Sulfuric acid) , Sulfuric acid (reaction product with Naphthalene) ; 100 min, 70 °C; 70 °C → rt
1.2 Reagents: Dichloromethane ; > 1 min, heated

参考文献：

Carbon-based solid acid as an efficient and reusable catalyst for cross-aldol condensation of ketones with aromatic aldehydes under solvent-free conditions

Zali, Abbas; Ghani, Kamal; Shokrolahi, Arash; Keshavarz, Mohammad Hossein, Cuihua Xuebao, 2008, 29(7), 602-606

合成路线：1 步

_95%

反应条件：

1.1 Catalysts: Potassium carbonate , Sodium hydroxide ; 8 min

参考文献：

Rapid synthesis of chalcones without solvent

Wang, Cunde; Guo, Ming-zhu; Zhou, Zhi-feng, Huaxue Shiji, 2004, 26(1),

合成路线：1 步

35086-79-4

960-16-7

_95%

反应条件：

1.1 Catalysts: Chlorodiphenylphosphine , Palladium chloride , Cellulose Solvents: Acetone

参考文献：

Study on the coupling reaction of organotins and acid chlorides catalyzed by cellulose oxyphosphine palladium complex

Wu, Chun; Li, Jian; Kong, Qi, Huaxue Tongbao, 2001, (3), 171-174

合成路线：1 步

_94%

反应条件：

1.1 Reagents: Sodium hydroxide Solvents: Ethanol , Water ; 5 min, 0 °C
1.2 Solvents: Ethanol ; overnight, rt

参考文献：

Concentrated Aqueous Peroxodicarbonate: Efficient Electrosynthesis and Use as Oxidizer in Epoxidations, S-, and N-Oxidations

Seitz, Ann-Katrin; Kohlpaintner, Philipp J.; van Lingen, Tim ; Dyga, Marco ; Sprang, Fiona; et al, Angewandte Chemie, 2022, 61(25),

合成路线：1 步

_94%