95882-33-0 (3-氧代-3-环丙基丙腈,3-Cyclopentyl-3-oxopropanenitrile)

_100%

反应条件：

1.1 Reagents: Sodium hydride Solvents: 1,4-Dioxane ; 30 min, rt
1.2 30 min, rt; 16 h, 105 °C; cooled
1.3 Reagents: Hydrochloric acid Solvents: Water ; acidified

参考文献：

Preparation of 7-oxo-4,7-dihydro-pyrazolo[1,5-a]pyrimidine derivatives which are useful in the treatment, amelioration or prevention of a viral disease

, World Intellectual Property Organization, , ,

合成路线：1 步

_100%

反应条件：

1.1 Reagents: Sodium hydride Solvents: 1,4-Dioxane ; 30 min, rt
1.2 30 min, rt; 16 h, 105 °C

参考文献：

Preparation of oxothiazolopyridine carbonic acid derivatives for use as antiviral agents

, World Intellectual Property Organization, , ,

合成路线：1 步

_93%

反应条件：

1.1 Reagents: Sodium bis(trimethylsilyl)amide Solvents: Tetrahydrofuran ; -14.6 °C; 50 min, -14.6 °C; < -3 °C; 10 min, -10 °C; -10 °C → 20 °C; 1 h, 20 °C; overnight, 24 °C; 24 °C → 3 °C
1.2 Reagents: Hydrochloric acid Solvents: Water ; < 27 °C

参考文献：

Process for preparing enantiomerically enriched JAK inhibitors

, United States, , ,

合成路线：1 步

_93%

反应条件：

1.1 Reagents: Sodium hydride Solvents: Tetrahydrofuran ; rt → 75 °C; 15 h, 70 °C

参考文献：

Preparation of Ruxolitinib intermediate

, China, , ,

合成路线：1 步

_93%

反应条件：

1.1 Reagents: Sodium hydride Solvents: Tetrahydrofuran ; reflux; 50 min, reflux; overnight, reflux; reflux → rt

参考文献：

Preparation of quinazoline derivatives as RAF kinase modulators for treating cancers, inflammations and immune diseases

, World Intellectual Property Organization, , ,

合成路线：1 步

_92%

反应条件：

1.1 Reagents: Sodium hydride Solvents: Tetrahydrofuran ; 65 °C; 16 h, 65 °C
1.2 Reagents: Water ; cooled
1.3 pH 4 - 5

参考文献：

Preparation of substituted pyrimidines as modulators of MYC family proto-oncogene protein

, World Intellectual Property Organization, , ,

合成路线：1 步

_90%

反应条件：

1.1 Reagents: Sodium hydride Solvents: Tetrahydrofuran ; overnight, reflux
1.2 Solvents: Water ; pH 8

参考文献：

Preparation of pyridine-based compounds as kinase inhibitors useful for treatment of proliferative diseases

, World Intellectual Property Organization, , ,

合成路线：1 步

_90%

反应条件：

1.1 Reagents: Sodium hydride Solvents: Tetrahydrofuran ; rt; overnight, reflux
1.2 Reagents: Hydrogen ion Solvents: Water ; pH 8

参考文献：

Preparation of heterocyclic ureas as kinase inhibitors useful for the treatment of proliferative and inflammatory diseases

, World Intellectual Property Organization, , ,

合成路线：1 步

4524-93-0

_86%

反应条件：

1.1 Reagents: Butyllithium Solvents: Tetrahydrofuran , Hexane ; -78 °C; 1 h, -78 °C
1.2 -78 °C; 1 h, -78 °C; -78 °C → rt
1.3 Reagents: Hydrochloric acid Solvents: Water

参考文献：

Preparation of pyrazoloquinazolinone and pyrroloquinazolinone derivatives as mGluR2 allosteric modulators useful for treatment of neurological, psychiatric, and other disorders

, World Intellectual Property Organization, , ,

合成路线：1 步

_77%