96801-39-7 (12-(7-硝基苯并呋咱-4-氨基)十二酸,12-(7-Nitrobenzofurazan-4-ylamino)dodecanoic acid)

_93%

反应条件：

1.1 Reagents: Sodium methoxide Solvents: Methanol ; 5 min, rt
1.2 Solvents: Methanol ; 18 h, 25 °C

参考文献：

Sensitive assay for hormone-sensitive lipase using NBD-labeled monoacylglycerol to detect low activities in rat adipocytes

Petry, Stefan; Ben Ali, Yassine; Chahinian, Henri; Jordan, Holger; Kleine, Horst; et al, Journal of Lipid Research, 2005, 46(3), 603-614

合成路线：1 步

_87%

反应条件：

1.1 Reagents: Sodium bicarbonate Solvents: Acetonitrile , Water ; 65 °C; 2 h, 65 °C

参考文献：

Shining new light on ancient drugs: preparation and subcellular localisation of novel fluorescent analogues of Cinchona alkaloids in intraerythrocytic Plasmodium falciparum

Woodland, John G.; Hunter, Roger; Smith, Peter J.; Egan, Timothy J., Organic & Biomolecular Chemistry, 2017, 15(3), 589-597

合成路线：1 步

_81%

反应条件：

1.1 Reagents: Sodium bicarbonate Solvents: Methanol ; 0.5 h, 0 °C; 1.5 h, rt; 1.5 h, 50 °C; 50 °C → rt

参考文献：

Synthesis of fluorescent C24-ceramide: Evidence for acyl chain length dependent differences in penetration of exogenous NBD-ceramides into human skin

Novotny, Jakub; Pospechova, Katerina; Hrabalek, Alexandr; Cap, Robert; Vavrova, Katerina, Bioorganic & Medicinal Chemistry Letters, 2009, 19(24), 6975-6977

合成路线：1 步

_78%

反应条件：

1.1 Reagents: Sodium bicarbonate Solvents: Methanol , Water ; 1.5 h, 50 °C
1.2 Reagents: Hydrochloric acid Solvents: Water

参考文献：

Porous Particle-Based Inkjet Printing of Flexible Fluorescent Films: Enhanced Sensing Performance and Advanced Encryption

Li, Min; Liu, Jianfei; Shang, Congdi; Liu, Ke; Qi, Yanyu; et al, Advanced Materials Technologies (Weinheim, 2019, 4(8),

合成路线：1 步

1611440-96-0

_67%

反应条件：

1.1 Reagents: Potassium trimethylsilanolate Solvents: Diethyl ether ; 48 h, rt

参考文献：

Development of a Novel FRET Probe for the Real-Time Determination of Ceramidase Activity

Bhabak, Krishna P.; Hauser, Anett; Redmer, Susanne; Banhart, Sebastian; Heuer, Dagmar; et al, ChemBioChem, 2013, 14(9), 1049-1052

合成路线：1 步

_65%

反应条件：

1.1 Reagents: Diisopropylethylamine Solvents: Methanol ; overnight, rt
1.2 Reagents: Hydrochloric acid Solvents: Water ; rt

参考文献：

Differential sensing for the regio- and stereoselective identification and quantitation of glycerides

Diehl, Katharine L.; Ivy, Michelle Adams; Rabidoux, Scott; Petry, Stefan Matthias; Muller, Gunter; et al, Proceedings of the National Academy of Sciences of the United States of America, 2015, 112(30),

合成路线：1 步

_64%

反应条件：

1.1 Reagents: Sodium bicarbonate Solvents: Methanol , Water ; 1.5 h, 50 °C; 50 °C → rt
1.2 Reagents: Hydrochloric acid Solvents: Water ; neutralized

参考文献：

Visualization of sialyl LewisX glycosphingolipid microdomains in model membranes as selectin recognition motifs using a fluorescence label

Gege, Christian; Schumacher, Gabriele; Rothe, Ulrich; Schmidt, Richard R.; Bendas, Gerd, Carbohydrate Research, 2008, 343(14), 2361-2368

合成路线：1 步

_56%

反应条件：

1.1 Reagents: Sodium bicarbonate Solvents: Ethanol , Water ; 10 min, 37 °C
1.2 overnight, 37 °C
1.3 Reagents: Hydrochloric acid Solvents: Water

参考文献：

Design and synthesis of fluorescence-labeled closo-dodecaborate lipid: its liposome formation and in vivo imaging targeting of tumors for boron neutron capture therapy

Nakamura, Hiroyuki; Ueda, Noriko; Ban, Hyun Seung; Ueno, Manabu; Tachikawa, Shoji, Organic & Biomolecular Chemistry, 2012, 10(7), 1374-1380

合成路线：1 步

_36%

反应条件：

1.1 Reagents: Sodium bicarbonate Solvents: Methanol ; 3 h, 50 °C

参考文献：

Identification and characterization of a single high-affinity fatty acid binding site in human serum albumin

Wenskowsky, Lea; Schreuder, Herman; Derdau, Volker; Matter, Hans; Volkmar, Julia; et al, Angewandte Chemie, 2018, 57(4), 1044-1048

合成路线：1 步

_36%

反应条件：

1.1 Reagents: Sodium bicarbonate Solvents: Methanol ; rt → 80 °C; 3 h, 80 °C; 80 °C → rt
1.2 Reagents: Hydrochloric acid Solvents: Water ; pH 3

参考文献：

Fluorescence-labelled fatty acids binding to fatty acid-binding compound to elicit FRET (Foerster resonance energy transfer) and uses thereof

, World Intellectual Property Organization, , ,

合成路线：1 步

反应条件：

1.1 Reagents: Diisopropylethylamine Solvents: Methanol ; overnight, rt

参考文献：

Calcium ions enable noncovalent dimers of phosphopeptides to form self-oriented filaments

Guo, Jiaqi; Liu, Chen; Huang, Yimeng; Tan, Weiyi; He, Hongjian; et al, ChemRxiv, 2022, , 1-19

合成路线：1 步