97614-43-2 (2-脱氧-2-氟-1,3,5-三苯甲酰基-alpha-D-阿拉伯呋喃糖,2-Deoxy-2-fluoro-1,3,5-tri-O-benzoyl-D-ribofuranose)

_95%

反应条件：

1.1 Reagents: (Diethylamino)sulfur trifluoride Solvents: Dichloromethane ; rt; 12 h, rt → 40 °C; 12 h, 40 °C
1.2 Reagents: Sodium bicarbonate Solvents: Dichloromethane , Water

参考文献：

Positron emission tomography probe demonstrates a striking concentration of ribose salvage in the liver

Clark, Peter M.; Flores, Graciela; Evdokimov, Nikolai M.; McCracken, Melissa N.; Chai, Timothy; et al, Proceedings of the National Academy of Sciences of the United States of America, 2014, 111(28),

合成路线：1 步

_95%

反应条件：

1.1 Reagents: Triethylamine trihydrofluoride Solvents: Ethyl acetate ; 60 °C; 60 °C → 70 °C
1.2 Reagents: Triethylamine ; 10 h, 70 °C; 70 °C → rt
1.3 Reagents: Sodium bicarbonate Solvents: Water ; neutralized, cooled

参考文献：

Process for preparation of Clofarabine intermediate 2-deoxy-2-fluoro-3,5-di-O-benzoyl-α-D-arabinofuranosyl bromide

, China, , ,

合成路线：1 步

_95%

反应条件：

1.1 Reagents: Hydrofluoric acid , Potassium bifluoride Solvents: (±)-Propylene glycol , Water ; rt → 160 °C; 130 - 160 °C; 5 h, 130 - 160 °C; cooled
1.2 Reagents: Water ; 1 h, cooled

参考文献：

Method for preparing clofarabine with high yield

, China, , ,

合成路线：1 步

_95%

反应条件：

1.1 Reagents: Deoxo-Fluor Solvents: Toluene
1.2 Reagents: Sodium bicarbonate Solvents: Water

参考文献：

Synthesis of 2-deoxy-2-fluoro-arabinose derivatives

, European Patent Organization, , ,

合成路线：1 步

69339-86-2

_94%

反应条件：

1.1 Reagents: (Diethylamino)sulfur trifluoride Solvents: Dichloromethane ; 15 h, reflux

参考文献：

Reactivity between acetone and single-stranded DNA containing a 5'-capped 2'-fluoro-N7-methyl guanine

Mohan, Utpal; Burai, Ritwik; McNaughton, Brian R., Tetrahedron Letters, 2014, 55(22), 3358-3360

合成路线：1 步

314289-48-0

_91%

反应条件：

1.1 Reagents: (Diethylamino)sulfur trifluoride Solvents: Dichloromethane ; 15 h, reflux

参考文献：

Synthesis and Structure of Duplex DNA Containing the Genotoxic Nucleobase Lesion N7-Methylguanine

Lee, Seongmin; Bowman, Brian R.; Ueno, Yoshihito; Wang, Shuyu; Verdine, Gregory L., Journal of the American Chemical Society, 2008, 130(35), 11570-11571

合成路线：1 步

_91%

反应条件：

1.1 Reagents: Triethylamine , Hydrofluoric acid Solvents: Ethyl acetate , Water ; 3 h, 80 °C
1.2 Reagents: Triethylamine ; 3 h, heated

参考文献：

Synthesis of clofarabine

Chen, Lili; Cen, Junda, Zhongguo Yiyao Gongye Zazhi, 2006, 37(8), 508-510

合成路线：1 步

97614-50-1

_90%

反应条件：

1.1 Reagents: Triethylamine trihydrofluoride Solvents: Ethyl acetate

参考文献：

Triethylamine poly(hydrogen fluorides) in the synthesis of a fluorinated nucleoside glycon

Chou, T. S.; Becke, Lisa M.; O'Toole, John C.; Carr, M. Austin; Parker, Bruce E., Tetrahedron Letters, 1996, 37(1), 17-20

合成路线：1 步

_87%

反应条件：

1.1 Reagents: Triethylamine trihydrofluoride Solvents: Ethyl acetate ; 3 h, rt → 60 °C; 1.5 h, 70 °C
1.2 Reagents: Water ; cooled

参考文献：

Pharmaceutical application of 2'-fluoro-4'-azido-nucleoside analog or its salt

, China, , ,

合成路线：1 步

_85%

反应条件：

1.1 Reagents: Benzyltriethylammonium chloride , Potassium fluoride Solvents: Chloroform , Water ; 4 h, 60 °C
1.2 Reagents: Ammonia Solvents: Water ; pH 7 - 8, cooled

参考文献：

Improved synthesis of clofarabine

Guo, Shunmin; Deng, Sishan; Qi, Yiping; Lin, Sui, Zhongguo Xiandai Yingyong Yaoxue, 2009, 26(2), 123-125

合成路线：1 步

_85%

反应条件：

1.1 Reagents: Hydrofluoric acid Catalysts: Iron(III) acetylacetonate Solvents: 1,4-Dioxane

参考文献：

Preparation of fluoro-sugars and other fluoro compounds

, World Intellectual Property Organization, , ,

合成路线：1 步

_83%

反应条件：

1.1 Reagents: Deoxo-Fluor Solvents: Dichloromethane ; 50 °C

参考文献：

Sulfur, Trifluoro[2-methoxy-N-(2-methoxyethyl)ethanaminato-κN]-,(T-4)-

Cannon, Kevin C.; Krow, Grant R., e-EROS Encyclopedia of Reagents for Organic Synthesis, 2010, , 1-7

合成路线：1 步

_83%

反应条件：

1.1 Reagents: Deoxo-Fluor Solvents: Dichloromethane ; 50 °C

参考文献：

Synthesis of 2',3'-Dideoxy-2'-fluoro-3'-thioarabinothymidine and its 3'-Phosphoramidite Derivative

Elzagheid, Mohamed I.; Tedeschi, Anna Lisa; Damha, Masad J., Nucleosides, 2003, 22(5-8), 1343-1346

合成路线：1 步

97614-41-0

_78%

反应条件：

1.1 Reagents: Triethylamine , Triethylamine trihydrofluoride Solvents: Acetonitrile ; 36 h, 60 °C
1.2 Reagents: Water

参考文献：

Preparation of thiouracil nucleoside analogs for treatment of viruses and cancer

, India, , ,

合成路线：1 步

_73%

反应条件：

1.1 Reagents: Pyridine , Trifluoromethanesulfonic acid Solvents: Acetonitrile ; 0.5 h, rt
1.2 Reagents: Triethylamine , Triethylamine trihydrofluoride ; 18 h, 50 °C
1.3 Solvents: Water

参考文献：

Direct and convenient conversion of alcohols to fluorides

Yin, Jingjun; Zarkowsky, Devin S.; Thomas, David W.; Zhao, Matthew M.; Huffman, Mark A., Organic Letters, 2004, 6(9), 1465-1468

合成路线：1 步

_71%

反应条件：

1.1 Reagents: (Diethylamino)sulfur trifluoride Solvents: Dichloromethane

参考文献：

2'-Deoxy-2'-fluoro-β-D-arabinonucleosides and oligonucleotides (2'F-ANA): synthesis and physicochemical studies

Wilds, Christopher J.; Damha, Masad J., Nucleic Acids Research, 2000, 28(18), 3625-3635

合成路线：1 步

_66%

反应条件：

1.1 Reagents: (Diethylamino)sulfur trifluoride Solvents: Dichloromethane ; 18 h, 40 - 42 °C

参考文献：

Method for synthesizing nucleoside analog clofarabine

, China, , ,

合成路线：1 步

_66%

反应条件：

1.1 Reagents: Triethylamine trihydrofluoride Solvents: Ethyl acetate ; rt → 60 °C; 3 h, 60 °C; 1.5 h, 70 °C
1.2 Reagents: Sodium chloride Solvents: Water ; cooled

参考文献：

Preparation of 2'-fluoro-4'-substituted nucleoside analogs as antiviral agents

, China, , ,

合成路线：1 步

_58%